JP2005535599A5 - - Google Patents
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- Publication number
- JP2005535599A5 JP2005535599A5 JP2004507476A JP2004507476A JP2005535599A5 JP 2005535599 A5 JP2005535599 A5 JP 2005535599A5 JP 2004507476 A JP2004507476 A JP 2004507476A JP 2004507476 A JP2004507476 A JP 2004507476A JP 2005535599 A5 JP2005535599 A5 JP 2005535599A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- group
- groups
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 claims 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- -1 hydroxy, cyano, Phenyl Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000005936 piperidyl group Chemical group 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- UEESMNRENCAKTF-WMDTUVAQSA-N C1=C(O)C(S(=O)(=O)C)=CC(OC[C@@H](O)CN[C@@H]2CC[C@H](CC2)C=2C=CC(=CC=2)C(=O)N2CCC(CC2)C(O)C=2C=CC=CC=2)=C1 Chemical compound C1=C(O)C(S(=O)(=O)C)=CC(OC[C@@H](O)CN[C@@H]2CC[C@H](CC2)C=2C=CC(=CC=2)C(=O)N2CCC(CC2)C(O)C=2C=CC=CC=2)=C1 UEESMNRENCAKTF-WMDTUVAQSA-N 0.000 claims 1
- JSVQZRWWUMYFNO-HVCNVCAESA-N CC1CCN(CC1)C(=O)c1ccc(cc1)[C@H]1CC[C@@H](CC1)NC[C@H](O)COc1ccc(O)c(NS(C)(=O)=O)c1 Chemical compound CC1CCN(CC1)C(=O)c1ccc(cc1)[C@H]1CC[C@@H](CC1)NC[C@H](O)COc1ccc(O)c(NS(C)(=O)=O)c1 JSVQZRWWUMYFNO-HVCNVCAESA-N 0.000 claims 1
- RPVOZYDEMJLEIE-ASVWTAOFSA-N CS(=O)(=O)Nc1cc(OC[C@@H](O)CN[C@H]2CC[C@@H](CC2)c2ccc(cc2)C(=O)N2CCC(Cc3ccccc3)CC2)ccc1O Chemical compound CS(=O)(=O)Nc1cc(OC[C@@H](O)CN[C@H]2CC[C@@H](CC2)c2ccc(cc2)C(=O)N2CCC(Cc3ccccc3)CC2)ccc1O RPVOZYDEMJLEIE-ASVWTAOFSA-N 0.000 claims 1
- WXDGALPMEZUDDL-CAVYSCNFSA-N CS(=O)(=O)c1cc(OC[C@@H](O)CN[C@H]2CC[C@@H](CC2)c2ccc(cc2)C(=O)N2Cc3ccccc3C2)ccc1O Chemical compound CS(=O)(=O)c1cc(OC[C@@H](O)CN[C@H]2CC[C@@H](CC2)c2ccc(cc2)C(=O)N2Cc3ccccc3C2)ccc1O WXDGALPMEZUDDL-CAVYSCNFSA-N 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 101100379080 Emericella variicolor andB gene Proteins 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- MJVWJMNBPKKIEJ-JOYXZSCHSA-N N1(CCC2(CC1)CC1=CC=CC=C1C2)C(=O)C1=CC=C(C=C1)[C@@H]1CC[C@H](CC1)NC[C@@H](COC1=CC(=C(C=C1)O)S(=O)(=O)C)O Chemical compound N1(CCC2(CC1)CC1=CC=CC=C1C2)C(=O)C1=CC=C(C=C1)[C@@H]1CC[C@H](CC1)NC[C@@H](COC1=CC(=C(C=C1)O)S(=O)(=O)C)O MJVWJMNBPKKIEJ-JOYXZSCHSA-N 0.000 claims 1
- XZJYOCQFJMSINF-NSGJQZOKSA-N N1(CCC2(CC1)CCC1=CC=CC=C12)C(=O)C1=CC=C(C=C1)[C@@H]1CC[C@H](CC1)NC[C@@H](COC1=CC(=C(C=C1)O)S(=O)(=O)C)O Chemical compound N1(CCC2(CC1)CCC1=CC=CC=C12)C(=O)C1=CC=C(C=C1)[C@@H]1CC[C@H](CC1)NC[C@@H](COC1=CC(=C(C=C1)O)S(=O)(=O)C)O XZJYOCQFJMSINF-NSGJQZOKSA-N 0.000 claims 1
- JSLXSDQUICOIKD-NAYUSWPISA-N N1(CCC2(CC1)CCCC1=CC=CC=C12)C(=O)C1=CC=C(C=C1)[C@@H]1CC[C@H](CC1)NC[C@@H](COC1=CC(=C(C=C1)O)S(=O)(=O)C)O Chemical compound N1(CCC2(CC1)CCCC1=CC=CC=C12)C(=O)C1=CC=C(C=C1)[C@@H]1CC[C@H](CC1)NC[C@@H](COC1=CC(=C(C=C1)O)S(=O)(=O)C)O JSLXSDQUICOIKD-NAYUSWPISA-N 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000000883 anti-obesity agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229940005513 antidepressants Drugs 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000000030 antiglaucoma agent Substances 0.000 claims 1
- 229940125710 antiobesity agent Drugs 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000008991 intestinal motility Effects 0.000 claims 1
