KR20150041938A - Mixture for protecting skin and Cosmetic composition comprising thereof for protecting skin from ultraviolet rays - Google Patents

Abstract

The present invention relates to a mixture for protecting skin and to a cosmetic composition including the same for protecting skin from ultraviolet rays. The mixture for protecting skin, based on the total weight thereof, includes 80-95 wt% of vegetable oil, 1-10 wt% of a UV-blocking component, 1-10 wt% of an emulsifier, 0.1-5 wt% of a skin soothing component, and 0.1-5 wt% of a nucleotide precursor or a derivative thereof, and the cosmetic composition for protecting skin from ultraviolet rays includes 0.1-10 wt% of the mixture for protecting skin. The mixture for protecting skin and cosmetic composition including the same according to the present invention protect skin from ultraviolet rays. More specifically, skin cells and DNA can be protected, the recovery of skin from damage caused by external stress such as ultraviolet rays can be improved, and skin-aging can be prevented. Moreover, the components of the mixture for protecting skin and cosmetic composition including the same of the present invention are made of natural components, thus having low irritation on skin.

Description

[0001] The present invention relates to a cosmetic composition for protecting skin from ultraviolet rays,

The present invention relates to a skin protecting composition and a cosmetic composition for protecting the skin from ultraviolet rays including the same. More particularly, the present invention relates to a skin protecting composition capable of not only blocking ultraviolet rays from the skin but also restoring the skin damaged by ultraviolet rays, And a cosmetic composition containing the same.

Generally, when ultraviolet rays contained in sunlight are excessively irradiated to the skin, erythema can be formed on the skin, and it can cause stains and dullness through promotion of melanin production. In the long term, wrinkles increase, And relaxation, as well as cause skin cancer in severe cases.

Ultraviolet rays are rays that have a wavelength of 400 nm or less emitted from the sun and damage the skin. The ultraviolet rays have a shorter wavelength than the visible light and act intensely. Ultraviolet rays are divided into long-wave ultraviolet (UV-A) (320-400 nm), medium-wave ultraviolet (UV-B) and short-wave ultraviolet It induces sunburn, pigmentation, photoaging, skin cancer, etc., and causes various skin damage depending on wavelength.

Short-wave ultraviolet rays (UV-C, 200-380 nm) cause bactericidal action and apoptosis but are mostly absorbed in the ozone layer and hard to reach the skin. Medium-wave ultraviolet rays (UV-B, 280-320 nm) It causes skin keratinization, and causes sunburn and pigmentation such as erythema and vesicle. It causes cell membrane damage and skin cancer as well as sunburn (sunburn). Furthermore, it directly damages the DNA of the skin cells and exerts severe pressure on the skin regeneration mechanism.

In particular, long-wave ultraviolet (UV-A, 320-400 nm) reaches the dermis deep into the skin and can cause chronic photoaging due to immediate pigmentation, delayed erythema, phototoxicity, photoallergic reaction, free radical generation, Of the elastic fibers and the collagen fibers, thereby reducing the elasticity of the skin and causing wrinkles and skin atrophy. It also indirectly affects the DNA of skin cells, increasing the risk of skin cancer. Therefore, in order to protect the skin from ultraviolet rays, the use of a sunscreen agent is essential.

Sunburn, which is caused by excessive exposure to ultraviolet light, is a reaction that occurs when the skin is inflamed, which begins to appear when the amount of ultraviolet light irradiated to the skin exceeds the amount of ultraviolet light that the skin regeneration mechanism can handle.

In order to effectively block such ultraviolet rays, various kinds of organic and inorganic ultraviolet screening agents should be used in an excessive amount. However, in such a case, the composition may cause problems such as feeling of touch such as stickiness or bundling, . Recently, in order to overcome the disadvantages of the organic UV-ray blocking agent and the inorganic UV-ray blocking agent, research on an organic-inorganic hybrid type hybrid composite has been actively conducted. However, most of the manufacturing methods are complicated and it is very difficult to obtain the desired particle size And the manufacturing cost is so high that it can not be easily used industrially.

