TW200533382A - Cosmetic - Google Patents

Abstract

A cosmetic containing L-ascorbic acid 2-phosphate sodium salt that excels in long-term storage stability. In particular, there is provided a cosmetic characterized in that L-ascorbic acid 2-phosphate sodium salt (A) and at least one compound (B) selected from the group consisting of arginine, urea and triethanolamine are contained in a mixing mass ratio of (A):(B) ranging from 1:0.001 to 1:0.5.

Description

200533382 (1) IX. Description of the invention [Technical field to which the invention belongs] The present invention relates to a cosmetic product containing L-ascorbic acid-sodium 2-diacetate. More specifically, it relates to a cosmetic material which can suppress yellowing and flavor change due to the decomposition of L-ascorbic acid 2-sodium phosphate by containing a specific component ′ which has excellent storage stability. [Previous Technology] Toners, lotions, creams, lotions, skin creams, lotions, etc. have been used for the purpose of improving or preventing skin darkening caused by tanning, and dark spots and freckles caused by pigmentation. Whitening cosmetics, anti-aging cosmetics, such as detergents, dispersions, ointments, liquids, sprays, and adhesives, are widely used as their active ingredient, L-ascorbic acid. However, L-ascorbic acid is relatively easy to be oxidized and hydrolyzed, and it is easy to decompose when it is directly combined with cosmetics, which not only improves or prevents the whitening effect of dark spots and freckles, but also may cause yellowing or discoloration, which may damage the quality of cosmetics. Therefore, in order to mix L-ascorbic acid in cosmetics, various derivatives are used for chemical finishing to improve stability. L-ascorbic acid 2-sodium phosphate is also a derivative developed for the purpose of providing the storage stability of L-ascorbic acid. Compared with L-ascorbic acid, this compound greatly improves the storage stability, but when the cosmetic materials are stored for a long time at a temperature of more than 30 ° C, it still produces yellowing and odor due to decomposition, and is used as makeup The storage stability of the material is insufficient. In terms of whitening effect, its applicability is also reduced. A 4- 200533382 (2) Therefore, in order to improve the storage stability of L-ascorbic acid-sodium 2-disylate in cosmetics, an in-depth review was conducted to compare L-ascorbic acid 2-sodium phosphate with more than two valence salts Combination method (see Japanese Patent Application Laid-Open No. 9-1 1 8 6 1 3 •) and L-ascorbic acid 2-sodium phosphate and a compound having a thiol group or a 41 disulfide bond, and an amino acid having sulfurous acid and a hydroxyl group A combination method (WO: 01/043702) and the like. However, when L-ascorbic acid 2-sodium phosphate is combined with a bivalent or higher salt B, the yellowing and odor caused by decomposition of L-ascorbic acid 2-sodium phosphate stored at a temperature higher than 3 ° C for a long time are suppressed. Insufficient. In addition, when L-ascorbic acid 2-sodium phosphate, a compound having a thiol group or a disulfide bond, and an amino acid having sulfurous acid and a hydroxyl group are combined, it is possible to inhibit L-ascorbic acid 2-sodium phosphate. Yellowing due to decomposition, but insufficient suppression of flavor. Furthermore, when stored at a temperature of 3 ° C or higher, it is caused by a chemical compound having a thiol group or a disulfide bond as a storage stabilizer. The peculiar smell is also its shortcomings. [Summary of the Invention] [Problems to be Solved by the Invention] Therefore, development is sought to prevent L-ascorbic acid 2-sodium phosphate from being mixed in cosmetics and stored under local temperature conditions for a long time. [Method for solving the problem] In view of such facts, the colleagues of the workpiece of the present invention have not been further studied / 5-200533382 (3) As a result of investigation, it was found that when L-ascorbic acid 2-phosphate is contained sodium When a specific nitrogen-containing compound is contained in a cosmetic at a predetermined compounding ratio, yellowing and discoloration of L-ascorbic acid 2-sodium phosphate can be suppressed, and the cosmetic can be stored stably for a long time, and the present invention is completed. SP, the present invention The cosmetic material is characterized in that (A): (B) has a blending mass ratio of 1: 〇〇〇〇1〜〇 · 5, containing the following components (a) and (B); (A) L -Ascorbic acid 2-sodium phosphate (B)-One or two or more compounds selected from the group consisting of arginine, urea, and triethanolamine. In addition, in the present invention, the compounding mass ratio of (A): (C) is ！