JP2006501265A5 - - Google Patents
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- JP2006501265A5 JP2006501265A5 JP2004535478A JP2004535478A JP2006501265A5 JP 2006501265 A5 JP2006501265 A5 JP 2006501265A5 JP 2004535478 A JP2004535478 A JP 2004535478A JP 2004535478 A JP2004535478 A JP 2004535478A JP 2006501265 A5 JP2006501265 A5 JP 2006501265A5
- Authority
- JP
- Japan
- Prior art keywords
- metabotropic glutamate
- glutamate receptor
- antagonist
- drug
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 55
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 41
- 229960002715 nicotine Drugs 0.000 claims description 41
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 41
- 239000003814 drug Substances 0.000 claims description 38
- 229940079593 drug Drugs 0.000 claims description 34
- 239000005557 antagonist Substances 0.000 claims description 33
- 229960003920 cocaine Drugs 0.000 claims description 27
- NEWKHUASLBMWRE-UHFFFAOYSA-N 2-methyl-6-(phenylethynyl)pyridine Chemical group CC1=CC=CC(C#CC=2C=CC=CC=2)=N1 NEWKHUASLBMWRE-UHFFFAOYSA-N 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 23
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 claims description 21
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- 102100038352 Metabotropic glutamate receptor 3 Human genes 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 108010038445 metabotropic glutamate receptor 3 Proteins 0.000 claims description 17
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 16
- 229930195712 glutamate Natural products 0.000 claims description 16
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
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- 229940127240 opiate Drugs 0.000 claims description 3
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- AHOUBRCZNHFOSL-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine Chemical compound C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 5
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- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 3
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- DHMLNZRDVQLQBB-UHFFFAOYSA-N 4-iodo-n-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-n-pyridin-2-ylbenzamide Chemical compound COC1=CC=CC=C1N1CCN(CCN(C(=O)C=2C=CC(I)=CC=2)C=2N=CC=CC=2)CC1 DHMLNZRDVQLQBB-UHFFFAOYSA-N 0.000 description 2
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- IXRNQIKIVWWFBH-UHFFFAOYSA-N n-(1-phenylethenyl)acetamide Chemical compound CC(=O)NC(=C)C1=CC=CC=C1 IXRNQIKIVWWFBH-UHFFFAOYSA-N 0.000 description 1
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- WIQRCHMSJFFONW-UHFFFAOYSA-N norfluoxetine Chemical compound C=1C=CC=CC=1C(CCN)OC1=CC=C(C(F)(F)F)C=C1 WIQRCHMSJFFONW-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40986702P | 2002-09-10 | 2002-09-10 | |
| PCT/EP2003/010061 WO2004024150A2 (en) | 2002-09-10 | 2003-09-10 | Mglu receptors antagonists for treating disorders associated with mglu receptors including addiction and depression |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010113270A Division JP2010174039A (ja) | 2002-09-10 | 2010-05-17 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
| JP2013231434A Division JP2014074032A (ja) | 2002-09-10 | 2013-11-07 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006501265A JP2006501265A (ja) | 2006-01-12 |
| JP2006501265A5 true JP2006501265A5 (https=) | 2006-10-26 |
Family
ID=31994019
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004535478A Withdrawn JP2006501265A (ja) | 2002-09-10 | 2003-09-10 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
| JP2010113270A Pending JP2010174039A (ja) | 2002-09-10 | 2010-05-17 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
| JP2013231434A Pending JP2014074032A (ja) | 2002-09-10 | 2013-11-07 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010113270A Pending JP2010174039A (ja) | 2002-09-10 | 2010-05-17 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
| JP2013231434A Pending JP2014074032A (ja) | 2002-09-10 | 2013-11-07 | 嗜癖および鬱病を含むｍｇｌｕレセプターに関連する疾患を処置するためのｍｇｌｕレセプターアンタゴニスト |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8354447B2 (https=) |
| EP (1) | EP1539149B1 (https=) |
| JP (3) | JP2006501265A (https=) |
| CN (2) | CN1694701A (https=) |
| AT (1) | ATE539768T1 (https=) |
| AU (1) | AU2003270166A1 (https=) |
| BR (1) | BR0314192A (https=) |
| CA (1) | CA2498022C (https=) |
| ES (1) | ES2381664T3 (https=) |
| WO (1) | WO2004024150A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| PT1578422E (pt) | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| AU2007224584A1 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| CN101801930B (zh) | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
| PL2200985T3 (pl) | 2007-09-14 | 2011-12-30 | Ortho Mcneil Janssen Pharmaceuticals Inc | 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| US8685404B2 (en) * | 2011-01-31 | 2014-04-01 | Oregon Health & Science University | Recombinant T-cell receptor ligand for the treatment of cognitive and neuropsychiatric impairment induced by substance addiction |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| MX386697B (es) | 2014-01-21 | 2025-03-19 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso |
| ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
| EP3661500B1 (en) | 2017-07-31 | 2026-01-07 | Novartis AG | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN110151184A (zh) * | 2019-04-19 | 2019-08-23 | 昆明依利科特科技有限公司 | 非接触式吸毒人员快速检测系统及方法 |
| IL303248A (en) * | 2020-12-11 | 2023-07-01 | Novartis Ag | Use of mglur5 antagonists for treating amphetamine addiction |
| CN114088427A (zh) * | 2021-11-22 | 2022-02-25 | 昆明理工大学 | 一种用于惯容器/悬架的性能测试试验台及试验方法 |
Family Cites Families (3)
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|---|---|---|---|---|
| BR0014859A (pt) * | 1999-10-15 | 2002-07-16 | Hoffmann La Roche | Derivados de benzodiazepina |
| GB0005700D0 (en) | 2000-03-09 | 2000-05-03 | Glaxo Group Ltd | Therapy |
| US6916821B2 (en) * | 2001-04-02 | 2005-07-12 | Brown University | Methods of treating disorders with Group I mGluR antagonists |
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2003
- 2003-09-10 CN CNA038250217A patent/CN1694701A/zh active Pending
- 2003-09-10 AU AU2003270166A patent/AU2003270166A1/en not_active Abandoned
- 2003-09-10 CA CA2498022A patent/CA2498022C/en not_active Expired - Fee Related
- 2003-09-10 AT AT03750512T patent/ATE539768T1/de active
- 2003-09-10 ES ES03750512T patent/ES2381664T3/es not_active Expired - Lifetime
- 2003-09-10 CN CN2012102160928A patent/CN102793698A/zh active Pending
- 2003-09-10 JP JP2004535478A patent/JP2006501265A/ja not_active Withdrawn
- 2003-09-10 EP EP03750512A patent/EP1539149B1/en not_active Expired - Lifetime
- 2003-09-10 BR BR0314192-6A patent/BR0314192A/pt not_active Application Discontinuation
- 2003-09-10 WO PCT/EP2003/010061 patent/WO2004024150A2/en not_active Ceased
- 2003-09-10 US US10/527,525 patent/US8354447B2/en not_active Expired - Fee Related
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2010
- 2010-05-17 JP JP2010113270A patent/JP2010174039A/ja active Pending
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2012
- 2012-12-19 US US13/694,637 patent/US20130210849A1/en not_active Abandoned
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- 2013-11-07 JP JP2013231434A patent/JP2014074032A/ja active Pending
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