Accordingly, development of ultraviolet screening agents having an excellent ultraviolet screening ability while greatly shielding ultraviolet rays is desperately required, and in addition, when a cosmetic composition capable of simultaneously recovering skin damage due to continuous exposure to ultraviolet rays is developed, It is expected that it can be used.

Accordingly, one aspect of the present invention is to provide a skin-protecting composition capable of protecting skin from ultraviolet rays or the like.

Another aspect of the present invention is to provide a cosmetic composition comprising the skin protection mixture and capable of protecting skin from ultraviolet rays.

According to one aspect of the present invention, there is provided a skin care composition comprising 80-95% by weight vegetable oil, 1-10% by weight of an ultraviolet barrier ingredient, 1-10% by weight of an emulsifier, 0.1-5% 0.1-5% by weight of a nucleotide precursor or derivative thereof.

The vegetable oil is preferably sunflower seed oil, safflower seed oil, grape seed oil, green tea seed oil, macadamia seed oil, jojoba seed oil, castor oil, coconut oil, citron seed oil, peanut oil or a mixture thereof.

Wherein the ultraviolet shielding component is selected from the group consisting of ethylpellulate, glyceryl parabe, drometrizol trisiloxane, drometrizol, dipaloyyltriolate, diethylhexylbutamidotriazone, and dihexylmethoxycinnamate At least one kind selected from the group consisting of

The emulsifier is polyglyceryl oleate -5 tree, arachidyl alcohol, behenyl alcohol and arachidyl glucoside, C _{14 - 22} alcohol, C _{12 - 20} alkyl glucosides, cetearyl alcohol, cetearyl glucoside, coco-glucoside , Coconut alcohol, myristyl alcohol, myristyl glucoside, cetearyl olivate, and sorbitan olivate.

Preferably, the skin soothing component is at least one member selected from the group consisting of rosemary leaf extract, lavender extract, chamomile extract, cucumber extract, aloe vera leaf extract, licorice extract, and positional hazel extract.

The nucleotide precursor is preferably a precursor of at least one nucleotide selected from adenosine phosphate, guanosine phosphate, cytosine phosphate, thymidine phosphate, inosine phosphate, and disodium uridine phosphate or a derivative thereof.

According to another aspect of the present invention, there is provided a cosmetic composition for protecting the skin from ultraviolet rays containing 0.1 to 10% by weight of the skin protective composition of the present invention based on the total weight of the cosmetic composition.

The cosmetic composition preferably contains 0.1 to 10% by weight of the skin-protecting composition, 80 to 98% by weight of solvent, and 1 to 10% by weight of other additives.

The solvent is preferably water, a polyhydric alcohol or a mixture thereof.

The other additives are preferably at least one selected from the group consisting of preservatives, perfumes, thickeners, antioxidants and surfactants.

The skin protecting composition according to the present invention and the cosmetic composition containing the same can protect skin from ultraviolet rays, more specifically protect skin cells and DNA, and can improve the recovery of skin damage due to external stress such as ultraviolet rays And may further delay skin aging. In addition, the skin-protecting composition of the present invention and the cosmetic composition containing the skin-protecting composition are all made of natural ingredients, so that they are less irritating to the skin.

Fig. 1 shows a visual confirmation result of a DNA damage prevention experiment by ultraviolet rays.
Fig. 2 shows the result of quantitative confirmation of DNA damage prevention experiment by ultraviolet rays.
FIG. 3 shows the results of an experiment for reducing erythema caused by ultraviolet rays.
FIG. 4 shows the results of experiments on the effect of reducing the erythema depending on the content of the skin-protecting mixture.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. However, the embodiments of the present invention can be modified into various other forms, and the scope of the present invention is not limited to the embodiments described below.

According to the present invention, a skin-protecting composition is provided, and the skin-protecting composition of the present invention and a cosmetic composition containing the same can effectively protect the skin from external stress and irritation, particularly skin damage caused by ultraviolet rays, Can be improved.

The skin protection composition of the present invention may comprise, based on the total weight of the skin protection composition, from 80 to 95% by weight vegetable oil, from 1-10% by weight of an ultraviolet barrier component, from 1-10% by weight of an emulsifier, 0.1-5% by weight of the precursor or derivative thereof.

