JP2006241018A - Promoting agent of new hair growth, white hair preventing and/or treating agent, antipruritic composition, and wound healing accelerating agent - Google Patents
Promoting agent of new hair growth, white hair preventing and/or treating agent, antipruritic composition, and wound healing accelerating agent Download PDFInfo
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本発明は、発毛促進剤、白髪防止及び／又は治療剤、止痒性組成物及び創傷治癒促進組成物に関する。 The present invention relates to a hair growth promoter, an agent for preventing and / or treating gray hair, an antipruritic composition, and a composition for promoting wound healing.
従来、頭髪等の発毛促進剤、白髪防止及び／又は治療剤として、種々の動植物抽出物や化合物を有効成分とするものが提案されている。有効成分として熊笹エキスを使用した発毛促進剤、白髪防止及び／又は治療剤も提案されている。例えば、オトギリソウ抽出物と熊笹抽出物等を併用した養毛・育毛剤（特許文献１）、ヒアルロン酸、デルマタン酸又はケラタン硫酸とササ抽出物又は田七ニンジン抽出物等を併用した発毛促進剤（特許文献２）、ツバキ、マツ、イチョウ、ササ等の葉の粉剤物と米酢とを含む葉類米酢液を有効成分とする発毛育毛組成物（特許文献３）、既存の養毛育毛剤に鳳仙花、イチョウ、センブリ、黒ゴマ、熊笹等の抽出物を添加した養毛育毛剤（特許文献４）等が提案されている。
しかし、その発毛促進、育毛、白髪防止、脱毛防止、白髪の治療効果は、充分なものとはいえない。
Conventionally, as hair growth promoters for hair and the like, and for preventing and / or treating white hair, those containing various animal and plant extracts and compounds as active ingredients have been proposed. Hair growth promoters and white hair prevention and / or treatment agents that use kumar extract as an active ingredient have also been proposed. For example, a hair growth / hair restoration agent that uses a combination of hypericum extract and bear extract (Patent Document 1), a hair growth promoter that uses a combination of hyaluronic acid, dermatanic acid or keratan sulfate and Sasa extract or Tabuchi carrot extract (Patent Document 2), a hair growth composition (Patent Document 3) comprising a leaf rice vinegar solution containing leaf powder and rice vinegar, such as camellia, pine, ginkgo, sasa, etc., existing hair nourishment A hair nourishing agent (Patent Document 4) or the like in which an extract such as sensen flower, ginkgo biloba, assembly, black sesame, kumabuchi or the like is added as a hair restoring agent has been proposed.
However, it cannot be said that the effect of promoting hair growth, preventing hair growth, preventing white hair, preventing hair loss, and treating white hair is sufficient.
一方、近年、アトピー症、老人性掻痒症、透析患者の全身の痒み、糖尿病やＣ型肝炎に由来する全身の痒み、更年期や閉経時の外陰部掻痒症、カンジダ、インキン、水虫、タムシ等の菌に由来する痒み、あせも、できもの、かぶれ、床ずれ、虫刺され、火傷、切傷等の回復時の痒み、パーマネント液や毛染め液等の理容美容液が引き起こす薬傷によるただれなど（以下アトピー等と称する）の痒みを伴う炎症性皮膚疾患の患者の急増が問題となっている。痒みも痛みも炎症に伴う感覚で、これは炎症時に感じる知覚が痒みから痛みにおよぶ広範囲の領域にあるためと考えられている。
痒みや痛みの軽減、治療にはステロイド剤を使用することが多い。しかし、特に乳幼児等においてはステロイド剤による免疫の低下などで症状がさらに悪化したり、感染症が重症化する場合も少なくない。さらに、従来のステロイド剤などが効かない症例の出現はアトピー等の問題をより深刻なものとしている。
そこで、従来のステロイド剤に代わるものとして、天然の植物成分が注目されている。例えば、クマザサは、昔から抗アレルギー作用を有することが報告されている。本発明者等もクマザサエキスが、マウスにおける消炎作用や抗菌作用、創傷治癒効果を有意に増加させることを見いだしている。
On the other hand, in recent years, atopic dermatitis, senile pruritus, general itching of dialysis patients, general itching from diabetes and hepatitis C, vulvar pruritus in menopause and menopause, Candida, Inkin, athlete's foot, worm, etc. Itching due to fungi, rashes, rashes, bed slips, insect bites, itching when recovering from burns, cuts, etc., sores from chemical wounds caused by barber cosmetics such as permanent liquid and hair dyeing liquid (hereinafter referred to as atopy) The rapid increase in the number of patients with inflammatory skin diseases accompanied by itch). Itching and pain are sensations associated with inflammation, which is thought to be because the perception felt during inflammation is in a wide range of areas ranging from itching to pain.
