JP2006322889A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006322889A5 JP2006322889A5 JP2005148253A JP2005148253A JP2006322889A5 JP 2006322889 A5 JP2006322889 A5 JP 2006322889A5 JP 2005148253 A JP2005148253 A JP 2005148253A JP 2005148253 A JP2005148253 A JP 2005148253A JP 2006322889 A5 JP2006322889 A5 JP 2006322889A5
- Authority
- JP
- Japan
- Prior art keywords
- biosensor
- cygdh
- layer
- electrode
- cell membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 43
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 38
- 239000008103 glucose Substances 0.000 claims description 38
- 150000003904 phospholipids Chemical class 0.000 claims description 32
- 210000004027 cell Anatomy 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 27
- 102000018832 Cytochromes Human genes 0.000 claims description 21
- 108010052832 Cytochromes Proteins 0.000 claims description 21
- 230000027756 respiratory electron transport chain Effects 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 13
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical group CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 claims description 12
- 230000003100 immobilizing effect Effects 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 11
- 108090000790 Enzymes Proteins 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 10
- 210000000170 cell membrane Anatomy 0.000 claims description 9
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 238000006356 dehydrogenation reaction Methods 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052804 chromium Inorganic materials 0.000 claims description 2
- 239000011651 chromium Substances 0.000 claims description 2
- 239000010410 layer Substances 0.000 description 90
- 102000004316 Oxidoreductases Human genes 0.000 description 31
- 108090000854 Oxidoreductases Proteins 0.000 description 31
- 239000008280 blood Substances 0.000 description 21
- 210000004369 blood Anatomy 0.000 description 21
- 239000003153 chemical reaction reagent Substances 0.000 description 21
- 239000000758 substrate Substances 0.000 description 21
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 20
- 229910052799 carbon Inorganic materials 0.000 description 20
- 230000004044 response Effects 0.000 description 19
- 238000005259 measurement Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 238000000089 atomic force micrograph Methods 0.000 description 7
- 244000005700 microbiome Species 0.000 description 6
- 230000004043 responsiveness Effects 0.000 description 6
- 125000006850 spacer group Chemical group 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 241000589513 Burkholderia cepacia Species 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 4
- 238000002848 electrochemical method Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 238000004040 coloring Methods 0.000 description 3
- 150000004696 coordination complex Chemical class 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000007650 screen-printing Methods 0.000 description 3
- 239000002344 surface layer Substances 0.000 description 3
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004502 linear sweep voltammetry Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 108091005703 transmembrane proteins Proteins 0.000 description 2
- 102000035160 transmembrane proteins Human genes 0.000 description 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
- OXYZDRAJMHGSMW-UHFFFAOYSA-N 3-chloropropyl(trimethoxy)silane Chemical compound CO[Si](OC)(OC)CCCCl OXYZDRAJMHGSMW-UHFFFAOYSA-N 0.000 description 1
- UUEWCQRISZBELL-UHFFFAOYSA-N 3-trimethoxysilylpropane-1-thiol Chemical compound CO[Si](OC)(OC)CCCS UUEWCQRISZBELL-UHFFFAOYSA-N 0.000 description 1
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 229920002978 Vinylon Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009118 appropriate response Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000003851 corona treatment Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- WOXXJEVNDJOOLV-UHFFFAOYSA-N ethenyl-tris(2-methoxyethoxy)silane Chemical compound COCCO[Si](OCCOC)(OCCOC)C=C WOXXJEVNDJOOLV-UHFFFAOYSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- -1 monosodium salt Chemical class 0.000 description 1