More preferably, the skin protection composition of the present invention comprises 85-95% by weight of vegetable oil, 1-5% by weight of an ultraviolet barrier ingredient, 1-5% by weight of an emulsifier, 0.1-2.5 By weight, and 0.1-2.5% by weight of a nucleotide precursor or derivative thereof.

When the vegetable oil is contained in an amount of less than 80% by weight based on the total weight of the skin-protecting composition, there is an uneconomical problem. When the vegetable oil is more than 90% by weight, the effect is insignificant.

When the ultraviolet shielding component is less than 1% by weight, there is a problem that the ultraviolet absorbing power and the antioxidant effect are insufficient and the skin protection effect is reduced. When the content exceeds 10% by weight, the effect of increasing the content is insignificant, have.

When the amount of the emulsifier is less than 1% by weight, the skin softening effect and the surfactant effect are insufficient. When the amount of the emulsifying agent is more than 10% by weight, the effect of increasing the content is insignificant. When the skin soothing component is less than 0.1% by weight, there is a problem that the skin soothing effect is insufficient. When the skin soaking composition is more than 2.5% by weight, the effect of increasing the content is insignificant.

On the other hand, when the amount of the nucleotide precursor or derivative thereof is less than 0.1% by weight, the skin recovery and regenerating effect is deteriorated. When the amount is more than 2.5% by weight, the effect of increasing the content is insignificant.

The vegetable oils that may be used in the present invention include, but are not limited to, sunflower seed oil, safflower seed oil, grape seed oil, green tea seed oil, macadamia seed oil, jojoba seed oil, castor oil, coconut oil, citron seed oil, peanut oil, But it is not particularly limited thereto, and it is preferable to use sunflower seed oil.

The sunflower seed oil (Helianthus Annuus Seed Oil) may contain ingredients such as phytosterol, tocopherol, squalane and the like to nourish the skin.

The ultraviolet screening component that may be used in the present invention may be selected from water-soluble organic ultraviolet screening components, oil-soluble organic ultraviolet screening components, inorganic ultraviolet screening components, or mixtures thereof.

More specifically, the ultraviolet shielding component is selected from the group consisting of ethercellulate, glyceryl parabe, drometrizol trisiloxane, drometrizol, dipaloyyltriolate, diethylhexylbutamidotriazone, and diai-methoxy cinnamate At least one member selected from the group consisting of ethylcyclohexane, ethylcyclohexane, ethylcyclohexane, and ethylcyclohexane.

As used herein, "at least one species" is used in the same sense as "at least one species ", and is intended to include all kinds of components of the listed components and various mixtures in which two or more components are mixed.

Ethyl 3- (4-Hydroxy-3-Methoxyphenyl) -2-Propenoate) obtained from ferulic acid can be obtained from ferulic acid It is a plant-derived component, which can be obtained from rice after esterification with enzymes. The ethylpyrrolate can act as an antioxidant to counteract the oxidative stress of the cells by canceling the radicals damaging the cells, effectively blocking the ultraviolet ray damage, and offsetting the oxygen radicals generated by ultraviolet rays.

The ethyl ferulate can exhibit a maximum absorption wavelength band in the range of 270 to 290 nm and can exhibit a considerably large ultraviolet absorption wavelength band in the UV-A region of about 325 to 340 nm. Therefore, when it is used together with an ultraviolet blocking agent exhibiting a different absorption wavelength band, the ultraviolet blocking effect can be remarkably improved.

Emulsifiers of the present invention, arachidyl alcohol, behenyl alcohol and arachidyl glucoside, C _14-22 alcohol, C _{12 - 20} alkyl glucosides, cetearyl alcohol, cetearyl glucoside, coco-glucoside coconut alcohol, myristyl alcohol , Myristyl glucoside, cetearyl olivate, and sorbitan olivate. Among them, polyglyceryl-5 trioleate (polyglyceryl-5 trioleate ), Which is triester of oleic acid and polyglycerin-5, and can have effects as a skin softening agent and a surfactant.

Furthermore, the skin-protecting composition of the present invention comprises a skin soothing component, wherein the skin soothing component is selected from the group consisting of rosemary leaf extract, lavender extract, chamomile extract cucumber extract, aloe vera leaf extract, licorice extract, But the present invention is not limited thereto, and preferably includes rosemary leaf extract in the present invention.