Steroids are often used to reduce or treat itching and pain. However, particularly in infants and the like, there are many cases in which symptoms worsen due to a decrease in immunity due to steroids, and infections become severe. Furthermore, the emergence of cases where conventional steroids and the like are ineffective makes problems such as atopy more serious.
Therefore, natural plant components have attracted attention as an alternative to conventional steroid agents. For example, Kumazasa has long been reported to have an antiallergic effect. The present inventors have also found that Kumazasa extract significantly increases the anti-inflammatory, antibacterial and wound healing effects in mice.
しかしながら、従来のクマザサエキス含有組成物は、アトピー等に対する改善効果、止痒効果はほとんど認められず、創傷治癒効果も充分なものではなかった。
従って、アトピー等の症状軽減効果、止痒効果に優れ、アトピーを含めた皮膚疾患の痒みの治療に使用することのできる止痒性組成物及び創傷治癒促進組成物が望まれている。
本発明者は、有効成分としてクマザサエキスを固形分で１〜１０質量％、好ましくは２〜８質量％、さらに好ましくは３〜６質量％含有する止痒性組成物及び創傷治癒促進組成物を開発している（特許文献５）。しかし、その止痒性効果又は創傷治癒促進効果のさらなる改良が望まれている。
However, the conventional Kumazasa extract-containing composition has almost no improvement and antipruritic effect on atopy and the like, and the wound healing effect is not sufficient.
Therefore, an antipruritic composition and a wound healing promoting composition that are excellent in symptom-reducing effects such as atopy and antipruritic effect and can be used for treatment of itching of skin diseases including atopy are desired.
The present inventor has an antipruritic composition and a wound healing promoting composition containing 1 to 10% by mass, preferably 2 to 8% by mass, more preferably 3 to 6% by mass of Kumazasa extract as an active ingredient. Developed (Patent Document 5). However, further improvement of its antipruritic effect or wound healing promoting effect is desired.
従って、本発明の目的は、発毛促進、育毛促進、脱毛防止、白髪防止、白髪治療に有効な製剤を提供することである。
本発明の他の目的は、止痒性組成物及び創傷治癒促進組成物を提供することである。
Accordingly, an object of the present invention is to provide a preparation effective for promoting hair growth, promoting hair growth, preventing hair loss, preventing white hair, and treating white hair.
Another object of the present invention is to provide an antipruritic composition and a wound healing promoting composition.
本発明は以下に示す発毛促進剤、白髪防止及び／又は治療剤を提供するものである。
１．ササエキス、有機酸及びアニオン系界面活性剤を有効成分として含有する発毛促進剤。
２．洗浄剤の形態である上記１記載の発毛促進剤。
３．石けんの形態である上記２記載の発毛促進剤。
４．ササエキス、有機酸及びアニオン系界面活性剤を有効成分として含有する白髪防止及び／又は治療剤。
５．洗浄剤の形態である上記１記載の白髪防止及び／又は治療剤。
６．石けんの形態である上記２記載の白髪防止及び／又は治療剤。
７．ササエキス、有機酸及びアニオン系界面活性剤を有効成分として含有する止痒性組成物及び創傷治癒促進組成物。
８．洗浄剤の形態である上記７記載の止痒性組成物及び創傷治癒促進組成物。
９．石けんの形態である上記８記載の止痒性組成物及び創傷治癒促進組成物。
The present invention provides the following hair growth promoter, white hair prevention and / or treatment agent.
1. A hair growth promoter containing sasa extract, an organic acid and an anionic surfactant as active ingredients.
2. 2. The hair growth promoter according to 1 above, which is in the form of a cleaning agent.
3. 3. The hair growth promoter according to 2 above, which is in the form of soap.
4). An agent for preventing and / or treating gray hair comprising Sasa extract, an organic acid and an anionic surfactant as active ingredients.
5. The agent for preventing and / or treating gray hair according to 1 above, which is in the form of a cleaning agent.
6). The agent for preventing and / or treating gray hair according to 2 above, which is in the form of soap.