: 0 · 0 0 1 ～ 1 contains the component (C); (C) Zinc oxide or a salt that generates alkali metal ions in water. [Embodiments of the invention] ® Ingredient (A) used in the present invention L-Ascorbic Acid 2-Sodium Phosphate is a well-known substance; it is used to improve the cosmetics and prevent skin darkening, darkening of the skin, dark spots, freckles, or elderly pigmented liver spots caused by sunburn. Whitening effect of pigmentation, and prevent skin elasticity caused by tanning " Anti-aging effect of low, skin sagging, wrinkles, etc., and users. The content of the component (A) in the cosmetic of the present invention is not particularly limited, and it is preferably 0.001 to 20% by mass of the total composition, and 0.1 to 5 mass% is better. Also, the ingredient (B) used in the present invention is arginine, urea and tri-6-200533382 (4) ethanolamine, for the purpose of improving the storage stability of the ingredient (A) and users; Can be used by ordinary users in cosmetics. The content of ingredient (B) in the cosmetic of the present invention is the mass ratio of ingredient (A) and ingredient (B) 1.... 0.001 to 0.5, with 1: 0.0 0 5 ~ 0.3 is more preferable. For ingredients (a), (B), when the mass ratio of ingredients is less than 0.001, a sufficient storage stabilization effect cannot be obtained; and when the ingredient (B) exceeds 0.5 mass ratio, it cannot be more Improve its storage stability above. Φ When the component (B) is a combination of arginine and urea, it is extremely suitable from the viewpoint of dramatically improving the storage stability of L-ascorbic acid-2 -sodium phosphate. In this combination, there is no particular limitation on the blending mass ratio of arginine: urea. When it is 1: 1 to 10: 1, storage stability is particularly improved, which is very suitable. In the present invention, although only the component (B) can be used to suppress the yellowing and taste-suppressing effects, in order to obtain a more excellent effect, the zinc oxide of the component (C) is additionally blended or a salt of an alkali metal ion is generated in water Better. ® Among this ingredient (C), zinc oxide is generally used in cosmetics. It can be used by users; by combining with this ingredient (B), the storage stability of ingredient (A) can be further improved. Among the ingredients (C), the salts that generate alkali metal ions in water are sodium chloride, potassium chloride, potassium citrate, sodium citrate, sodium lactate, sodium monohydrate, sodium disodium, and malic acid. Sodium, sodium aspartate, potassium aspartate, potassium sulfate, sodium sulfate, potassium carbonate, sodium carbonate, sodium bicarbonate, sodium monohydrogen phosphate, sodium monohydrogen phosphate, potassium monobasic acid, potassium dihydrogen phosphate Wait, potassium chloride, sodium chloride, etc. are more preferred. The content of the cosmetic ingredient (C), the blending ratio of the ingredient (A) and the ingredient 200533382 (5) (c) in the present invention is 1: 0.001 to 1, more preferably 1: 0.01 to 0.5. For ingredients (A) and (C), when the blending mass ratio is less than 0.001, it is difficult to obtain an improvement in storage stabilization effect, and when the blending mass ratio of ingredient (C) is more than 1, the storage stability cannot be improved more than effect. Therefore, the compounding mass ratio of ingredient (A): ingredient (B): ingredient (C) is 1: 0.001 to 0.5: 0.00 1 to 1, and more preferably 1: 0. 05 to 0.3: 0.01 to 0.5. In the cosmetic of the present invention, in addition to the above-mentioned ingredients, various ingredients used in mouth-opening cosmetics, medicines, medicines, and the like can be formulated according to demand. Such optional ingredients are, for example, alcohols, humectants, oily ingredients, emulsifiers, emulsifier stabilizers, tackifiers, preservatives, powders other than zinc oxide (C), pigments, pigments, and ultraviolet absorbers , PH regulators, fragrances, medicinal ingredients other than ingredient (A), etc. The cosmetic material of the present invention can be produced according to its formulation according to a conventional method. Examples of the dosage form include lotions, lotions, creams, skin creams, sticks, washing creams, makeup cosmetics, dispersions, ointments, liquids, sprays, adhesives, and the like. Especially preferred are lotions and water-based cosmetics. The above-mentioned cosmetic of the present invention is more preferably used as a whitening cosmetic and an anti-aging cosmetic. The cosmetic material of the present invention preferably has a pH in the range of 7 to 9. When the pH is less than 7, yellowing and odor may be caused, and storage stability may be deteriorated. ′ On the contrary, when the pH is more than 9, the safety to the skin may decrease. In addition, the cosmetic material of the present invention is not limited to general skin cosmetic materials, but also includes all skin external preparations such as pharmaceutical external products and medicines. [Embodiment] -8-200533382

