JP2006105985A - ゲート電圧源を用いたバイオポリマの共鳴トンネル効果 - Google Patents

ゲート電圧源を用いたバイオポリマの共鳴トンネル効果 Download PDF

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JP2006105985A
JP2006105985A JP2005283300A JP2005283300A JP2006105985A JP 2006105985 A JP2006105985 A JP 2006105985A JP 2005283300 A JP2005283300 A JP 2005283300A JP 2005283300 A JP2005283300 A JP 2005283300A JP 2006105985 A JP2006105985 A JP 2006105985A
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electrode
biopolymer
nanopore
gate
ring
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JP2005283300A
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Japanese (ja)
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JP2006105985A5 (enExample
Inventor
Curt A Flory
カート・エイ・フローリー
Richard J Pittaro
リチャード・ジェイ・ピッタロ
Phillip W Barth
フィリップ・ダブリュー・バース
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Agilent Technologies Inc
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Agilent Technologies Inc
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Priority claimed from US10/957,378 external-priority patent/US20060068401A1/en
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Publication of JP2006105985A publication Critical patent/JP2006105985A/ja
Publication of JP2006105985A5 publication Critical patent/JP2006105985A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2005283300A 2004-09-30 2005-09-29 ゲート電圧源を用いたバイオポリマの共鳴トンネル効果 Pending JP2006105985A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/957,378 US20060068401A1 (en) 2004-09-30 2004-09-30 Biopolymer resonant tunneling with a gate voltage source
US10/996,846 US8563237B2 (en) 2004-09-30 2004-11-23 Biopolymer resonant tunneling with a gate voltage source

Publications (2)

Publication Number Publication Date
JP2006105985A true JP2006105985A (ja) 2006-04-20
JP2006105985A5 JP2006105985A5 (enExample) 2008-05-01

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JP2005283300A Pending JP2006105985A (ja) 2004-09-30 2005-09-29 ゲート電圧源を用いたバイオポリマの共鳴トンネル効果

Country Status (3)

Country Link
US (1) US8563237B2 (enExample)
EP (1) EP1643234A1 (enExample)
JP (1) JP2006105985A (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013076943A1 (ja) * 2011-11-22 2013-05-30 パナソニック株式会社 生体分子の１分子検出方法および１分子検出装置、疾病マーカ検査装置
JP2014529296A (ja) * 2011-07-20 2014-11-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ２細孔装置
JP2017167156A (ja) * 2009-05-12 2017-09-21 ダニエル ワイ−チョン ソウ 分子の解析と識別のための方法及び装置
WO2018034437A1 (ko) * 2016-08-16 2018-02-22 서울대학교산학협력단 박막 물성측정 및 분석용 시료 제작 방법 및 이에 의해 제작된 시료
JP2020500296A (ja) * 2016-10-12 2020-01-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ナノポア電圧方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050202446A1 (en) * 2004-03-11 2005-09-15 Yang Dan-Hui D. Methods for biopolymer sequencing using metal inclusions
US8563237B2 (en) 2004-09-30 2013-10-22 Agilent Technologies, Inc. Biopolymer resonant tunneling with a gate voltage source
US20070020146A1 (en) * 2005-06-29 2007-01-25 Young James E Nanopore structure and method using an insulating substrate
US20070202008A1 (en) * 2006-02-28 2007-08-30 Schembri Carol T Systems and methods of lipoprotein size fraction assaying
WO2011108540A1 (ja) 2010-03-03 2011-09-09 国立大学法人大阪大学 ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置
JP5670278B2 (ja) * 2011-08-09 2015-02-18 株式会社日立ハイテクノロジーズ ナノポア式分析装置
CN106104274B (zh) 2013-09-18 2018-05-22 量子生物有限公司 生物分子测序装置、系统和方法
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
WO2015170782A1 (en) 2014-05-08 2015-11-12 Osaka University Devices, systems and methods for linearization of polymers
CN115595360A (zh) * 2016-04-27 2023-01-13 因美纳剑桥有限公司（Gb） 用于生物分子的测量和测序的系统和方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04127002A (ja) * 1990-09-19 1992-04-28 Hitachi Ltd トンネル現象検出評価方法
US20030141189A1 (en) * 2002-01-28 2003-07-31 Lee James W. DNA and RNA sequencing by nanoscale reading through programmable electrophoresis and nanoelectrode-gated tunneling and dielectric detection
US6627067B1 (en) * 1999-06-22 2003-09-30 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
JP2004233353A (ja) * 2003-01-31 2004-08-19 Agilent Technol Inc ナノポアを介するバイオポリマーの転位を制御するための装置及び方法
JP2004233356A (ja) * 2003-01-27 2004-08-19 Agilent Technol Inc ナノポアを通って移動するバイオポリマーの識別装置及び方法
JP2005257687A (ja) * 2004-03-10 2005-09-22 Agilent Technol Inc トンネルコンダクタンスの変化を検出することによってポリマーをシーケンシングするための方法及び装置

