JPWO2005067867A1 - Cosmetics - Google Patents
CosmeticsInfo
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- JPWO2005067867A1 JPWO2005067867A1 JP2005517108A JP2005517108A JPWO2005067867A1 JP WO2005067867 A1 JPWO2005067867 A1 JP WO2005067867A1 JP 2005517108 A JP2005517108 A JP 2005517108A JP 2005517108 A JP2005517108 A JP 2005517108A JP WO2005067867 A1 JPWO2005067867 A1 JP WO2005067867A1
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- ascorbic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
L−アスコルビン酸−2−リン酸ナトリウムを含有しながら、長期保存安定性に優れる化粧料を提供することを目的とし、特に(A)L−アスコルビン酸−2−リン酸ナトリウムおよび(B)アルギニン、尿素及びトリエタノールアミンよりなる群から選ばれる化合物の一種又は二種以上を、(A):(B)の配合質量比として、1:0.001〜0.5の割合で含有することを特徴とする化粧料を提供することを目的とする。An object of the present invention is to provide a cosmetic that is excellent in long-term storage stability while containing L-ascorbic acid-2-sodium phosphate, and in particular, (A) L-ascorbic acid-2-phosphate and (B) arginine. 1 or 2 or more types of compounds selected from the group consisting of urea and triethanolamine are contained in a ratio of 1: 0.001 to 0.5 as a blending mass ratio of (A) :( B). It aims at providing the cosmetics characterized.
Description
本発明は、L−アスコルビン酸−2−リン酸ナトリウムを含有する化粧料に関するものであり、より詳細には、特定の成分を含有することにより、L−アスコルビン酸−2−リン酸ナトリウムの分解に伴う黄変及び変臭を抑制し、保存安定性が優れた化粧料に関するものである。 The present invention relates to a cosmetic containing L-ascorbic acid-2-sodium phosphate, and more specifically, by containing a specific component, the decomposition of L-ascorbic acid-2-sodium phosphate. It is related with the cosmetics which suppressed yellowing and a foul smell accompanying and which were excellent in storage stability.
従来より、日焼け等により生じる皮膚の黒化、色素沈着により生ずるシミ、ソバカス等の改善又は予防を目的として、化粧水、乳液、クリーム、美容液、パック、洗浄料、分散液、軟膏、液剤、エアゾール、貼付剤等の美白化粧料や老化防止化粧料が使用されているが、その有効成分としてL−アスコルビン酸が広く使用されている。 Conventionally, for the purpose of improving or preventing skin blackening caused by sunburn, stains caused by pigmentation, buckwheat, etc., lotion, emulsion, cream, cosmetic liquid, pack, cleaning agent, dispersion, ointment, liquid, Whitening cosmetics such as aerosols and patches and anti-aging cosmetics are used, and L-ascorbic acid is widely used as an active ingredient.
しかし、L−アスコルビン酸は比較的容易に酸化および加水分解されるため、そのまま化粧料に配合しても容易に分解され、シミ、ソバカスを改善又は予防するという美白効果そのものの低下や、黄変したり、あるいは変臭を生じたり等の化粧料としての品質を損なうなどが懸念されている。そこでL−アスコルビン酸を化粧料に配合するために、これに化学修飾を施して安定性を向上させた各種誘導体が用いられている。 However, since L-ascorbic acid is oxidized and hydrolyzed relatively easily, it is easily decomposed even if it is added to cosmetics as it is, and the whitening effect itself of improving or preventing spots and freckles is reduced or yellowed. There is a concern that the quality of the cosmetics may be impaired, such as causing or changing odor. Therefore, in order to blend L-ascorbic acid into cosmetics, various derivatives that have been chemically modified to improve stability have been used.
L−アスコルビン酸−2−リン酸ナトリウムも、L−アスコルビン酸の保存安定性を向上させる目的で開発された誘導体の一種である。このものは、L−アスコルビン酸に比べ保存安定性が大幅に向上したものの、これを配合した化粧料を長期に、特に30℃以上の温度条件で保存した場合、やはり分解に伴う黄変及び変臭が生じ、化粧料としての保存安定性は十分とは言えなかった。また、美白効果の面からもその有用性が低下してしまう懸念が残っている。 L-ascorbic acid-2-sodium phosphate is also a kind of derivative developed for the purpose of improving the storage stability of L-ascorbic acid. Although this product has significantly improved storage stability compared to L-ascorbic acid, when a cosmetic containing the same is stored for a long period of time, particularly at a temperature condition of 30 ° C. or higher, yellowing and discoloration associated with decomposition also occur. Odor was generated, and the storage stability as a cosmetic was not sufficient. Moreover, the concern that the usefulness falls also from the surface of the whitening effect remains.
そこで、L−アスコルビン酸−2−リン酸ナトリウムの化粧料中での保存安定生を更に向上させる目的で、L−アスコルビン酸−2−リン酸ナトリウムと2価以上の塩を組み合わせる方法(特開平9−118613号公報参照)やL−アスコルビン酸−2−リン酸ナトリウム、チオール基若しくはジスルフィド結合を有する化合物、亜硫酸及び水酸基を有するアミノ酸とを組み合わせる方法(WO01/043702号公報)等が検討されている。 Therefore, a method of combining L-ascorbic acid-2-phosphate sodium salt with a divalent or higher salt for the purpose of further improving the storage stability of cosmetic L-ascorbic acid-2-phosphate salt in cosmetics (Japanese Patent Laid-Open 9-118613), a method of combining L-ascorbic acid-2-phosphate sodium, a compound having a thiol group or disulfide bond, sulfurous acid and an amino acid having a hydroxyl group (WO01 / 043702), etc. Yes.
