CN1909879B - Cosmetic - Google Patents
Cosmetic Download PDFInfo
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- CN1909879B CN1909879B CN2005800028472A CN200580002847A CN1909879B CN 1909879 B CN1909879 B CN 1909879B CN 2005800028472 A CN2005800028472 A CN 2005800028472A CN 200580002847 A CN200580002847 A CN 200580002847A CN 1909879 B CN1909879 B CN 1909879B
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- cosmetics
- composition
- ascorbic acid
- sodium phosphate
- storage stability
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Birds (AREA)
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- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
A cosmetic containing L-ascorbic acid 2-phosphate sodium salt that excels in long-term storage stability. In particular, there is provided a cosmetic characterized in that L-ascorbic acid 2-phosphate sodium salt (A) and at least one compound (B) selected from the group consisting of arginine, urea and triethanolamine are contained in a mixing mass ratio of (A):(B) ranging from 1:0.001 to 1:0.5.
Description
Technical field
The present invention relates to the cosmetics of a kind of L-of containing ascorbic acid-2-sodium phosphate, more specifically, relate to a kind of by containing flavescence and the cosmetics spoiled and that storage stability is good that the special component inhibition follows the decomposition of L-ascorbic acid-2-sodium phosphate to produce.
Background technology
Up to now, to improve or prevention is a purpose because of the skin darkening of generations such as Exposure to Sunlight, brown patch that pigementation causes, freckle etc., use skin-lightening cosmetic or aging resistance cosmetics such as astringent, emulsion, emulsifiable paste, beautifying liquid, facial film, washing product, dispersion liquid, ointment, liquor, aerosol, alite paste, wherein extensively adopt the L-ascorbic acid as effective ingredient.
But, because L-ascorbic acid ratio is easier to oxidized or hydrolysis, therefore directly itself and cosmetics are used also and decompose easily, might cause improving or preventing the reduction of whitening effects such as brown patch, freckle itself, flavescence or spoiled etc. takes place, the quality of infringement cosmetics.Therefore, for the L-ascorbic acid is matched with in the cosmetics, use carried out the various derivants that chemical modification has improved stability to it more.
L-ascorbic acid-2-sodium phosphate also is to be a kind of in the derivant developed of purpose with the storage stability that improves the L-ascorbic acid.This material is compared storage stability with the L-ascorbic acid and is increased substantially, but will be combined with the cosmetics long preservation of this material, particularly under the temperature conditions more than 30 ℃ during long preservation, still produce the flavescence follow decomposition and spoiled, as the storage stability of cosmetics and insufficient.In addition, its effectiveness also might reduce aspect whitening effect.
Therefore, ascorbic acid-storage stability of 2-sodium phosphate in cosmetics is purpose with further raising L-, worked out the method (with reference to Japanese kokai publication hei 9-118613 communique) that L-ascorbic acid-2-sodium phosphate and the salt more than the divalent are used in combination, or be used in combination L-ascorbic acid-2-sodium phosphate, have sulfydryl or disulfide bond chemical compound, have the amino acid whose method (No. 01/043702 communique of WO) of sulfurous acid and hydroxyl etc.
But, when being used in combination L-ascorbic acid-2-sodium phosphate and the salt more than the divalent, abundant inadequately to being accompanied by particularly under the high temperature more than 30 ℃ the L-of long preservation ascorbic acid-flavescence that decomposition took place of 2-sodium phosphate or spoiled inhibitory action.In addition, be used in combination L-ascorbic acid-2-sodium phosphate, have the chemical compound of sulfydryl or disulfide bond, when having sulfurous acid and hydroxyl amino acid whose, though can suppress to follow the flavescence of L-ascorbic acid-2-sodium phosphate decomposition, it is not very abundant suppressing spoiled effect.In addition, under the high temperature preservation condition more than 30 ℃, there is the shortcoming that produces abnormal flavour owing to the chemical compound that is used as preserving stabilizer itself with sulfydryl or disulfide bond.
Summary of the invention
Invent problem to be solved
In sum, the objective of the invention is to develop a kind of being used for L-ascorbic acid-2-sodium phosphate is engaged in cosmetics,, also can prevent the method for the decomposition of this material under long-term and pyritous condition even when it is preserved.
