JP2005535597A5 - - Google Patents
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- Publication number
- JP2005535597A5 JP2005535597A5 JP2004507468A JP2004507468A JP2005535597A5 JP 2005535597 A5 JP2005535597 A5 JP 2005535597A5 JP 2004507468 A JP2004507468 A JP 2004507468A JP 2004507468 A JP2004507468 A JP 2004507468A JP 2005535597 A5 JP2005535597 A5 JP 2005535597A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazin
- alkyl
- phenylethyl
- benzimidazol
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 51
- 125000003118 aryl group Chemical group 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- -1 NR 8 R 9 Chemical group 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 6
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 101000844245 Homo sapiens Non-receptor tyrosine-protein kinase TYK2 Proteins 0.000 claims 3
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 3
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims 3
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 claims 3
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 3
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 3
- 230000001413 cellular effect Effects 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- CYOIRCQXBZKWDU-CQSZACIVSA-N 6-(benzimidazol-1-yl)-n-[(1r)-1-phenylethyl]pyrazin-2-amine Chemical compound C1([C@H](NC=2N=C(C=NC=2)N2C3=CC=CC=C3N=C2)C)=CC=CC=C1 CYOIRCQXBZKWDU-CQSZACIVSA-N 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 claims 2
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
- XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical compound NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- ITWCTJUVSJFJPS-SFHVURJKSA-N 1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]-n-(pyridin-3-ylmethyl)benzimidazol-5-amine Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2NCC1=CC=CN=C1 ITWCTJUVSJFJPS-SFHVURJKSA-N 0.000 claims 1
- HMEBYGNNEPEWQH-ZDUSSCGKSA-N 1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-amine Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC=C(N)C=C3N=C2)C)=CC=CC=C1 HMEBYGNNEPEWQH-ZDUSSCGKSA-N 0.000 claims 1
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- AHFIWNGCDPUHGP-HNNXBMFYSA-N 2-methoxy-n-[1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]acetamide Chemical compound C1([C@H](C)NC=2C=NC=C(N=2)N2C3=CC=C(C=C3N=C2)NC(=O)COC)=CC=CC=C1 AHFIWNGCDPUHGP-HNNXBMFYSA-N 0.000 claims 1
- ZZXLEEPCFZQVCW-HNNXBMFYSA-N 2-methoxy-n-[3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]acetamide Chemical compound C1([C@H](C)NC=2C=NC=C(N=2)N2C=NC3=CC=C(C=C32)NC(=O)COC)=CC=CC=C1 ZZXLEEPCFZQVCW-HNNXBMFYSA-N 0.000 claims 1
- LYXMUFYMDITEBX-ZDUSSCGKSA-N 3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-amine Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC(N)=CC=C3N=C2)C)=CC=CC=C1 LYXMUFYMDITEBX-ZDUSSCGKSA-N 0.000 claims 1
- VNEVOIWOIVWJCP-ZDUSSCGKSA-N 3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC(=CC=C3N=C2)C(N)=O)C)=CC=CC=C1 VNEVOIWOIVWJCP-ZDUSSCGKSA-N 0.000 claims 1
- SMYPGAWUFKCWCH-ZDUSSCGKSA-N 6-(benzimidazol-1-yl)-n-[(1s)-1-(4-bromophenyl)ethyl]pyrazin-2-amine Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC=CC=C3N=C2)C)=CC=C(Br)C=C1 SMYPGAWUFKCWCH-ZDUSSCGKSA-N 0.000 claims 1
- HCONYHAGNYACEY-AWEZNQCLSA-N 6-(benzimidazol-1-yl)-n-[(1s)-1-(4-methoxyphenyl)ethyl]pyrazin-2-amine Chemical compound C1=CC(OC)=CC=C1[C@H](C)NC1=CN=CC(N2C3=CC=CC=C3N=C2)=N1 HCONYHAGNYACEY-AWEZNQCLSA-N 0.000 claims 1
- NVZSNPAFRBNVBH-SFHVURJKSA-N 6-(benzimidazol-1-yl)-n-[(1s)-1-(4-phenylphenyl)ethyl]pyrazin-2-amine Chemical compound C1=CC([C@@H](NC=2N=C(C=NC=2)N2C3=CC=CC=C3N=C2)C)=CC=C1C1=CC=CC=C1 NVZSNPAFRBNVBH-SFHVURJKSA-N 0.000 claims 1