しかしながら、L−アスコルビン酸−2−リン酸ナトリウムと2価以上の塩を組み合わせた場合、特に30℃以上の高温における長期保存でのL−アスコルビン酸−2−リン酸ナトリウムの分解に伴う黄変及び変臭を抑制するには十分ではなかった。又、L−アスコルビン酸−2−リン酸ナトリウム、チオール基若しくはジスルフィド結合を有する化合物、亜硫酸及び水酸基を有するアミノ酸とを組み合わせた場合、L−アスコルビン酸−2−リン酸ナトリウムの分解に伴う黄変を抑制することは可能であるが、変臭を抑制するには十分ではなかった。更に、30℃以上の高温保存においては、保存安定化剤として配合したチオール基若しくはジスルフィド結合を有する化合物自身に起因すると思われる異臭も発生してしまう欠点があった。 However, when L-ascorbic acid-2-phosphate sodium salt and a divalent or higher salt are combined, yellowing due to decomposition of L-ascorbic acid-2-sodium phosphate in long-term storage particularly at a high temperature of 30 ° C. or higher And it was not enough to suppress odor. Further, when L-ascorbic acid-2-phosphate sodium, a compound having a thiol group or a disulfide bond, sulfurous acid and an amino acid having a hydroxyl group are combined, yellowing due to decomposition of L-ascorbic acid-2-sodium phosphate Although it is possible to suppress odor, it was not sufficient to suppress odor. Furthermore, in high-temperature storage at 30 ° C. or higher, there is a drawback that a strange odor that may be caused by the compound itself having a thiol group or disulfide bond added as a storage stabilizer is generated.
従って、L−アスコルビン酸−2−リン酸ナトリウムを化粧料中に配合し、これを長期に、しかも高い温度条件で保存した場合であっても、この物質の分解を防ぐための手段の開発が求められていた。 Therefore, even if L-ascorbic acid-2-phosphate sodium salt is blended in cosmetics and stored for a long period of time under high temperature conditions, a means for preventing the decomposition of this substance has been developed. It was sought after.
かかる実情を鑑み、本発明者らは、鋭意検討を重ねた結果、L−アスコルビン酸−2−リン酸ナトリウムを含有する化粧料に、特定の含窒素化合物を所定の配合比率で含有させると、L−アスコルビン酸−2−リン酸ナトリウムの黄変及び変臭が抑制され、化粧料が長期に亘り安定に保たれることを見出し、本発明を完成した。 In view of such a situation, the present inventors, as a result of intensive studies, when the cosmetic containing L-ascorbic acid-2-phosphate contains a specific nitrogen-containing compound at a predetermined blending ratio, The present inventors completed the present invention by finding that the yellowing and odor of L-ascorbic acid-2-phosphate sodium were suppressed and the cosmetics were kept stable for a long time.
すなわち、本発明は、次の成分(A)および(B);
(A)L−アスコルビン酸−2−リン酸ナトリウム
(B)アルギニン、尿素及びトリエタノールアミンよりなる群から選ばれる化合物の一
種又は二種以上
を、(A):(B)の配合質量比として、1:0.001〜0.5の割合で含有することを特徴とする化粧料である。That is, the present invention provides the following components (A) and (B);
(A) L-ascorbic acid-2-sodium phosphate (B) One or more compounds selected from the group consisting of arginine, urea and triethanolamine are mixed in (A) :( B). As a cosmetic, it is contained at a ratio of 1: 0.001 to 0.5.
また本発明は、更に、成分(C)として
(C)酸化亜鉛または水中でアルカリ金属イオンを生成する塩
を、(A):(C)の配合質量比として、1:0.001〜1の割合で含有する前記化粧料である。In addition, the present invention further includes (C) zinc oxide or a salt that generates an alkali metal ion in water as component (C), with a blending mass ratio of (A) :( C) of 1: 0.001-1. It is the said cosmetics contained in a ratio.
本発明の化粧料は、L−アスコルビン酸−2−リン酸ナトリウムを配合しながら、長期間、高温下の保存条件であってもその黄変や変臭が抑えられ、保存安定性に優れるものである。従って、例えば美白化粧料、老化防止化粧料等の種々の化粧料として広く利用できるものである。 The cosmetic of the present invention is excellent in storage stability because it can suppress yellowing and deodorization under long-term storage conditions at high temperatures while blending with L-ascorbic acid-2-sodium phosphate. It is. Therefore, it can be widely used as various cosmetics such as whitening cosmetics and anti-aging cosmetics.
本発明で用いられる成分(A)のL−アスコルビン酸−2−リン酸ナトリウムは公知の物質であり、日焼けによる皮膚の黒化、皮膚のくすみ、シミ、ソバカス又は老人性色素斑及び肝斑等の色素沈着の改善・防止などの美白効果、また、日焼けによる皮膚の弾力性の低下や、皮膚のタルミ、シワの防止などの老化防止効果を化粧料に付与するために用いられるものである。本発明の化粧料における成分(A)の含有量は、特に限定はされないが、全組成分中0.001〜20質量%(以下単に「%」で示す)が好ましく、0.1〜5%がより好ましい。 The component (A) L-ascorbic acid-2-sodium phosphate used in the present invention is a known substance, such as skin darkening due to sunburn, dull skin, spots, freckles or senile pigment spots and liver spots. It is used for imparting whitening effects such as improvement and prevention of pigmentation of skin, and anti-aging effects such as reduction of skin elasticity due to sunburn, prevention of skin talmi and wrinkles to cosmetics. The content of the component (A) in the cosmetic of the present invention is not particularly limited, but is preferably 0.001 to 20% by mass (hereinafter simply referred to as “%”) in the total composition, and is 0.1 to 5%. Is more preferable.
