JP2006241075A - Transparent aqueous composition - Google Patents
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- JP2006241075A JP2006241075A JP2005059463A JP2005059463A JP2006241075A JP 2006241075 A JP2006241075 A JP 2006241075A JP 2005059463 A JP2005059463 A JP 2005059463A JP 2005059463 A JP2005059463 A JP 2005059463A JP 2006241075 A JP2006241075 A JP 2006241075A
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- ubiquinone
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- 239000000203 mixture Substances 0.000 title claims abstract description 50
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims abstract description 28
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000017471 coenzyme Q10 Nutrition 0.000 claims abstract description 26
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940035936 ubiquinone Drugs 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003921 oil Substances 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- -1 polyoxyethylene Polymers 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 8
- 239000004359 castor oil Substances 0.000 claims description 8
- 235000019438 castor oil Nutrition 0.000 claims description 8
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 8
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000006210 lotion Substances 0.000 description 12
- 239000002537 cosmetic Substances 0.000 description 11
- 238000013329 compounding Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- WMNULTDOANGXRT-UHFFFAOYSA-N bis(2-ethylhexyl) butanedioate Chemical compound CCCCC(CC)COC(=O)CCC(=O)OCC(CC)CCCC WMNULTDOANGXRT-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229940110767 coenzyme Q10 Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960004747 ubidecarenone Drugs 0.000 description 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
- WAYINTBTZWQNSN-UHFFFAOYSA-N 11-methyldodecyl 3,5,5-trimethylhexanoate Chemical compound CC(C)CCCCCCCCCCOC(=O)CC(C)CC(C)(C)C WAYINTBTZWQNSN-UHFFFAOYSA-N 0.000 description 1
- NFIHXTUNNGIYRF-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCC NFIHXTUNNGIYRF-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 239000004129 EU approved improving agent Substances 0.000 description 1
- 108091006149 Electron carriers Proteins 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical group CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- GORMSINSWZJIKL-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-dimethylpropyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(C)(C)COC(=O)C(CC)CCCC GORMSINSWZJIKL-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- HGKOWIQVWAQWDS-UHFFFAOYSA-N bis(16-methylheptadecyl) 2-hydroxybutanedioate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCCCCCCCCCC(C)C HGKOWIQVWAQWDS-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000490 cosmetic additive Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940124274 edetate disodium Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000008811 mitochondrial respiratory chain Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229940116422 propylene glycol dicaprate Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明は、水中にユビキノン及びIOB値が0.1〜0.4の油剤を配合した、透明水性組成物に関するものであり、化粧料、医薬部外品、医薬品、皮膚外用剤等として使用可能な透明水性組成物に関するものである。より詳細には、結晶性が高く、油剤への溶解性が悪いユビキノンを水中に安定に配合し、透明性に優れ、しかもべたつき感等のない良好な使用性の透明水性組成物に関するものである。 The present invention relates to a transparent aqueous composition comprising ubiquinone and an oil agent having an IOB value of 0.1 to 0.4 in water, and can be used as cosmetics, quasi-drugs, pharmaceuticals, skin external preparations, and the like. The present invention relates to a transparent aqueous composition. More specifically, the present invention relates to a clear aqueous composition having a high crystallinity and a poorly soluble ubiquinone in water, stably blended in water, excellent in transparency, and free from stickiness. .
ユビキノンは、別名コエンザイムQ10、ユビデカレノン、補酵素Q10等と呼ばれ、生体内でミトコンドリアの呼吸鎖の電子伝達体として作用しており、生体の重要なバイオファクターとして存在している物質である。これまで、代謝性強心剤として実用化されているほか、食品添加剤、化粧品添加剤としても使われており、安全性が高く、有用な化合物である。 Ubiquinone, also known as coenzyme Q10, ubidecarenone, called coenzyme Q 10 or the like, and acts as an electron carrier in the mitochondrial respiratory chain in vivo is a material present as an important bio factor of the living body. So far, it has been put to practical use as a metabolic cardiotonic agent, is also used as a food additive and cosmetic additive, and is a highly safe and useful compound.