Solve the method for problem
In view of the foregoing, the inventor furthers investigate, found that, in the cosmetics that contain L-ascorbic acid-2-sodium phosphate, when containing specific nitrogen-containing compound with specific cooperation ratio, can suppress the flavescence of L-ascorbic acid-2-sodium phosphate and spoiled, can keep the long-term consistent stability of cosmetics, thereby finish the present invention.
That is, the present invention is a kind of cosmetics, it is characterized by with (A): fit quality ratio (B) is that 1: 0.001～0.5 ratio contains following compositions (A) and (B):
(A) L-ascorbic acid-2-sodium phosphate
(B) be selected from one or more chemical compounds in arginine, carbamide and the triethanolamine.
The present invention further refers to above-mentioned cosmetics, and it is with (A): fit quality ratio (C) is that 1: 0.001～1 the ratio salt that contains (C) zinc oxide or generate alkali metal ion in water is as composition (C).
The invention effect
Cosmetics of the present invention are a kind of when cooperating L-ascorbic acid-2-sodium phosphate, also can suppress its flavescence and spoiled, storage stability good quality production under long-term, pyritous preservation condition.Therefore, can be used as various cosmetics such as skin-lightening cosmetic, aging resistance cosmetics extensively utilizes.
The specific embodiment
L-ascorbic acid-2-the sodium phosphate of the composition that uses among the present invention (A) is known material, be to be used to give cosmetics improving and to prevent, and prevent that the skin elasticity that causes because of Exposure to Sunlight from reducing or the material of antiageing effect such as lax, the wrinkle of skin because of the skin darkening that Exposure to Sunlight causes, dimness, brown patch, freckle or the sedimentary whitening effects of pigment such as old mottle and chloasma hepaticum of skin.The content of the composition in the cosmetics of the present invention (A) is not particularly limited, and preferably all accounting for 0.001～20 quality % (following only with " % " expression) in the composition, more preferably accounts for 0.1～5%.
In addition, arginine, carbamide and the triethanolamine of the composition that uses among the present invention (B) is the material of the storage stability that is used to improve composition (A), can make apply some make up in normally used material.The fit quality ratio of the content of the composition in the cosmetics of the present invention (B) between composition (A) and composition (B) is 1: 0.001～0.5, more preferably 1: 0.05～0.3.With respect to composition (A), the fit quality of composition (B) can't be preserved stabilization effect during than less than 0.001 fully, and when the fit quality of composition (B) when surpassing 0.5, also can not obtain the raising of more storage stabilities.
When mentioned component (B) is the combination of arginine and carbamide, because of the storage stability that can improve L-ascorbic acid-2-sodium phosphate tremendously therefore preferred.Under the situation of this combination, arginine: the fit quality ratio of carbamide is not particularly limited, and especially improves and by preferred at 1: 10～10: 1 o'clock storage stabilities.
In the present invention, though only cooperate mentioned component (B) can obtain flavescence or spoiled inhibition effect, in order to obtain better effect, the salt that further preferably is used zinc oxide or generates alkali metal ion in water is as composition (C).
In this composition (C), zinc oxide is that normally used zinc oxide gets final product in the cosmetics, be by and mentioned component (B) between combination, be used for further improving the material of the storage stability of composition (A).In addition, in the composition (A), can enumerate sodium chloride, potassium chloride, potassium citrate, sodium citrate, sodium lactate, sodium succinate, disodium succinate, natrium malicum, NaAsp, potassium aspartate, potassium sulfate, sodium sulfate, potassium carbonate, sodium carbonate, sodium bicarbonate, dibastic sodium phosphate, sodium dihydrogen phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate etc. as the salt that in water, generates alkali metal ion, especially preferred potassium chloride, sodium chloride etc.
The content of the composition in the cosmetics of the present invention (C) is, the fit quality ratio between composition (A) and the composition (C) is 1: 0.001～1, more preferably 1: 0.01～0.5.Composition (C) is difficult to further obtain the raising of storage stability effect for the fit quality of composition (A) during than less than 0.001, and the fit quality of composition (C) also can not obtain the raising of more storage stability effects than surpassing at 1 o'clock.Therefore, composition (A): composition (B): the fit quality ratio of composition (C) is 1: 0.001～0.5: 0.001～1, more preferably 1: 0.05～0.3: 0.01～0.5.