また、本発明に用いられる成分(B)のアルギニン、尿素及びトリエタノールアミンは、成分(A)の保存安定性の向上を図るため用いられるものであり、化粧料に一般に使用されているものを利用できる。本発明の化粧料における成分(B)の含有量は、成分(A)と成分(B)との配合質量比において1:0.001〜0.5であり、1:0.05〜0.3がより好ましい。成分(A)に対して成分(B)の配合質量比が0.001未満では充分な保存安定化効果がみられず、また、成分(B)の配合質量比が0.5を超えても、それ以上の保存安定性の向上は認められない。 In addition, the components (B) arginine, urea and triethanolamine used in the present invention are used for improving the storage stability of the component (A), and are generally used in cosmetics. Available. Content of the component (B) in the cosmetics of this invention is 1: 0.001-0.5 in the compounding mass ratio of a component (A) and a component (B), and 1: 0.05-0.00. 3 is more preferable. When the blending mass ratio of the component (B) to the component (A) is less than 0.001, no sufficient storage stabilization effect is observed, and even when the blending mass ratio of the component (B) exceeds 0.5. No further improvement in storage stability is observed.
上記成分(B)は、アルギニン及び尿素の組み合わせであることが、L−アスコルビン酸−2−リン酸ナトリウムの保存安定性が飛躍的に向上させる点から好ましい。この組み合わせの場合、アルギニン:尿素の配合質量比は特に限定はされないが、1:10〜10:1であると保存安定性が特に向上するので好ましい。 The component (B) is preferably a combination of arginine and urea from the viewpoint of dramatically improving the storage stability of L-ascorbic acid-2-sodium phosphate. In the case of this combination, the blending mass ratio of arginine: urea is not particularly limited, but is preferably 1:10 to 10: 1 because the storage stability is particularly improved.
本発明においては、上記成分(B)の配合のみで黄変や変臭の抑制効果が得られるが、更に優れた効果を得るためには、更に成分(C)として、酸化亜鉛または水中でアルカリ金属イオンを生成する塩を配合することが好ましい。 In the present invention, an effect of suppressing yellowing and odor is obtained only by blending the above component (B), but in order to obtain a further excellent effect, as component (C), an alkali in zinc oxide or water is used. It is preferable to add a salt that generates metal ions.
この成分(C)のうち、酸化亜鉛は、化粧料に一般に使用できるものであれば良く、前記成分(B)との組み合わせにより、成分(A)の保存安定性の更なる向上を図るため用いられるものである。また、成分(C)のうち、水中でアルカリ金属イオンを生成する塩としては、塩化ナトリウム、塩化カリウム、クエン酸カリウム、クエン酸ナトリウム、乳酸ナトリウム、コハク酸ナトリウム、コハク酸二ナトリウム、リンゴ酸ナトリウム、アスパラギン酸ナトリウム、アスパラギン酸カリウム、硫酸カリウム、硫酸ナトリウム、炭酸カリウム、炭酸ナトリウム、炭酸水素ナトリウム、リン酸一水素ナトリウム、リン酸二水素ナトリウム、リン酸一水素カリウム、リン酸二水素カリウム等が挙げられ、特に、塩化カリウム、塩化ナトリウム等が好ましい。 Of these components (C), zinc oxide may be used as long as it can be generally used in cosmetics, and is used to further improve the storage stability of component (A) by combining with component (B). It is what Among the components (C), salts that generate alkali metal ions in water include sodium chloride, potassium chloride, potassium citrate, sodium citrate, sodium lactate, sodium succinate, disodium succinate, and sodium malate. Sodium aspartate, potassium aspartate, potassium sulfate, sodium sulfate, potassium carbonate, sodium carbonate, sodium bicarbonate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, potassium monohydrogen phosphate, potassium dihydrogen phosphate, etc. In particular, potassium chloride, sodium chloride and the like are preferable.
本発明の化粧料における成分(C)の含有量は、成分(A)と成分(C)との配合質量比において1:0.001〜1であり、1:0.01〜0.5がより好ましい。成分(A)に対して成分(C)の配合質量比が0.001未満では更なる保存安定化効果の向上は得られ難く、また、成分(C)の配合質量比が1を超えても、それ以上の保存安定性効果の向上は認められない。従って、成分(A):成分(B):成分(C)の配合質量比は、1:0.001〜0.5:0.001〜1であり、1:0.05〜0.3:0.01〜0.5がより好ましい。 Content of the component (C) in the cosmetics of this invention is 1: 0.001-1 in the compounding mass ratio of a component (A) and a component (C), and 1: 0.01-0.5. More preferred. If the blending mass ratio of the component (C) to the component (A) is less than 0.001, it is difficult to further improve the storage stabilization effect, and even if the blending mass ratio of the component (C) exceeds 1. No further improvement in storage stability effect is observed. Accordingly, the blending mass ratio of component (A): component (B): component (C) is 1: 0.001 to 0.5: 0.001 to 1, and 1: 0.05 to 0.3: 0.01-0.5 is more preferable.
本発明の化粧料には、上記成分の他に通常化粧品や医薬部外品、医薬品等に用いられる各種成分を必要に応じて適宜配合することができる。このような任意成分としては、例えば、アルコール類、保湿剤、油性成分、乳化剤、乳化安定剤、増粘剤、防腐剤、成分(C)の酸化亜鉛以外の粉体、顔料、色素、紫外線吸収剤、pH調整剤、香料、成分(A)以外の薬効成分等が挙げられる。 In the cosmetic of the present invention, various components used in normal cosmetics, quasi-drugs, pharmaceuticals and the like can be appropriately blended as necessary in addition to the above components. Examples of such optional components include alcohols, humectants, oily components, emulsifiers, emulsion stabilizers, thickeners, preservatives, powders other than zinc oxide of component (C), pigments, dyes, and ultraviolet absorption. Agents, pH adjusters, fragrances, medicinal components other than the component (A), and the like.
