JP2006076903A - Antiallergic cosmetic formulation and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiallergic cosmetic formulation which can be produced relatively inexpensively, is highly safe, and is excellent in an antiallergic effect and a moisturizing effect. <P>SOLUTION: The antiallergic cosmetic formulation contains as an active ingredient a fermentate obtained by fermenting a raw material containing at least a part selected from among leaves, stems, and roots of buckwheat (Fagopyrum esculentum) with lactobacillus and optionally yeast or a supernatant of the fermentate. This composition can be obtained by grinding a raw material containing at least a part of leaves, stems, and roots of buckwheat (Fagopyrum esculentum), forming a solution of the ground product, and subjecting the solution to fermentation with lactobacillus and optionally yeast. It is preferable that the buckwheat (Fagopyrum esculentam) used is in the growth stage of new sprouts. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a cosmetic composition having anti-allergic properties, and in particular, a cosmetic comprising as an active ingredient a fermented product that is fermented by adding lactic acid bacteria and yeast as needed to buckwheat leaves, stems, roots, etc. The present invention relates to a material composition and a method for producing the same.

  People suffering from allergic dermatitis such as sensitive skin, skin irritation and atopic dermatitis due to various causes such as eating habits, mainly eating out and processed foods, worsening air pollution, exposure to allergens, etc. ing.

  For the treatment of such allergic dermatitis, external preparations such as steroids and non-steroids, antiallergic agents, antihistamines, etc. are taken. Although these drugs have an excellent antiallergic effect, they have strong side effects and are not preferable for long-term use.

Therefore, many anti-allergic skin external preparations and cosmetic compositions, which have natural ingredients derived from natural products that are safer and have no side effects even when used on a daily basis, have been proposed. For example, buckwheat is a food ingredient that has been familiar for a long time in the Japanese dietary life. As an external preparation using the extract of buckwheat, Patent Document 1 listed below includes sesame, forsythia, syringen, and Korean. Forsythia, Ginseng, Pinus, Enju, Inuenju, Hanemi Inuenju, Plants belonging to the genus Shajixou, Plants belonging to the genus Harienju, Plants belonging to the genus Quercus other than Forsythia, Buckwheat, Tartary buckwheat, Vulgaris, Prunus An antiallergic skin external preparation comprising one or two or more selected from products is disclosed.
JP-A-11-180885

  However, it is difficult to say that conventional antiallergic skin external preparations and cosmetic compositions containing active ingredients derived from natural products are sufficiently satisfactory in their antiallergic effects, and those having higher antiallergic effects are desired. It was done.

  In addition, when using natural products as raw materials, in addition to the problem of securing stable raw materials, a large amount of solvent is required for extraction of active ingredients from raw materials, and it takes time and effort, resulting in high costs. There was also.

  Accordingly, an object of the present invention is to provide an antiallergic cosmetic composition that can be produced at a relatively low cost, has high safety, and has an excellent antiallergic effect and moisturizing effect, and a method for producing the same. .

  In the process of studying the bioactive effect of buckwheat, the present inventors found that a fermented product obtained by pulverizing whole buckwheat and lactic acid fermentation has an excellent antiallergic effect and moisturizing effect. It came to be completed.

  That is, one of the present invention is characterized by containing as an active ingredient a fermented product obtained by fermenting a raw material containing at least a part selected from buckwheat leaves, stems and roots with lactic acid bacteria. A cosmetic composition is provided.

  The antiallergic cosmetic composition of the present invention contains, as an active ingredient, a fermented product obtained by fermenting a raw material containing at least a part selected from buckwheat leaves, stems and roots with lactic acid bacteria. Compared with the extract of buckwheat, it has an anti-allergic effect, and a high therapeutic effect can be expected for allergic dermatitis such as atopic dermatitis. Moreover, since it has an excellent moisturizing effect, it can also be expected to improve dry skin.

  In the antiallergic cosmetic composition of the present invention, a fermented product obtained by fermenting a raw material containing at least a part selected from buckwheat leaves, stems and roots with yeast and lactic acid bacteria may be used as an active ingredient. By performing alcoholic fermentation with yeast, harmful bacteria are removed, so that the sterilization temperature can be lowered, and fermentation of lactic acid bacteria can be promoted by the metabolites of yeast.