[Examples] Next, the present invention will be described in more detail by way of test examples and examples, but the present invention is not limited to these. [Example 1] (Cream) The composition shown in Table 1 was used to prepare a cream according to the following method. The obtained cream was subjected to the following storage stability test () and storage stability test (2). The results are also shown in Table 1. (Manufacturing method) A. Mix ingredients (1) ~ (6), heat and keep at 7 (TC.) B. Keep ingredients (7) ~ (16), keep at 70 ° C. C. Add B to A and emulsify After cooling, a cream is obtained. ≪ Storage stability test (1) > Φ Using each cream as a sample, store it in a 5 ° C thermostatic bath for one month, and then quantify L-by high-speed liquid chromatography. Residual amount of ascorbic acid 2-sodium phosphate. As a result, the residual amount of the blending amount when the sample was made is expressed as a percentage •. ≪ Storage stability test (2) > Each cream was used as a sample, and each package was packed in two One of the same glass containers was stored in a thermostatic bath at 5 ° C and the other was stored in a thermostatic bath at 40 ° C for 6 months, respectively. After comparison, the appearance color and odor of the two samples over a long period of time were compared. -9- 200533382 (7). The evaluation is based on the sample stored at 5 ° C, and compared with the sample stored at 4 (TC, evaluated by the following evaluation criteria. Evaluation criteria:-Evaluation assessment Content, ◎: No change from the reference product (yellowing, discoloration) 〇: Slight change from the reference product (yellowing, discoloration) Taste) △: Compared with the reference product, there is a change (yellowing, taste change) ® X: Compared with the reference product, it has a significant change (yellowness, taste change)

-10- 200533382

[Table 1]

Ingredient (%) Comparative product of this invention] 2 3 4 5 6 7 8 9 1 2 3 4 ⑴ beeswax 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 5.0 5.0 (2) cetyl alcohol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 (3) Hardened oil 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 (4) Tricosane 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 (5) Lipophilic Glyceryl Monostearate 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 (6) Polyoleic acid sorbitan monooleate (20EΌ.) 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 (7) L · Ascorbic acid · 2 · Sodium phosphate 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 (8) Arginine 0.2 0.2 0.2 0.4 0.2 0.6 • 0.001 •-0.0005 (9) Urea 0.4 0.4 0.4 0.8 0.4 • 0.6 0.002 • • 0.002 0.0010 (10) triethanolamine 0.6 (Π) zinc oxide 0.5 0.01 1.0 0.5 • • • 0.003 • 0.5.-0.00] (12) malic acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 (13) Glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Π4)】, 3 · Butanediol 10.0 10.0】 0.0] 0.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 (15) Preservatives Appropriate Appropriate Appropriate Proper Appropriate Proper Appropriate Proper Proper Residual Residual Residual Residual Residual Residual Residual Residual Residual Residual Residual Residual Residual Residual Residual Evaluation of Storage Stability (Appearance) 98.5 97.8 98.8 99.3 94.3 92.3 91.7 91.3 90.1 68.7 69.3 75.5 78.4 Occupation Stability ◎ ◎ ◎ ○ 〇〇〇〇〇〇〇XX Δ △ (odor) ◎ ◎ ◎ ◎ ◎ ◎ 〇〇〇 × XXX -11-200533382 (9) [Example 2] (Toner) The composition shown in Table 2, Make up lotion in the usual way. The obtained cosmetic water was subjected to the following storage stability (appearance) test and storage stability (odor) δ formula fe °. The results are also shown in Table 2. < Storage stability (appearance) test > The same sample was stored in a constant temperature bath at 5.0 and 40 t after three months of service. Take Chu Fangfang 5. (: It is the reference mouth, and the appearance of the rain sample is compared according to the following reference. ≪ Storage stability (odor) test > The same sample is stored separately. The one stored at 5 ° C is the reference Odor. 5t: Three months in a constant temperature bath for 3 months @ '彳 衣 T's benchmark comparison of two samples Evaluation criteria: Yanping estimate evaluation content ◎: No change from the reference product (yellowing, odor) 〇 · Slightly changed compared to the reference product (fading, smelly) △: Compared with the reference product, there is a change (yellowish, smelly) X: Compared with the reference product, it has changed greatly (yellowing, tastey) 200533382 (10) [ Table 2] Ingredients (%) Comparison of the product of the present invention: Product 10 11 12 13 14 15 5 6 7 A Sodium ascorbic acid-2-phosphate 2 2 2 2 2 2 2 2 2 9 Arginine 0.2 0.2 B Urea 0.2 0.2 1 0.02 2 〇〇〇1 Triethanolamine 0.2 \ J * V / J. Alcohol 5 5 5 5 5 5 5 D 3-Butanediol 10 10 10 10 10 10 10 10 10 Refined water residual amount residual amount residual amount residual Amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount, amount Storage stability (appearance) 〇〇〇 ◎ 〇〇X Λ X Storage stability (odor) 〇〇〇 ◎ ◎ XXXX 〇 As shown in the results in Table 2, combined with the quantified component (B}% $ weiming 10 ～ 15 lotion can inhibit _ $ parts (A) of L-ascorbic acid-2-sodium phosphonate from yellowing and tarnishing during long-term storage at high temperature, and has excellent storage stability. Here, as shown in Comparative Product 5, the storage stability of the lotion without the ingredient (B) is poor, and as shown in Comparative Products 6 and 7, although the ingredient (B) is contained, its blending amount is outside the scope of the present invention. When it was outside, yellowing and odor occurred, and storage stability was not sufficiently satisfied. [Example 3] (Toner) The composition shown in Table 3 was used to prepare a toner according to a conventional method. ) The toner was subjected to a storage stability (appearance) test and a storage stability (odor) test in the same manner as in Example 2. The results are also shown in Table 3.