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US4288303A (en) * 1978-10-20 1981-09-08 Environmental Sciences Associates, Inc. Electrochemical processing system
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
EP1285252A1 (en) * 2000-04-24 2003-02-26 Eagle Research & Development, LLC An ultra-fast nucleic acid sequencing device and a method for making and using the same
US7001792B2 (en) * 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
WO2002035580A2 (en) 2000-10-24 2002-05-02 Molecular Electronics Corporation Three-terminal field-controlled molecular devices
JP4325133B2 (ja) * 2001-08-27 2009-09-02 株式会社デンソー ガスセンサおよびその製造方法
JP4127002B2 (ja) 2001-12-26 2008-07-30 東ソー株式会社 高分子電解質膜、固体高分子型燃料電池用膜−電極接合体および固体高分子型燃料電池
US20050202446A1 (en) * 2004-03-11 2005-09-15 Yang Dan-Hui D. Methods for biopolymer sequencing using metal inclusions
US8563237B2 (en) 2004-09-30 2013-10-22 Agilent Technologies, Inc. Biopolymer resonant tunneling with a gate voltage source

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04127002A (ja) * 1990-09-19 1992-04-28 Hitachi Ltd トンネル現象検出評価方法
US6627067B1 (en) * 1999-06-22 2003-09-30 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
US20030141189A1 (en) * 2002-01-28 2003-07-31 Lee James W. DNA and RNA sequencing by nanoscale reading through programmable electrophoresis and nanoelectrode-gated tunneling and dielectric detection
JP2004233356A (ja) * 2003-01-27 2004-08-19 Agilent Technol Inc ナノポアを通って移動するバイオポリマーの識別装置及び方法
JP2004233353A (ja) * 2003-01-31 2004-08-19 Agilent Technol Inc ナノポアを介するバイオポリマーの転位を制御するための装置及び方法
JP2005257687A (ja) * 2004-03-10 2005-09-22 Agilent Technol Inc トンネルコンダクタンスの変化を検出することによってポリマーをシーケンシングするための方法及び装置

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017167156A (ja) * 2009-05-12 2017-09-21 ダニエル ワイ−チョン ソウ 分子の解析と識別のための方法及び装置
JP2014529296A (ja) * 2011-07-20 2014-11-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ２細孔装置
US9863912B2 (en) 2011-07-20 2018-01-09 The Regents Of The University Of California Dual-pore device
WO2013076943A1 (ja) * 2011-11-22 2013-05-30 パナソニック株式会社 生体分子の１分子検出方法および１分子検出装置、疾病マーカ検査装置
JPWO2013076943A1 (ja) * 2011-11-22 2015-04-27 パナソニックＩｐマネジメント株式会社 生体分子の１分子検出方法および１分子検出装置、疾病マーカ検査装置
WO2018034437A1 (ko) * 2016-08-16 2018-02-22 서울대학교산학협력단 박막 물성측정 및 분석용 시료 제작 방법 및 이에 의해 제작된 시료
US11543376B2 (en) 2016-08-16 2023-01-03 Seoul National University R&Db Foundation Method for manufacturing sample for thin film property measurement and analysis, and sample manufactured thereby
JP2020500296A (ja) * 2016-10-12 2020-01-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ナノポア電圧方法
JP7060590B2 (ja) 2016-10-12 2022-04-26 エフ．ホフマン－ラ ロシュ アーゲー ナノポア電圧方法

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EP1643234A1 (en) 2006-04-05
US8563237B2 (en) 2013-10-22
US20060071209A1 (en) 2006-04-06

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