CN111479547A

CN111479547A - Oil-in-water cosmetic composition with high-content calamine stabilized in inner phase

Info

Publication number: CN111479547A
Application number: CN201880075382.0A
Authority: CN
Inventors: 朴安那
Original assignee: Amorepacific Corp
Current assignee: Amorepacific Corp
Priority date: 2017-11-22
Filing date: 2018-11-21
Publication date: 2020-07-31
Anticipated expiration: 2038-11-21
Also published as: KR20190058950A; CN111479547B; WO2019103453A3; TW201924646A; WO2019103453A2; TWI791684B; KR102394535B1

Abstract

The present invention relates to an oil-in-water type cosmetic composition containing a high content of calamine stabilized in the inner phase, which comprises a mixture of a sorbitol surfactant and a saccharide surfactant. Furthermore, the present invention relates to the use of a mixture of a sorbitol-based surfactant and a saccharide surfactant as an internal phase stabilizer in the preparation of an oil-in-water type cosmetic composition containing a high content of calamine in the internal phase. Furthermore, the present invention relates to a method of stabilizing high levels of calamine in the internal phase of an oil-in-water cosmetic composition. Further, the present invention relates to a method for applying the oil-in-water type cosmetic composition with a high content of calamine stabilized in the internal phase of the present invention on the skin, thereby maximizing the functional activity of calamine.

Description

Oil-in-water cosmetic composition with high-content calamine stabilized in inner phase

Technical Field

Cross Reference to Related Applications

This application claims priority to korean patent application No. 10-2017-0156407 (application date: 2017, 11/22), the entire contents of which are incorporated herein by reference.

Technical Field

The present invention relates to an oil-in-water type cosmetic composition containing high content of Calamine (Calamine) stabilized in the inner phase, which uses a sorbitol (Sorbitan) surfactant and a saccharide surfactant in combination. Furthermore, the present invention relates to the use of a mixture of a sorbitol-based surfactant and a saccharide surfactant as an internal phase stabilizer in the preparation of an oil-in-water type cosmetic composition containing a high content of calamine in the internal phase. Furthermore, the present invention relates to a method of stabilizing high levels of calamine in the internal phase of an oil-in-water cosmetic composition. Further, the present invention relates to a method for applying the oil-in-water type cosmetic composition with a high content of calamine stabilized in the internal phase of the present invention on the skin, thereby maximizing the functional activity of calamine.

Background

Calamine (Calamine) is a reddish fine powder obtained by mixing zinc oxide and 0.5 to 1% of iron (III) oxide, and the zinc oxide contained in Calamine plays a role in diminishing inflammation and protecting. Therefore, calamine is included in skin external preparations such as ointments and spacers, and is used as a protective agent, an astringent, a preservative, and the like for treating skin diseases. In addition, in the cosmetic field, calamine is contained in an emulsion base, and thus is used for the purpose of improving acne-type skin and calming the skin, and the like.

However, most of the existing calamine cosmetics are water-in-oil type, are dry and astringent in spreadability, and have low absorption power. Further, although oil-in-water type calamine cosmetics are occasionally tried, in most cases, calamine is prepared by forcibly dispersing it in an external phase, not in an internal phase, and in this case, although spreadability is improved, there is a limitation in that absorbability is decreased. Korean granted patent No. 10-1590803 discloses a cosmetic composition for immediate whitening or for improving skin color containing calamine. However, this patent also uses water-in-oil as an effective formulation, and does not use oil-in-water.

The main key to stabilize calamine in oil-in-water dosage forms and to improve long-term stability is to overcome the phenomenon of gelation (gelation) where the polymer coagulates with calamine to precipitate as particles or polymer. In the present invention, in order to prevent direct contact of the calamine with the polymer when preparing the oil-in-water type calamine cosmetic composition, it is attempted to stabilize the calamine in the internal phase and separate it from the external phase in which the polymer is present. As such a method, a method of using a sorbitol-based surfactant and a saccharide-based surfactant together with calamine has been studied, and by this method, it is possible to stabilize a high content of calamine in the internal phase of an oil-in-water type cosmetic, thereby ensuring long-term stability and improving the feeling of use of the cosmetic.