Rosmarinus Officinalis Leaf Extract contains ingredients such as Flavonoids, Phenols, Essential Oils and Terpenes and has a soothing and antibacterial effect. Furthermore, it can protect the skin from free radicals or radical stresses generated by ultraviolet rays.

Further, the nucleotide precursor or derivative thereof contained in the skin-protecting composition of the present invention may be a precursor of at least one nucleotide selected from adenosine phosphate, guanosine phosphate, cytosine phosphate, thymidine phosphate, inosine phosphate, and disodium uridine phosphate, But is not limited thereto and is not particularly limited as long as it can precisely accelerate the regeneration of DNA by satisfying the elements required for regeneration of the nucleotide as a precursor of nucleotide synthesis.

In the present invention, it is preferable to use Disodium Uridine Phosphate, but it is not limited thereto. Disodium Uridine Phosphate is a component that can be extracted from sugar beet through yeast fermentation process.

According to the present invention, there is provided a cosmetic composition comprising the skin protection mixture of the present invention, wherein a cosmetic composition capable of effectively protecting the skin from ultraviolet rays is obtained when 0.1 to 10% by weight of the skin protective composition is contained . When the ingredients of the skin protecting composition of the present invention fall within the above range, the skin protection and recovery effect of ultraviolet rays of the cosmetic composition of the present invention can be optimized.

Preferably, the cosmetic composition of the present invention comprises 0.1-10% by weight of the skin-protecting composition, 80-98% by weight of solvent and 1-10% by weight of other additives, more preferably 0.5-10% by weight of the skin- %, Solvent 85-95 wt%, and other additives 1-10 wt%. The more preferable content of the skin protection mixture is 2 to 7% by weight, and the more preferable content is 3 to 5% by weight.

In the present invention, it is preferable that the solvent is water, a polyhydric alcohol or a mixture thereof, and the water is preferably purified water. The polyhydric alcohol may be glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol , Dipropylene glycol, sorbitol, and xylitol, but is not limited thereto.

The other additives may be at least one selected from the group consisting of preservatives, flavors, thickeners, antioxidants and surfactants, but is not limited thereto.

For example, the preservative that may be added to the present invention is selected from the group consisting of phenoxyethanol, caprylic glycol, paraoxybenzoic acid alkyl ester, paraben, pentanediol, ethylhexylglycerin, 1,2-hexanediol, At least one selected from the group consisting of p-oxybenzoic acid esters, 3-trifluoromethyl-4,4'-dichlorocarbabanilide, and 2,4,4'-trichloro-2-hydroxydiphenyl ether It can be one kind.

On the other hand, the thickeners are carbomers, acrylates / C _{10 -} can all at least one selected from ₃₀ alkyl acrylate cross-linked polymer, sodium polyacrylate, xanthan gum, cellulose gum and hydroxy groups consisting of seven cellulose.

The cosmetic composition of the present invention may be prepared in various formulations and may be in various forms such as a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, But are not limited to, those formulated from the group consisting of hand creams, foundations, essences, nutritional essences, packs, gels, soaps, cleansing foams, cleansing lotions, cleansing creams, body lotions and body cleansers.

Hereinafter, the present invention will be described more specifically by way of specific examples. The following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited thereto.

Example

Example  One

88 g of sunflower seed oil, 5 g of ethylperailrate, 5 g of polyglyceryl-5 trioleate, 1 g of rosemary leaf extract and 1 g of disodium uridine phosphate were mixed to prepare a skin protection mixture.

2 g of the skin protection mixture prepared above, 92 g of purified water, 5 g of glycerin, 0.5 g of carbomer and 0.5 g of phenoxyethanol as a preservative were mixed to prepare a cream gel.

Example  2

1 g of a skin-protecting mixture, and 93 g of purified water were prepared in the same manner as in Example 1 above.

Example  3

A skin-protecting mixture (0.5 g), and purified water (93.5 g) were prepared in the same manner as in Example 1.