7). An antidiarrheal composition and a wound healing promoting composition containing a sasa extract, an organic acid and an anionic surfactant as active ingredients.
8). 8. The antidiarrheal composition and the wound healing promoting composition according to the above 7, which are in the form of a cleaning agent.
9. 9. The antipruritic composition and the wound healing promoting composition according to 8 above, which are in the form of soap.
本発明の製剤は、ササエキス、有機酸及びアニオン系界面活性剤を有効成分として含有するものであり、副作用がなく、優れた発毛促進、育毛促進、脱毛抑制、白髪防止、白髪治療、痒み防止、創傷治癒に顕著な効果を示す。この明細書において、本発明の発毛促進、育毛促進、脱毛抑制、白髪防止、白髪治療効果を単に「本発明の製剤の効果」と総称することもある。また、白髪治療効果とは、白髪が元の毛髪の色に戻る効果をいう。 The preparation of the present invention contains sasa extract, an organic acid and an anionic surfactant as active ingredients, has no side effects, excellent hair growth promotion, hair growth promotion, hair loss inhibition, white hair prevention, white hair treatment, itching prevention , Show significant effect on wound healing. In this specification, hair growth promotion, hair growth promotion, hair loss suppression, gray hair prevention, and gray hair treatment effects of the present invention may be collectively referred to simply as “effects of the preparation of the present invention”. In addition, the gray hair treatment effect refers to an effect in which white hair returns to the original hair color.
この明細書において、発毛促進剤とは、発毛を促進し、育毛を促進し、及び／又は脱毛を抑制する効果を有する製剤を総称し、本発明の発毛促進剤、白髪防止及び／又は治療剤、止痒性組成物及び創傷治癒促進組成物を単に「本発明の製剤」と総称することもある。
本発明の製剤の有効成分であるササエキスの原料として使用するササは、特に限定されず、ササ属（Sasa）に属するすべてのササが例示される。例えば、クマイザサ、クマザサ、チシマザサ、オクヤマザサ、エゾミヤマザサ、チマキザサ、ヤヒコザサ、オオバザサ、ミヤマザサ、センダイザサ、ユカワザサ、アボイザサ、オヌカザサ等が挙げられる。これらのうち、市販品の具体例としてはクマイザサ、クマザサ（チュウゴクザサ、ヒダザサ）等が挙げられる。例えば、北海道天塩山系で７〜１０月に採取されたクマイザサ、クマザサの水抽出物等が好ましい。
In this specification, the hair growth promoter is a generic term for preparations having effects of promoting hair growth, promoting hair growth, and / or suppressing hair loss. The hair growth promoter of the present invention, preventing white hair, and / or Alternatively, the therapeutic agent, antipruritic composition and wound healing promoting composition may be collectively referred to simply as “the preparation of the present invention”.
The Sasa used as a raw material of Sasa extract which is an active ingredient of the formulation of this invention is not specifically limited, All the Sasa which belongs to Sasa (Sasa) is illustrated. For example, Kumizasa, Kumazasa, Chishimazasa, Okuyamamasasa, Ezomiyamasasa, Chikimaza, Yahikozasa, Oobazasa, Miyamasa, Sendaizasa, Yukawazasa, Aboizasa, Onukazasa and the like. Among these, specific examples of commercially available products include Kumizasa, Kumazasa (Chugosa Kasa, Hidazasa) and the like. For example, Kumizasa collected from July to October in the Hokkaido Teshioyama system, a water extract of Kumazasa, and the like are preferable.
本発明の製剤に使用するササエキスは、ササの生葉又は乾燥葉、好ましくは乾燥葉を、１００〜１８０℃の水で、常圧又は加圧抽出して得られるものが好ましい。
抽出方法は特に限定されないが、例えば、特許第３２１２２７８号（特開平１１−１９６８１８号公報）に記載された方法を使用することができる。さらに具体的には、加圧熱水抽出機により１００〜１８０℃、５〜３０分処理してエキスを抽出し、該エキスを水分分離器により含水固形分（含水率４０〜７０％）と分離し、次に飽和水蒸気加熱処理機により該含水固形分を１００℃〜２００℃で５分〜６０分処理した後、再度加圧熱水抽出機により１００℃〜１８０℃で５〜３０分処理してエキスを抽出させ、第１回目と第２回目のエキスを合わせて使用する。また、ササ乾燥葉を例えば、６０〜１００℃の水で３０分〜１２時間程度抽出して得られるエキスも使用できる。
ササエキスを固形分で５０質量％程度含有する市販品としては、株式会社クロロランド・モシリ製「ＡＨＳＳ」、株式会社鳳凰堂の「ＴＷＥＢＳ」がある。
The Sasa extract used in the preparation of the present invention is preferably obtained by extracting fresh or dried leaves of Sasa, preferably dried leaves, with water at 100 to 180 ° C. under normal pressure or pressure.