-14-200533382 (12) [Table 3]

Comparative product of the present invention 16 Π 18 19 20 21 22 23 24 5 6 7 A Sodium ascorbic acid-2-phosphate 2 2 2 2 2 2 2 2 2 2 2 2 Arginine 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Urea 0.2 2 0.001 Triethanolamine 0.2 KC1 0.2 0.2 0.2 NaCl 0.2 Sodium sulfate 0.2 C Sodium carbonate 0.2 Sodium phosphate-sodium hydrogen phosphate 0.2 Sodium citrate 0.2 Sodium lactate 0.2 Alcohol 5 5 5 5 5 5 5 5 5 5 5 D 1,3-butanediol 10 10 10 10 10 10 10 10 10 10 10 10 10 Refined water residual amount residual amount residual amount residual amount residual amount residual amount residual amount residual amount malate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount Appropriate storage stability (appearance) ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ X Δ X Storage stability (odor) ◎ ◎ 〇〇〇〇〇〇 ◎ XX 〇-15- 200533382 (13) As shown in the results of Table 3 It shows that according to the ingredients (B) and ingredients (C) of the present invention, the makeup water of 16 to 24 can be suppressed during long-term storage at high temperature. Component (A) of a L-ascorbic acid 2 - sodium phosphate and yellow sour 'in particular of having excellent storage stability. [Example 4] (Toner) A composition shown in Table 4 was used to prepare a toner. The obtained cosmetic water was subjected to a storage stability (appearance) test and a storage stability (odor) test in the same manner as in Example 2. The results are also shown in Table 4. [Table 4] Ingredient (%) 7. Comparative product of the second invention 25 26 27 28 29 5 6 7 A Sodium ascorbic acid-2-phosphate 2 2 2 2 2 2 2 2 B Urea 1 0.02 0.2 0.2 1 2 0.001 C KC1 0.2 0.2 2 0.02 2 D alcohol 5 5 5 5 5 5 5 5 1,3-butanediol 10 10 10 10 10 10 10] 〇 Refined water residual amount residual halo residual halo residual halo residual halo malic acid Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate storage stability (appearance) 〇 ◎ 〇 ◎ X Λ X Storage stability (odor) ◎ 〇〇 ◎ 〇XX 〇

As shown in the results of Table 4, when the ingredients (B) and -16-200533382 (14) parts (C) of the lotion of the present invention 25 ~ 29 are blended within the specified amount, they can be stored for a long time at high temperature, Inhibits the yellowing and tarnishing of L-ascorbic acid 2-sodium phosphate of ingredient (A), and has excellent storage stability. [Example 5] (emulsion) (ingredient) (%) (1) sorbitan monostearate 0.3