In the cosmetics of the present invention,, also can suitably cooperate the various compositions that are used in usually in cosmetics or medical cosmetics, the pharmaceuticals etc. as required except mentioned component.As this type of any composition, can enumerate powder outside the zinc oxide of for example alcohols, wetting agent, oiliness composition, emulsifying agent, emulsion stabilizer, thickening agent, antiseptic, composition (C), pigment, pigment, UV absorbent, pH regulator agent, spice, composition (A) active ingredient in addition etc.
Cosmetics of the present invention can be made with method commonly used according to its dosage form.The example of above-mentioned dosage form can be enumerated emulsion, astringent, emulsifiable paste, facial film, stick, detergent, color make-up cosmetics, dispersion liquid, ointment, liquor, aerosol, alite paste etc., especially preferred and water system cosmetics.The cosmetics of the invention described above preferably use as skin-lightening cosmetic or aging resistance cosmetics.
In addition, cosmetics of the present invention are preferably in the scope of pH7～9.Flavescence or spoiled took place less than 7 o'clock in pH easily, and storage stability is worsened, and opposite pH often caused skin safety is reduced greater than 9 o'clock.
Need to prove that cosmetics of the present invention are not limited to general cosmetics for skin, also comprise all medical cosmetics, pharmaceuticals, skin preparations for extenal use.
[embodiment]
The present invention will be described in more detail below to enumerate test example and embodiment, but the present invention is not subjected to their any qualification.
Embodiment 1
Emulsifiable paste:
According to the composition shown in the table 1, according to following method preparation emulsifiable paste.The emulsifiable paste that obtains is carried out following storage stability test (1) and storage stability test (2).This result is in the lump shown in the table 1.
(method for making)
A. heat blending constituent (1)～(6), remains on 70 ℃.
B. heat blending constituent (7)～(16), remains on 70 ℃.
C. after adding B carried out emulsifying in A, cooling obtained emulsifiable paste.
＜storage stability test (1) 〉
With each emulsifiable paste as sample, they are preserved 1 month in 50 ℃ temperature chamber after, by high performance liquid chromatography, the residual quantity of L-ascorbic acid-2-sodium phosphate is carried out quantitatively.The residual quantity of the amount that the result cooperates for respect to the perparation of specimen time is represented with percentage ratio.
＜storage stability test (2) 〉
With each emulsifiable paste as sample, each emulsifiable paste is filled up two parts of same glass containers respectively, and portion is kept in 5 ℃ the temperature chamber, and another part is contained in 40 ℃ the temperature chamber, after preserving 6 months respectively, relatively two duplicate samples through the time appearance color that produced and the variation of abnormal smells from the patient.Evaluation is a standard sample with the sample of preserving down at 5 ℃,, estimates according to following evaluation criterion relatively at 40 ℃ of samples of preserving down with respect to it.
Evaluation criterion:
Estimate evaluation content
◎: compare nothing with standard substance and change (flavescence, spoiled).
Zero: compare visible minor alteration (flavescence, spoiled) with standard substance.
△: compare with standard substance change (flavescence, spoiled).
*: compared very big change (flavescence, spoiled) with standard substance.
Table 1
[0048]Embodiment 2
Astringent:
According to the composition shown in the table 2, according to common method preparation astringent.The astringent that obtains is carried out following storage stability (outward appearance) test and storage stability (abnormal smells from the patient) test.This result is in the lump shown in the table 2.
＜storage stability (outward appearance) test 〉
Same sample was preserved respectively 3 months in the temperature chamber of 5 ℃ and 40 ℃ respectively.Then with 5 ℃ of samples of preserving down as standard substance, according to following standard the outward appearance of two samples is estimated.
＜storage stability (abnormal smells from the patient) test 〉
Same sample was preserved respectively 3 months in the temperature chamber of 5 ℃ and 40 ℃ respectively.Then with 5 ℃ of samples of preserving down as standard substance, according to following standard the abnormal smells from the patient of two samples is estimated.
Evaluation criterion:
Estimate evaluation content
◎: compare nothing with standard substance and change (flavescence, spoiled).
Zero: compare visible minor alteration (flavescence, spoiled) with standard substance.
△: compare with standard substance change (flavescence, spoiled).
*: compared very big change (flavescence, spoiled) with standard substance.
Table 2
[0063]Shown in the result of table 2, cooperate the astringent of the present invention's product 10～15 of the composition (B) of specified quantitative, even under high temperature long preservation condition, also can suppress the flavescence, spoiled of the L-ascorbic acid-2-sodium phosphate of composition (A), have good storage stability.With respect to this, shown in relatively product 5, the storage stability of the astringent of gradation composition (B) is not poor, in addition shown in relatively product 6 and 7, even contain composition (B), if its use level is outside scope of the present invention, flavescence or spoiled will take place, and can not fully satisfy storage stability.