しかし、ユビキノンは、結晶性が高い常温固体の油溶性物質であるため、水性組成物への配合が困難であった。特に、透明化粧水等の透明水性組成物として、ユビキノンを安定に配合する技術は見出されていなかった。 However, since ubiquinone is a room-temperature solid oil-soluble substance having high crystallinity, it has been difficult to blend into an aqueous composition. In particular, a technique for stably blending ubiquinone has not been found as a transparent aqueous composition such as transparent lotion.
このため、ユビキノンを水性組成物に配合するために、様々な検討がなされてきた。例えば、平均重合度10のポリグリセリンと炭素数18の脂肪酸のモノエステルと、平均重合度3〜6のポリグリセリンと炭素数18の脂肪酸のエステルとを併用して、ユビキノンを水中に微分散させる技術(例えば、特許文献1参照。)、ステロールと併用し、ユビキノンを乳化させる技術(例えば、特許文献2参照。)、ポリオキシエチレン40モル付加水素化ひまし油を用いて、水中にユビキノンを配合する技術(例えば、特許文献3参照。)等が挙げられる。 For this reason, in order to mix | blend ubiquinone with an aqueous composition, various examination has been made | formed. For example, polyglycerin having an average polymerization degree of 10 and a monoester of a fatty acid having 18 carbon atoms and polyglycerol having an average polymerization degree of 3 to 6 and an ester of a fatty acid having 18 carbon atoms are used together to finely disperse ubiquinone in water. Incorporating ubiquinone in water using a technique (for example, see Patent Document 1), a technique for emulsifying ubiquinone in combination with a sterol (for example, see Patent Document 2), polyoxyethylene 40 mol addition hydrogenated castor oil. Technology (for example, refer patent document 3) etc. are mentioned.
しかしながら、前記従来の技術は、水中にユビキノンを多量に配合することを目的としており、透明水性組成物とすることは開示されていない。また、平均重合度10のポリグリセリン脂肪酸モノエステルと、平均重合度3〜6のポリグリセリン脂肪酸エステルとを併用する技術等でも、界面活性剤によるべたつき感等を生じる場合があり、良好な使用性を得ることが困難であった。 However, the above-mentioned conventional technique aims to blend a large amount of ubiquinone in water, and does not disclose a transparent aqueous composition. In addition, even in a technique using a polyglycerin fatty acid monoester having an average degree of polymerization of 10 and a polyglycerin fatty acid ester having an average degree of polymerization of 3 to 6 in some cases, a sticky feeling due to the surfactant may occur, and the usability is good. It was difficult to get.
このため、ユビキノンを水中に安定に配合し、透明性に優れ、しかもべたつき感等のない良好な使用性の透明水性組成物の開発が求められていた。 For this reason, there has been a demand for the development of a transparent aqueous composition having a good usability in which ubiquinone is stably blended in water, excellent in transparency, and without stickiness.
かかる実情に鑑み、本発明者は鋭意検討した結果、ユビキノンをIOB値が0.1〜0.4の油剤に溶解し、水中に分散させると、上記課題が解決された透明水性組成物が得られることを見出し、本発明を完成させた。 In view of this situation, the present inventors have conducted intensive studies. As a result, when ubiquinone is dissolved in an oil agent having an IOB value of 0.1 to 0.4 and dispersed in water, a transparent aqueous composition in which the above-described problems are solved is obtained. The present invention has been completed.
すなわち本発明は、水中に次の成分(a)及び(b);
(a)ユビキノン
(b)IOB値が0.1〜0.4の油剤
を配合することを特徴とする透明水性組成物を提供するものである。
That is, the present invention provides the following components (a) and (b) in water:
(A) Ubiquinone (b) The transparent aqueous composition characterized by mix | blending the oil agent whose IOB value is 0.1-0.4 is provided.
また、成分(a)の配合量が0.0001〜0.05質量%であることを特徴とする前記透明水性組成物、成分(b)の配合量が0.0004〜0.12質量%であることを特徴とする前記透明水性組成物を提供するものである。 Moreover, the blending amount of the component (a) is 0.0001 to 0.05% by mass, and the blending amount of the component (b) is 0.0004 to 0.12% by mass. The transparent aqueous composition is characterized by being provided.