本発明の化粧料は、その剤形に応じ、常法に従って製造することができる。その剤型の例としては、乳液、化粧水、クリーム、パック、スティック、洗浄料、メーキャップ化粧料、分散液、軟膏、液剤、エアゾール、貼付剤等が挙げられ、特に乳液や水系化粧料が好ましい。上記した本発明化粧料は、美白化粧料や老化防止化粧料として使用することが好ましい。 The cosmetic of the present invention can be produced according to a conventional method according to the dosage form. Examples of the dosage form include emulsions, lotions, creams, packs, sticks, cleaning agents, makeup cosmetics, dispersions, ointments, solutions, aerosols, patches, and the like, and emulsions and aqueous cosmetics are particularly preferable. . The above-described cosmetic of the present invention is preferably used as a whitening cosmetic or anti-aging cosmetic.
また、本発明の化粧料は、pHが7〜9の範囲にあることが好ましい。pHが7より小さい場合は、黄変や変臭が生じやすく、保存安定性に劣る場合があり、逆にpHが9より大きい場合は、皮膚に対する安全性が低下する場合がある。 Further, the cosmetic of the present invention preferably has a pH in the range of 7-9. If the pH is less than 7, yellowing or odor is likely to occur and storage stability may be poor. Conversely, if the pH is greater than 9, safety to the skin may be reduced.
なお、本発明の化粧料は、一般の皮膚化粧料に限定されるものではなく、医薬部外品、医薬品等、皮膚外用剤全般を包含するものである。 The cosmetics of the present invention are not limited to general skin cosmetics, but include all skin external preparations such as quasi drugs and pharmaceuticals.
次に試験例及び実施例を挙げて本発明を更に詳細に説明するが、本発明はこれらに何ら制約されるものではない。 EXAMPLES Next, although a test example and an Example are given and this invention is demonstrated still in detail, this invention is not restrict | limited at all by these.
実 施 例 1
クリーム:
表1に示す組成により、下記方法に従ってクリームを調製した。得られたクリームについて、下記保存安定性試験(1)および保存安定性試験(2)を行った。この結果もあわせて表1に示す。Example 1
cream:
A cream was prepared according to the following method according to the composition shown in Table 1. The obtained cream was subjected to the following storage stability test (1) and storage stability test (2). The results are also shown in Table 1.
( 製 法 )
A. 成分(1)〜(6)を混合し、加熱して70℃に保つ。
B. 成分(7)〜(16)を加熱して70℃に保つ。
C. AにBを加え乳化した後、冷却してクリームを得た。(Production method)
A. Ingredients (1) to (6) are mixed and heated to keep at 70 ° C.
B. Ingredients (7)-(16) are heated and maintained at 70 ° C.
C. B was added to A and emulsified, and then cooled to obtain a cream.
<保存安定性試験(1)>
各クリームをサンプルとし、これらを50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの残存量を定量した。結果はサンプル作製時に配合した量に対する残存量を百分率にて表した。<Storage stability test (1)>
Each cream was used as a sample, and these were stored in a thermostat at 50 ° C. for 1 month, and then the residual amount of sodium L-ascorbate-2-phosphate was quantified by high performance liquid chromatography. As a result, the remaining amount relative to the amount blended at the time of sample preparation was expressed as a percentage.
<保存安定性試験(2)>
各クリームをサンプルとし、それぞれ2つずつ同一のガラス容器に詰め、片方を5℃の恒温槽に、もう片方を40℃の恒温槽に、それぞれ6ヶ月間保存した後、両サンプルの経日による外観色ならびに臭いの変化を比較した。評価は、5℃保存のサンプルを基準品とし、これに対して40℃保存のサンプルを比較し、下記の評価基準により評価した。<Storage stability test (2)>
Each cream is sampled and packed in the same glass container, and one is stored in a 5 ° C constant temperature bath and the other is stored in a 40 ° C constant temperature bath for 6 months. The changes in appearance color and odor were compared. The evaluation was performed according to the following evaluation criteria by comparing a sample stored at 40 ° C. with a sample stored at 5 ° C. as a reference product.
評 価 基 準 ;
評 価 評 価 内 容
◎ : 基準品と変化(黄変、変臭)がない。
○ : 基準品と比べわずかに変化(黄変、変臭)がみられる。
△ : 基準品と比べ変化(黄変、変臭)がある。
× : 基準品と比べ大きな変化(黄変、変臭)がある。Evaluation criteria ;
Evaluation Evaluation Contents ◎: There is no change (yellowing, odor) from the standard product.
○: A slight change (yellowing, odor) is seen compared to the standard product.
Δ: Change (yellowing, odor) compared to the standard product.
X: There is a large change (yellowing, odor) compared to the standard product.
実 施 例 2
化 粧 水:
表2に示す組成により、常法に従って化粧水を調製した。得られた化粧水について、下記保存安定性(外観)試験および保存安定性(臭い)を行った。この結果もあわせて表2に示す。Example 2
Cosmetic water:
With the composition shown in Table 2, lotion was prepared according to a conventional method. The obtained lotion was subjected to the following storage stability (appearance) test and storage stability (odor). The results are also shown in Table 2.
<保存安定性(外観)試験>
同一試料を5℃および40℃の恒温槽中で、それぞれ3ヶ月間保存した。その後、両サンプルの外観を、5℃で保存したものを基準品とし、下記基準で比較した。<Storage stability (appearance) test>
The same sample was stored for 3 months in a constant temperature bath at 5 ° C. and 40 ° C., respectively. Thereafter, the appearances of both samples were stored at 5 ° C. as reference products and compared according to the following criteria.