  Moreover, it is preferable that the antiallergic cosmetic composition of this invention contains the supernatant of the said fermented material as an active ingredient. According to this, since an insoluble matter is not included, an easy-to-use antiallergic cosmetic composition that can be blended into various cosmetics can be provided.

  The buckwheat is preferably a new shoot of buckwheat. According to this, the antiallergic cosmetic composition which has the more superior antiallergic effect and moisturizing effect can be provided.

Furthermore, the fermented product is preferably a product obtained by lactic acid fermentation using Lactobacillus plantarum . Lactobacillus plantarum is also called a plant lactic acid bacterium and can efficiently ferment a raw material containing at least a part selected from leaves, stems and roots of buckwheat. An antiallergic cosmetic composition having an effect and a moisturizing effect can be provided.

  Another aspect of the present invention is a pulverization step in which a raw material containing at least a part selected from buckwheat leaves, stems and roots is pulverized to form a solution, and lactic acid bacteria are added to the obtained pulverized product for fermentation. A method for producing an antiallergic cosmetic composition comprising a fermentation step.

  According to the production method of the present invention, an antiallergic cosmetic composition having high safety and excellent antiallergic and moisturizing effects can be produced at low cost.

  In the production method of the present invention, a raw material containing at least a part selected from buckwheat leaves, stems and roots is pulverized to form a solution, and yeast and lactic acid bacteria are added to the obtained pulverized product. It preferably includes a fermentation process for fermentation. According to this, since harmful bacteria are removed by alcohol fermentation with yeast, the sterilization temperature can be lowered, and further, fermentation of lactic acid bacteria can be promoted by the metabolites of yeast.

  In the manufacturing method of this invention, it is preferable to include the process of collect | recovering supernatants from the obtained fermented material after the said fermentation process. According to this, an easy-to-use antiallergic cosmetic composition that can be blended into various cosmetics can be obtained.

  Moreover, it is preferable to use a new young shoot of buckwheat as the buckwheat. According to this, an antiallergic cosmetic composition having a more excellent antiallergic effect and moisture retention can be obtained.

Furthermore, it is preferable to use Lactobacillus plantarum as the lactic acid bacteria. According to this, as mentioned above, the raw material containing at least a part selected from the leaves, stems and roots of buckwheat can be efficiently fermented.

  According to the present invention, a raw material containing at least a part selected from buckwheat leaves, stems and roots contains, as an active ingredient, a lactic acid fermentation and a fermented product obtained by adding and fermenting yeast as necessary. Therefore, it has an anti-allergic effect superior to that of unfermented buckwheat extract, and a high therapeutic effect can be expected for allergic dermatitis such as atopic dermatitis. Moreover, since it has an excellent moisturizing effect, it can also be expected to improve dry skin.

The buckwheat used as a raw material of the antiallergic cosmetic composition of the present invention is an annual herb of the genus Buckwheat, and at least a part selected from its leaves, stems and roots is used. And whole plants including roots can also be used. In the present invention, at least a part selected from the leaves, stems and roots of buckwheat new shoots, or whole buckwheat new shoots is preferably used. In the present invention, buckwheat new shoots (sprouts) usually mean buckwheat 5 to 14 days after germination, and those having a plant height of 5 to 20 cm are preferably used. In addition to buckwheat (scientific name: Fagopyrum esculentum ), buckwheat (scientific name: Fagopyrum tataricum ) and shakchisoba (student buckwheat) (scientific name: Fagopyrum mo cyrum) In the present invention, any of the above buckwheat can be used.