そして、成分(b)の配合量が、成分(a)の配合質量の1〜8倍であることを特徴とする前記何れかの透明水性組成物を提供するものである。 And the compounding quantity of a component (b) is 1-8 times the compounding mass of a component (a), The said any one transparent aqueous composition characterized by the above-mentioned is provided.
そして更に、成分(c)として可溶化剤を配合することを特徴とする前記何れかの透明水性組成物を提供するものである。また、成分(c)が、ポリオキシエチレン硬化ひまし油及び/又はイソステアリン酸ポリオキシエチレン硬化ひまし油であることを特徴とする前記何れかの透明水性組成物を提供するものである。 Further, the present invention provides any one of the above-described transparent aqueous compositions, wherein a solubilizer is blended as the component (c). In addition, the present invention provides any one of the above-described transparent aqueous compositions, wherein the component (c) is polyoxyethylene hydrogenated castor oil and / or polyoxyethylene hydrogenated castor oil isostearate.
そして、成分(c)の配合量が、成分(a)及び(b)の合計配合質量の3〜8倍であることを特徴とする前記何れかの透明水性組成物を提供するものである。 And the compounding quantity of a component (c) is 3-8 times the sum total compounding mass of a component (a) and (b), The said any one of the clear aqueous composition characterized by the above-mentioned is provided.
また、更に、成分(d)として低級アルコールを配合することを特徴とする前記何れかの透明水性組成物を提供するものである。 Further, the present invention provides any one of the above-described transparent aqueous compositions, wherein a lower alcohol is blended as the component (d).
本発明の透明水性組成物は、結晶性が高く、油剤への溶解性が悪いユビキノンを水中に安定に配合することができ、透明性に優れ、しかもべたつき感等のない良好な使用性を得ることができる。 The transparent aqueous composition of the present invention can stably blend ubiquinone, which has high crystallinity and poor solubility in an oil agent, into water, has excellent transparency, and has good usability without stickiness. be able to.
本発明に用いられる成分(a)のユビキノンは、別名コエンザイムQ10、ユビデカレノン、補酵素Q10等と呼ばれているものであり、2,3−ジメトキシ−5−メチル−6−ポリプレニル−1,4−ベンゾキノンの側鎖のイソプレン単位が10のユビキノン類である。このようなユビキノンは、化学合成や発酵等により製造されるが、本発明に用いるユビキノンは、製造方法には限定されず、何れのものも使用することができる。 Ubiquinone component (a) used in the present invention, also known as coenzyme Q10, are those which are referred to as ubidecarenone, coenzyme Q 10, etc., 2,3-dimethoxy-5-methyl-6-polyprenyl-1,4 -Ubiquinones having 10 isoprene units in the side chain of benzoquinone. Such ubiquinone is produced by chemical synthesis, fermentation, or the like, but the ubiquinone used in the present invention is not limited to the production method, and any one can be used.
本発明の水性透明組成物中における成分(a)の配合量は、特に限定されるものではないが、0.0001〜0.05質量%(以下、単に「%」と略す)が好ましく、0.001〜0.03%が好ましい。成分(a)をこの範囲で配合すると、安定性及び透明性がより良好な組成物を得ることができる。 The blending amount of component (a) in the aqueous transparent composition of the present invention is not particularly limited, but is preferably 0.0001 to 0.05% by mass (hereinafter simply referred to as “%”). 0.001 to 0.03% is preferable. When component (a) is blended in this range, a composition with better stability and transparency can be obtained.
本発明に用いられる成分(b)の油剤は、IOB値(※)が0.1〜0.4の油剤である。
※IOB値:無機性−有機性の比を示す値であり、油剤の極性を表し、
IOB値=無機性値/有機性値で規定される値である。
(甲田善生,「有機概念図―基礎と応用―」,三共出版(1984))
The oil agent of component (b) used in the present invention is an oil agent having an IOB value (*) of 0.1 to 0.4.
* IOB value: A value indicating the ratio of inorganic to organic, indicating the polarity of the oil,
IOB value = value defined by inorganic value / organic value.