Documents of the prior art

[ patent document ]

(patent document 1)1 Korean patent laid-open No. 10-1590803

Disclosure of Invention

Technical problem

The present inventors have attempted to prepare an oil-in-water type cosmetic having a high content of calamine stabilized in order to obtain a feeling of use improved over that of conventional water-in-oil type calamine cosmetics. However, in the process of stabilizing calamine in an oil-in-water type, there is a problem of polymer gelation, and in order to solve this problem, a method of dispersing a polymer and calamine in different phases has been studied.

That is, the present inventors have found that this problem can be solved by a method of stabilizing calamine in an oil phase as an inner phase, blending it at a certain ratio, and using a sorbitol-based surfactant and a saccharide surfactant together, unlike a conventional method of forcibly dispersing calamine in an aqueous phase as an outer phase, and thus have completed the present invention.

Accordingly, an object of the present invention is to provide an oil-in-water type cosmetic composition in which a high content of calamine is stabilized in the inner phase.

Technical scheme

In order to achieve the above object, the present invention provides an oil-in-water type cosmetic composition containing calamine, a sorbitol surfactant and a saccharide surfactant, which stabilizes calamine in the internal phase, and stabilizes high-content calamine.

Further, the present invention provides a use of a mixture of a sorbitol-based surfactant and a saccharide-based surfactant as an internal phase stabilizer in the preparation of an oil-in-water type cosmetic composition containing a high content of calamine in the internal phase. Further, the present invention provides a method of stabilizing a high content of calamine in the internal phase of an oil-in-water type cosmetic composition. Further, the present invention provides a method for maximizing the functional activity of calamine by applying the oil-in-water type cosmetic composition having a high content of calamine stabilized in the internal phase of the present invention to the skin.

Effects of the invention

The cosmetic composition of the present invention can improve the stability and long-term stability of an oil-in-water formulation containing calamine by using a sorbitol surfactant and a saccharide surfactant together. In addition, a high content of calamine can be stabilized in the oil-in-water type internal phase, so that a bad feeling in use such as a dry spreadability can be improved, and the skin absorption ability can be improved.

Drawings

FIG. 1 is a photograph showing the appearance of the composition in order to observe the degree of separation between the water phase and the oil phase after storage at 45 ℃ for 2 weeks after production example 1 and comparative examples 1 to 5.

FIG. 2 is a photograph of the frosted appearance of the composition of stabilizing example 1 in an oil-in-water type. The lower right micrograph of fig. 2 shows a state where the cream was applied to the skin, and it was confirmed that the powder particles were uniformly dispersed and were not coagulated.

Detailed Description

The present invention relates to an oil-in-water type cosmetic composition containing calamine stabilized in a high content in an internal phase, which contains calamine, a sorbitol surfactant and a saccharide surfactant.

The present invention will be described in more detail below.

Calamine (Calamina)

Calamine contained as an effective ingredient in cosmetics is a fine powder raw material in a pale red color, and is used mainly for the purpose of improving acne-type skin and calming the skin. In addition, calamine is also known to be included in water-in-oil type cosmetics to have whitening and moisturizing effects.

The present invention provides a cosmetic composition containing a high content of calamine having the above-mentioned effects and stabilizing calamine in an oil-in-water type internal phase, but not stabilizing calamine in a water-in-oil type internal phase.

The above calamine may be contained in the cosmetic composition according to the present invention in an amount of 0.01 to 15 wt%, preferably 5 to 15 wt%, based on the total weight of the composition. When the amount of the calamine exceeds 15% by weight, the dispersion stability is lowered, and when the amount of the calamine is less than 0.01% by weight, the effect of the calamine on the skin is small.