Experimental Example  1: Ultraviolet DNA  Damage Prevention Experiment

(1) Experimental method

3D skin specimens were irradiated with ultraviolet light for 30 minutes using MEGA-Ray UV-A and UV-B lamps. The light emitted from MEGA-Ray's UV-A and UV-B lamps is very similar to the UV-A and UV-B emitted from the sun. After irradiation of light, keratinocytes were observed using a 3D model to measure DNA damage.

As a result of the preliminary experiments, there was no DNA damage at the irradiated light energy of 200 mJ / cm 2, and slight damage only at 500 mJ / cm 2. It was confirmed that DNA damage was remarkably occurred at 1000-1500 mJ / cm 2. When the energy of light is 1500 mJ / cm², it is generally similar to the case where human skin is exposed to sunlight at noon for about 3 hours. Therefore, it was set to irradiate the skin with light of 1500 mJ / cm 2 for this experiment.

(A), untreated untreated sample (b), and caprylic / capric triglyceride, which were left to stand for 30 minutes after the cream gel of the present invention prepared in Example 1 was applied to the skin, / Capric triglyceride) and left for 30 minutes (c).

After irradiating the above samples with light, the degree of DNA damage was visually observed after 30 minutes, 1 hour, 4 hours and 24 hours, respectively.

The degree of DNA damage was determined based on the formation of TT dimers (Thymine dimmers, TT dimers), which can be visually confirmed through the generation of black spots.

(2) Experimental results

1) Visual confirmation result

As shown in FIG. 1, the cream gel of the present invention prepared in Example 1 was applied to the skin in comparison with the untreated sample (b) and the placebo sample (c), and the sample (a ), The DNA damage was remarkably reduced.

That is, from the one hour after the light irradiation, the skin of the sample (a) did not show damaged DNA, but the skin of the untreated sample (b) and the placebo sample (c)

2) Results of quantitative confirmation

The quantitative evaluation results of the DNA damage as in the above 1) were performed, and the results of the experiment are shown in FIG. For quantitative confirmation, the number of black dots generated as a result of visual inspection was counted, which corresponds to a cell transformed into DNA damage.

As a result of the quantitative analysis, it was found that the damage of the cell immediately occurred after the ultraviolet ray irradiation, and that the degree of ultraviolet ray damage decreased over time, and it was clearly confirmed that the cell was regenerated by itself over time.

Experimental Example  2: Reduced effect of erythema caused by ultraviolet rays

(1) Experimental method

Excessive sunlight transmitted to the skin has a lot of effect on the DNA damage of the cell, and it can be seen that the skin starts to turn red and alarms the cells and DNA to operate the regeneration system. The faster the regeneration of cells and DNA, the faster the redness of skin becomes. Experiments were conducted to confirm that erythema on skin after UV irradiation was reduced by the cosmetic composition of the present invention.

In this experiment, a colorimeter (Minolta Co., Chromameter CR 200) capable of measuring human skin color change such as erythema was used. Subtle differences in skin color were observed through emission of light. The colorimetry was a tristimulus method method, L * a * b * color system) is used. The color range of the L * a * b * system is such that L * represents the brightness level, a * and b * represent the color coordinate system, a * represents red and green, and b * represents blue and yellow. Thus, an increase in a * value indicates increased skin erythema, and a decrease in a * value indicates reduced skin erythema. On the other hand, the increase in b * indicates the reflectance of the skin as well as the tanning effect, and at the same time, the decrease in the L * value indicating the degree of brightness can be measured. In order to minimize the color deviation measured in the same place, the measurement was made again after 3 measurements at the same point, and the result was automatically stored by the equipment and the average value was obtained.

Twenty subjects aged between 33 and 79 who had different skin conditions were selected and tested. The experimental site was placed above the thigh. Since the response time for each stimulus is different for each person, the MED (Minimum Erythema Dose) of each volunteer is checked, and the MED value (2.0-2.2) is set differently according to the result and the UVB lamp (medisun, LH600 (Schulze & Bohm )).