- KBJFYLLAMSZSOG-UHFFFAOYSA-N n-(3-trimethoxysilylpropyl)aniline Chemical compound CO[Si](OC)(OC)CCCNC1=CC=CC=C1 KBJFYLLAMSZSOG-UHFFFAOYSA-N 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000000276 potassium ferrocyanide Substances 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- GQIUQDDJKHLHTB-UHFFFAOYSA-N trichloro(ethenyl)silane Chemical compound Cl[Si](Cl)(Cl)C=C GQIUQDDJKHLHTB-UHFFFAOYSA-N 0.000 description 1
- JXUKBNICSRJFAP-UHFFFAOYSA-N triethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CCO[Si](OCC)(OCC)CCCOCC1CO1 JXUKBNICSRJFAP-UHFFFAOYSA-N 0.000 description 1
- QQQSFSZALRVCSZ-UHFFFAOYSA-N triethoxysilane Chemical compound CCO[SiH](OCC)OCC QQQSFSZALRVCSZ-UHFFFAOYSA-N 0.000 description 1
- DQZNLOXENNXVAD-UHFFFAOYSA-N trimethoxy-[2-(7-oxabicyclo[4.1.0]heptan-4-yl)ethyl]silane Chemical compound C1C(CC[Si](OC)(OC)OC)CCC2OC21 DQZNLOXENNXVAD-UHFFFAOYSA-N 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 239000005050 vinyl trichlorosilane Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005148253A JP5021183B2 (ja) | 2005-05-20 | 2005-05-20 | タンパク質固定化膜および固定化方法、ならびにバイオセンサ |
| EP06746594.8A EP1884771B1 (en) | 2005-05-20 | 2006-05-18 | Protein-immobilized membrane, method for immobilization of protein, enzyme-immobilized electrode, and biosensor |
| US11/920,782 US20090101499A1 (en) | 2005-05-20 | 2006-05-18 | Protein-Immobilized membrane, method for immobilization of protein, enzyme-immobilized electrode, and biosensor |
| PCT/JP2006/309906 WO2006123730A1 (ja) | 2005-05-20 | 2006-05-18 | タンパク質固定膜、タンパク質の固定化方法、酵素固定化電極、およびバイオセンサ |
| CN2006800226213A CN101203748B (zh) | 2005-05-20 | 2006-05-18 | 蛋白质固定膜、蛋白质的固定化方法、酶固定化电极和生物传感器 |
| US14/850,576 US9702843B2 (en) | 2005-05-20 | 2015-09-10 | Biosensor incorporating protein-immobilized membrane and method of immobilizing protein in biosensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005148253A JP5021183B2 (ja) | 2005-05-20 | 2005-05-20 | タンパク質固定化膜および固定化方法、ならびにバイオセンサ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006322889A JP2006322889A (ja) | 2006-11-30 |
| JP2006322889A5 true JP2006322889A5 (enExample) | 2008-03-06 |
| JP5021183B2 JP5021183B2 (ja) | 2012-09-05 |
Family
ID=37431302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005148253A Expired - Fee Related JP5021183B2 (ja) | 2005-05-20 | 2005-05-20 | タンパク質固定化膜および固定化方法、ならびにバイオセンサ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090101499A1 (enExample) |
| EP (1) | EP1884771B1 (enExample) |
| JP (1) | JP5021183B2 (enExample) |
| CN (1) | CN101203748B (enExample) |
| WO (1) | WO2006123730A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060091006A1 (en) * | 1999-11-04 | 2006-05-04 | Yi Wang | Analyte sensor with insertion monitor, and methods |
| EP1661516B1 (en) * | 2003-09-02 | 2012-08-15 | Koji Sode | Glucose sensor and glucose level measuring apparatus |
| JP2008243380A (ja) * | 2007-03-23 | 2008-10-09 | Sony Corp | 酵素固定化電極、燃料電池、電子機器、酵素反応利用装置および酵素固定化基体 |
| US8268604B2 (en) * | 2007-12-20 | 2012-09-18 | Abbott Point Of Care Inc. | Compositions for forming immobilized biological layers for sensing |
| US9653006B2 (en) | 2008-09-17 | 2017-05-16 | Avery Dennison Corporation | Activatable adhesive, labels, and related methods |
| WO2010090271A1 (ja) | 2009-02-09 | 2010-08-12 | アークレイ株式会社 | 電気化学センサーおよびその作製方法 |
| JP5432575B2 (ja) * | 2009-04-21 | 2014-03-05 | グンゼ株式会社 | バイオセンサ及びその製造方法 |
| WO2010126139A1 (ja) | 2009-04-30 | 2010-11-04 | 池田食研株式会社 | 蛋白質性電子メディエータ |
| CN102449086B (zh) | 2009-09-17 | 2014-08-13 | 艾利丹尼森公司 | 可活化粘合剂、标签及相关方法 |
| JP5665070B2 (ja) * | 2009-09-25 | 2015-02-04 | 独立行政法人産業技術総合研究所 | 酸化還元タンパク質固定化ナノ構造電極 |
| CN103344639B (zh) * | 2013-07-11 | 2015-10-28 | 山东大学 | 一种快速检测尿中吡咯加合物的检测管 |
| CN105492902B (zh) * | 2013-08-07 | 2020-07-24 | 爱科来株式会社 | 使用电化学式生物传感器的物质测量方法和测量装置 |