Embodiment 3
Astringent:
According to the composition shown in the table 3, according to common method preparation astringent.The astringent that obtains is carried out following storage stability (outward appearance) test and storage stability (abnormal smells from the patient) test.This result is in the lump shown in the table 3.
Table 3
[0069]Shown in the result of table 3, the astringent of the composition (B) of cooperation specified quantitative and the present invention's product 16～24 of composition (C), even under high temperature long preservation condition, also can suppress the flavescence, spoiled of the L-ascorbic acid-2-sodium phosphate of composition (A), have good especially storage stability.
Embodiment 4
Astringent:
According to the composition shown in the table 4, according to common method preparation astringent.The astringent that obtains is carried out following storage stability (outward appearance) test and storage stability (abnormal smells from the patient) test.This result is in the lump shown in the table 4.
Table 4
[0075]Shown in the result of table 4, the astringent of the composition (B) of cooperation specified quantitative and the present invention's product 25～29 of composition (C), even under high temperature long preservation condition, also can suppress the flavescence, spoiled of the L-ascorbic acid-2-sodium phosphate of composition (A), have good storage stability.
Embodiment 5
Emulsion:
(composition) (%)
(1) sorbitan monostearate 0.3
(2) Tween-81 0.1
(20.E.O.)
(3) the lipophile glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) hexadecanol 0.5
(6) olive oil 3.0
(7) liquid paraffin 4.0
(8) three-2 ethyl hexanoic acid glyceride 2.0
(9) methyl polysiloxane 1.0
(10) the hydrogenation soybean lecithin 0.1
(11) acetic acid dl-alpha-tocopherol 0.05
(12) PEMULEN TR-1 (annotating 1) 0.2
(13) sodium hydroxide 0.08
(14) glycerol 5.0
(15) 1,3 butylene glycol 7.0
(16) L-ascorbic acid-2-sodium phosphate 3.0
(17) arginine 0.2
(18) carbamide 0.4
(19) malic acid 0.2
(20) zinc oxide 0.5
(21) Purified Water surplus
(22) antiseptic is an amount of
(23) spice is an amount of
(24) ethanol 5.0
Annotating 1:BFGoodrich company produces
(method for making)
A. heat blending constituent (12)～(21), remains on 70 ℃.
B. heat blending constituent (1)～(11), remains on 70 ℃.
C. after adding B mixes in A, carry out the emulsifying of homogeneous.
D. after cooling off C, add composition (22)～(24) uniform mixing and obtain emulsion.
The emulsion of embodiment 5 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 98.8%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, flavescence, spoiled phenomenon are to have good storage stability and the also good emulsion of whitening effect seldom.
Embodiment 6
Ointment:
(composition) (%)
(1) stearic acid 18.0
(2) hexadecanol 4.0
(3) acetic acid dl-alpha-tocopherol 0.2
(4) vitamin A palmitate 0.2
(5) antiseptic is an amount of
(6) hydrochlorinate potassium 0.5
(7) glycerol 5.0
(8) sodium lactate 0.5
(9) L-ascorbic acid-2-sodium phosphate 20.0
(10) arginase 12 .0
(11) triethanolamine 1.0
(12) zinc oxide 5.0
(13) Purified Water surplus
(method for making)
A. heat blending constituent (6)～(13), be kept at 75 ℃.
B. heat blending constituent (1)～(5), be kept at 75 ℃.
C. in B, slowly add A, obtain ointment.
The ointment of embodiment 6 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 93.5%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, flavescence, spoiled phenomenon are the ointment with good storage stability seldom.
Embodiment 7
Beautifying liquid:
(composition) (%)
(1) PEMULEN TR-2 (annotating 1) 0.2
(2) xanthan gum 0.2
(3) Purified Water surplus
(4) glycerol 2.0
(5) ethanol 20.0
(6) sodium hydroxide 0.05
(7) lactic acid 0.05
(8) succinic acid 0.15
(9) L-ascorbic acid-2-sodium phosphate 0.1
(10) arginine 0.01
(11) carbamide 0.01
(12) zinc oxide 0.05
(13) Purified Water 10.0
Annotating 1:BFGoodrich company produces
(method for making)
A. heat blending constituent (1)～(3) postcooling.
B. add composition (4)～(13), obtain beautifying liquid.
The beautifying liquid of embodiment 7 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 98.1%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, flavescence, spoiled phenomenon are to have good storage stability and the also good beautifying liquid of whitening effect seldom.