In the cosmetic composition according to the present invention, commercially available raw materials may be used for the calamine, and also, a modified calamine which can be prepared in a usual manner by adjusting the blending ratio of components constituting the calamine may be used.

Sugar surfactant and sorbitol surfactant

In the present invention, a nonionic surfactant is used to stabilize the above-mentioned calamine in an oil-in-water type internal phase, and one or more kinds of sugar surfactants and one or more kinds of sorbitol surfactants are used together with the nonionic surfactant.

In the cosmetic composition according to the present invention, the Sugar-based surfactant refers to alkyl glycoside (APGs) type surfactants, Sugar ester (Sugar ester) type surfactants, or a mixture thereof.

In the alkyl glycoside-based surfactant, the alkyl glycoside is a conventional alkyl glycoside represented by the following chemical formula 1. In addition, the alkyl glycoside-based surfactant in the present invention may include a mixture of alkyl glycoside represented by the following chemical formula 1 and fatty alcohol.

[ chemical formula 1]

In the sugar ester surfactant, the sugar ester is mainly sugar fatty acid ester, which refers to substances that are formed by ester bond of glucose and C10-C30 fatty acid, preferably C12-C26 fatty acid. In addition, in the present invention, the sugar ester-based surfactant includes a conventional sugar fatty acid ester, and also includes an ester compound formed by combining a condensation reactant of sugar and other substances with a fatty acid.

Preferably, in the cosmetic composition according to the present invention, the alkyl glycoside surfactant may be one or more surfactants selected from the group consisting of mixtures of C6 to C30 higher alcohols and C10 to C30 glucoside derivatives. More specifically, the Alcohol may be one or more selected from the group consisting of C14-22 Alcohol and C12-20 Alkyl glucosides (C14-22 Alcohols and C12-20 Alkyl glucosides), Cetearyl Alcohol and Cetearyl Glucoside (Cetearyl Alcohol and Arachidyl Glucoside), Behenyl Alcohol and Arachidyl Glucoside (benzoyl Alcohol and Arachidyl Glucoside), and Cetearyl stearyl Alcohol and cocoyl Glucoside (Cetearyl Alcohol and Coco-Glucoside).

Further, preferably, in the cosmetic composition according to the present invention, the sugar ester-based surfactant may be Polyglyceryl-3 methylglucidistearate (Polyglyceryl-3Methylglucose stearate).

More preferably, in the cosmetic composition according to the present invention, the saccharide surfactant may use Cetearyl Alcohol and Cetearyl Glucoside (Cetearyl Alcohol and Cetearyl Glucoside) alone as the alkyl glycoside surfactant, or may be mixed and used together with the Cetearyl Alcohol and Cetearyl Glucoside and the polyglycerol-3 MethylglucoseDistearate (Polyglyceryl-3 methylglucosestearate) as the saccharide ester surfactant.

The saccharide surfactant used in the present invention functions to stabilize oil-in-water (O/W) emulsified particles. In particular, the Cetearyl Alcohol and Cetearyl Glucoside (Cetearyl Alcohol and Cetearyl Glucoside) useful in the present invention comprise Cetearyl Alcohol and thus are surfactants having a higher content of fatty Alcohol, and the fatty Alcohol contained therein forms liquid crystals around an O/W interfacial film formed by Cetearyl Glucoside, thereby serving to more firmly maintain the interfacial film. Therefore, the present invention can maintain an excellent emulsion stability even under severe conditions or in long-term storage, and thus can be an important component for preventing coagulation or separation of calamine.

The cosmetic composition according to the present invention may include the saccharide surfactant in an amount of 0.1 to 8 wt%, preferably 1 to 5 wt%, based on the total weight of the composition. When the saccharide surfactant exceeds 8% by weight, a dosage form cannot be formed, and when the saccharide surfactant is less than 0.1% by weight, the effect as a surfactant is little.