Moreover, as lactic acid bacteria used when fermenting a raw material containing at least a part selected from buckwheat leaves, stems and roots, lactic acid bacteria belonging to the genus Lactobacillus or Streptococcus can be used. Specifically, as lactic acid bacteria belonging to the genus Lactobacillus, Lactobacillus bulgaricus (Lactobacillus bulgaricus), Lactobacillus acidophilus (Lactobacillusacidophilus), Lactobacillus casei (Lactobacillus casei), Lactobacillus plantarum (Lactobacillusplantarum), Lactobacillus -A fermentum ( Lactobacillus fermentum ) etc. can be illustrated. Further, as lactic acid bacteria belonging to the genus Streptococcus, Streptococcus lactis (Streptococcuslactis), Streptococcus cremoris (Streptococcus cremoris), Streptococcus thermophilus (Streptococcusthermophilus) and the like. These lactic acid bacteria are bacteria that are used in the production of yogurt, lactic acid bacteria beverages, cheese, and the like, and are generally available. In the present invention, among the above lactic acid bacteria, Lactobacillus plantarum ( Lactobacillus plantarum, such as ATCC 8014, IFO 3074, IFO 12006, IFO 12011, IFO 12519, etc.) is particularly preferably used.

  The fermented product which is an active ingredient of the antiallergic cosmetic composition of the present invention can be produced, for example, as follows.

  At least a portion selected from buckwheat leaves, stems and roots, or whole buckwheat, is immersed in hot water of 65 to 80 ° C. for 5 to 10 minutes for sterilization and blanching, and then an appropriate amount as necessary. Water is added and pulverized with a mixer or the like to form a solution. By blanching, the production of pheophorbide derived from chlorophyll, which causes allergic symptoms such as photosensitivity, can be suppressed. As other raw materials, buckwheat berries, buckwheat stems, buckwheat flowers, sugars and the like may be added. For example, fermentation can be promoted by adding buckwheat berries or sugars.

  The obtained solution is sterilized by heating as necessary, and then a lactic acid fermentation is performed by adding a pre-culture solution of lactic acid bacteria cultured according to a conventional method. The heat sterilization is preferably performed at 100 ° C. or less, and more preferably at 70 to 85 ° C. for 5 to 10 minutes. Moreover, it is preferable to perform lactic acid fermentation until the pH of a fermented liquid becomes about 3.5, and it is normally fermented at 15-37 degreeC, Preferably it is 20-28 degreeC for 3 to 14 days.

In addition, before lactic acid fermentation, yeast may be added and alcohol fermentation may be performed. Alcohol fermentation may be carried out by adding a precultured yeast solution cultured according to a conventional method to the above-mentioned raw material that has been appropriately heat-sterilized after pulverization and fermenting at 25-30 ° C. for 3-20 days. By performing alcoholic fermentation, harmful bacteria can be removed, so that the sterilization temperature can be lowered, and furthermore, lactic acid bacteria can be easily fermented by the metabolites of yeast. The yeast, such as Saccharomyces cerevisiae (Saccharomyces cerevisiae) can be used.

  The fermented product thus obtained can be used as it is as an antiallergic cosmetic composition after heat sterilization (usually at 60 to 85 ° C. for 2 to 60 minutes) as necessary. Further, the insoluble matter can be removed from the fermented product by means such as centrifugation, and the supernatant can be used. Furthermore, a supernatant obtained by removing cells by filtration can be used.

  In addition to the fermented product or the supernatant of the fermented product, the anti-allergic cosmetic composition of the present invention is a component commonly used in cosmetics as other components, such as a moisturizer, an oily component, and a surfactant. Agents, preservatives, perfumes and the like.

  The antiallergic cosmetic composition of the present invention can be blended in various cosmetics, and specific examples include skin lotions, emulsions, creams, packs, lotions, bath agents, soaps and the like.

  The amount of the anti-allergic cosmetic composition in the cosmetic is preferably 1 to 10% by mass, more preferably 2 to 5% by mass in terms of solid content of the fermented product.

  Hereinafter, the present invention will be specifically described with reference to examples.

Example 1
Wash 1000g of buckwheat new shoots (including leaves, stems and roots. 10 days after germination) with water, soak in hot water at 85 ° C for 20 minutes to sterilize and blanch, then add 2 L of sterile water. It grind | pulverized with the mixer. An appropriate amount of a pre-culture solution of lactic acid bacteria ( Lactobacillus plantarum ) was added thereto, and fermentation was performed at 32 ° C. for 14 days (pH of fermented product at the end of fermentation: 3.48).

  This fermented product was sterilized at 75 ° C. for 30 minutes to obtain an antiallergic cosmetic composition. Further, a part of the fermentation broth was centrifuged to remove insoluble matters, and the supernatant was recovered.