(Yoshio Koda, “Organic Conceptual Diagram: Fundamentals and Applications”, Sankyo Publishing (1984))
このような成分(b)の油剤は、具体的には、トリ2-エチルヘキサン酸グリセリル、ジ-2-エチルヘキサン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジカプリン酸プロピレングリコール、イソノナン酸イソトリデシル、2−エチルヘキサン酸セチル、コハク酸ジ2-エチルヘキシル、イソステアリン酸、オクチルドデカノール、トリ(カプリル・カプリン酸)グリセリル、テトラオクタン酸ペンタエリスチル等が挙げられ、これらを一種又は二種以上用いることができる。
尚、これら成分(b)の油性の油剤の中でも、成分(d)の低級アルコールと相溶する油剤が好ましい。
Specifically, the oil agent of component (b) is glyceryl tri-2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, diisostearyl malate, propylene glycol dicaprate, isotridecyl isononanoate, Examples include cetyl 2-ethylhexanoate, di-2-ethylhexyl succinate, isostearic acid, octyldodecanol, glyceryl tri (capryl / capric acid), pentaerythryl tetraoctanoate, and the like. Can do.
Of these oily oils of component (b), oils that are compatible with the lower alcohol of component (d) are preferred.
本発明の透明水性組成物中における成分(b)の配合量は、特に限定されるものではないが、0.0004%〜0.12%が好ましい。更には、成分(a)のユビキノンの配合質量の1〜8倍が好ましく、1〜4倍がより好ましい。この範囲で成分(b)を配合すると、水中に成分(a)を安定に配合することができ、可溶化に用いる界面活性剤の配合量を低減できるため、べたつき感等の使用性の悪さをより低減することができる。 Although the compounding quantity of the component (b) in the transparent aqueous composition of this invention is not specifically limited, 0.0004%-0.12% are preferable. Furthermore, 1-8 times of the compounding mass of the ubiquinone of a component (a) is preferable, and 1-4 times are more preferable. When component (b) is blended in this range, component (a) can be blended stably in water, and the blending amount of surfactant used for solubilization can be reduced. It can be further reduced.
本発明の透明水性組成物には、成分(c)として可溶化剤を配合することが好ましい。このような成分(c)の可溶化剤は、通常の化粧料等に用いられる可溶化剤であり、水中に成分(a)及び(b)をより透明状態で、安定に配合するための成分である。このような成分(c)の可溶化剤は、イオン性界面活性剤、非イオン性界面活性剤、両イオン性界面活性剤等の何れでも良い。尚、より少量で成分(a)及び(b)を可溶化できる成分として、ポリオキシエチレン硬化ひまし油及び/又はイソステアリン酸ポリオキシエチレン硬化ひまし油を選択することが好ましい。 The transparent aqueous composition of the present invention preferably contains a solubilizer as component (c). Such a solubilizer of component (c) is a solubilizer used for ordinary cosmetics and the like, and a component for stably blending components (a) and (b) in water in a more transparent state. It is. Such a solubilizer for component (c) may be any of an ionic surfactant, a nonionic surfactant, an amphoteric surfactant, and the like. In addition, it is preferable to select polyoxyethylene hydrogenated castor oil and / or polyoxyethylene hydrogenated castor oil isostearate as a component capable of solubilizing components (a) and (b) with a smaller amount.
本発明の透明水性組成物における成分(c)の配合量は、特に限定されるものではないが、成分(a)及び(b)の合計配合質量の3〜8倍が好ましい。成分(c)をこの範囲で配合すると、べたつき感が無く使用性がより良好な組成物を得ることができる。 Although the compounding quantity of the component (c) in the transparent aqueous composition of this invention is not specifically limited, 3-8 times the sum total compounding mass of a component (a) and (b) is preferable. When component (c) is blended in this range, a composition having no stickiness and better usability can be obtained.
本発明の透明水性組成物には、成分(d)として低級アルコールを配合することにより、べたつき感が無く使用性がより良好な組成物を得ることができる。このような成分(d)としては、エタノール等が挙げられる。 By blending the transparent aqueous composition of the present invention with a lower alcohol as the component (d), a composition having no stickiness and better usability can be obtained. Examples of such component (d) include ethanol.