Although the extraction method is not particularly limited, for example, the method described in Japanese Patent No. 312278 (Japanese Patent Laid-Open No. 11-196818) can be used. More specifically, the extract is extracted by processing at 100 to 180 ° C. for 5 to 30 minutes with a pressurized hot water extractor, and the extract is separated from the water-containing solid content (water content 40 to 70%) with a moisture separator. Next, the water-containing solid content is treated at 100 ° C. to 200 ° C. for 5 minutes to 60 minutes with a saturated steam heat treatment machine, and then treated again at 100 ° C. to 180 ° C. for 5 to 30 minutes with a pressurized hot water extractor. Extract the extract and use the first and second extracts together. Further, for example, an extract obtained by extracting dried Sasa leaves with water at 60 to 100 ° C. for about 30 minutes to 12 hours can be used.
Commercial products containing about 50% by mass of Sasa extract in solid content include “AHSS” manufactured by Chloroland Moshiri Co., Ltd. and “TWEBS” manufactured by Tsujido Co., Ltd.
上記ササエキスは静置すると茶褐色の沈殿物を形成するので、本発明の製剤の形態によっては、ササエキスを水で２倍程度に希釈して、固形分２５質量％程度とし、これを細菌除去用のフィルター、例えば、ミリポアフィルター（ミリポア社製）を用いて吸引ろ過して得られる茶色透明の濾液を使用しても良い。さらにこの濾液を分画分子量５０００〜３００００、好ましくは５０００の遠心式フィルター、例えば、アミコンウルトラ（ミリポア社製）を使用して、室温で２時間程度遠心ろ過して得られる薄茶色透明の濾液を使用してもよい。この濾液は固形分約２０質量％である。
本発明の製剤中に含まれるササエキスの量は特に限定されず、適宜選択すればよいが、製剤中、乾燥質量換算で、好ましくは０．５〜５０質量％、さらに好ましくは１〜８質量％、最も好ましくは５〜７質量％程度とするのがよい。
When the Sasa extract is allowed to stand, a brownish brown precipitate is formed. Depending on the form of the preparation of the present invention, the Sasa extract is diluted about 2 times with water to obtain a solid content of about 25% by mass, which is used for removing bacteria. A brown transparent filtrate obtained by suction filtration using a filter such as a Millipore filter (Millipore) may be used. Further, this filtrate is subjected to centrifugal filtration at room temperature for about 2 hours using a centrifugal filter having a molecular weight cut-off of 5000 to 30000, preferably 5000, for example, Amicon Ultra (manufactured by Millipore). May be used. The filtrate has a solid content of about 20% by weight.
The amount of Sasa extract contained in the preparation of the present invention is not particularly limited and may be appropriately selected. In the preparation, preferably 0.5 to 50% by mass, more preferably 1 to 8% by mass in terms of dry mass. The most preferable content is about 5 to 7% by mass.
本発明の製剤に使用する有機酸としては、リンゴ酸、クエン酸、乳酸、シュウ酸、マロン酸、コハク酸、フマル酸、酢酸、安息香酸、フェニル酢酸、サリチル酸、フェノール類等が挙げられるが、特にリンゴ酸が好ましい。
有機酸の使用量は、本発明の製剤中、好ましくは０．０１〜５質量％、さらに好ましくは０．０２〜３質量％、最も好ましくは０．０５〜１．５質量％である。
Examples of the organic acid used in the preparation of the present invention include malic acid, citric acid, lactic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, acetic acid, benzoic acid, phenylacetic acid, salicylic acid, and phenols. Malic acid is particularly preferable.
The amount of the organic acid used is preferably 0.01 to 5% by mass, more preferably 0.02 to 3% by mass, and most preferably 0.05 to 1.5% by mass in the preparation of the present invention.