Embodiment 8
Facial film:
(composition) (%)
(1) polyvinyl alcohol 15.0
(2) silicic acid anhydride 0.5
(3) Polyethylene Glycol 0.5
(4) the methyl glucoside polyethenoxy ether 5.0
(5) glycerol 5.0
(6) Purified Water surplus
(7) ethanol 10.0
(8) antiseptic is an amount of
(9) sodium hydroxide 0.05
(10) sodium citrate 0.05
(11) tartaric acid 0.15
(12) L-ascorbic acid-2-sodium phosphate 1.0
(13) carbamide 0.1
(14) triethanolamine 0.1
(15) zinc oxide 0.5
(16) Purified Water 10.0
(method for making)
A. blending constituent (1)～(6) are heated to 70 ℃ and dissolve.
B. with composition (7)～(8) mixed dissolution.
C. in above-mentioned A, add B, mix postcooling, composition (9)～(16) are carried out homodisperse, obtained facial film.
The facial film of embodiment 8 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 92.2%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, flavescence, spoiled phenomenon are the facial films with good storage stability seldom.
Embodiment 9
Liquid foundation:
(composition) (%)
(1) dipentaerythritol fatty acid ester (annotating 1) 2.0
(2) liquid paraffin 5.0
(3) stearic acid 2.0
(4) hexadecanol 1.0
(5) the self-emulsifying type glyceryl monostearate 1.0
(6) p-methoxycinnamate-2-ethyl hexyl ester 8.0
(7) antiseptic is an amount of
(8) glycerol 5.0
(9) hydrochlorinate potassium 0.2
(10) carboxymethyl cellulose 0.2
(11) bentonite 0.5
(12) Purified Water surplus
(13) silica alumina is handled titanium oxide 6.0
(14) fluoride is handled micropartical titanium oxide 2.0
(15) coloring pigment 5.0
(16) Muscovitum 2.0
(17) Talcum 4.0
(18) zinc oxide 1.0
(19) sodium lactate 0.3
(20) malic acid 0.2
(21) L-ascorbic acid-2-sodium phosphate 3.0
(22) arginine 0.2
(23) carbamide 0.4
(24) Purified Water 10.0
Annotate 1: コ ス モ one Le 168AR (a day clear オ イ リ オ Co., Ltd. produces)
(method for making)
A. heat mixed dissolution composition (1)～(7).
B. add composition (13)～(18) in A, uniform mixing remains on 70 ℃.
C. with composition (8)～(12) uniform dissolution, remain on 70 ℃.
D. in C, add B, carry out the emulsifying of homogeneous.
E. after cooling off D, add composition (19)～(24) uniform mixing and obtain liquid foundation.
The emulsion of embodiment 9 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 97.3%.In addition, even preserve after 6 months in 40 ℃ temperature chamber, spoiled phenomenon is the liquid foundation with good storage stability seldom.
Embodiment 10
Ultra light sun block lotion:
(composition) (%)
(1) the polyoxyalkylene modified polyorganosiloxanes 1.0
(2) dimethyl polysiloxane 5.0
(3) octamethylcy-clotetrasiloxane 20.0
(4) the different tridecane ester 5.0 of different n-nonanoic acid
(5) p-methoxycinnamate-2-ethyl hexyl ester 5.0
(6) antiseptic is an amount of
(7) spice is an amount of
(8) polysiloxanes is handled micropartical titanium oxide 10.0
(9) polysiloxanes is handled titanium oxide 5.0
(10) the polystyrene end 3.0
(11) trimethylsiloxy silicic acid 0.5
(12) dipropylene glycol 3.0
(13) ethanol 10.0
(14) Purified Water surplus
(15) sodium chloride 0.2
(16) zinc oxide 1.0
(17) citric acid 0.2
(18) malic acid 0.2
(19) L-ascorbic acid-2-sodium phosphate 3.0
(20) arginine 0.2
(21) carbamide 0.4
(22) triethylamine 0.1
(23) Purified Water 10.0
(method for making)
A. mix dispersion component (1)～(11).
B. mixed dissolution composition (12)～(15).
C. in A, add B, carry out uniformly emulsify.
D. in C, add composition (16)～(23) and obtain ultra light sun block lotion.
The ultra light sun block lotion of embodiment 10 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 99.0%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, variable color, spoiled phenomenon are the ultra light sun block lotion with good storage stability seldom.