(2) Polyethylene oxide sorbitan monooleate (20eO) 0.1 (3) Glyceryl monostearate 0.2 (4) 0.5 stearic acid 0.5 (5) cetyl alcohol. 5 (6) Olive oil 3.0 (7) Liquid paraffin 4.0 (8) Glyceryl tri-2-ethylhexanoate 2.0 (9) Methylpolysiloxane 1.0 (1) Hydrogenated soybean phosphate 0.1 (1 1) Acetic acid dl-oi-tocopherol 0.05 (12) PEMULEN TR-l (Note 1) 0.2 (13) sodium hydroxide 0.08 (1 4) glycerol 5.0 (15) 1,3-butanediol 7.0 (1 6) L.Ascorbic acid-2-sodium phosphate 3.0 (17) Arginine 0.2 (18) Urea 0.4 -17- 200533382 (15) (19) Malate 0.2 (20) Zinc oxide 0.5 (21) Refined water residue ( 22) Appropriate amount of preservative (23) Appropriate amount of fragrance (24) Ethanol 5.0 Note 1: Made by BF Gugliqi (manufacturing method) A: Heat and mix ingredients (12) ~ (21) and keep at 70 ° C. B: Put ingredients ( 1) ~ (1 1) Heat and mix and keep at 70 ° CC: Add B to A and mix and emulsify uniformly D: After C is cooled, add (22) ~ (24) and mix well to obtain an emulsion. After storing the emulsion of Example 5 in a thermostatic bath at 50 ° C for one month ®, the amount of L-ascorbic acid 2-sodium phosphate was quantified by high-speed liquid chromatography, and the residual rate was calculated to be 9 8.8%. In addition, after being stored in a constant temperature bath at 40 ° C for 6 months, it is an emulsion with very little yellowing and odor, excellent storage stability *, and excellent whitening effect. [Example 6] (ointment) (ingredient) (%) (1) stearic acid (2) cetyl alcohol 18.0 4.0 -18- 200533382 (16) (3) dl-oi-tocopherol 0.2 (4) vitamin A Palmitate 0.2 (5) Preservatives (6) Potassium hydroxide 0.5 (7) Glycerin 5.0 (8) Sodium lactate 0.5 (9) L-ascorbic acid 2-sodium phosphate 20.0 (10) Arginine 2.0 (1 1) Triethanolamine 1.0 (12) Zinc oxide 5.0 (13) Refined water residue (manufacturing method) A: Heat and mix ingredients (6) ~ (1 3) and keep at 7 5 ° C B: Put ingredients (1) ~ (1 5 ) Heat and mix and keep at 75 ° C # C: Add A slowly to B to obtain ointment. After storing the ointment obtained in Example 6 in a thermostatic bath at 50 ° C for one month, the amount of L-ascorbic acid-2-phosphate * sodium was quantified by high-speed liquid chromatography, and the residual rate was calculated to be 93.5%. Also, in a thermostatic oven at 40 ° C * After 6 months of storage, it is also an ointment with very little yellowing and odor, and excellent storage stability. [Example 7] (beauty liquid) (ingredients) (%) -19- 200533382 (17) (1) PEMULEN TR-2 (Note 2) 0.2 (2) Gutton gum 0.2 (3) refined Water Residue (4) Glycerin 2.0 (5) Ethanol 20.0 (6) Sodium Hydroxide 0.05 (7) Lactic Acid 0.05 (8) Succinic Acid 0.15 (9) L-Ascorbic acid 2-sodium phosphate 0.1 (10) Arginine 0.01 (1 1) Urea 0.01 (12) Zinc oxide 0.05 (13) Refined water 10.0 Note 1: BF Gugliqi (manufacturing method) A · The components (1) to (3) are heated and mixed, and then cooled. B: Add ingredients (4) to (1 3) to get a beauty liquid. The cosmetic liquid obtained in Example 7 was stored in a thermostatic bath at 50 ° C for one month, and then the amount of L-ascorbic acid-2-sodium phosphate was quantified by high-speed liquid chromatography to calculate a residual rate of 98.1%. In addition, after being stored for 6 months in a thermostatic bath at 4 ° C, it is also a beauty liquid with very little yellowing and flavor change, excellent storage stability, and whitening effect. -20- 200533382 (18) [Example 8] (Skin cream) (ingredients) (%) (1) Polyvinyl alcohol 15 · 0 • (2) Silicic anhydride 0.5 (3) Polyethylene glycol 0.5 (4) Polypropylene oxide methyl glucoside 5.0 (5) Glycerin 5.0 • (6) Residual water content (7) Ethanol 10.0 (8) Preservatives (9) Sodium hydroxide 0.05 (10) Sodium citrate 0.05 (1 1) Tartrate 0.15 (1 2) L- Ascorbic acid 2-sodium phosphate 1.0 (13) urea 0.1% (14) triethanolamine 0.1 (1 5) zinc oxide 0.5 (16) purified water 10.0 (manufacturing method) A: mix the ingredients (1) to (6) in 7 (TC heats and dissolves B: mix ingredients (7) and (8), dissolve C: add B to A and mix, and then disperse the cooling ingredients (9) ~ (16)) uniformly to obtain skin cream. -21- 200533382 (19) After storing the skin cream obtained in Example 8 in a thermostatic bath at 50 ° C for one month, the amount of L-ascorbic acid 2-sodium phosphate was quantified by high-speed liquid chromatography, and the residual rate was calculated. 92.2%. Again, at 40 After 6 months of storage in a constant temperature bath at ° C, it is also a skin cream with very little yellowing and odor, and excellent storage stability. [Example 9] (Liquid Foundation Cream) • (ingredient) (%) (1) Dipentaerythritol fatty acid ester (Note 1) 2.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetyl alcohol 1 · 0 (5) Self-emulsifying glyceryl monostearate 1.0 (6) P-methoxycinnamic acid 2-ethylhexyl ester 8.0 (7) Preservative amount • (8) Glycerin 5.0 (9) Potassium hydroxide 0.2 (10) Carboxymethyl cellulose 0.2 ^ (11) Bentonite 0.5 • (12) Residual water content (13) Silica-alumina-treated titanium oxide 6.0 (14) Fluoride-treated titanium oxide particles 2.0 (1 5) Colored pigment 5.0 (16) Mica-22- 200533382 (20) 4.0 1.0 0.3 0.2 3.0 0.2 0.4 10.0 (17) Talc powder (1 8) Zinc oxide (19) Sodium lactate. (20) Malate (21) L —Ascorbic acid 2 —Sodium phosphate (22) Arginine (23) Urea • ( 24) refined water