本発明の製剤に使用するアニオン系界面活性剤としては、種々のものが使用しうるが、特にＮ−アシルグルタミン酸塩が好ましい。Ｎ−アシルグルタミン酸塩のアシル基としては、飽和又は不飽和の脂肪族カルボン酸、例えば、ヤシ油脂肪酸、パーム脂肪酸、ラウリン酸、ミリスチン酸、ステアリン酸等の脂肪族カルボン酸残基が挙げられる。Ｎ−アシルグルタミン酸塩としては、アルカリ金属塩（例えば、ナトリウム塩、カリウム塩等）、アミン塩（例えば、トリエタノールアミン塩、トリメタノールアミン塩等）等が挙げられる。特に、パーム脂肪酸残基をアシル基として有するＮ−アシルグルタミン酸のナトリウム塩が好ましい。本発明の製剤に特に好ましいアニオン系界面活性剤の市販品としては、例えば、アミソフト（登録商標）シリーズ（味の素株式会社製）が挙げられる。これらの界面活性剤は完全中和型、部分中和型、いずれでもよいが、完全中和型が好ましい。
本発明の製剤中、アニオン系界面活性剤の使用量は、目的の使用形態に合わせて適宜調整すれば良いが、例えば、固形石けんの場合には、固形石けん全体に対して、好ましくは７６〜８４質量％、さらに好ましくは７８〜８１質量％、最も好ましくは７８〜７９質量％である。
Various anionic surfactants used in the preparation of the present invention can be used, and N-acyl glutamate is particularly preferable. Examples of the acyl group of N-acyl glutamate include saturated or unsaturated aliphatic carboxylic acids, for example, aliphatic carboxylic acid residues such as coconut oil fatty acid, palm fatty acid, lauric acid, myristic acid and stearic acid. Examples of the N-acyl glutamate include alkali metal salts (for example, sodium salt and potassium salt), amine salts (for example, triethanolamine salt, trimethanolamine salt, etc.) and the like. In particular, a sodium salt of N-acyl glutamic acid having a palm fatty acid residue as an acyl group is preferred. Examples of commercially available anionic surfactants particularly preferable for the preparation of the present invention include Amisoft (registered trademark) series (manufactured by Ajinomoto Co., Inc.). These surfactants may be either completely neutralized or partially neutralized, but are preferably completely neutralized.
In the preparation of the present invention, the amount of the anionic surfactant used may be appropriately adjusted in accordance with the intended use form. For example, in the case of solid soap, it is preferably 76 to the total amount of solid soap. 84 mass%, More preferably, it is 78-81 mass%, Most preferably, it is 78-79 mass%.
本発明の製剤の剤型としては種々の形態のものを適宜選択できる。好ましい具体的形態としては、石けん、シャンプー、ヘアトニック、ヘアクリーム、パック、コンディショナー、リンス、ヘアオイル、等の洗浄剤が挙げられるが、石けん、シャンプーが好ましく、特に石けんが好ましい。石けんは固形状でも液状でも良い。
本発明の製剤のｐＨは６〜８が好ましく、石けんのｐＨは好ましくは６〜７、さらに好ましくは６．２〜６．８である。
The dosage form of the preparation of the present invention can be appropriately selected from various forms. Preferable specific forms include soaps, shampoos, hair tonics, hair creams, packs, conditioners, rinses, hair oils, and other detergents, with soaps and shampoos being preferred, with soaps being particularly preferred. The soap may be solid or liquid.
The pH of the preparation of the present invention is preferably 6-8, and the pH of the soap is preferably 6-7, more preferably 6.2-6.8.
本発明の製剤の製造には、所定量の上記ササエキス、有機酸、アニオン系界面活性剤の他に、着色剤、保存剤、香料等や他の医薬品等を配合してもよい。また、通常の医薬組成物、化粧品、皮膚用組成物等に使用される油性成分等の基材成分、保湿剤、防腐剤、安定化剤、創傷治癒剤、上記アニオン系界面活性剤以外の界面活性剤等を使用することができる。製剤に水を使用する場合、水道水、天然水、精製水等、特に限定されないが、一般にイオン交換水等の精製水が好ましい。 In the preparation of the preparation of the present invention, in addition to a predetermined amount of the above Sasa extract, organic acid, and anionic surfactant, a coloring agent, a preservative, a fragrance, and other pharmaceuticals may be blended. In addition, base components such as oily components used in normal pharmaceutical compositions, cosmetics, skin compositions, etc., moisturizers, preservatives, stabilizers, wound healing agents, and interfaces other than the above anionic surfactants An activator or the like can be used. When water is used for the preparation, tap water, natural water, purified water and the like are not particularly limited, but purified water such as ion exchange water is generally preferable.