Embodiment 11
Emulsion:
(composition) (%)
(1) sorbitan monostearate 0.5
(2) Tween-81 0.5
(20.E.O.)
(3) the lipophilic glyceryl monostearate 0.5
(4) stearic acid 1.0
(5) hexadecanol 0.5
(6) olive oil 3.0
(7) liquid paraffin 4.0
(8) three-2 ethyl hexanoic acid glyceride 2.0
(9) dimethyl polysiloxane 1.0
(10) the hydrogenation soybean lecithin 0.1
(11) acetic acid dl-alpha-tocopherol 0.05
(12) acrylic acid alkyl methacrylate copolymer 0.2
(13) sodium hydroxide 0.08
(14) glycerol 5.0
(15) 1,3 butylene glycol 5.0
(16) L-ascorbic acid-2-sodium phosphate 3.0
(17) arginine 0.2
(18) carbamide 0.4
(19) malic acid 0.2
(20) potassium chloride 0.5
(21) Purified Water surplus
(22) antiseptic is an amount of
(23) spice is an amount of
(24) ethanol 5.0
(method for making)
A. heat blending constituent (12)～(21), remain on 70 ℃.
B. heat blending constituent (1)～(11), remain on 70 ℃.
C. in A, add B and mix, carry out uniformly emulsify.
After the D.C cooling, add composition (22)～(24) uniform mixing and obtain emulsion.
The ultra light sun block lotion of embodiment 11 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 94.2%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, variable color, spoiled phenomenon are the emulsions with good storage stability seldom.
Embodiment 12
Beautifying liquid:
(composition) (%)
(1) acrylic acid alkyl methacrylate copolymer 0.2
(2) xanthan gum 0.2
(3) Purified Water surplus
(4) glycerol 2.0
(5) ethanol 10.0
(6) sodium hydroxide 0.05
(7) lactic acid 0.05
(8) succinic acid 0.15
(9) L-ascorbic acid-2-sodium phosphate 0.5
(10) carbamide 0.1
(11) sodium carbonate 0.05
(12) Purified Water 10.0
(method for making)
A. heat blending constituent (1)～(3) postcooling.
C. add composition (4)～(12), obtain beautifying liquid.
The beautifying liquid of embodiment 12 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 97.7%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, flavescence, spoiled phenomenon are the beautifying liquids with good storage stability seldom.
Embodiment 13
Facial film:
(composition) (%)
(1) polyvinyl alcohol 15.0
(2) silicic acid anhydride 0.5
(3) Polyethylene Glycol 0.5
(4) glycerol 5.0
(5) Purified Water surplus
(6) ethanol 10.0
(7) antiseptic is an amount of
(8) sodium hydroxide 0.05
(9) sodium citrate 0.2
(10) tartaric acid 0.15
(11) L-ascorbic acid-2-sodium phosphate 1.0
(12) carbamide 0.1
(13) triethanolamine 0.1
(14) Purified Water 10.0
(method for making)
A. blending constituent (1)～(5) are heated to 70 ℃ and dissolve.
B. with composition (6)～(7) mixed dissolution.
C. in above-mentioned A, add B, mix postcooling, composition (8)～(14) are carried out homodisperse, obtained facial film.
The facial film of embodiment 13 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 96.8%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, flavescence, spoiled phenomenon are the facial films with good storage stability seldom.
Embodiment 14
Liquid foundation:
(composition) (%)
(1) dipentaerythritol fatty acid ester (annotating 1) 2.0
(2) liquid paraffin 5.0
(3) stearic acid 2.0
(4) hexadecanol 1.0
(5) the self-emulsifying type glyceryl monostearate 1.0
(6) p-methoxycinnamate-2-ethyl hexyl ester 8.0
(7) antiseptic is an amount of
(8) glycerol 5.0
(9) hydrochlorinate potassium 0.2
(10) carboxymethyl cellulose 0.2
(11) bentonite 0.5
(12) Purified Water surplus
(13) silica alumina is handled titanium oxide 6.0
(14) fluoride is handled micropartical oxidation 2.0
(15) coloring pigment 5.0
(16) Muscovitum 2.0
(17) Talcum 4.0
(18) malic acid 0.2
(19) L-ascorbic acid-2-sodium phosphate 2.0
(20) arginine 0.5
(21) carbamide 0.3
(22) Purified Water 10.0
Annotate 1: コ ス モ one Le 168AR (a day clear オ イ リ オ Co., Ltd. produces)
(method for making)
