JP2005535676A5 - - Google Patents
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- Publication number
- JP2005535676A5 JP2005535676A5 JP2004522646A JP2004522646A JP2005535676A5 JP 2005535676 A5 JP2005535676 A5 JP 2005535676A5 JP 2004522646 A JP2004522646 A JP 2004522646A JP 2004522646 A JP2004522646 A JP 2004522646A JP 2005535676 A5 JP2005535676 A5 JP 2005535676A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- radioimmunotherapy
- pharmaceutically acceptable
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 55
- 238000011363 radioimmunotherapy Methods 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 21
- 229940051022 radioimmunoconjugate Drugs 0.000 claims description 14
- -1 4-Methylpiperazin-1-ylmethyl Chemical group 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 201000002528 pancreatic cancer Diseases 0.000 claims description 5
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims description 3
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- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 3
- 206010039491 Sarcoma Diseases 0.000 claims description 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 208000005017 glioblastoma Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
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- 239000007787 solid Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 19
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 12
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- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 3
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 3
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- 230000004614 tumor growth Effects 0.000 description 3
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 2
- 208000007766 Kaposi sarcoma Diseases 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 description 2
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- 241001385733 Aesculus indica Species 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 229940124292 CD20 monoclonal antibody Drugs 0.000 description 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N Cc(ccc(NC(c1ccc(CN2CCN(C)CC2)cc1)=O)c1)c1Nc1nc(-c2cnccc2)ccn1 Chemical compound Cc(ccc(NC(c1ccc(CN2CCN(C)CC2)cc1)=O)c1)c1Nc1nc(-c2cnccc2)ccn1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000032320 Germ cell tumor of testis Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 108010063954 Mucins Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 102000007000 Tenascin Human genes 0.000 description 1
- 108010008125 Tenascin Proteins 0.000 description 1
- 201000000331 Testicular germ cell cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960000548 alemtuzumab Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002494 anti-cea effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229910052789 astatine Inorganic materials 0.000 description 1
- RYXHOMYVWAEKHL-UHFFFAOYSA-N astatine atom Chemical compound [At] RYXHOMYVWAEKHL-UHFFFAOYSA-N 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012148 binding buffer Substances 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 101150061829 bre-3 gene Proteins 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000003021 clonogenic effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 229960003297 gemtuzumab ozogamicin Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
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- 230000000955 neuroendocrine Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 101150047061 tag-72 gene Proteins 0.000 description 1
- 208000002918 testicular germ cell tumor Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960005267 tositumomab Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39734702P | 2002-07-19 | 2002-07-19 | |
| PCT/IB2003/003257 WO2004009089A1 (en) | 2002-07-19 | 2003-07-17 | Enhancing the effect of radioimmunotherapy in the treatment of tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535676A JP2005535676A (ja) | 2005-11-24 |
| JP2005535676A5 true JP2005535676A5 (https=) | 2006-09-07 |
Family
ID=30771040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522646A Pending JP2005535676A (ja) | 2002-07-19 | 2003-07-17 | 腫瘍の処置における放射免疫療法の効果の増強 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070037825A1 (https=) |
| EP (1) | EP1530474A1 (https=) |
| JP (1) | JP2005535676A (https=) |
| AU (1) | AU2003247094A1 (https=) |
| CA (1) | CA2492878A1 (https=) |
| WO (1) | WO2004009089A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1544213B1 (en) * | 2003-12-19 | 2008-02-20 | Charité - Universitätsmedizin Berlin | Use of ligands of the antigen cd52 for the treatment of solid tumours and bone-related cancerous diseases |
| ATE437657T1 (de) * | 2004-03-02 | 2009-08-15 | Cellectar Inc | Phospholipid-analoga für die behandlung von krebs |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| US6498181B1 (en) * | 1999-01-06 | 2002-12-24 | Maxim Pharmaceuticals | Synergistic tumorcidal response induced by histamine |
| JP2001002586A (ja) * | 1999-06-21 | 2001-01-09 | Toagosei Co Ltd | 重粒子線療法用薬剤 |
| EP1223952B1 (en) * | 1999-10-07 | 2008-04-16 | Carlos Estuardo Aguilar-Cordova | Methods for treatment of solid tumors and metastasis by gene therapy |
| US20020147197A1 (en) * | 1999-10-08 | 2002-10-10 | Newman Michael J. | Methods and compositions for enhancing pharmaceutical treatments |
-
2003
- 2003-07-17 US US10/521,299 patent/US20070037825A1/en not_active Abandoned
- 2003-07-17 CA CA002492878A patent/CA2492878A1/en not_active Abandoned
- 2003-07-17 WO PCT/IB2003/003257 patent/WO2004009089A1/en not_active Ceased
- 2003-07-17 EP EP03765252A patent/EP1530474A1/en not_active Withdrawn
- 2003-07-17 JP JP2004522646A patent/JP2005535676A/ja active Pending
- 2003-07-17 AU AU2003247094A patent/AU2003247094A1/en not_active Abandoned
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