JP2006199611A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic that is highly safe and exhibits excellent effects for suppressing wrinkle generation or improving wrinkles. <P>SOLUTION: The cosmetic and the wrinkle-improving agent comprise as an effective ingredient a plant selected from among Cynanchum paniculatum (Bge.) Kitag., Semiaquilegia adoxoides (DC.) Mak. , Euonymus alatus (Thunb.) Sieb., Viscum coloratum (Kom.) Nakai, and Echinopsis multiplex Zucc., or an extract thereof. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a cosmetic and a wrinkle improving agent having an effect of suppressing the generation of wrinkles and improving wrinkles.

  Maintaining healthy and beautiful skin is a very interesting issue, especially for women. However, the skin condition is always influenced by factors such as humidity, ultraviolet rays, cosmetics, aging, illness, stress, and eating habits. As a result, various skin problems such as deterioration of skin functions and skin aging are caused. appear.

  Among these, wrinkles are caused by skin aging due to aging, photoaging due to exposure to sunlight, and the like. In other words, the cells that make up the dermis fibers become smaller and fewer with increasing exposure to sunlight and age, and especially the collagen fibers are greatly lost, and the skin ages due to degeneration of the dermis and reduction of subcutaneous adipose tissue. Causes wrinkles, relaxation and loss of elasticity.

  Conventionally, various compositions and methods have been proposed to suppress or treat such aging effects such as wrinkles (for example, Patent Document 1, Patent Document 2, Patent Document 3, and Patent Document 4). , Patent Document 5 and Patent Document 6).

However, none of these were fully satisfactory in the effect of improving wrinkles. Therefore, a skin cosmetic that is excellent in the effect of improving wrinkles has been desired.
Japanese Unexamined Patent Publication No. 62-185005 JP-A-62-502546 JP-A-2-72157 JP-A-2-288822 JP 7-41419 A Japanese translation of PCT publication No. 6-510542

  An object of this invention is to provide the cosmetics and wrinkle improving agent which are high in safety | security and are excellent in the effect which suppresses generation | occurrence | production of wrinkles or improves wrinkles.

  As a result of searching for a highly safe natural product, the present inventors have found that a specific plant such as Jojokei or an extract thereof has an excellent wrinkle improving action.

  That is, the present invention relates to a cosmetic comprising, as an active ingredient, a plant selected from Ginkgo biloba, Tenki, Sensou, Sokisei and Senninsho, or an extract thereof.

  The present invention also relates to a wrinkle improving agent comprising as an active ingredient a plant selected from Ginkgo biloba, Tenki, Sensou, Sokisei, and Senninsho.

  According to the cosmetic and the wrinkle improving agent of the present invention, the generation of wrinkles can be suppressed, the appearance of wrinkles can be reduced, wrinkles can be made inconspicuous, or wrinkles can be eliminated.

In the present invention, “Jochokei” refers to Cynanchum paniculatum (Bge.) Kitag., And “tenxi” refers to Semiaquilegia adoxoides (DC.) Mak. ), Egoniaceae (Euonymus alatus (Thunb.) Sieb.) And Sokisei (mulberry parasitism) are mistletoe (Viscum coloratum (Kom.) Nakai) The term “sennin show” means Echinopsis multiplex Zucc.
These plants can be used intact or crushed, such as whole grass, leaves, bark, branches, fruits or roots. It is preferable to use leaves and stems for Sokisei and stems for Senninsha.

  In addition, the extract in the present invention refers to various solvent extracts obtained by extracting the above-mentioned plants at room temperature or under heating or using an extraction tool such as a Soxhlet extractor, a diluted solution thereof, It means a concentrated liquid or its dry powder.

  As the extraction solvent used for obtaining the extract of the present invention, either a polar solvent or a nonpolar solvent can be used, and these can also be used in combination. For example, water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; tetrahydrofuran and diethyl ether Linear and cyclic ethers such as polyethylene; polyethers such as polyethylene glycol; halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride; hydrocarbons such as hexane, cyclohexane and petroleum ether; aroma such as benzene and toluene Group hydrocarbons; pyridines; supercritical carbon dioxide; fats and oils, waxes, and other oils. Among these, water, alcohols, and water-alcohol mixtures are preferable, particularly ethanol water, and in particular, 20 to 80% ethanol. water vol / vol) preferably used.

  Extraction conditions vary depending on the solvent to be used. For example, when extraction is performed with water, alcohols or a water-alcohol mixture, 1 to 50 parts by weight of solvent is used per 1 part by weight of the plant, preferably 4 to 100 ° C. Is preferably extracted at a temperature of room temperature to 60 ° C. for 1 hour to 150 days, more preferably 1 day to 30 days.

  The above extract can be used as it is, but after the extract is diluted, concentrated or lyophilized, it can also be used in the form of powder or paste as necessary. In addition, inert impurities can be removed from the extract by a technique such as liquid-liquid distribution, and it is preferable to use such a material in the present invention. These may be used after performing treatments such as deodorization and decolorization by a known method if necessary.