A. heat mixed dissolution composition (1)～(7).
B. add composition (13)～(17) in A, uniform mixing remains on 70 ℃.
C. with composition (8)～(12) uniform dissolution, remain on 70 ℃.
D. in C, add B, carry out the emulsifying of homogeneous.
E. after cooling off D, add composition (18)～(22) uniform mixing and obtain liquid foundation.
The emulsion of embodiment 14 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 92.1%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, variable color, spoiled phenomenon are the liquid foundation with good storage stability seldom.
Embodiment 15
Ultra light sun block lotion:
(composition) (%)
(1) the polyoxyalkylene modified polyorganosiloxanes 1.0
(2) dimethyl polysiloxane 5.0
(3) octamethylcy-clotetrasiloxane 20.0
(4) the different tridecane ester 5.0 of different n-nonanoic acid
(5) p-methoxycinnamate-2-ethyl hexyl ester 5.0
(6) antiseptic is an amount of
(7) spice is an amount of
(8) polysiloxanes is handled micropartical titanium oxide 10.0
(9) polysiloxanes is handled titanium oxide 5.0
(10) the polystyrene end 3.0
(11) trimethylsiloxy silicic acid 0.5
(12) dipropylene glycol 3.0
(13) ethanol 10.0
(14) Purified Water surplus
(15) sodium chloride 1.0
(16) malic acid 0.5
(17) L-ascorbic acid-2-sodium phosphate 5.0
(18) arginine 0.2
(19) carbamide 0.4
(20) diethanolamine 0.1
(21) Purified Water 10.0
(method for making)
A. mix dispersion component (1)～(11).
B. mixed dissolution composition (12)～(15).
C. in A, add B, carry out uniformly emulsify.
D. in C, add composition (16)～(21) and obtain ultra light sun block lotion.
The ultra light sun block lotion of embodiment 15 is kept in 50 ℃ the temperature chamber after 1 month, by high performance liquid chromatography the amount of L-ascorbic acid-2-sodium phosphate carried out quantitatively, obtaining its residual rate is 93.5%.In addition, even preserve in 40 ℃ temperature chamber after 6 months, variable color, spoiled phenomenon are the ultra light sun block lotion with good storage stability seldom.
Industrial applicability
Cosmetics of the present invention are when containing L-AA-2-sodium phosphate, even also can suppress the decomposition of this material under the preservation of long preservation or the condition of high temperature. Therefore, the present invention can be used in L-AA-2-sodium phosphate effectively as the cosmetics of active ingredient, such as in skin-lightening cosmetic etc.
Claims (8)
1. cosmetics is characterized by with (A): fit quality ratio (B) is that 1: 0.001～0.5 ratio contains following compositions (A) and (B):
(A) L-ascorbic acid-2-sodium phosphate
(B) be selected from two or more chemical compounds in carbamide, arginine and the triethanolamine.
2. cosmetics as claimed in claim 1, these cosmetics are with (A): fit quality ratio (C) is that 1: 0.001～1 the ratio salt that contains (C) zinc oxide or generate alkali metal ion in water is as composition (C).
3. cosmetics as claimed in claim 1 or 2, these cosmetics contain the composition (A) of 0.001～20 quality %.
4. cosmetics as claimed in claim 1 or 2, wherein composition (B) is the combination of arginine and carbamide.
5. cosmetics as claimed in claim 2, the salt that wherein generates alkali metal ion in the composition (C) in water is potassium chloride or sodium chloride.
6. cosmetics as claimed in claim 1 or 2, these cosmetics are aqueous cosmetic or emulsification cosmetic.
7. cosmetics as claimed in claim 1 or 2, the pH of these cosmetics are 7～9.