本発明の透明水性組成物における成分(d)の配合量は、特に限定されるものではないが、1〜30%が好ましく、3〜20%がより好ましい。成分(d)をこの範囲で配合すると、べたつき感が無く使用性がより良好な組成物を得ることができる。 Although the compounding quantity of the component (d) in the transparent aqueous composition of this invention is not specifically limited, 1-30% is preferable and 3-20% is more preferable. When component (d) is blended in this range, a composition having no stickiness and better usability can be obtained.
本発明の透明水性組成物には、前記成分の他に、通常の化粧料等に使用される成分として、成分(c)以外の界面活性剤、多価アルコール類、水溶性高分子、パラオキシ安息香酸誘導体、フェノキシエタノール等の防腐剤、紫外線吸収剤、保湿剤、抗菌剤、香料、塩類、酸化防止剤、pH調整剤、キレート剤、清涼剤、抗炎症剤、美肌用成分(美白剤、細胞賦活剤、肌荒れ改善剤、血行促進剤、皮膚収斂剤、抗脂漏剤等)、ビタミン類、アミノ酸類、核酸、ホルモン、包接化合物等を本発明の効果を損なわない範囲で適宜配合することができる。 In the transparent aqueous composition of the present invention, in addition to the above-mentioned components, surfactants other than component (c), polyhydric alcohols, water-soluble polymers, paraoxybenzoates, as components used in normal cosmetics and the like. Preservatives such as acid derivatives, phenoxyethanol, ultraviolet absorbers, moisturizers, antibacterial agents, fragrances, salts, antioxidants, pH adjusters, chelating agents, refreshing agents, anti-inflammatory agents, skin beautifying agents (whitening agents, cell activation agents) Agents, rough skin improving agents, blood circulation promoters, skin astringents, antiseborrheic agents, etc.), vitamins, amino acids, nucleic acids, hormones, clathrate compounds, etc. may be appropriately blended within the range not impairing the effects of the present invention. it can.
本発明の透明水性組成物の製造方法は、特に限定されるものではないが、例えば、成分(a)を成分(b)に溶解し、必要に応じて成分(c)〜(d)と混合し、水中に分散させる方法等が挙げられる。 Although the manufacturing method of the transparent aqueous composition of this invention is not specifically limited, For example, a component (a) is melt | dissolved in a component (b), and it mixes with a component (c)-(d) as needed. And a method of dispersing in water.
本発明の透明水性組成物は、化粧料、医薬部外品、医薬品、皮膚外用剤等として使用可能である。また、化粧料としての用途は、化粧水、美容液、ボディローション等が挙げられる。そして、化粧料としての性状は、液状が好ましいが、水性増粘剤を添加して、粘性を付与した性状でも良い。更に、化粧料としての使用方法は、手や指を用いて顔や体に塗布する方法、噴射剤と供に容器に充填しエアロゾルとして塗布する方法、不織布に含浸させて使用する方法等が挙げられる。 The transparent aqueous composition of the present invention can be used as cosmetics, quasi-drugs, pharmaceuticals, skin external preparations and the like. In addition, examples of the use as a cosmetic include skin lotion, cosmetic liquid, and body lotion. And the property as cosmetics is preferably liquid, but it may be a property imparted with viscosity by adding an aqueous thickener. Furthermore, examples of usage as cosmetics include a method of applying to the face and body using hands and fingers, a method of filling a container together with a propellant and applying as an aerosol, a method of using by impregnating a nonwoven fabric, and the like. It is done.
以下に、実施例を挙げて、本発明を更に詳細に説明する。尚、これらは本発明を何ら限定するものではない。 Hereinafter, the present invention will be described in more detail with reference to examples. Note that these do not limit the present invention.
実施例1〜7及び比較例1〜3:化粧水
表1〜3に示す組成の化粧水を以下に示す製造方法により調製し、「透明性」、「使用性」、「経時安定性」について、以下に示す評価方法により評価し、結果を併せて表1〜3に示した。
Examples 1 to 7 and Comparative Examples 1 to 3: Lotion Toner lotions having the compositions shown in Tables 1 to 3 were prepared by the production method shown below, and "transparency", "usability", and "aging stability" were used. Evaluation was made by the following evaluation method, and the results are shown in Tables 1 to 3.