- CYOIRCQXBZKWDU-AWEZNQCLSA-N 6-(benzimidazol-1-yl)-n-[(1s)-1-phenylethyl]pyrazin-2-amine Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC=CC=C3N=C2)C)=CC=CC=C1 CYOIRCQXBZKWDU-AWEZNQCLSA-N 0.000 claims 1
- IMPHYSWXPMRTHU-UHFFFAOYSA-N 6-(benzimidazol-1-yl)-n-[(4-fluorophenyl)methyl]pyrazin-2-amine Chemical compound C1=CC(F)=CC=C1CNC1=CN=CC(N2C3=CC=CC=C3N=C2)=N1 IMPHYSWXPMRTHU-UHFFFAOYSA-N 0.000 claims 1
- IIEVOFLNCFEHRU-UHFFFAOYSA-N 6-(benzimidazol-1-yl)-n-benzylpyrazin-2-amine Chemical compound C=1N=CC(N2C3=CC=CC=C3N=C2)=NC=1NCC1=CC=CC=C1 IIEVOFLNCFEHRU-UHFFFAOYSA-N 0.000 claims 1
- YUMKLEJFLYELSK-CYBMUJFWSA-N 6-imidazo[4,5-b]pyridin-1-yl-n-[(1r)-1-phenylethyl]pyrazin-2-amine Chemical compound C1([C@H](NC=2N=C(C=NC=2)N2C3=CC=CN=C3N=C2)C)=CC=CC=C1 YUMKLEJFLYELSK-CYBMUJFWSA-N 0.000 claims 1
- ZMHFXTFGYZQVLN-ZDUSSCGKSA-N 6-imidazo[4,5-c]pyridin-1-yl-n-[(1s)-1-phenylethyl]pyrazin-2-amine Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC=NC=C3N=C2)C)=CC=CC=C1 ZMHFXTFGYZQVLN-ZDUSSCGKSA-N 0.000 claims 1
- TXVXSTSDJXAYHO-ZDUSSCGKSA-N 6-imidazo[4,5-c]pyridin-3-yl-n-[(1s)-1-phenylethyl]pyrazin-2-amine Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CN=CC=C3N=C2)C)=CC=CC=C1 TXVXSTSDJXAYHO-ZDUSSCGKSA-N 0.000 claims 1
- RYHUZVZJUFGLIZ-UHFFFAOYSA-N 6-imidazol-1-yl-n-(4-morpholin-4-ylphenyl)pyrazin-2-amine Chemical compound C1COCCN1C(C=C1)=CC=C1NC1=CN=CC(N2C=NC=C2)=N1 RYHUZVZJUFGLIZ-UHFFFAOYSA-N 0.000 claims 1
- QXECMTMDCNYJIX-GFCCVEGCSA-N 6-imidazol-1-yl-n-[(1r)-1-phenylethyl]pyrazin-2-amine Chemical compound N([C@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N1C=CN=C1 QXECMTMDCNYJIX-GFCCVEGCSA-N 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- GRFXQRHQHMBBBN-AWEZNQCLSA-N [3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]methanol Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC(CO)=CC=C3N=C2)C)=CC=CC=C1 GRFXQRHQHMBBBN-AWEZNQCLSA-N 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- VFQXVTODMYMSMJ-UHFFFAOYSA-N isonicotinamide Chemical compound NC(=O)C1=CC=NC=C1 VFQXVTODMYMSMJ-UHFFFAOYSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- HCSRDMABCOGSGF-HNNXBMFYSA-N n-(2-hydroxyethyl)-1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound C1([C@@H](NC=2N=C(C=NC=2)N2C3=CC=C(C=C3N=C2)C(=O)NCCO)C)=CC=CC=C1 HCSRDMABCOGSGF-HNNXBMFYSA-N 0.000 claims 1
- LXRQJCTZKHYZAC-IBGZPJMESA-N n-(3-imidazol-1-ylpropyl)-3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=C2)C=NC1=CC=C2C(=O)NCCCN1C=CN=C1 LXRQJCTZKHYZAC-IBGZPJMESA-N 0.000 claims 1
- QVIFPDJBZARZKN-FQEVSTJZSA-N n-(3-morpholin-4-ylpropyl)-1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2C(=O)NCCCN1CCOCC1 QVIFPDJBZARZKN-FQEVSTJZSA-N 0.000 claims 1
- FWJZBODPFYJPAL-FQEVSTJZSA-N n-(3-morpholin-4-ylpropyl)-3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=C2)C=NC1=CC=C2C(=O)NCCCN1CCOCC1 FWJZBODPFYJPAL-FQEVSTJZSA-N 0.000 claims 1
- QTLKKALMYOUKSH-MRXNPFEDSA-N n-[(1r)-1-phenylethyl]-6-(4-phenylimidazol-1-yl)pyrazin-2-amine Chemical compound N([C@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C=1)C=NC=1C1=CC=CC=C1 QTLKKALMYOUKSH-MRXNPFEDSA-N 0.000 claims 1
- MPYDDLHUZYERQY-KRWDZBQOSA-N n-[(1s)-1-phenylethyl]-6-(5-pyridin-3-ylbenzimidazol-1-yl)pyrazin-2-amine Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2C1=CC=CN=C1 MPYDDLHUZYERQY-KRWDZBQOSA-N 0.000 claims 1
- FBYYYXGTTUXWDI-KRWDZBQOSA-N n-[(1s)-1-phenylethyl]-6-(5-pyridin-4-ylbenzimidazol-1-yl)pyrazin-2-amine Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2C1=CC=NC=C1 FBYYYXGTTUXWDI-KRWDZBQOSA-N 0.000 claims 1
- FPUPKWCIZHCASW-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-6-imidazol-1-ylpyrazin-2-amine Chemical compound C1=CC(F)=CC=C1CNC1=CN=CC(N2C=NC=C2)=N1 FPUPKWCIZHCASW-UHFFFAOYSA-N 0.000 claims 1