8. cosmetics as claimed in claim 1 or 2, these cosmetics are skin-lightening cosmetic or aging resistance cosmetics.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004011253 | 2004-01-20 | ||
| JP011253/2004 | 2004-01-20 | ||
| PCT/JP2005/000583 WO2005067867A1 (en) | 2004-01-20 | 2005-01-19 | Cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1909879A CN1909879A (en) | 2007-02-07 |
| CN1909879B true CN1909879B (en) | 2010-11-24 |
Family
ID=34792326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800028472A Expired - Fee Related CN1909879B (en) | 2004-01-20 | 2005-01-19 | Cosmetic |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP4589236B2 (en) |
| KR (1) | KR101128349B1 (en) |
| CN (1) | CN1909879B (en) |
| HK (1) | HK1098371A1 (en) |
| TW (1) | TW200533382A (en) |
| WO (1) | WO2005067867A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2095807A1 (en) * | 2008-02-28 | 2009-09-02 | Chanh-Dinh Nguyen-Petersen | Cream against cellulite and freckles |
| WO2011011808A1 (en) * | 2009-07-30 | 2011-02-03 | Roman Buga | A cosmetic composition comprising sodium chloride in combination with one or more of protein, collagen, gelatin or amino acid |
| JP6001902B2 (en) * | 2012-03-30 | 2016-10-05 | 株式会社コーセー | Composition containing ascorbic acid derivative |
| JP6241871B2 (en) * | 2013-08-06 | 2017-12-06 | 日本メナード化粧品株式会社 | Emulsifying powder cosmetic |
| WO2022034874A1 (en) * | 2020-08-11 | 2022-02-17 | ミヨシ油脂株式会社 | Preparation or composition containing ascorbic acid compound and method for stabilizing ascorbic acid compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2973511B2 (en) * | 1990-11-06 | 1999-11-08 | ライオン株式会社 | Oral composition |
| JPH05229927A (en) * | 1992-02-21 | 1993-09-07 | Kao Corp | Skin-whitening cosmetic |
| JP3314478B2 (en) * | 1993-08-30 | 2002-08-12 | ぺんてる株式会社 | Eyeliner liquid |
| JP2613865B2 (en) * | 1993-09-14 | 1997-05-28 | 鐘紡株式会社 | Cosmetics |
| JPH07252114A (en) * | 1994-01-28 | 1995-10-03 | Pentel Kk | Liquid cosmetic |
| JPH07229927A (en) * | 1994-02-22 | 1995-08-29 | Mitsubishi Electric Corp | Current sensor |
| JP3772468B2 (en) * | 1997-06-11 | 2006-05-10 | 昭和電工株式会社 | L-ascorbic acid-2-phosphate zinc salt and method for producing the same |
| JP4535215B2 (en) * | 2000-02-08 | 2010-09-01 | ライオン株式会社 | Oral composition and method for improving stabilization of ascorbic acid ester or salt thereof in oral composition |
| JP3385464B2 (en) * | 2000-02-21 | 2003-03-10 | 独立行政法人産業技術総合研究所 | Lithium ion secondary battery including carbon material in negative electrode and method of identifying carbon material |
| JP4257479B2 (en) * | 2000-06-30 | 2009-04-22 | ライオン株式会社 | Method for producing dentifrice composition containing ascorbic acid phosphate or salt thereof |
| JP2002226494A (en) * | 2001-01-31 | 2002-08-14 | Nippon Surfactant Kogyo Kk | Method for preventing crystallization of l-ascorbyl magnesium phosphate and skin care preparation using the method |
-
2005
- 2005-01-19 KR KR1020067014544A patent/KR101128349B1/en not_active IP Right Cessation
- 2005-01-19 CN CN2005800028472A patent/CN1909879B/en not_active Expired - Fee Related
- 2005-01-19 JP JP2005517108A patent/JP4589236B2/en not_active Expired - Fee Related
- 2005-01-19 WO PCT/JP2005/000583 patent/WO2005067867A1/en active Application Filing
- 2005-01-20 TW TW094101697A patent/TW200533382A/en not_active IP Right Cessation
-
2007
- 2007-05-08 HK HK07104914.8A patent/HK1098371A1/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| JP特开平5-229927A 1993.09.07 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1909879A (en) | 2007-02-07 |
| KR101128349B1 (en) | 2012-03-26 |
| TW200533382A (en) | 2005-10-16 |
| JP4589236B2 (en) | 2010-12-01 |
| HK1098371A1 (en) | 2007-07-20 |
| KR20060130613A (en) | 2006-12-19 |
| WO2005067867A1 (en) | 2005-07-28 |
| TWI337874B (en) | 2011-03-01 |
| JPWO2005067867A1 (en) | 2007-12-27 |
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