| EP3305721B1 (en) | 2015-06-08 | 2023-10-18 | Japan Science And Technology Agency | High-density micro-chamber array and measurement method using same |
| CN105355530B (zh) * | 2015-10-30 | 2017-08-11 | 三诺生物传感股份有限公司 | 一种用于试条电极预处理的等离子处理装置和方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0810208A (ja) | 1994-06-30 | 1996-01-16 | Toshiba Corp | 食器洗浄機 |
| US5650062A (en) * | 1995-03-17 | 1997-07-22 | Matsushita Electric Industrial Co., Ltd. | Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same |
| CN1321245A (zh) * | 1999-09-13 | 2001-11-07 | 松下电器产业株式会社 | 脂质修饰酶的制备方法及生物传感器 |
| JP2003525320A (ja) * | 2000-02-18 | 2003-08-26 | アスピラ バイオシステムズ,インコーポレイティド | 分子インプリンティング組成物、並びに高分子の結合及び分析方法 |
| US6458599B1 (en) | 2000-02-18 | 2002-10-01 | Aspira Biosystems, Inc. | Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules |
| JP2004512062A (ja) * | 2000-07-28 | 2004-04-22 | エモリー ユニバーシテイ | 人工膜から成る生物学的構成要素 |
| JP2002055076A (ja) * | 2000-09-08 | 2002-02-20 | Nec Corp | 電気化学センサ |
| WO2002036779A1 (fr) * | 2000-10-31 | 2002-05-10 | Koji Sode | Nouvelle glucose deshydrogenase et procede de production de la deshydrogenase |
| JP4385219B2 (ja) * | 2001-09-14 | 2009-12-16 | アークレイ株式会社 | 濃度測定方法 |
| EP1522592B1 (en) * | 2002-06-17 | 2008-08-06 | ARKRAY, Inc. | Glucose sensor with the use of glucose dehydrogenase |
| CN1672280A (zh) * | 2002-07-25 | 2005-09-21 | 松下电器产业株式会社 | 电解质膜和使用其的膜电极接合体以及燃料电池 |
| JP4250481B2 (ja) * | 2003-08-11 | 2009-04-08 | キヤノン株式会社 | 多孔質構造体 |
| EP1661516B1 (en) * | 2003-09-02 | 2012-08-15 | Koji Sode | Glucose sensor and glucose level measuring apparatus |
| WO2005030807A1 (ja) * | 2003-09-30 | 2005-04-07 | Koji Sode | グルコース脱水素酵素とシトクロームとの融合蛋白質 |
-
2005
- 2005-05-20 JP JP2005148253A patent/JP5021183B2/ja not_active Expired - Fee Related
-
2006
- 2006-05-18 EP EP06746594.8A patent/EP1884771B1/en not_active Not-in-force
- 2006-05-18 CN CN2006800226213A patent/CN101203748B/zh not_active Expired - Fee Related
- 2006-05-18 US US11/920,782 patent/US20090101499A1/en not_active Abandoned
- 2006-05-18 WO PCT/JP2006/309906 patent/WO2006123730A1/ja not_active Ceased
-
2015
- 2015-09-10 US US14/850,576 patent/US9702843B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9702843B2 (en) | Biosensor incorporating protein-immobilized membrane and method of immobilizing protein in biosensor | |
| Jung et al. | Polymeric mercaptosilane-modified platinum electrodes for elimination of interferants in glucose biosensors | |
| JP4184074B2 (ja) | バイオセンサ | |
| CA2474912C (en) | Electrochemical biosensor strip for analysis of liquid samples | |
| JP4073969B2 (ja) | 小さなサンプル容量中の被検体の測定のための電極 | |
| CA2328751C (en) | Microsphere containing sensor | |
| JP5052525B2 (ja) | 埋め込み可能な被分析物質センサで使用するための膜 | |
| JP2006322889A5 (enExample) | ||
| Turyan et al. | Patterning and characterization of surfaces with organic and biological molecules by the scanning electrochemical microscope | |
| US20110042225A1 (en) | Electrochemical nanocomposite biosensor system | |
| CN102308204B (zh) | 电化学传感器及其制备方法 | |
| CN101191783A (zh) | 生物传感器 | |
| JP3910148B2 (ja) | 排気口付き分析用具 | |
| JP2009500601A (ja) | 電極プリコンディショニング | |
| Turcu et al. | Ink‐Jet Microdispensing for the Formation of Gradients of Immobilised Enzyme Activity | |
| AU2006201650A1 (en) | Electrochemical-based analytical test strip with hydrophilicity enhanced metal electrodes | |
| Cai et al. | Miniaturized electroanalytical sensor systems in micromachined structures | |
| AU2006201649A1 (en) | Method for manufacturing an electrochemical-based analytical test strip with hydrophilicity enhanced metal electrodes | |
| Zhu et al. | An overview of Si-based biosensors | |
| Hiratsuka et al. | Electron transfer mediator micro-biosensor fabrication by organic plasma process | |
| JP2004212393A (ja) | バイオセンサ | |
| JP4089975B2 (ja) | 電気化学測定用電極およびその製造方法ならびに電気化学バイオセンサー | |
| JP2005083965A (ja) | 酵素機能電極及びコレステロールセンサ | |
| Zhang et al. | A Self‐Sampling‐and‐Flow Biosensor for Continuous Monitoring | |
| JP3525588B2 (ja) | グルコースバイオセンサ |