(製造方法)
A.成分1〜12を均一に溶解する。(必要に応じて、50℃に加温する。)
B.成分13〜17を均一に溶解する。
C.Bを攪拌しながら、Aを添加し、均一に混合する。
D.Cを容器に充填して、化粧水を得た。
(Production method)
A. Ingredients 1-12 are uniformly dissolved. (If necessary, heat to 50 ° C.)
B. Ingredients 13-17 are uniformly dissolved.
C. While stirring B, add A and mix uniformly.
D. C was filled in a container to obtain a skin lotion.
〔評価方法1:透明性〕
実施例及び比較例の化粧水の製造直後の状態を目視観察し、以下の基準に従って評価した。
[外観状態] :[基 準]
透明 : ◎
青白色(微濁): △
白色(濁り) : ×
[Evaluation Method 1: Transparency]
The state immediately after manufacture of the lotion of an Example and a comparative example was observed visually, and it evaluated according to the following references | standards.
[Appearance state]: [Standard]
Transparent: ◎
Blue white (slight turbidity): △
White (turbid): ×
〔評価方法2:使用性〕
化粧品評価専門パネル20名に前記実施例及び比較例の化粧水を使用してもらい、塗布後のべたつき感の無さについて、各自が以下の基準に従って5段階評価し、化粧水毎に評点を付し、更に全パネルの評点の平均点を以下の判定基準に従って判定した。
評価基準:
[評価結果] :[評 点]
非常に良好 : 5点
良好 : 4点
普通 : 3点
やや不良 : 2点
不良 : 1点
判定基準:
[評点の平均点] :[判 定]
4.5以上 : ◎
3.5以上〜4.5未満 : ○
1.5以上〜3.5未満 : △
1.5未満 : ×
[Evaluation Method 2: Usability]
Twenty cosmetic panel specialists used the lotions of the above-mentioned examples and comparative examples, and evaluated each of the lotions according to the following criteria for the absence of stickiness after application. Furthermore, the average score of all panels was determined according to the following criteria.
Evaluation criteria:
[Evaluation Result]: [Score]
Very good: 5 points Good: 4 points Normal: 3 points Somewhat bad: 2 points Bad: 1 point Criteria:
[Average score]: [Judgment]
4.5 or more: ◎
3.5 or more and less than 4.5: ○
1.5 or more and less than 3.5: △
Less than 1.5: ×
〔評価方法3:経時安定性〕
実施例及び比較例の化粧水を5℃、室温、50℃の暗所にて1ヶ月間静置し、外観状態を目視観察し、下記基準に従って評価した。
[外観状態] :[基 準]
透明 : ◎
青白色(微濁): △
白色(濁り) : ×
[Evaluation Method 3: Stability over time]
The lotions of Examples and Comparative Examples were allowed to stand for 1 month in a dark place at 5 ° C., room temperature, and 50 ° C., and the appearance was visually observed and evaluated according to the following criteria.
[Appearance state]: [Standard]
Transparent: ◎
Blue white (slight turbidity): △
White (turbid): ×
表1〜表3の結果から明らかなように、本発明の実施品である実施例1〜7の化粧水は、「透明性」、「使用性」、「経時安定性」の全ての項目に優れたものであった。一方、
IOB値が0.1〜0.4の範囲外の油剤を用いた比較例1〜3の化粧水は何れも、製造直後より、透明性が確保できなかった。
As is clear from the results of Tables 1 to 3, the lotions of Examples 1 to 7 which are the products of the present invention are classified into all items of “Transparency”, “Usability”, and “Stability over time”. It was excellent. on the other hand,
Transparency of the lotions of Comparative Examples 1 to 3 using an oil having an IOB value outside the range of 0.1 to 0.4 could not ensure transparency immediately after production.