- 208000037805 labour Diseases 0.000 claims 1
- 230000002366 lipolytic effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229940001470 psychoactive drug Drugs 0.000 claims 1
- 239000004089 psychotropic agent Substances 0.000 claims 1
- 230000000506 psychotropic effect Effects 0.000 claims 1
- 230000036573 scar formation Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- YJPRMAKYHDHWRV-YGGJGDQASA-N 4-[4-[benzyl-[(2s)-2-hydroxy-3-(3-methylsulfonyl-4-phenylmethoxyphenoxy)propyl]amino]cyclohexyl]benzoic acid Chemical compound C([C@H](O)COC=1C=C(C(=CC=1)OCC=1C=CC=CC=1)S(=O)(=O)C)N(C1CCC(CC1)C=1C=CC(=CC=1)C(O)=O)CC1=CC=CC=C1 YJPRMAKYHDHWRV-YGGJGDQASA-N 0.000 description 1
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0206560A FR2840304B1 (fr) | 2002-05-29 | 2002-05-29 | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
| PCT/FR2003/001579 WO2003099819A2 (fr) | 2002-05-29 | 2003-05-26 | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005535599A JP2005535599A (ja) | 2005-11-24 |
| JP2005535599A5 true JP2005535599A5 (enExample) | 2006-07-13 |
| JP4478013B2 JP4478013B2 (ja) | 2010-06-09 |
Family
ID=29558807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004507476A Expired - Lifetime JP4478013B2 (ja) | 2002-05-29 | 2003-05-26 | オキソフェニルシクロヘキシルプロパノールアミン誘導体、それらの製造法、およびそれらの治療的適用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7625929B2 (enExample) |
| EP (1) | EP1511728B1 (enExample) |
| JP (1) | JP4478013B2 (enExample) |
| AT (1) | ATE356805T1 (enExample) |
| AU (1) | AU2003260569A1 (enExample) |
| DE (1) | DE60312511T2 (enExample) |
| FR (1) | FR2840304B1 (enExample) |
| WO (1) | WO2003099819A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| EP2011490A1 (en) * | 2007-07-05 | 2009-01-07 | Sanofi-Aventis | Beta adrenergic receptor ligand derivatives for modulating apoptosis |
| FR2935141B1 (fr) * | 2008-08-21 | 2010-10-08 | Sanofi Aventis | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6130217A (en) * | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
| AU6050000A (en) * | 1999-07-22 | 2001-02-13 | Eli Lilly And Company | Improved method of treating type ii diabetes and obesity |
| CN1423637A (zh) * | 1999-12-16 | 2003-06-11 | 旭化成株式会社 | 新的取代的三环化合物 |
| FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| US6770645B2 (en) * | 2001-03-16 | 2004-08-03 | Pfizer Inc. | Pharmaceutically active compounds |
-
2002
- 2002-05-29 FR FR0206560A patent/FR2840304B1/fr not_active Expired - Fee Related
-
2003
- 2003-05-26 WO PCT/FR2003/001579 patent/WO2003099819A2/fr not_active Ceased
- 2003-05-26 JP JP2004507476A patent/JP4478013B2/ja not_active Expired - Lifetime
- 2003-05-26 AT AT03755201T patent/ATE356805T1/de not_active IP Right Cessation
- 2003-05-26 US US10/515,093 patent/US7625929B2/en not_active Expired - Fee Related
- 2003-05-26 EP EP03755201A patent/EP1511728B1/fr not_active Expired - Lifetime
- 2003-05-26 AU AU2003260569A patent/AU2003260569A1/en not_active Abandoned
- 2003-05-26 DE DE60312511T patent/DE60312511T2/de not_active Expired - Lifetime
-
2009
- 2009-11-30 US US12/627,536 patent/US20100075986A1/en not_active Abandoned
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