JP2005534295A5 - - Google Patents
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- Publication number
- JP2005534295A5 JP2005534295A5 JP2004508744A JP2004508744A JP2005534295A5 JP 2005534295 A5 JP2005534295 A5 JP 2005534295A5 JP 2004508744 A JP2004508744 A JP 2004508744A JP 2004508744 A JP2004508744 A JP 2004508744A JP 2005534295 A5 JP2005534295 A5 JP 2005534295A5
- Authority
- JP
- Japan
- Prior art keywords
- ksr
- expression
- oligonucleotide
- cancer
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38422802P | 2002-05-30 | 2002-05-30 | |
| US46002303P | 2003-04-03 | 2003-04-03 | |
| PCT/US2003/016961 WO2003101386A2 (en) | 2002-05-30 | 2003-05-29 | Kinase suppressor of ras inactivation for therapy of ras mediated tumorigenesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534295A JP2005534295A (ja) | 2005-11-17 |
| JP2005534295A5 true JP2005534295A5 (https=) | 2006-06-22 |
| JP4646625B2 JP4646625B2 (ja) | 2011-03-09 |
Family
ID=29715317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508744A Expired - Fee Related JP4646625B2 (ja) | 2002-05-30 | 2003-05-29 | Ｒａｓ媒介性腫瘍形成の治療のためのＲａｓ不活性化キナーゼサプレッサ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7528116B2 (https=) |
| EP (1) | EP1513859B1 (https=) |
| JP (1) | JP4646625B2 (https=) |
| AT (1) | ATE474045T1 (https=) |
| AU (1) | AU2003238804A1 (https=) |
| CA (1) | CA2488048A1 (https=) |
| DE (1) | DE60333365D1 (https=) |
| WO (1) | WO2003101386A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7301017B2 (en) * | 2002-05-30 | 2007-11-27 | Kolesnick Richard N | Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis |
| WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| US8507200B2 (en) | 2007-02-09 | 2013-08-13 | Northwestern University | Particles for detecting intracellular targets |
| DK2160464T3 (da) | 2007-05-30 | 2014-08-04 | Univ Northwestern | Nukleinsyrefunktionaliserede nanopartikler til terapeutiske anvendelser |
| US8741967B2 (en) | 2007-12-12 | 2014-06-03 | Children's Hospital & Research Center At Oakland | Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer |
| US8895701B2 (en) * | 2008-01-05 | 2014-11-25 | Sloan-Kettering Institute For Cancer Research | Peptide-conjugated oligonucleotide therapeutic and method of making and using same |
| CN106955360A (zh) | 2008-11-24 | 2017-07-18 | 西北大学 | 多价rna纳米颗粒组合物 |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| EP2419535B1 (en) * | 2009-04-15 | 2022-08-17 | Northwestern University | Delivery of oligonucleotide-functionalized nanoparticles |
| CA2768042C (en) * | 2009-07-24 | 2017-11-21 | Universite De Montreal | Bret-based biosensors and methods for monitoring raf dimerization |
| DK2494075T3 (en) | 2009-10-30 | 2018-07-23 | Univ Northwestern | TABLE-MANAGED NANOCONJUGATES |
| EP2652153B1 (en) | 2010-12-17 | 2017-07-05 | The Trustees of Columbia University in the City of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| US9889209B2 (en) | 2011-09-14 | 2018-02-13 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
| WO2013154999A2 (en) | 2012-04-09 | 2013-10-17 | The Trustees Of Columbia University In The City Of New York | Method of preparation of nanopore and uses thereof |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2016028940A1 (en) | 2014-08-19 | 2016-02-25 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| KR20170078843A (ko) | 2014-11-21 | 2017-07-07 | 노오쓰웨스턴 유니버시티 | 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수 |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US5218105A (en) | 1990-07-27 | 1993-06-08 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US5138045A (en) | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| US5591721A (en) | 1994-10-25 | 1997-01-07 | Hybridon, Inc. | Method of down-regulating gene expression |
| US5700675A (en) * | 1995-12-13 | 1997-12-23 | Regents Of The University Of California | Protein kinase required for Ras signal transduction |
| GB9620749D0 (en) * | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Identifying antisense oligonucleotides |
| WO1999001139A1 (en) * | 1997-07-03 | 1999-01-14 | Thomas Jefferson University | An improved method for design and selection of efficacious antisense oligonucleotides |
| GB2335035B (en) * | 1998-03-03 | 2003-05-28 | Brax Genomics Ltd | Screening for functional antisense agents |
| US6310047B1 (en) | 1999-08-24 | 2001-10-30 | Virginia Commonwealth University | High affinity DNA binding compounds as adjuvants in antisense technology |
| US20030051267A1 (en) * | 2001-05-10 | 2003-03-13 | Pfizer Inc. | Targeted disruption of kinase suppressor of RAS |
| US20030109466A1 (en) * | 2001-09-20 | 2003-06-12 | Isis Pharmaceuticals Inc. | Antisense modulation of KSR expression |
-
2003
- 2003-05-29 DE DE60333365T patent/DE60333365D1/de not_active Expired - Lifetime
- 2003-05-29 US US10/516,342 patent/US7528116B2/en not_active Expired - Fee Related
- 2003-05-29 WO PCT/US2003/016961 patent/WO2003101386A2/en not_active Ceased
- 2003-05-29 AT AT03734263T patent/ATE474045T1/de not_active IP Right Cessation
- 2003-05-29 CA CA002488048A patent/CA2488048A1/en not_active Abandoned
- 2003-05-29 JP JP2004508744A patent/JP4646625B2/ja not_active Expired - Fee Related
- 2003-05-29 AU AU2003238804A patent/AU2003238804A1/en not_active Abandoned
- 2003-05-29 EP EP03734263A patent/EP1513859B1/en not_active Expired - Lifetime
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