  In addition, you may use the plant of these invention or those extracts in mixture of 2 or more types.

  The plant of the present invention or an extract thereof, as shown in Examples below, suppresses the generation of wrinkles due to ultraviolet irradiation or thins the appearance of wrinkles, reduces wrinkles, eliminates wrinkles, makes wrinkles less noticeable, Since it has a wrinkle improving effect such as the ability to eliminate wrinkles, it can be used as a cosmetic or wrinkle improving agent for preventing or improving wrinkles.

  The cosmetics of the present invention may have various forms and uses, such as oil / water type, water / oil type emulsified cosmetics, creams, cosmetic emulsions, lotions, oily cosmetics, packs, foundations and the like. it can. Moreover, the wrinkle improving agent of the present invention is not limited to general skin cosmetics, but also includes quasi-drugs, pharmaceuticals, medicinal cosmetics and the like. The administration form of the wrinkle improving agent may be either an oral preparation or a parenteral preparation, but an external preparation is preferable, and creams, ointments, gels, lotions, solutions, packs, foundations and the like are particularly preferable.

  The cosmetic and wrinkle improving agent of the present invention include, in addition to the plant of the present invention or an extract thereof, anti-inflammatory agents such as allantoin, vitamin E derivatives, glycyrrhizin, ascorbic acid derivatives, α-tocopherol, ascorbic acid and the like. By adding antioxidants, wrinkle improvement effect can be improved, and other oils, moisturizers (hyaluronic acid, ceramide, etc.) commonly used as cosmetics and pharmaceutical ingredients, UV absorbers, Alcohols, chelating agents, pH adjusters, preservatives, thickeners, dyes, fragrances, surfactants, gelling agents, and the like can be combined in any combination.

  The content of the plant or the extract thereof in the cosmetic and the wrinkle improving agent can be selected from a wide range, although it varies depending on the addition form and the administration form. For example, in the case of cosmetics or external preparations, it is preferably 0.001% by weight or more, particularly preferably 0.005 to 1% by weight in the composition in terms of a solvent-extracted dried product. In terms of dried solvent extract, it is preferably 0.001 to 10 g, particularly 0.01 to 1 g per day for an adult.

Hereinafter, the present invention will be described in more detail with reference to examples.
Manufacture example 1 Preparation of Jojokei extract Take 40g of whole grass of Jojokei (produced in Hebei Province, China), add 400mL of 50% (v / v) EtOH water, leave it at room temperature for 27 days, extract and filter. An extract was obtained.

Production Example 2
Each plant extract shown in Table 1 below was prepared according to Production Example 1.

Example 1 Wrinkle improvement test in hairless mouse

For the experiment, 8-week-old ICR / HR female mice prepared by crossing HR / HR and HaM / ICR were used. Food and water were freely ingested, and the animals were reared in an environment free from the influence of temperature 23 ° C., humidity 55% and UVB. UVB irradiation was placed in a cage and irradiated using a Toshiba SE lamp. The amount of UVB used was a value measured with UVRADIOMETER (UVR-305 / 365D, Eisai). Literature (Bissett DL, Hannon DP, Orr TV .: Photochem., Photobio., 1987; 46: 367-378, Kiss I, Chen S, Tramposch KM .: Photochem., Photobiol., 1991; 53: 109-112) According to the method described, the 6-10 week-old hairless mice were exposed to 0 weeks of irradiation, 0 to 1 week 65 mJ / cm ² , 1 to 2 weeks 75 mJ / cm ² , 2 to 3 weeks 85 mJ / cm ^2, 4 weeks later when 95mJ / cm ^2, both 1MED (minimum erythema UVB amount) or less of the UVB 1 day 1 times a week 5 times, 12 weeks continuous irradiation, was a long period of time to create the UVB irradiated mice.
Next, 100 μL of the plant extract prepared in Production Examples 1 and 2 (evaporation residue 0.05%) was applied to the entire back skin of the mouse twice a day, 5 times a week for 4 weeks. Six mice were used for Jojokei, and five mice were used for the others. In addition, the solvent object was used as control.

  The wrinkle visual evaluation is based on the above-mentioned document (Bissett DL, Hannon DP, Orr TV .: Photochem., Photobio., 1987; 46: 367-378). Evaluated.

Score 0: No wrinkles Score 1: Slight wrinkles are observed Score 2: Slight wrinkles are observed Score 3: Wrinkles are observed Score 4: Wrinkles are noticeable

Claims (2)

  A cosmetic comprising, as an active ingredient, a plant selected from Ganoderma, Tenki, Sensou, Sokisei, and Senninsho, or an extract thereof.   A wrinkle improving agent comprising, as an active ingredient, a plant selected from jojobakei, tenki, senso, sokisei, and senninsho.