<保存安定性(臭い)試験>
同一試料を5℃および40℃の恒温槽中で、それぞれ3ヶ月間保存した。その後、両サンプルの臭いを、5℃で保存したものを基準品とし、下記基準で比較した。<Storage stability (odor) test>
The same sample was stored for 3 months in a constant temperature bath at 5 ° C. and 40 ° C., respectively. Thereafter, the odors of both samples were stored at 5 ° C. as a standard product and compared according to the following criteria.
評 価 基 準 ;
評 価 評 価 内 容
◎ : 基準品と変化(黄変、変臭)がない。
○ : 基準品と比べわずかに変化(黄変、変臭)がみられる。
△ : 基準品と比べ変化(黄変、変臭)がある。
× : 基準品と比べ大きな変化(黄変、変臭)がある。Evaluation criteria ;
Evaluation Evaluation Contents ◎: There is no change (yellowing, odor) from the standard product.
○: A slight change (yellowing, odor) is seen compared to the standard product.
Δ: Change (yellowing, odor) compared to the standard product.
X: There is a large change (yellowing, odor) compared to the standard product.
表2の結果に示すように、所定量の成分(B)を配合する本発明品10〜15の化粧水は、高温での長期保存においても、成分(A)であるL−アスコルビン酸−2−リン酸ナトリウムの黄変、変臭を抑制し、優れた保存安定性を有するものであった。これに対し、比較品5に示すように、成分(B)を配合しない化粧水の保存安定性は悪く、また比較品6および7に示すように、成分(B)を含んでいてもその配合量が本発明の範囲外の場合は、黄変や変臭が生じ、保存安定性を十分に満足するものではなかった。 As shown in the results of Table 2, the lotion of the present invention products 10 to 15 containing a predetermined amount of the component (B) is L-ascorbic acid-2 which is the component (A) even during long-term storage at high temperatures. -It suppressed the yellowing and odor of sodium phosphate and had excellent storage stability. On the other hand, as shown in comparative product 5, the storage stability of the skin lotion not containing component (B) is poor, and even if it contains component (B) as shown in comparative products 6 and 7, the formulation When the amount was out of the range of the present invention, yellowing and odor were generated, and the storage stability was not sufficiently satisfied.
実 施 例 3
化 粧 水 :
表3に示す組成により、常法に従って化粧水を調製した。得られた化粧水について、実施例2と同様にして保存安定性(外観)試験および保存安定性(臭い)を行った。この結果もあわせて表3に示す。Example 3
Cosmetic lotion:
With the composition shown in Table 3, a lotion was prepared according to a conventional method. The obtained lotion was subjected to a storage stability (appearance) test and storage stability (odor) in the same manner as in Example 2. The results are also shown in Table 3.
表3の結果に示すように、所定量の成分(B)と成分(C)を配合する本発明品16〜24の化粧水は、高温での長期保存においても、成分(A)であるL−アスコルビン酸−2−リン酸ナトリウムの黄変、変臭を抑制することができ、特に優れた保存安定性を有するものであった。 As shown in the results of Table 3, the lotion of the present invention products 16 to 24 containing a predetermined amount of the component (B) and the component (C) is L which is the component (A) even during long-term storage at high temperatures. -Ascorbic acid-2-sodium phosphate was able to suppress yellowing and deodorization, and had particularly excellent storage stability.
実 施 例 4
化 粧 水 :
表4に示す組成により、常法に従って化粧水を調製した。得られた化粧水について、実施例2と同様にして保存安定性(外観)試験および保存安定性(臭い)を行った。この結果もあわせて表4に示す。Example 4
Cosmetic lotion:
With the composition shown in Table 4, a lotion was prepared according to a conventional method. The obtained lotion was subjected to a storage stability (appearance) test and storage stability (odor) in the same manner as in Example 2. The results are also shown in Table 4.
表4の結果に示すように、成分(B)と成分(C)を所定量内で配合する本発明品25〜29の化粧水は、高温での長期保存においても、成分(A)であるL−アスコルビン酸−2−リン酸ナトリウムの黄変、変臭を抑制し、優れた保存安定性を有するものであった。 As shown in the results of Table 4, the skin lotion of the present invention products 25 to 29 containing the component (B) and the component (C) within a predetermined amount is the component (A) even in long-term storage at a high temperature. The yellowing and deodorization of L-ascorbic acid-2-phosphate sodium were suppressed, and the storage stability was excellent.
実 施 例 5
乳 液 :
Example 5
Milk liquid:
( 製 法 )
A. 成分(12)〜(21)を加熱混合し、70℃に保つ。
B. 成分(1)〜(11)を加熱混合し、70℃に保つ。
C. AにBを加えて混合し、均一に乳化する。
D. Cを冷却後、(22)〜(24)を加え均一に混合して乳液を得た。(Production method)
A. Ingredients (12) to (21) are heated and mixed and kept at 70 ° C.
B. Ingredients (1) to (11) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix, and uniformly emulsify.
D. After cooling C, (22) to (24) were added and mixed uniformly to obtain an emulsion.
実施例5の乳液について、50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、98.8%であった。また、40℃の恒温槽中で6ヶ月保存後においても、黄変、変臭が少なく、優れた保存安定性を有し、美白効果にも優れた乳液であった。 About the emulsion of Example 5, after storing in a thermostatic bath at 50 ° C. for 1 month, the amount of L-ascorbic acid-2-sodium phosphate was quantified by high performance liquid chromatography, and the residual rate was examined. It was 98.8%. Further, even after 6 months storage in a constant temperature bath at 40 ° C., the emulsion had little yellowing and odor, had excellent storage stability, and had excellent whitening effect.