Test example 1
Thirty volunteers with atopic skin disease were divided into 3 groups of 10 people in each group. The test group 1 contains the fermented product obtained in Example 1 above, and the test group 2 contains the fermented product. The supernatant was applied to the affected area twice a day. On the other hand, in the comparative example, the stock solution before lactic acid fermentation was applied to the affected area in the same manner as in Example 1. The test period was 3 days, and a questionnaire was conducted on whether or not itching was reduced in each volunteer on the last day. The results are shown in Table 1.

  From Table 1, it can be seen that the proportion of people with reduced itching was higher in test groups 1 and 2 than in the comparison group. Therefore, it is understood that the lactic acid fermented product of buckwheat's new shoots has an anti-allergic effect superior to that of the unfermented product.

Test example 2
A pre-culture solution of lactic acid bacteria ( Lactobacillus casei ) was added to 1 L of milk, fermented at 30 ° C. for 72 hours, and then centrifuged (8000 rpm) to recover the supernatant. The obtained supernatant was sterilized at 75 ° C. for 10 minutes to prepare a lactic acid fermentation broth supernatant of milk.

  40 volunteers with dry skin are divided into 4 groups of 10 people in each group, the test group 1 contains the fermented product obtained in Example 1 above, the test group 2 contains the supernatant of the fermented product, Each was applied to the affected area twice a day. On the other hand, purified water was applied to the control group, and the supernatant of the milk lactic acid fermentation broth was applied to the affected group in the same manner. The test period was 3 days, and a questionnaire was given to each volunteer on the degree of symptom improvement on the last day. The results are shown in Table 2.

  From Table 2, it can be seen that test groups 1 and 2 have a higher proportion of people with reduced dry skin symptoms than the control group. In addition, the improvement effect of dry skin equal to or higher than the supernatant (comparison group) of lactic acid fermentation broth of milk that is known to contain an excellent moisturizing component has been obtained. Or it turns out that the supernatant has the outstanding moisturizing effect.

  The antiallergic cosmetic composition of the present invention can be used as a raw material for various cosmetics such as lotions, emulsions, creams, packs, lotions, bathing agents, soaps and the like. And the prevention of atopic skin disease etc., a therapeutic effect, a moisturizing provision effect, etc. can be anticipated by utilizing the cosmetics containing this cosmetic composition.

Claims (10)

  An antiallergic cosmetic composition comprising a fermented product obtained by fermenting a raw material containing at least a part selected from buckwheat leaves, stems and roots with lactic acid bacteria as an active ingredient.   The antiallergic cosmetic composition according to claim 1, comprising a fermented product obtained by fermenting a raw material containing at least a part selected from buckwheat leaves, stems and roots with yeast and lactic acid bacteria as an active ingredient.   The antiallergic cosmetic composition according to claim 1 or 2, comprising the supernatant of the fermented product as an active ingredient.   The anti-allergic cosmetic composition according to any one of claims 1 to 3, wherein the buckwheat is a new shoot of buckwheat. The anti-allergic cosmetic composition according to any one of claims 1 to 4, wherein the fermented product is fermented using Lactobacillus plantarum .   It includes a pulverizing step of pulverizing a raw material containing at least a part selected from buckwheat leaves, stems and roots into a solution, and a fermentation step of adding lactic acid bacteria to the obtained pulverized product for fermentation. A method for producing an antiallergic cosmetic composition.   Crushing a raw material containing at least a part selected from buckwheat leaves, stems and roots into a solution, and a fermentation step of adding yeast and lactic acid bacteria to the obtained pulverized product for fermentation. The manufacturing method of the antiallergic cosmetic composition of Claim 6.   The manufacturing method of the antiallergic cosmetic composition of Claim 6 or 7 including the process of collect | recovering supernatants from the obtained fermented material after the said fermentation process.   The method for producing an antiallergic cosmetic composition according to any one of claims 6 to 8, wherein a new buckwheat bud is used as the buckwheat. The method for producing an antiallergic cosmetic composition according to any one of claims 6 to 9, wherein Lactobacillus plantarum is used as the lactic acid bacterium.