油性成分としては、スクワラン、牛脂、豚脂、馬油、ラノリン、蜜蝋等の動物性油、ユーカリ油、オリーブ油、グレープシード油、パーム油、ホホバ油、胚芽油（例えば、米胚芽油）等の植物性油、流動パラフィン、高級脂肪酸エステル（例えば、パルミチン酸オクチル、パルミチン酸イソプロピル、ミリスチン酸オクチルドデシル）、シリコーン油等の合成油、半合成油が挙げられる。ユーカリ油は刺激緩和効果があり好ましい。
油性成分は、皮膚の保護、エモリエント性付与効果（皮膚表面を薄膜で覆い、乾燥を防ぐと共に、柔軟性、弾力性を与える効果）、さっぱり感等の要求性能に合わせて適宜組み合わせて用いられる。スクワラン、オリーブ油及びミリスチン酸オクチルドデシルの組合せは好ましい例の一つである。
製剤の硬さ、流動性を調節するために、ステアリン酸、ステアリルアルコール、ベヘニン酸、セタノール、ワセリン等の固体油が用いられ、好ましくはステアリン酸とセタノールが組み合わせて用いられる。
Oily ingredients include animal oils such as squalane, beef tallow, lard, horse oil, lanolin, beeswax, eucalyptus oil, olive oil, grape seed oil, palm oil, jojoba oil, germ oil (eg, rice germ oil), etc. Examples include vegetable oils, liquid paraffin, higher fatty acid esters (for example, octyl palmitate, isopropyl palmitate, octyldodecyl myristate), synthetic oils such as silicone oil, and semi-synthetic oils. Eucalyptus oil is preferable because it has a stimulating effect.
The oily component is used in combination as appropriate according to the required performance such as skin protection, emollient imparting effect (effect of covering the skin surface with a thin film to prevent drying and imparting flexibility and elasticity), refreshing feeling and the like. A combination of squalane, olive oil and octyldodecyl myristate is one preferred example.
In order to adjust the hardness and fluidity of the preparation, solid oils such as stearic acid, stearyl alcohol, behenic acid, cetanol and petrolatum are used, and stearic acid and cetanol are preferably used in combination.
本発明の組成物の特に好ましい形態としては、Ｎ−アシルグルタミン酸塩、特にＮ−（パーム脂肪酸）グルタミン酸ナトリウム７６〜８４質量％、好ましくは７８〜８１質量％、水５〜１０質量％、好ましくは６〜９質量％、セタノール５〜９質量％、好ましくは６〜８質量％、クマザサエキス（株式会社鳳凰堂製ＴＷＥＢＳ−ＶＩ（クマザサエキス固形分２７．２質量％、リンゴ酸４質量％含有））３〜７質量％、好ましくは４〜６質量％を含み、ｐＨ５．５〜７．５、好ましくは６．０〜７．０のものであり、さらに好ましくは上記成分に加えて、ポリエチレングリコール０．１〜１質量％、酢酸ステアリン酸スクロース０．１〜１質量％、酸化チタン０．０５〜０．３０質量％を含む石けんが挙げられる。 As a particularly preferred form of the composition of the present invention, N-acyl glutamate, particularly 76-84% by mass of sodium N- (palm fatty acid) glutamate, preferably 78-81% by mass, water 5-10% by mass, preferably 6-9% by mass, cetanol 5-9% by mass, preferably 6-8% by mass, Kumazasa extract (TWEBS-VI manufactured by Tsujido Co., Ltd. (contains 27.2% by mass of Kumazasa extract, 4% by mass of malic acid) 3-7 wt%, preferably 4-6 wt%, pH 5.5-7.5, preferably 6.0-7.0, more preferably in addition to the above components, polyethylene glycol Examples include soaps containing 0.1 to 1% by mass, sucrose acetate 0.1 to 1% by mass, and titanium oxide 0.05 to 0.30% by mass.
