JP4772325B2 - キナーゼ阻害剤 - Google Patents

キナーゼ阻害剤 Download PDF

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Publication number
JP4772325B2
JP4772325B2 JP2004507468A JP2004507468A JP4772325B2 JP 4772325 B2 JP4772325 B2 JP 4772325B2 JP 2004507468 A JP2004507468 A JP 2004507468A JP 2004507468 A JP2004507468 A JP 2004507468A JP 4772325 B2 JP4772325 B2 JP 4772325B2
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JP
Japan
Prior art keywords
pyrazin
phenylethyl
alkyl
benzimidazol
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004507468A
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English (en)
Japanese (ja)
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JP2005535597A (ja
JP2005535597A5 (https=
Inventor
アンドリュー・フレデリック・ウィルクス
シャンヨン・ブ
クリストファー・ジョン・バーンズ
Original Assignee
ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド
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Application filed by ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド filed Critical ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド
Priority claimed from PCT/AU2003/000628 external-priority patent/WO2003099811A1/en
Publication of JP2005535597A publication Critical patent/JP2005535597A/ja
Publication of JP2005535597A5 publication Critical patent/JP2005535597A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004507468A 2002-05-23 2003-05-23 キナーゼ阻害剤 Expired - Fee Related JP4772325B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPS2514A AUPS251402A0 (en) 2002-05-23 2002-05-23 Kinase inhibitors
AUPS2514 2002-05-23
US39899802P 2002-07-26 2002-07-26
US60/398,998 2002-07-26
PCT/AU2003/000628 WO2003099811A1 (en) 2002-05-23 2003-05-23 Kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2005535597A JP2005535597A (ja) 2005-11-24
JP2005535597A5 JP2005535597A5 (https=) 2010-04-15
JP4772325B2 true JP4772325B2 (ja) 2011-09-14

Family

ID=3836078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004507468A Expired - Fee Related JP4772325B2 (ja) 2002-05-23 2003-05-23 キナーゼ阻害剤

Country Status (3)

Country Link
JP (1) JP4772325B2 (https=)
AU (1) AUPS251402A0 (https=)
ZA (1) ZA200409346B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4769720B2 (ja) * 2003-08-21 2011-09-07 オーエスアイ・ファーマシューテイカルズ・エル・エル・シー Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤
NZ545694A (en) * 2003-12-03 2010-04-30 Ym Bioscience Australia Pty Lt Azole-based kinase inhibitors
US8513276B2 (en) * 2006-12-22 2013-08-20 Astex Therapeutics Limited Imidazo[1,2-a]pyridine compounds for use in treating cancer
GB0720038D0 (en) * 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) * 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
EP2338888A1 (en) * 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062778A1 (en) * 1999-04-15 2000-10-26 Bristol-Myers Squibb Co. Cyclic protein tyrosine kinase inhibitors
WO2002024681A2 (en) * 2000-09-20 2002-03-28 Ortho-Mcneil Pharmaceutical, Inc. Pyrazine derivatives as modulators of tyrosine kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062778A1 (en) * 1999-04-15 2000-10-26 Bristol-Myers Squibb Co. Cyclic protein tyrosine kinase inhibitors
WO2002024681A2 (en) * 2000-09-20 2002-03-28 Ortho-Mcneil Pharmaceutical, Inc. Pyrazine derivatives as modulators of tyrosine kinases

Also Published As

Publication number Publication date
JP2005535597A (ja) 2005-11-24
AUPS251402A0 (en) 2002-06-13
ZA200409346B (en) 2006-02-22

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