In the cosmetic composition according to the present invention, the sorbitol-based surfactant comprises sorbitol Ester (Sorbitan Ester) or an addition polymer of sorbitol Ester and ethylene oxide. Although sorbitol esters are also generally classified as sugar surfactants, in the present invention sorbitol esters and/or their polymeric components have a large influence on the dosage form stability of the cosmetic composition of the present invention, and thus are considered important to be classified separately.

In the cosmetic composition according to the present invention, the Sorbitan-based surfactant preferably uses Sorbitan fatty acid ester, and may comprise one or more selected from the group consisting of Sorbitan Olivate (Sorbitan Olivate), Sorbitan Stearate (Sorbitan Stearate), Sorbitan Isostearate (Sorbitan Isostearate), Sorbitan tristearate (Sorbitan tristearate), Sorbitan Sesquistearate (Sorbitan Sesquistearate), Sorbitan Palmitate (Sorbitan Palmitate), Sorbitan laurate (Sorbitan L aurate), Sorbitan oleate (Sorbitan Oleate), Sorbitan oleate (Sorbitan Sesquiolate), Sorbitan trioleate (Sorbitan trileate), Sorbitan Stearate/Sorbitan laurate (Sorbitan Stearate and Sorbityl L aurate), Polysorbate 20(Polysorbate 20), Polysorbate 40, Polysorbate 60, Polysorbate 80 and Polysorbate 85.

The sorbitol-based surfactant used in the present invention serves to increase dispersibility so that the calamine powder can be uniformly dispersed in the oil-in-water internal phase. In particular, it is possible to stabilize a high content of calamine very effectively in an oil-in-water type internal phase when used in combination with Polysorbate (Polysorbate), which is a surfactant for Polyethylene Glycol (PEG) having very excellent surface active ability in combination with sorbitol ester.

The cosmetic composition according to the present invention may include 0.01 to 5 wt% of the sorbitol-based surfactant, preferably 0.5 to 4 wt%, with respect to the total weight of the composition. When the sorbitol surfactant is more than 5% by weight, the formation of the dosage form is inhibited, and when the sorbitol surfactant is less than 0.01% by weight, the ability to improve dispersibility is difficult to expect.

In the cosmetic composition according to the present invention, it is preferable to use one or more of the sugar surfactant and the sorbitol surfactant together, and when only the sugar surfactant or the sorbitol surfactant is used, the composition cannot be formed into an oil-in-water type formulation well or the stability is significantly lowered. Preferably, the sugar surfactant and the sorbitol surfactant are mixed in a ratio of 2.5:0.6 to 2.5 by weight, and thus excellent dosage form stability and long-term stability can be exhibited.

Furthermore, in the cosmetic composition according to the present invention, it may be not preferable to use other nonionic surfactants or to use anionic surfactants instead of the sorbitol-based surfactant. For example, when PEG-100Stearate (PEG-100Stearate) or Glyceryl MonoStearate (Glyceryl MonoStearate) which are commonly used as nonionic surfactants, or Glyceryl Stearate Citrate (Glyceryl Stearate Citrate) or Potassium Cetyl Phosphate (Potassium Cetyl Phosphate) which is an anionic surfactant are used alone without mixing a saccharide surfactant and a sorbitol surfactant, it is difficult to stabilize calamine in an oil-in-water type internal phase, and a dosage form cannot be formed and directly separated at the time of preparation, or even when a dosage form is formed, the long-term stability is lowered.

Other ingredients

The cosmetic composition according to the present invention may contain, in addition to calamine, the above-mentioned saccharide and sorbitol-based surfactant, oil, polyol, thickener, water, and the like.

In order to impart a suitable moisturizing ability to the cosmetic composition of the present invention, oils may be contained in an amount of about 10% by weight based on the total weight of the composition, and for example, ester oils and hydrocarbon (hydro) oils may be used. In addition, the polyol may be included in an amount of 5 to 15 wt% with respect to the total weight of the composition.