- KTDPDMKDKVEPBS-SFHVURJKSA-N n-[1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]benzamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2NC(=O)C1=CC=CC=C1 KTDPDMKDKVEPBS-SFHVURJKSA-N 0.000 claims 1
- XUMVPGTWOXZFPA-KRWDZBQOSA-N n-[1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]pyridine-3-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2NC(=O)C1=CC=CN=C1 XUMVPGTWOXZFPA-KRWDZBQOSA-N 0.000 claims 1
- BMQMERQEAYPENO-SFHVURJKSA-N n-[3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]benzamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=C2)C=NC1=CC=C2NC(=O)C1=CC=CC=C1 BMQMERQEAYPENO-SFHVURJKSA-N 0.000 claims 1
- NYJVWVWUKWICRC-HNNXBMFYSA-N n-[3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]cyclopropanecarboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=C2)C=NC1=CC=C2NC(=O)C1CC1 NYJVWVWUKWICRC-HNNXBMFYSA-N 0.000 claims 1
- UJMNKZRXKFMMJU-KRWDZBQOSA-N n-[3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazol-5-yl]pyridine-4-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=C2)C=NC1=CC=C2NC(=O)C1=CC=NC=C1 UJMNKZRXKFMMJU-KRWDZBQOSA-N 0.000 claims 1
- ZDIGKJPZEZPRCY-IBGZPJMESA-N n-benzyl-1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2C(=O)NCC1=CC=CC=C1 ZDIGKJPZEZPRCY-IBGZPJMESA-N 0.000 claims 1
- NRHGKCQFSSHNIO-UHFFFAOYSA-N n-benzyl-6-imidazol-1-ylpyrazin-2-amine Chemical compound C=1C=CC=CC=1CNC(N=1)=CN=CC=1N1C=CN=C1 NRHGKCQFSSHNIO-UHFFFAOYSA-N 0.000 claims 1
- KJPVPLWULMMQDU-AWEZNQCLSA-N n-methyl-3-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound C1([C@H](C)NC=2C=NC=C(N=2)N2C=NC3=CC=C(C=C32)C(=O)NC)=CC=CC=C1 KJPVPLWULMMQDU-AWEZNQCLSA-N 0.000 claims 1
- TZFXLCWCXZEXNL-SFHVURJKSA-N n-phenyl-1-[6-[[(1s)-1-phenylethyl]amino]pyrazin-2-yl]benzimidazole-5-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(N=1)=CN=CC=1N(C1=CC=2)C=NC1=CC=2C(=O)NC1=CC=CC=C1 TZFXLCWCXZEXNL-SFHVURJKSA-N 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical compound NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPS2514A AUPS251402A0 (en) | 2002-05-23 | 2002-05-23 | Kinase inhibitors |
| AUPS2514 | 2002-05-23 | ||
| US39899802P | 2002-07-26 | 2002-07-26 | |
| US60/398,998 | 2002-07-26 | ||
| PCT/AU2003/000628 WO2003099811A1 (en) | 2002-05-23 | 2003-05-23 | Kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005535597A JP2005535597A (ja) | 2005-11-24 |
| JP2005535597A5 true JP2005535597A5 (https=) | 2010-04-15 |
| JP4772325B2 JP4772325B2 (ja) | 2011-09-14 |
Family
ID=3836078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004507468A Expired - Fee Related JP4772325B2 (ja) | 2002-05-23 | 2003-05-23 | キナーゼ阻害剤 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4772325B2 (https=) |
| AU (1) | AUPS251402A0 (https=) |
| ZA (1) | ZA200409346B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4769720B2 (ja) * | 2003-08-21 | 2011-09-07 | オーエスアイ・ファーマシューテイカルズ・エル・エル・シー | Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤 |
| NZ545694A (en) * | 2003-12-03 | 2010-04-30 | Ym Bioscience Australia Pty Lt | Azole-based kinase inhibitors |
| US8513276B2 (en) * | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| GB0720038D0 (en) * | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) * | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| EP2338888A1 (en) * | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1169038B9 (en) * | 1999-04-15 | 2013-07-10 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| HK1054393B (en) * | 2000-09-20 | 2009-08-28 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
-
2002
- 2002-05-23 AU AUPS2514A patent/AUPS251402A0/en not_active Abandoned
-
2003
- 2003-05-23 JP JP2004507468A patent/JP4772325B2/ja not_active Expired - Fee Related
-
2004
- 2004-11-19 ZA ZA200409346A patent/ZA200409346B/en unknown
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