(A), no treatment (b), and caprylic / capric triglyceride (C) were applied to the top of each thigh of each volunteer after applying the cream gel of the present invention prepared in Example 1 for 30 minutes / Capric triglyceride) and left for 30 min. (C) The experiment was conducted by irradiating ultraviolet rays to each. Further, in case of (a) and (b), the cream gel of the present invention and caprylic / capric triglyceride were applied continuously once a day. During the test period, subjects did not use any other cosmetics and did not sunbathe. The values were then measured every morning for five days, and three times at the same time.

(2) Experimental results

As shown in FIG. 3, when the cream gel of the present invention prepared in Example 1 was used (a), skin regeneration with respect to ultraviolet rays was accelerated and erythema was rapidly reduced Able to know. In particular, when (a) the cream gel of the present invention was used, it was confirmed that the skin regeneration was doubled by one day as compared with (b) and (c).

Experimental Example  3: Changes in the effect of skin protection mixture on erythema reduction

(1) Experimental method

Experiments were carried out in the same manner as in Experimental Example 2, except that (a) the case where the cream gel of the present invention prepared in Example 1 was used, (c) the case where the cream gel of the present invention prepared in Example 2 was used (a '), (b) in the case of using the cream gel of the present invention prepared in Example 3 (a ") and (b), and Caprlic / Capric triglyceride And (c) when they were left to stand for 30 minutes after the application, they were irradiated with ultraviolet rays.

The results are shown in FIG. 4, and it was confirmed that the cream gel of the present invention can sufficiently exhibit the erythema reduction effect even when it contains 1% by weight and further 0.5% by weight of the skin protection mixture.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be obvious to those of ordinary skill in the art.

Claims (10)

Skin protection composition comprising from 80 to 95% by weight vegetable oil, from 1 to 10% by weight of an ultraviolet barrier ingredient, from 1 to 10% by weight of an emulsifier, from 0.1 to 5% by weight of a skin soothing agent, and from 0.1 to 5% by weight of a nucleotide precursor or derivative thereof, 0.0 >%< / RTI > by weight.
The vegetable oil according to claim 1, wherein the vegetable oil is selected from the group consisting of sunflower seed oil, safflower seed oil, grape seed oil, green tea seed oil, macadamia seed oil, jojoba seed oil, castor oil, coconut oil, citron seed oil, peanut oil, Mixture for skin protection.
2. The composition of claim 1, wherein the ultraviolet barrier component is selected from the group consisting of ethylpellulate, glyceryl paraben, drometrizol trisiloxane, drometrizole, dipaloyl trioleate, diethylhexylbutamidotriazone, Cinnamate, and cinnamate.
The method of claim 1 wherein the emulsifier is polyglyceryl oleate -5 tree, arachidyl alcohol, behenyl alcohol and arachidyl glucoside, C _{14 - 22} alcohol, C _{12 - 20} alkyl glucosides, cetearyl alcohol, three Te Wherein the skin protection composition is at least one selected from the group consisting of ricinoleic acid, ricinoleic acid, ricinoleic acid, ricinoleic acid, ricinoleic acid, ricinoleic acid, ricinoleic acid,
The skin protection composition according to claim 1, wherein the skin soothing component is at least one selected from the group consisting of rosemary leaf extract, lavender extract, chamomile extract, cucumber extract, aloe vera leaf extract, licorice extract and locust extract.
2. The method of claim 1, wherein the nucleotide precursor or derivative thereof is a precursor of at least one nucleotide selected from adenosine phosphate, guanosine phosphate, cytosine phosphate, thymidine phosphate, inosine phosphate, and disodium uridine phosphate, Protective mixture.
A cosmetic composition for protecting the skin from ultraviolet rays, comprising 0.1 to 10% by weight of the skin-protecting composition according to any one of claims 1 to 6 based on the total weight of the cosmetic composition.
8. The cosmetic composition according to claim 7, wherein the cosmetic composition comprises 0.1 to 10% by weight of the skin-protecting composition, 80 to 98% by weight of a solvent and 1-10% by weight of other additives.
The cosmetic composition according to claim 8, wherein the solvent is water, a polyhydric alcohol, or a mixture thereof, to protect the skin from ultraviolet rays.
The cosmetic composition according to claim 8, wherein the other additives are at least one selected from the group consisting of preservatives, perfumes, thickeners, antioxidants and surfactants.

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