本発明の製剤をクリーム形態として製造するためには、ササエキス、水、油性成分をクリーム状にするためのクリーム化剤が用いられる。クリーム化剤は、特に限定されないが、モノステアリン酸グリセリンと自己乳化型モノステアリン酸グリセリン（モノステアリン酸グリセリンに乳化剤を添加したもの）とを組み合わせて使用するのが一般的である。
本発明の製剤の有効成分であるササエキスは笹属の抽出物であり、その１．２５質量％水溶液はヒトの胎児腎臓由来の２９３細胞に対して毒性を示さない。
In order to produce the preparation of the present invention in the form of cream, a creaming agent for creaming Sasa extract, water and oily ingredients is used. The creaming agent is not particularly limited, but it is common to use a combination of glyceryl monostearate and self-emulsifying glyceryl monostearate (glyceryl monostearate with an emulsifier added).
Sasa extract, which is an active ingredient of the preparation of the present invention, is an extract of the genus Genus, and its 1.25% by mass aqueous solution does not show toxicity to 293 cells derived from human fetal kidney.
次に、参考例、実施例及び臨床試験例を示し本発明をさらに詳細に説明する。
参考例１ ササエキスの製造
北海道天塩山系で９月に採集されたササの乾燥葉を、加圧熱水抽出タンクに入れ、１２５℃で１０分処理し、冷却水で熱水を８０℃程度まで冷却し、エキスと含水固形分をスクリュープレスで分離して、含水率を約５０質量％とした。次に、約５０質量％含水固形分をオートクレーブに入れ、１８０℃で１０分、飽和水蒸気による加圧熱処理を行った。処理した含水固形分を、再度加圧熱水抽出タンクに入れて１１０℃で５分処理してエキスを抽出させた。第１回目と第２回目のエキスを合わせ、珪藻土濾過し、固形分５０質量％となるまで減圧濃縮し、１１０〜１３０℃の流動殺菌処理をしてササエキスを得た。
このササエキス中の硫黄含有量は３８５０μｇ／ｍｌ（７．７ｍｇ／固形分１ｇ）であった。
Next, the present invention will be described in more detail with reference examples, examples and clinical test examples.
Reference Example 1 Manufacture of Sasa Extract The dried leaves of Sasa collected in September in Hokkaido Teshioyama are placed in a pressurized hot water extraction tank, treated at 125 ° C for 10 minutes, and cooled with cooling water to about 80 ° C. Then, the extract and the water-containing solid content were separated by a screw press, and the water content was adjusted to about 50% by mass. Next, about 50% by mass of water-containing solid content was put in an autoclave and subjected to pressure heat treatment with saturated steam at 180 ° C. for 10 minutes. The treated water-containing solid content was again placed in a pressurized hot water extraction tank and treated at 110 ° C. for 5 minutes to extract the extract. The first and second extracts were combined, filtered through diatomaceous earth, concentrated under reduced pressure to a solid content of 50% by mass, and subjected to fluid sterilization at 110 to 130 ° C. to obtain a sasa extract.
The sulfur content in this Sasa extract was 3850 μg / ml (7.7 mg / solid content 1 g).
参考例２
ササエキス（Bambuseae Sasa)(株式会社鳳凰堂より入手）の成分を分析したところ下記の結果が得られた。
水 ５９．５質量％
蛋白質 ８．６
脂質 ０．６
ミネラル ９．０
炭水化物 １９．８
タンニン ２．５
Reference example 2
Analysis of the components of Samba extract (obtained from Tsujido Co., Ltd.) gave the following results.
59.5% by mass of water
Protein 8.6
Lipid 0.6
Mineral 9.0
Carbohydrate 19.8
Tannin 2.5
実施例１（石けん）
下記の成分を含有する石けんを定法により製造した。
Example 1 (soap)
A soap containing the following components was produced by a conventional method.
クマザサエキス：株式会社鳳凰堂製ＴＷＥＢＳ−ＶＩ（クマザサエキス固形分２７．２質量％、リンゴ酸４質量％含有）
上記石けんのｐＨは６．３であった。
The soap had a pH of 6.3.
実施例２（シャンプー）
下記の成分を含有するシャンプーを定法により製造した。
コカミドプロピルベタイン：東邦化学工業株式会社製
ココイルグルタミン酸トリエタノールアミン：東邦化学工業株式会社製
コカミドＤＥＡ：東邦化学工業株式会社製
クマザサエキス：株式会社鳳凰堂製ＴＷＥＢＳ−ＶＩ
Example 2 (Shampoo)
A shampoo containing the following components was produced by a conventional method.
