JP2006501238A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006501238A5 JP2006501238A5 JP2004530464A JP2004530464A JP2006501238A5 JP 2006501238 A5 JP2006501238 A5 JP 2006501238A5 JP 2004530464 A JP2004530464 A JP 2004530464A JP 2004530464 A JP2004530464 A JP 2004530464A JP 2006501238 A5 JP2006501238 A5 JP 2006501238A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- hexyloxy
- carboxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- ZJKZKKPIKDNHDM-UHFFFAOYSA-L calcium;6-(5-carboxylato-5-methylhexoxy)-2,2-dimethylhexanoate Chemical compound [Ca+2].[O-]C(=O)C(C)(C)CCCCOCCCCC(C)(C)C([O-])=O ZJKZKKPIKDNHDM-UHFFFAOYSA-L 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 229940111134 coxibs Drugs 0.000 claims 3
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 3
- 150000001983 dialkylethers Chemical class 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 2
- 229960000590 celecoxib Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims 2
- 229960002004 valdecoxib Drugs 0.000 claims 2
- SDMBRCRVFFHJKR-UHFFFAOYSA-N 6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid Chemical compound OC(=O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O SDMBRCRVFFHJKR-UHFFFAOYSA-N 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 230000008407 joint function Effects 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 229960004662 parecoxib Drugs 0.000 claims 1
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40525002P | 2002-08-22 | 2002-08-22 | |
| PCT/IB2003/003664 WO2004017952A1 (en) | 2002-08-22 | 2003-08-13 | Method of treating osteoarthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006501238A JP2006501238A (ja) | 2006-01-12 |
| JP2006501238A5 true JP2006501238A5 (https=) | 2006-09-28 |
Family
ID=31946834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004530464A Withdrawn JP2006501238A (ja) | 2002-08-22 | 2003-08-13 | 骨関節炎を治療する方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1539127A1 (https=) |
| JP (1) | JP2006501238A (https=) |
| KR (1) | KR20050058454A (https=) |
| CN (1) | CN1678297A (https=) |
| AU (1) | AU2003255937A1 (https=) |
| BR (1) | BR0313883A (https=) |
| CA (1) | CA2494544A1 (https=) |
| IL (1) | IL166600A0 (https=) |
| MX (1) | MXPA05001254A (https=) |
| PL (1) | PL375742A1 (https=) |
| TW (1) | TW200410677A (https=) |
| WO (1) | WO2004017952A1 (https=) |
| ZA (1) | ZA200501133B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004105801A1 (en) * | 2003-05-30 | 2004-12-09 | Warner-Lambert Company Llc | Animal model for the alleviation of pain using il-6 |
| WO2005002557A1 (en) * | 2003-07-03 | 2005-01-13 | Warner-Lambert Company Llc | Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof |
| US20050026979A1 (en) * | 2003-07-31 | 2005-02-03 | Maha Ghazzi | Methods for treating inflammation and inflammation-associated diseases with a statin and ether |
| DE102008000237A1 (de) | 2007-02-06 | 2008-08-07 | Basf Se | Phenol-Imidazolderivate zur Stabilisierung von polymerisationsfähigen Verbindungen |
| IL181577A0 (en) * | 2007-02-26 | 2007-07-04 | Jacob Bar Tana | Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders |
| US8530420B2 (en) * | 2008-12-16 | 2013-09-10 | Kaohsiung Medical University | Treatment of arthritis with parathyroid hormone |
| TWI382841B (zh) | 2010-10-29 | 2013-01-21 | Univ China Medical | 用於抑制發炎之醫藥組合物 |
| CA3059073A1 (en) * | 2017-04-18 | 2018-10-25 | Gemphire Therapeutics Inc. | Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor |
| JP2022505033A (ja) * | 2018-10-18 | 2022-01-14 | ジェムフィアー セラピューティクス インコーポレイテッド | ゲムカベン、薬学的に許容されるその塩、その組成物、およびその使用方法 |
| CN114847223B (zh) * | 2022-02-19 | 2023-11-07 | 昆明理工大学 | 一种建立oa食蟹猴模型的方法 |
| US12208085B2 (en) * | 2022-05-31 | 2025-01-28 | Ecuphar Nv | Pyrazoline-derived compound for use in the prevention and/or treatment of pain and inflammation associated to surgery in mammals |
| CN118750511A (zh) * | 2024-06-24 | 2024-10-11 | 中南大学湘雅医院 | 多元酸镁盐及其水合物在制备治疗或/和减缓关节疼痛的药物中的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648387A (en) * | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
| SK10622002A3 (sk) * | 2000-01-25 | 2003-07-01 | Warner-Lambert Company | Étery dikarboxylátu vápenatého, metódy ich výroby a ich využitie na liečbu vaskulárnych chorôb a diabetu |
| US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
-
2003
- 2003-08-13 EP EP03792585A patent/EP1539127A1/en not_active Ceased
- 2003-08-13 AU AU2003255937A patent/AU2003255937A1/en not_active Abandoned
- 2003-08-13 PL PL03375742A patent/PL375742A1/xx not_active Application Discontinuation
- 2003-08-13 JP JP2004530464A patent/JP2006501238A/ja not_active Withdrawn
- 2003-08-13 BR BR0313883-6A patent/BR0313883A/pt not_active IP Right Cessation
- 2003-08-13 MX MXPA05001254A patent/MXPA05001254A/es unknown
- 2003-08-13 WO PCT/IB2003/003664 patent/WO2004017952A1/en not_active Ceased
- 2003-08-13 CA CA002494544A patent/CA2494544A1/en not_active Abandoned
- 2003-08-13 CN CNA038199513A patent/CN1678297A/zh active Pending
- 2003-08-13 KR KR1020057003022A patent/KR20050058454A/ko not_active Ceased
- 2003-08-21 TW TW092123032A patent/TW200410677A/zh unknown
-
2005
- 2005-01-31 IL IL16660005A patent/IL166600A0/xx unknown
- 2005-02-08 ZA ZA200501133A patent/ZA200501133B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006501238A5 (https=) | ||
| JP2003525933A5 (https=) | ||
| EP2266946A3 (en) | Compound For The Treatment Of Metabolic Disorders | |
| ATE530066T1 (de) | Verbindungen zur behandlung von stoffwechselstörungen | |
| JP2008540554A5 (https=) | ||
| JP2007534702A5 (https=) | ||
| JP2010533727A5 (https=) | ||
| JP2010534247A5 (https=) | ||
| JP2005539054A5 (https=) | ||
| JP2004518723A5 (https=) | ||
| JP2011520906A5 (https=) | ||
| JP2009530398A5 (https=) | ||
| ATE487474T1 (de) | Verbindungen zur behandlung von stoffwechselstörungen | |
| JP2004501940A5 (https=) | ||
| ATE526018T1 (de) | Verbindungen zur behandlung von stoffwechselstörungen | |
| UA95613C2 (ru) | Соединения для лечения расстройсв метаболизма | |
| EP1618086A4 (en) | COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER | |
| JP2004525183A5 (https=) | ||
| JP2005526773A5 (https=) | ||
| JP2002522385A5 (https=) | ||
| JP2004521150A5 (https=) | ||
| JP2002522386A5 (https=) | ||
| JP2007531717A5 (https=) | ||
| JP2005526149A5 (https=) | ||
| JP2008542386A5 (https=) |