Further, as the thickener, for example, Polyacrylate such as Hydroxyethyl Acrylate/Sodium Acryloyldimethyltaurate Copolymer, Ammonium Acryloyldimethyltaurate/VP Copolymer, Polyacrylate cross-linked polymer-6 (Polyacrylate cross-linker-6), Polyacrylate-13 (Polyacrylate-13) or Sodium Polyacrylate (Sodium Polyacrylate) can be used, and the thickener can be contained in an amount of 0.1 to 3% by weight based on the total weight of the composition.

In the cosmetic composition according to the present invention, when a polyacrylate is used as a thickener, the stability of the oil-in-water type formulation is more favorable than when a thickener of carbomer series is used. This is because when a carbomer-based thickener is used in an oil-in-water type, it is easily affected by electric charge and easily coagulates with powders such as calamine, thereby deteriorating quality.

In addition, the cosmetic composition according to the present invention may further comprise one or more additives selected from humectants, pigments, perfumes, preservatives and other additives, which are generally used in the preparation of conventional cosmetics, in addition to the above-mentioned components.

In the oil-in-water type cosmetic composition according to the present invention, the oil-in-water type is an emulsion type in which an outer phase (continuous phase) in the form of oil-in-water (O/W) is an aqueous phase and an inner phase (discontinuous phase) is an oil phase, and is prepared such that calamine, which is a main skin efficacy ingredient, is included in the inner phase.

For example, the oil-in-water type cosmetic composition according to the present invention may be prepared by separately dissolving the water phase component and the oil phase component with heating, and then adding the oil phase component to the water phase component and emulsifying, but the calamine is dispersed by being contained in the oil phase component. Then cooling the emulsified content, and then adding a thickening agent and dispersing to prepare the water-based emulsion.

The oil-in-water type cosmetic composition according to the present invention prepared by the above method does not cause precipitation of particles or separation of dosage forms even when mixed at a high temperature of 45 ℃ and a high speed of 9,000rpm, and can maintain a long-term stability of 12 months or more.

Further, the cosmetic composition of the present invention stabilized by the above method can improve the feeling of use such as spreadability and can improve the skin absorption ability.

The oil-in-water type cosmetic composition according to the present invention is not particularly limited, but may be formulated in the form of essence, emulsion, cream, or paste to be applied or sprayed on the skin or mucous membrane, and may be used in cosmetics for moisturizing, whitening, improving and finishing skin color in a short period of time, skin problem care (rouble care), calming, or improving sensitive skin, and the like.

Modes for carrying out the invention

The present invention will be described in more detail below with reference to examples and comparative examples. However, the following examples and comparative examples are only for the purpose of facilitating understanding of the present invention, and the examples according to the present invention may be modified into various other forms, and the scope of the present invention is not limited thereto.

Examples and comparative examples: preparation of oil-in-Water type cosmetic composition

The oil-in-water type cosmetic compositions of examples 1 to 7 and comparative examples 1 to 5 were prepared according to the respective components and contents described in the following tables 1 and 2 and according to the preparation methods described below.

In the preparation, Calamine was used under the product name "Calamine (manufactured by JUHWAN BIOCE LL Co.), in the examples, cetearyl alcohol and cetearyl glucoside (manufactured by Montanov 68, Seppic Co., France) and/or polyglycerin-3-methylglucdistearate (Tego care 450, manufactured by Evonik Co., Ltd.) were used as the saccharide surfactant, and sorbitan-based surfactant (manufactured by Olivem 1000, B & T Co., Ltd.) and/or polysorbate 60 (manufactured by Tween #60V, CRODA Co., Ltd.) was used as the sorbitol-based surfactant.

Preparation method

The raw materials were measured in accordance with the following tables 1 and 2,

(1) mixing purified water and water phase components such as polyalcohol in a beaker, and heating to 75 deg.C or higher for dissolving.