実施例３（スキンローション）
下記の成分を含有するスキンローションを定法により製造した。
カワラヨモギエキス：香栄興業株式会社製
チョウジエキス：香栄興業株式会社製
クマザサエキス：株式会社鳳凰堂製ＴＷＥＢＳ−ＶＩ
Example 3 (skin lotion)
A skin lotion containing the following components was produced by a conventional method.
実施例４（ヘアトニック）
下記の成分を含有するヘアトニックを定法により製造した。
Example 4 (hair tonic)
A hair tonic containing the following components was produced by a conventional method.
実施例５（フェイシャルパック（洗い流し用））
下記の成分を含有するフェイシャルパック（洗い流し用）を定法により製造した。
Example 5 (facial pack (for washing away))
A facial pack (for washing off) containing the following components was produced by a conventional method.
カルボマー：和光純薬株式会社製
スクワラン：マルハ株式会社製
ステアロイルグルタミン酸ナトリウム
クマザサエキス：株式会社鳳凰堂製ＴＷＥＢＳ−ＶＩ
試験例１
実施例１で製造した石けんを、前頭部が完全に禿げ上がった患者（５５歳、男性）が使用した。毎日１回、石けんの泡を約１０分間程度禿頭部に付着させた後、洗い流した。約３週間程度で、禿頭部に産毛が生えてきた。
試験例２
実施例１で製造した石けんを、前頭部が完全に禿げ上がった患者（６５歳、男性）が使用した。毎日１回、石けんの泡をつけたガーゼを約１０分間程度禿頭部に付着させた後、洗い流した。約２ヶ月程度で、禿頭部に明確な発毛が認められた。
Test example 1
The soap produced in Example 1 was used by a patient (55 years old, male) whose frontal head was completely bald. Once a day, soap bubbles were allowed to adhere to the groin for about 10 minutes and then washed away. In about 3 weeks, vellus hair has grown on the heel.
Test example 2
The soap produced in Example 1 was used by a patient (65 years old, male) whose frontal head was completely bald. Once every day, gauze with soap bubbles was allowed to adhere to the heel for about 10 minutes and then washed away. In about 2 months, clear hair growth was observed on the heel.
試験例３
実施例１で製造した石けんを、白髪の患者（８４歳、女性）が使用した。１週間に２回程度、毛髪に石けんの泡をつけ、５〜１０分間程度そのまま維持した後、洗い流した。約６週間程度で、白髪に混じって明らかに黒髪の発毛が認められた。
試験例４
実施例１で製造した石けんを、白髪の患者（９１歳、女性）が使用した。１日２回、毛髪に石けんの泡をつけ、１０分間程度そのまま維持した後、洗い流した。約６週間程度で、白髪に混じって明らかに黒髪の発毛が認められた。
Test example 3
The soap produced in Example 1 was used by a gray-haired patient (84 years old, female). About 2 times a week, soap was applied to the hair for about 5 to 10 minutes, and then washed away. In about 6 weeks, dark hair was clearly seen mixed with white hair.
Test example 4
The soap produced in Example 1 was used by a gray-haired patient (91 years old, female). The hair was soaped twice a day, kept for about 10 minutes, and then washed away. In about 6 weeks, dark hair was clearly seen mixed with white hair.
試験例５
全身に痒み症状を有する透析患者（５５歳女性、６２歳男性、他数名）が市販の普通の石けんに代えて、実施例１で製造した石けんを使用したところ、使用の初日から痒み症状が激減ないし完全に消滅した。
Test Example 5
Dialysis patients (55-year-old female, 62-year-old male, several others) who have itch symptoms throughout their body use the soap manufactured in Example 1 instead of the usual commercial soap. It drastically decreased or disappeared completely.
Claims (9)
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| JP2005056017A JP2006241018A (en) | 2005-03-01 | 2005-03-01 | Promoting agent of new hair growth, white hair preventing and/or treating agent, antipruritic composition, and wound healing accelerating agent |
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| JP2005056017A JP2006241018A (en) | 2005-03-01 | 2005-03-01 | Promoting agent of new hair growth, white hair preventing and/or treating agent, antipruritic composition, and wound healing accelerating agent |
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| CN105534998A (en) * | 2016-01-22 | 2016-05-04 | 冯志明 | External preparation for treating skin itch caused by dry skin and preparing method of external preparation |
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