実施例8:美容液(液状)
(成分) (%)
1.イソステアリン酸ポリオキシエチレン(50モル)
硬化ひまし油 0.5
2.ユビキノン 0.02
3.トリオクタン酸グリセリル 0.03
4.コハク酸ジ2−エチルヘキシル 0.03
5.ジ-2-エチルヘキサン酸ネオペンチルグリコール 0.05
6.エタノール 3
7.精製水 残量
8.エデト酸二ナトリウム 0.1
9.メチルパラベン 0.2
10.フェノキシエタノール 0.5
11.グリセリン 5
12.乳酸ナトリウム 0.5
13.キサンタンガム 0.05
14.精製水 10
15.香料 適量
Example 8: Cosmetic liquid (liquid)
(Ingredient) (%)
1. Polyoxyethylene isostearate (50 mol)
Hardened castor oil 0.5
2. Ubiquinone 0.02
3. Glyceryl trioctanoate 0.03
4). Di-2-ethylhexyl succinate 0.03
5. Di-2-ethylhexanoic acid neopentyl glycol 0.05
6). Ethanol 3
7). Purified water remaining amount 8. Edetate disodium 0.1
9. Methylparaben 0.2
10. Phenoxyethanol 0.5
11. Glycerin 5
12 Sodium lactate 0.5
13. Xanthan gum 0.05
14 Purified water 10
15. Perfume
(製造方法)
A.成分1〜6を均一に溶解する。
B.成分13を70℃に加熱し、成分14を添加して均一に混合する。
C.Bに成分7〜12を添加し、均一に混合する。
D.Cを攪拌しながら、A及び成分15を添加し、均一に混合する。
E.Dを容器に充填して、美容液を得た。
実施例8の美容液は、「透明性」、「使用性」、「経時安定性」の全ての項目に優れたものであった。
以 上
(Production method)
A. Ingredients 1-6 are uniformly dissolved.
B. Ingredient 13 is heated to 70 ° C. and ingredient 14 is added and mixed uniformly.
C. Add ingredients 7-12 to B and mix evenly.
D. While stirring C, A and component 15 are added and mixed uniformly.
E. D was filled into a container to obtain a serum.
The cosmetic liquid of Example 8 was excellent in all items of “transparency”, “usability”, and “aging stability”.
more than
Claims (8)
(a)ユビキノン
(b)IOB値が0.1〜0.4の油剤
を配合することを特徴とする透明水性組成物。 In water, the following components (a) and (b);
(A) Ubiquinone (b) A transparent aqueous composition comprising an oil agent having an IOB value of 0.1 to 0.4.
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05186340A (en) * | 1991-07-11 | 1993-07-27 | Idb Holding Spa | Orally administering drug in aqueous solution form containing ubiquinone |
JP2003300870A (en) * | 2002-02-08 | 2003-10-21 | Kyowa Hai Foods Kk | Ubiquinone-containing water-soluble composition |
JP2004115490A (en) * | 2002-09-24 | 2004-04-15 | Taiyo Sangyo Kk | Method for producing water-soluble preparation of ubidecarenone compound |
JP2004261005A (en) * | 2003-01-17 | 2004-09-24 | Taiyo Kagaku Co Ltd | Ubidecarenone preparation |
JP2004307353A (en) * | 2003-04-02 | 2004-11-04 | Shiseido Co Ltd | Oil-in-water emulsion composition |
JP2005047851A (en) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | Ubidecarenone-containing composition |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05186340A (en) * | 1991-07-11 | 1993-07-27 | Idb Holding Spa | Orally administering drug in aqueous solution form containing ubiquinone |
JP2003300870A (en) * | 2002-02-08 | 2003-10-21 | Kyowa Hai Foods Kk | Ubiquinone-containing water-soluble composition |
JP2004115490A (en) * | 2002-09-24 | 2004-04-15 | Taiyo Sangyo Kk | Method for producing water-soluble preparation of ubidecarenone compound |
JP2004261005A (en) * | 2003-01-17 | 2004-09-24 | Taiyo Kagaku Co Ltd | Ubidecarenone preparation |
JP2004307353A (en) * | 2003-04-02 | 2004-11-04 | Shiseido Co Ltd | Oil-in-water emulsion composition |
JP2005047851A (en) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | Ubidecarenone-containing composition |
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