Note 1: Kosmoru 168 AR (produced by Qingou Ellio Co., Ltd.) (manufacturing method) A: Ingredients (1) to (7) are mixed by heating and dissolving

B ·· Add ingredients (1 3) ~ (1 8) to A, mix well and keep them at 70 ° CC ·· Dissolve ingredients (8) ~ (12) and keep them at 70 ° CD: in C Add B to uniformly emulsify E: After cooling D, add ingredients (19) to (24) to obtain a liquid foundation cream. After the liquid foundation cream of Example 9 was stored in a thermostatic bath at 50 ° C for one month, the amount of L-ascorbic acid- 2 -P sodium was quantified by high-speed liquid chromatography, and the residual rate was calculated to be 9 7 · 3 %. In addition, after being stored in a thermostatic bath at 40 ° C for 6 months, it is a liquid foundation cream with very little flavor change and excellent storage stability. -23- 200533382 (21) [Example 10] (sunscreen emulsion) (ingredients) ^ (1) polyalkylene oxide modified organic polysiloxane (2) dimethyl polysiloxane ▲ (3) Cyclotetrasiloxane (4) Iso (tridecyl) isononanoate • (5) 2-Ethylhexyl p-methoxycinnamic acid (6) Preservatives (7) Perfume (8) Poly Siloxane-treated particulate titanium oxide (9) Polysiloxane-treated titanium oxide (10) Polystyrene powder (1 1) Dimethylsiloxysilicic acid (1 2) Dipropylene glycol # (1 3) Ethanol ( 14) purified water (1 5) sodium chloride ^ (16) zinc oxide ^ (1 7) citric acid (1 8) malic acid (1 9) L monoascorbic acid-2-sodium phosphate (20) arginine (21 ) Urea