実 施 例 6
軟 膏 :
Example 6
Ointment:
( 製 法 )
A. 成分(6)〜(13)を加熱混合し、75℃に保つ。
B. 成分(1)〜(5)を加熱混合し、75℃に保つ。
C. AをBに徐々に加え、軟膏を得た。(Production method)
A. Ingredients (6) to (13) are heated and mixed and kept at 75 ° C.
B. Ingredients (1) to (5) are heated and mixed and maintained at 75 ° C.
C. A was gradually added to B to obtain an ointment.
実施例6で得られた軟膏を、50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、93.5%であった。また、40℃の恒温槽中で6ヶ月保存後においても、黄変、変臭が少なく、優れた保存安定性を有する軟膏であった。 After the ointment obtained in Example 6 was stored in a thermostatic bath at 50 ° C. for one month, the amount of L-ascorbic acid-2-sodium phosphate was quantified by high performance liquid chromatography and the residual rate was examined. As a result, it was 93.5%. Further, even after 6 months storage in a constant temperature bath at 40 ° C., it was an ointment with little yellowing and deodorization and excellent storage stability.
実 施 例 7
美 容 液 :
Example 7
Beauty liquid:
( 製 法 )
A.成分(1)〜(3)を加熱混合したのち冷却する。
B. 成分(4)〜(13)を加え、美容液を得た。(Production method)
A. The components (1) to (3) are heated and mixed and then cooled.
B. Components (4) to (13) were added to obtain a cosmetic liquid.
実施例7で得られた美容液について、50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、98.1%であった。また、40℃の恒温槽中で6ヶ月保存後においても、黄変、変臭が少なく、優れた保存安定性を有し、美白効果にも優れた美容液であった。 About the cosmetic liquid obtained in Example 7, after storing for 1 month in a 50 degreeC thermostat, the quantity of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was calculated | required. When examined, it was 98.1%. Further, even after 6 months storage in a constant temperature bath at 40 ° C., the essence had little yellowing and odor, had excellent storage stability, and had excellent whitening effect.
実 施 例 8
パ ッ ク :
Example 8
Pack:
( 製 法 )
A. 成分(1)〜(6)を混合し、70℃に加熱して溶解する。
B. 成分(7)及び(8)を混合し溶解する。
C. Bを先のAに加え、混合した後、冷却して成分(9)〜(16)を均一に分散してパックを得た。(Production method)
A. Components (1) to (6) are mixed and dissolved by heating to 70 ° C.
B. Mix and dissolve components (7) and (8).
C. B was added to A, mixed, and then cooled to uniformly disperse components (9) to (16) to obtain a pack.
実施例8で得られたパックについて、50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、92.2%であった。また、40℃の恒温槽中で6ヶ月保存後においても、変色、変臭が少なく、優れた保存安定性を有するパックであった。 About the pack obtained in Example 8, after storing for 1 month in a 50 degreeC thermostat, the quantity of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. As a result, it was 92.2%. Further, even after 6 months storage in a 40 ° C. thermostat, the pack had little discoloration and odor change and excellent storage stability.
実 施 例 9
リキッドファンデーション:
Example 9
Liquid foundation:
( 製 法 )
A. 成分(1)〜(7)を加熱し混合溶解する。
B. Aに成分(13)〜(18)を加え、均一に混合し、70℃に保つ。
C. 成分(8)〜(12)を均一に溶解し、70℃に保つ。
D. CにBを添加して、均一に乳化する。
E. Dを冷却後、成分(19)〜(24)を添加してリキッドファンデーションを得た。(Production method)
A. The components (1) to (7) are heated and mixed and dissolved.
B. Add components (13) to (18) to A, mix uniformly, and maintain at 70 ° C.
C. Components (8) to (12) are uniformly dissolved and kept at 70 ° C.
D. Add B to C and emulsify uniformly.
E. After cooling D, components (19) to (24) were added to obtain a liquid foundation.
実施例9のリキッドファンデーションについて、50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、97.3%であった。また、40℃の恒温槽中で6ヶ月保存後においても、変臭が少なく、優れた保存安定性を有するリキッドファンデーションであった。 About the liquid foundation of Example 9, after preserve | saving for 1 month in a 50 degreeC thermostat, the quantity of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. 97.3%. Moreover, even after 6 months storage in a 40 ° C. constant temperature bath, the liquid foundation had little odor change and excellent storage stability.
実 施 例 10
日焼け止め乳液:
Example 10
Sunscreen latex:
( 製 法 )
A. 成分(1)〜(11)を混合分散する。
B. 成分(12)〜(15)を混合溶解する。
C. AにBを添加して、均一に乳化する。
D. Cに成分(16)〜(23)を添加して日焼け止め乳液を得た。(Production method)
A. Components (1) to (11) are mixed and dispersed.
B. Ingredients (12) to (15) are mixed and dissolved.
C. Add B to A and emulsify uniformly.
D. Components (16) to (23) were added to C to obtain a sunscreen emulsion.
実施例10の日焼け止め乳液について、50℃の恒温槽に1ヶ月間保存した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、99.0%であった。また、40℃の恒温槽中で6ヶ月保存後においても、変色、変臭が少なく、優れた保存安定性を有する日焼け止め乳液であった。 About the sunscreen emulsion of Example 10, after preserve | saving for 1 month in a 50 degreeC thermostat, the quantity of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. However, it was 99.0%. Further, even after storage for 6 months in a constant temperature bath at 40 ° C., it was a sunscreen emulsion with little discoloration and odor change and excellent storage stability.