(2) Heating oil phase components such as oil and surfactant to 75 deg.C or above for dissolving.

(3) The calamine is dispersed in the oil phase portion, rather than in the water phase portion.

(4) The oil phase portion was put into the water phase portion, and homogeneous mixing was performed to emulsify.

(5) Cooling the content emulsified in (4) for a certain period of time and then redispersing. When shear force (shear) is applied after a certain viscosity or more is formed, dispersion of calamine becomes easier.

(6) Adding a thickening agent for homogeneous dispersion.

[ Table 1]

[ Table 2]

[ test example 1: evaluation of emulsion stability

The formulations were evaluated for stability at high temperature and stability at 45 ℃ after storage at 45 ℃ for two weeks in examples 1 to 7 and comparative examples 1 to 5, and then the degree of separation between the water phase and the oil phase was visually observed.

The results are shown in fig. 1 and tables 3 and 4 below.

[ test example 2: evaluation of acceleration stability degree

The accelerated stability of the dosage forms was evaluated by observing the degree of separation and the degree of agglomeration of the dosage forms of examples 1 to 7 and comparative examples 1 to 5 using a cryostat (L ow temp. Incubator) L TI-1001SD (product name of EYE L A) at-15 to 45 ℃ for a 24-hour period (cycle).

The results are shown in tables 3 and 4 below.

[ Table 3]

[ Table 4]

○ good △ common × separated

From table 3 above, it was confirmed that in examples 1 to 7 containing 5 to 15 wt% of calamine and containing both a sugar surfactant and a sorbitol-based surfactant, calamine was well stabilized in the internal phase as an oil phase, and both high-temperature stability and accelerated stability showed excellent results. In examples 2 and 3, the content of calamine was increased by 2 to 3 times based on example 1, and a sorbitol-based surfactant effective for dispersion of calamine was also increased, and it was confirmed that a dosage form having excellent stability was obtained even when the content of calamine was 10 to 15 wt%. In this case, the mixing ratio of the sugar surfactant and the sorbitol surfactant is preferably 2.5:0.6 to 2.5 on a weight basis. In addition, the results of the test in which the content of calamine was fixed to 5% by weight and the types of surfactants were changed showed excellent results in both the high-temperature stability and the accelerated stability of examples 1 and 4 to 7, which contained one or more kinds of sugar surfactants and one or more kinds of sorbitol surfactants.

Among them, from the results of fig. 1, it was confirmed by naked eyes that example 1 did not cause separation of the water phase and the oil phase even after being stored at 45 ℃ for 2 weeks after the preparation, and example 1 was very stable as compared with comparative examples 1 to 5. Furthermore, it can be confirmed from fig. 2 that when the cream stabilized in the oil-in-water type with the composition of example 1 is applied to the skin, the powder particles are uniformly dispersed without coagulation at all.

In addition, in the examples, when comparing example 4 and example 5 using two kinds of saccharide surfactants in mixture, the results of example 5 in which the content of cetearyl alcohol and cetearyl glucoside is higher than that of example 4 were observed, and the hardness of the formed dosage form was the highest, so that it is highly possible to expect more excellent long-term stability. This seems to be a result of the fatty alcohol contained in cetearyl alcohol and cetearyl glucoside forming a liquid crystal around the O/W interfacial film formed by cetearyl glucoside, thereby more firmly holding the interfacial film and thus increasing the hardness.

However, from table 4, it was confirmed that, although the accelerated stability was good, the high temperature stability showed a general result in comparative example 4 using only the saccharide surfactant alone, and it was found that the high temperature stability was weaker than the accelerated stability. The high-temperature stability and the accelerated stability of the other comparative examples showed similar states, but comparative example 4 had a tendency to be more affected when exposed to high temperatures. In addition, as shown in fig. 1, the dosage form of comparative example 4 was gradually agglomerated at high temperature, calamine was coagulated, and water accumulated at the edges, thereby confirming again that the stability thereof as a whole was very unstable.