(%) 1 .0 5.0 2 0.C Appropriate amount 10.0 5.0 3.0 0.5 3.0 10.0 Residual amount 0.2 1 · 0 0.2 0.2 -24- .4 200533382 (22) (22) Triethanolamine 0.1 · (23) Purified water 1 (K () (Manufacturing method) A: Mix and disperse the ingredients ()) ~ (1 1) B: Mix and dissolve the ingredients (1 2) ~ (1 5) C: Add B to A 'emulsify uniformly D ... Add ingredients (1 6) to (2 3) to C to obtain a sunscreen lotion. After storing the sunscreen lotion of Example 10 in a thermostatic bath at 50 ° C for one month, quantify L by high-speed liquid chromatography. -Ascorbic acid- The amount of sodium 2-phosphate is calculated to have a residual rate of 99 · 0%. Also, after 6 months of storage in a constant temperature bath at 40 ° C, it also has very little yellowing and odor, and has excellent storage. [Example 1 1] (emulsion) (ingredient) (%) (1) sorbitan monostearate 0.5 (2) polyethylene oxide sorbitan monooleate (20 EO ·) 0.5 (3) lipophilic glyceryl monostearate 0.5 (4) stearic acid 1.0 (5) cetyl alcohol 0.5 (6) olive oil 3.0 (7) liquid paraffin 4 · 0- 25- 200533382 (23) (8) Triglyceryl 2-ethylhexanoate 2.0 (9) Di Polysiloxane 1.0 (10) Hydrogenated soybean phospholipid 0.1. (1 1) Acetic acid dl-α-tocopherol 0.05 (12) Acrylic acid alkyl methacrylate copolymer 0.2 (13) Sodium hydroxide 0.08 ( 1 4) Glycerin 5.0 # (15) 1,3-butanediol 5.0 (16) L-ascorbic acid 2- sodium phosphate 3.0 (17) arginine 0.2 (1 8) urea 0.4 (19) malate 0.2 (2 0) Potassium chloride 0 · 5 (2 1) Refined water residue (22) Appropriate amount of preservatives • (2 3) Appropriate amount of spices (2 4) Ethanol 5.0 (manufacturing method) A: Heat ingredients (12) to (21) Mix and keep at 7 (TC B: heat and mix ingredients (1) ~ (1 1) and keep at 70t: C: add B to A and mix and emulsify uniformly D: after cooling C, add (22) ~ ( 24) Mix evenly to obtain an emulsion. -26- 200533382 (24) After storing the emulsion obtained in Example 11 in a thermostatic bath at 50 ° C for one month, quantify L-ascorbic acid by high-speed liquid chromatography- The amount of 2-phosphate was 94.2%. In addition, after being stored in a 4 ° C thermostatic bath for 6 months, it was also an emulsion with very little yellowing and odor, and excellent storage stability. [Example 12] (Cosmetic liquid) φ (ingredient) (%) ( 1) Acrylic acid methacrylate copolymer 0.2 (2) Gut gum 0.2 (3) Residual water content (4) Glycerin 2.0 (5) Ethanol 10.0 (6) Sodium hydroxide 0.05 (7) Lactic acid 0.00 5 • (8) succinic acid 0.15 (9) L —ascorbic acid 2 —sodium phosphate 0.5 (10) urea 0.1 '(11) sodium carbonate 0.05-(12) purified water 10.0 (manufacturing method) A: the ingredients (1) ~ (3) After heating and mixing, cool B: add ingredients (4) to (12) to obtain a cosmetic liquid. -27-200533382 (25) Store the cosmetic liquid of Example 12 in a constant temperature of 50 ° C After one month in the tank, the amount of L-ascorbic acid 2-sodium phosphate was quantified by high-speed liquid chromatography, and the residual rate was calculated to be 97.7%. In addition, after 6 months of storage in a 40 ° C thermostatic bath, it was also Beauty liquid with very little yellowing and odor, and excellent storage stability. [Example 13] (Skin cream) (%) 15.0 0.5 0.5 5.0 Residual amount 10.0 Moderate amount 0.05 0.2 0.15 1.0 0.1 0.1 10.0 • ( Parts) (1) Polyvinyl alcohol (2) Silicic anhydride (3) Polyethylene glycol (4) Glycerin (5) Purified water (6) Ethanol (7) Preservatives (8) Sodium hydroxide (9) Citric acid Sodium (10) Tartaric acid (1 1) L Monoascorbic acid — 2-Sodium phosphate U (1 2) Urea (13) Triethanolamine (14) Refined water (manufacturing method) -28- 200533382 (26) A: Ingredient (1) ~ (5) mix, heat and dissolve B at 70 ° C: mix and dissolve ingredients (6) and (7) C: add B to A and mix, and disperse the cooled ingredients (8) ~ (1 4) evenly, The skin cream was obtained. ♦ After storing the skin cream of Example 13 in a thermostatic bath at 50 ° C for one month, the amount of L-ascorbic acid 2-sodium phosphate was quantified by high-speed liquid chromatography, and the residual amount was calculated. The rate is 96.8%. It is also a skin cream with very little discoloration and odor after storage for 6 months in a constant temperature bath at 40 ° C. [Example 14] (Liquid foundation cream) (Ingredients) (%) (1) Dipentaerythritol fatty acid ester (Note 1) 2.0 (2) Liquid stone 5.0 (3) Stearic acid 2.0 φ (4) Cetyl alcohol 1.0 (5) Self-emulsifying monostearate Glyceride 1.0 · (6) Oxycinnamic acid 2-ethylhexyl ester 8.0 * (7) Preservative amount '(8) Glycerin 5.0 (9) Potassium hydroxide 0.2 (10) Carboxymethyl cellulose (1 1) Bentonite 0.5 (12) Residual water content-29- 200533382 (27)

(13) Silica-alumina-treated titanium oxide (14) Fluoride-treated particulate titanium oxide (1 5) color pigment ^ (16) mica (17) talc (18) malic acid (1 9) L monoascorbic acid-2 —Sodium phosphate • (20) Arginine (21) Urea (22) Purified water

Note 1: Kosmoru-168AR (produced by Qingou Ellio Co., Ltd. (manufacturing method) A: Ingredients (1) ~ (7) are heated and mixed to dissolve Φ B: (1 3) ~ (1 7), mix well and keep at

