JP2005534666A5 - - Google Patents
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- Publication number
- JP2005534666A5 JP2005534666A5 JP2004512765A JP2004512765A JP2005534666A5 JP 2005534666 A5 JP2005534666 A5 JP 2005534666A5 JP 2004512765 A JP2004512765 A JP 2004512765A JP 2004512765 A JP2004512765 A JP 2004512765A JP 2005534666 A5 JP2005534666 A5 JP 2005534666A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- medicament according
- amino acid
- para
- body weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 21
- 208000010370 Adenoviridae Infections Diseases 0.000 claims 4
- 206010060931 Adenovirus infection Diseases 0.000 claims 4
- 208000011589 adenoviridae infectious disease Diseases 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- -1 amino acid residue ester Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38847002P | 2002-06-12 | 2002-06-12 | |
| US42026002P | 2002-10-21 | 2002-10-21 | |
| US10/281,399 US20030236218A1 (en) | 2002-06-12 | 2002-10-25 | Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV |
| PCT/US2003/018898 WO2003105863A1 (en) | 2002-06-12 | 2003-06-11 | Aryl phosphate derivatives with selective activity against adenovirus and hiv |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005534666A JP2005534666A (ja) | 2005-11-17 |
| JP2005534666A5 true JP2005534666A5 (enExample) | 2006-07-20 |
Family
ID=29740735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004512765A Pending JP2005534666A (ja) | 2002-06-12 | 2003-06-11 | アデノウイルス及びｈｉｖに対して選択的活性を有するアリールホスフェート誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030236218A1 (enExample) |
| EP (1) | EP1551420A4 (enExample) |
| JP (1) | JP2005534666A (enExample) |
| AU (1) | AU2003245508A1 (enExample) |
| CA (1) | CA2489357A1 (enExample) |
| WO (1) | WO2003105863A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7144874B2 (en) * | 2002-10-25 | 2006-12-05 | Parker Hughes Institute | Aryl phosphate derivatives of d4T having activity against resistant HIV strains |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4841039A (en) * | 1986-05-01 | 1989-06-20 | Emory University | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents |
| GB8719877D0 (en) * | 1987-08-22 | 1987-09-30 | Wellcome Found | Antiviral compounds |
| US6030957A (en) * | 1998-06-29 | 2000-02-29 | Wayne Hughes Institute | Aryl phosphate derivatives of d4T having anti-HIV activity |
| AU3897800A (en) * | 1999-03-19 | 2000-10-09 | Parker Hughes Institute | One pot synthesis of 5'-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby |
| DK1334108T3 (da) * | 2000-11-13 | 2005-07-11 | Parker Hughes Inst | Arylfosfatderivater af d4T |
-
2002
- 2002-10-25 US US10/281,399 patent/US20030236218A1/en not_active Abandoned
-
2003
- 2003-06-11 AU AU2003245508A patent/AU2003245508A1/en not_active Abandoned
- 2003-06-11 EP EP03739140A patent/EP1551420A4/en not_active Withdrawn
- 2003-06-11 WO PCT/US2003/018898 patent/WO2003105863A1/en not_active Ceased
- 2003-06-11 CA CA002489357A patent/CA2489357A1/en not_active Abandoned
- 2003-06-11 JP JP2004512765A patent/JP2005534666A/ja active Pending
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