From table 4, it was confirmed that the formulation of comparative example 5 using only the sorbitol surfactant alone was separated and not stabilized. From this fact, it was found that the stability of the formulation prepared by using only the sorbitol surfactant was not significantly improved when the sugar surfactant was excluded. From this fact, it is found that although a sorbitol-based surfactant has a great effect of promoting dispersion stability of the calamine powder, the effect is exhibited only when used together with a saccharide-based surfactant when forming stable O/W emulsion particles.

From table 4 and fig. 1, it was confirmed that comparative examples 1 and 2, in which an anionic surfactant was used instead of a sorbitol surfactant, were separated without being stabilized in the form of a dosage form. Upon exposure to 45 ℃ for approximately 2 weeks, a phenomenon was found in which water separated and the powder coagulated. Further, as can be seen from table 4 and fig. 1, in comparative example 3 in which PEG-based surfactant PEG-100stearate was used instead of the sorbitol-based surfactant, although a dosage form was also formed, the high-temperature stability and accelerated stability were poor, and the long-term stability was lowered.

It was confirmed from the above examples, comparative examples and test examples that when calamine is stabilized in the internal phase by using a saccharide surfactant and a sorbitol surfactant together, an oil-in-water type cosmetic composition containing a high content of calamine can be obtained. In particular, when a sugar surfactant and a sorbitol surfactant are used in a ratio of 2.5:0.6 to 2.5 by weight, a high content of calamine can be stabilized in an oil-in-water type internal phase, and long-term stability can be ensured. Therefore, the oil-in-water type cosmetic composition of the present invention in which a high content of calamine is stabilized in the inner phase can improve the feeling of use such as spreadability and can improve the skin absorption ability.

Claims

1. An oil-in-water type cosmetic composition for stabilizing calamine in an internal phase, which comprises a saccharide surfactant and a sorbitol-based surfactant as stabilizers.

2. A calamine-stabilized oil-in-water cosmetic composition as claimed in claim 1, wherein said sorbitol-based surfactant is sorbitol ester or an addition polymer of sorbitol ester and ethylene oxide.

3. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 2, wherein the sorbitan-based surfactant is one or more selected from the group consisting of sorbitan olivate, sorbitan stearate, sorbitan isostearate, sorbitan tristearate, sorbitan sesquistearate, sorbitan palmitate, sorbitan laurate, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan stearate/sorbitan laurate, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80 and polysorbate 85.

4. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 1, wherein the sugar surfactant is one or more selected from the group consisting of alkyl glycoside surfactants and sugar ester surfactants.

5. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 4, wherein the alkyl glycoside surfactant is one or more selected from the group consisting of C14-22 alcohol and C12-20 alkyl glucoside, cetearyl alcohol and cetearyl glucoside, behenyl alcohol and arachidyl alcohol glucoside, cetearyl alcohol and cocoyl glucoside.

6. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 4, wherein the sugar ester-based surfactant is polyglyceryl-3methylglucose distearate.

7. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 1, wherein the calamine is contained in an amount of 0.01 to 15% by weight based on the total weight of the composition.

8. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 1, wherein the saccharide surfactant is contained in an amount of 0.1 to 8% by weight based on the total weight of the composition.

9. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 1, wherein the content of the sorbitol surfactant is 0.01 to 5% by weight based on the total weight of the composition.

10. The oil-in-water type cosmetic composition in which calamine is stabilized in the internal phase according to claim 1, wherein the sugar surfactant and the sorbitol surfactant are contained in a ratio of 2.5:0.6 to 2.5 on a weight basis.

11. A cosmetic prepared by formulating the oil-in-water type cosmetic composition having the calamine stabilized in the internal phase as claimed in any one of claims 1 to 9.