実 施 例 11
乳 液 :
Example 11
Milk liquid:
( 製 法 )
A. 成分(12)〜(21)を加熱混合し、70℃に保つ。
B. 成分(1)〜(11)を加熱混合し、70℃に保つ。
C. AにBを加えて混合し、均一に乳化する。
D. Cを冷却後、(22)〜(24)を加え均一に混合して乳液を得た。(Production method)
A. Ingredients (12) to (21) are heated and mixed and kept at 70 ° C.
B. Ingredients (1) to (11) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix, and uniformly emulsify.
D. After cooling C, (22) to (24) were added and mixed uniformly to obtain an emulsion.
実施例11で得られた乳液について、50℃の恒温槽に1ヶ月間保管した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、94.2%であった。また、40℃の恒温槽中で6ヶ月保存した後においても、変色、変臭が少なく、優れた保存安定性を有する乳液であった。 About the emulsion obtained in Example 11, after storing it in a 50 degreeC thermostat for 1 month, the quantity of L-ascorbic acid-2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. As a result, it was 94.2%. Moreover, even after storing for 6 months in a constant temperature bath at 40 ° C., the emulsion was less discolored and odorless and had excellent storage stability.
実 施 例 12
美 容 液 :
Example 12
Beauty liquid:
( 製 法 )
A. 成分(1)〜(3)を加熱混合したのち冷却する。
B. 成分(4)〜(12)を加え、美容液を得た。(Production method)
A. The components (1) to (3) are heated and mixed and then cooled.
B. Components (4) to (12) were added to obtain a serum.
実施例12の美容液について、50℃の恒温槽に1ヶ月間保管した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、97.7%であった。また、40℃の恒温槽中で6ヶ月保存した後においても、変色、変臭が少なく、優れた保存安定性を有する美容液であった。 About the cosmetic liquid of Example 12, after storing for 1 month in a 50 degreeC thermostat, the amount of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. 97.7%. Further, even after 6 months storage in a constant temperature bath at 40 ° C., the cosmetic liquid had little storage discoloration and odor change and excellent storage stability.
実 施 例 13
パ ッ ク :
Example 13
Pack:
( 製 法 )
A. 成分(1)〜(5)を混合し、70℃に加熱して溶解する。
B. 成分(6)及び(7)を混合し溶解する。
C. Bを先のAに加え、混合した後、冷却して成分(8)〜(14)を均一に分散してパックを得た。(Production method)
A. Components (1) to (5) are mixed and dissolved by heating to 70 ° C.
B. Mix and dissolve components (6) and (7).
C. B was added to A above, mixed, and then cooled to uniformly disperse the components (8) to (14) to obtain a pack.
実施例13のパックについて、50℃の恒温槽に1ヶ月間保管した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量しその残存率を調べたところ、96.8%であった。また、40℃の恒温槽中で6ヶ月保存後においても、変色、変臭が少なく、優れた保存安定性を有するパックであった。 The pack of Example 13 was stored in a thermostatic bath at 50 ° C. for 1 month, and then the amount of L-ascorbic acid-2-sodium phosphate was quantified by high performance liquid chromatography. It was 8%. Further, even after 6 months storage in a 40 ° C. thermostat, the pack had little discoloration and odor change and excellent storage stability.
実 施 例 14
リキッドファンデーション:
Example 14
Liquid foundation:
( 製 法 )
A. 成分(1)〜(7)を加熱し混合溶解する。
B. Aに成分(13)〜(17)を加え、均一に混合し、70℃に保つ。
C. 成分(8)〜(12)を均一に溶解し、70℃に保つ。
D. CにBを添加して、均一に乳化する。
E. Dを冷却後、成分(18)〜(22)を添加してリキッドファンデーションを得た。(Production method)
A. The components (1) to (7) are heated and mixed and dissolved.
B. Add components (13) to (17) to A, mix uniformly, and maintain at 70 ° C.
C. Components (8) to (12) are uniformly dissolved and kept at 70 ° C.
D. Add B to C and emulsify uniformly.
E. After cooling D, components (18) to (22) were added to obtain a liquid foundation.
実施例14のリキッドファンデーションについて、50℃の恒温槽に1ヶ月間保管した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、92.1%であった。また、40℃の恒温槽中で6ヶ月保存後においても、変色、変臭が少なく、優れた保存安定性を有するリキッドファンデーションであった。 About the liquid foundation of Example 14, after storing for 1 month in a 50 degreeC thermostat, the quantity of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. 92.1%. Further, even after 6 months storage in a 40 ° C. thermostatic bath, the liquid foundation had little discoloration and odor change and excellent storage stability.
実 施 例 15
日焼け止め乳液:
Example 15
Sunscreen latex:
( 製 法 )
A. 成分(1)〜(11)を混合分散する。
B. 成分(12)〜(15)を混合溶解する。
C. AにBを添加して、均一に乳化する。
D. Cに成分(16)〜(21)を添加して日焼け止め乳液を得た。(Production method)
A. Components (1) to (11) are mixed and dispersed.
B. Ingredients (12) to (15) are mixed and dissolved.
C. Add B to A and emulsify uniformly.
D. Components (16) to (21) were added to C to obtain a sunscreen emulsion.
実施例15の日焼け止め乳液について、50℃の恒温槽に1ヶ月間保管した後、高速液体クロマトグラフィーにより、L−アスコルビン酸−2−リン酸ナトリウムの量を定量してその残存率を調べたところ、93.5%であった。また、40℃の恒温槽中で6ヶ月保存後においても、変色、変臭が少なく、優れた保存安定性を有する日焼け止め乳液であった。 About the sunscreen emulsion of Example 15, after storing it in a 50 degreeC thermostat for 1 month, the quantity of L-ascorbic acid 2-sodium phosphate was quantified by the high performance liquid chromatography, and the residual rate was investigated. However, it was 93.5%. Further, even after storage for 6 months in a constant temperature bath at 40 ° C., it was a sunscreen emulsion with little discoloration and odor change and excellent storage stability.