70 ° C: Dissolve ingredients (8) ~ (1 2) uniformly and keep at 70 ° C ^ D: Add B to C, emulsify evenly 'E: After cooling D, add ingredients (1 8) ~ ( 22) to obtain a liquid foundation cream. The liquid foundation cream of Example 14 was stored in a 5 ° C thermostatic bath-after one month, the amount of L-ascorbic acid-2-sodium phosphate was quantified by high-speed liquid chromatography, and the residue rate was calculated to be 92.1 %. Also, it is a liquid foundation cream with excellent storage stability after 6 months storage in a constant temperature -30-200533382 (28) tank at 40 ° C, which has very little discoloration and odor, and has excellent storage stability. ^ [Example 15] ( Sunscreen emulsion) (ingredients) (%) (1) Polyalkylene oxide modified organic polysiloxane 1 · 0 (2) Dimethyl polysiloxane 5 · 0 # (3) Octamethylcyclotetrasiloxane Alkane 20.0 (4) Iso (tridecyl) isononanoate 5.0 (5) 2-Ethylhexyl p-methoxycinnamate 5.0 (6) Preservatives (7) Perfume (8) Polysilicone Oxine-treated particulate titanium oxide 10.0 (9) Polysiloxane-treated titanium oxide 5.0 (10) Polystyrene powder 3.0 Φ (11) Trimethylsiloxyoxysilic acid 0.5 (12) Dipropylene glycol 3.0 (1 3) Ethanol 10.0 '(14) Residual water content " (15) Sodium chloride 1.0 (16) Malic acid 0.5 (17) L-Ascorbic acid-2-Sodium phosphate 5.0 (18) Arginine 0.2 (19) Urea 0.4- 31-200533382 (29) (20) diethanolamine ( 21) Refined water (manufacturing method) ♦ A: Mix and disperse ingredients (1) ~ (1 1) B ·· Mix and dissolve ingredients (1 2) ~ (1 5) C: Add B to A, emulsify evenly # D : Add ingredients (1 6) to (2 1) to C. 〇 After storing the sunscreen lotion of Example 15 at 50 ° C for one month, quantify L-anti-sodium sulfate by high-speed liquid chromatography. The residual rate is calculated as 93.5%. After 6 months of storage, it is also a stable sunscreen lotion with little discoloration and taste. [Industrial Applicability] The cosmetic of the present invention contains L -ascorbic acid-can be decomposed at the same time for long-term storage and storage at high temperature. Therefore, it is very suitable for cosmetics using L -ascorbic acid " sodium as an active ingredient, for example, it is suitable for use as [effect of the invention] The cosmetic material of the present invention is formulated with L-ascorbic acid 0.1 10.0 to obtain a thermostatic bath [blood acid-2-phosphorous 40 ° C in a thermostatic bath with sunscreen lotion, which has excellent storage of 2-sodium phosphate and inhibits this substance. L-Acid 2-Phosphate Whitening. Cosmetics Etc. 2-Sodium Phosphate-32- (30) 200533382, at the same time for a long time, Storage conditions under high temperature can also inhibit its yellowing and odor, and have excellent storage stability. Therefore, various cosmetics such as whitening cosmetics and anti-aging cosmetics can be widely used.

-33-

Claims (1)

200533382 (1) X. The scope of patent application 1. A cosmetic material characterized by (A): (B) a compounding mass ratio of 1 ·· 〇 · 〇〇〇〇1 ~ 0.5 ratio containing the following ingredients (A) And (B); * (A) L —ascorbic acid 2-sodium phosphate (B) — one or two or more compounds selected from the group consisting of arginine, urea and triethanolamine. 2. The cosmetic according to item 1 of the scope of the patent application, wherein (A) :( C) is a mass ratio of}: 〇 · 〇〇〗 ~! The proportion contains ingredients (匸 (C) zinc oxide, or salts which generate alkali metal ions in water. 3) The cosmetic material according to item 1 or 2 of the patent application scope, which contains 0.001 to 20% by mass of the ingredient (A). The cosmetic of the item, the salt of the cosmetic of the item, whose salt is potassium chloride or chlorine4. If the component (B) in any one of the items 1 to 3 of the patent application scope is arginine and urea. 5 · As in any of the items 2 to 4 of the scope of the patent application-the sodium component (C) which generates alkali metal ions in water. 6_ If any one of the items in the scope of the patent application—the cosmetic, it is an aqueous cosmetic or an emulsified cosmetic. 7. The cosmetic material according to any one of claims 1-6 to 6, whose pH is 7-9. 8. 8. If any of the items in the scope of the application for patent] ~ 7, the cosmetic is whitening cosmetic or anti-aging cosmetic. ^ -34- 200533382 嚅 Wuming said that the single abbreviation symbol table is the definitive figure designation table of the original drawing table: the plan, the table, and the one, two, and seven fingers. If there is a chemical formula in this case, please disclose The chemical formula that best shows the characteristics of the invention: 钃 -3-