本発明の化粧品は、L−アスコルビン酸−2−リン酸ナトリウムを含有しながら、長期間の保存や温度の高い状態での保存であってもこの物質の分解を抑制されたものである。従って、L−アスコルビン酸−2−リン酸ナトリウムを有効成分とする化粧品、例えば、美白化粧料等として有利に使用することができるものである。 The cosmetic of the present invention contains L-ascorbic acid-2-phosphate, and is inhibited from being decomposed even when stored for a long period of time or at a high temperature. Therefore, it can be advantageously used as a cosmetic product containing L-ascorbic acid-2-phosphate as an active ingredient, such as a whitening cosmetic.
Claims (8)
(A)L−アスコルビン酸−2−リン酸ナトリウム
(B)アルギニン、尿素及びトリエタノールアミンよりなる群から選ばれる化合物の一
種又は二種以上
を、(A):(B)の配合質量比として、1:0.001〜0.5の割合で含有することを特徴とする化粧料。The following components (A) and (B);
(A) L-ascorbic acid-2-sodium phosphate (B) One or more compounds selected from the group consisting of arginine, urea and triethanolamine are mixed in (A) :( B). As a cosmetic, characterized in that it is contained in a ratio of 1: 0.001 to 0.5.
(C)酸化亜鉛または水中でアルカリ金属イオンを生成する塩
を、(A):(C)の配合質量比として、1:0.001〜1の割合で含有する請求項1記載の化粧料。Furthermore, as component (C), (C) zinc oxide or a salt that generates an alkali metal ion in water is contained in a ratio of 1: 0.001 to 1 as a blending mass ratio of (A) :( C). Item 1. A cosmetic according to Item 1.
The cosmetic according to any one of claims 1 to 7, which is a whitening cosmetic or an anti-aging cosmetic.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2004011253 | 2004-01-20 | ||
JP2004011253 | 2004-01-20 | ||
PCT/JP2005/000583 WO2005067867A1 (en) | 2004-01-20 | 2005-01-19 | Cosmetic |
Publications (2)
Publication Number | Publication Date |
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JPWO2005067867A1 true JPWO2005067867A1 (en) | 2007-12-27 |
JP4589236B2 JP4589236B2 (en) | 2010-12-01 |
Family
ID=34792326
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JP2005517108A Expired - Fee Related JP4589236B2 (en) | 2004-01-20 | 2005-01-19 | Cosmetics |
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JP (1) | JP4589236B2 (en) |
KR (1) | KR101128349B1 (en) |
CN (1) | CN1909879B (en) |
HK (1) | HK1098371A1 (en) |
TW (1) | TW200533382A (en) |
WO (1) | WO2005067867A1 (en) |
Families Citing this family (5)
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EP2095807A1 (en) * | 2008-02-28 | 2009-09-02 | Chanh-Dinh Nguyen-Petersen | Cream against cellulite and freckles |
WO2011011808A1 (en) * | 2009-07-30 | 2011-02-03 | Roman Buga | A cosmetic composition comprising sodium chloride in combination with one or more of protein, collagen, gelatin or amino acid |
JP6001902B2 (en) * | 2012-03-30 | 2016-10-05 | 株式会社コーセー | Composition containing ascorbic acid derivative |
JP6241871B2 (en) * | 2013-08-06 | 2017-12-06 | 日本メナード化粧品株式会社 | Emulsifying powder cosmetic |
WO2022034874A1 (en) * | 2020-08-11 | 2022-02-17 | ミヨシ油脂株式会社 | Preparation or composition containing ascorbic acid compound and method for stabilizing ascorbic acid compound |
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-
2005
- 2005-01-19 KR KR1020067014544A patent/KR101128349B1/en not_active IP Right Cessation
- 2005-01-19 CN CN2005800028472A patent/CN1909879B/en not_active Expired - Fee Related
- 2005-01-19 JP JP2005517108A patent/JP4589236B2/en not_active Expired - Fee Related
- 2005-01-19 WO PCT/JP2005/000583 patent/WO2005067867A1/en active Application Filing
- 2005-01-20 TW TW094101697A patent/TW200533382A/en not_active IP Right Cessation
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2007
- 2007-05-08 HK HK07104914.8A patent/HK1098371A1/en not_active IP Right Cessation
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JPH04173727A (en) * | 1990-11-06 | 1992-06-22 | Lion Corp | Composition for oral cavity |
JPH05229927A (en) * | 1992-02-21 | 1993-09-07 | Kao Corp | Skin-whitening cosmetic |
JPH0769831A (en) * | 1993-08-30 | 1995-03-14 | Pentel Kk | Liquid cosmetic |
JPH0782127A (en) * | 1993-09-14 | 1995-03-28 | Kanebo Ltd | Cosmetic |
JPH07252114A (en) * | 1994-01-28 | 1995-10-03 | Pentel Kk | Liquid cosmetic |
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JP2001220336A (en) * | 2000-02-08 | 2001-08-14 | Lion Corp | Composition for oral cavity |
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JP2002226494A (en) * | 2001-01-31 | 2002-08-14 | Nippon Surfactant Kogyo Kk | Method for preventing crystallization of l-ascorbyl magnesium phosphate and skin care preparation using the method |
Also Published As
Publication number | Publication date |
---|---|
CN1909879B (en) | 2010-11-24 |
WO2005067867A1 (en) | 2005-07-28 |
KR101128349B1 (en) | 2012-03-26 |
JP4589236B2 (en) | 2010-12-01 |
TWI337874B (en) | 2011-03-01 |
HK1098371A1 (en) | 2007-07-20 |
CN1909879A (en) | 2007-02-07 |
KR20060130613A (en) | 2006-12-19 |
TW200533382A (en) | 2005-10-16 |
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