JP2005533811A5 - - Google Patents
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- Publication number
- JP2005533811A5 JP2005533811A5 JP2004516055A JP2004516055A JP2005533811A5 JP 2005533811 A5 JP2005533811 A5 JP 2005533811A5 JP 2004516055 A JP2004516055 A JP 2004516055A JP 2004516055 A JP2004516055 A JP 2004516055A JP 2005533811 A5 JP2005533811 A5 JP 2005533811A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- aryl
- heteroaryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- -1 substituted Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39028502P | 2002-06-20 | 2002-06-20 | |
| US45047803P | 2003-02-27 | 2003-02-27 | |
| PCT/US2003/019585 WO2004000821A1 (en) | 2002-06-20 | 2003-06-20 | Process for preparing 5-(1, 3-oxazol-2-yl) benzoic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533811A JP2005533811A (ja) | 2005-11-10 |
| JP2005533811A5 true JP2005533811A5 (cg-RX-API-DMAC7.html) | 2006-07-20 |
Family
ID=30003150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516055A Pending JP2005533811A (ja) | 2002-06-20 | 2003-06-20 | ５−（１，３−オキサゾル−２−イル）安息香酸誘導体の調製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7115747B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1532123B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005533811A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1324017C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE370131T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003249344A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0312439A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2489988A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO5670350A2 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60315664D1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA008389B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL165763A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04012630A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20045497L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ537390A (cg-RX-API-DMAC7.html) |
| PL (1) | PL374999A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004000821A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040762A1 (es) * | 2002-11-27 | 2004-11-06 | Elan Pharm Inc | Ureas substituidas y carbamatos utiles para el tratamiento de la enfermedad de alzheimer |
| TW200738701A (en) * | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| EP1971598A1 (en) | 2005-11-21 | 2008-09-24 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7745484B2 (en) * | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7872009B2 (en) | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
| US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US20080277393A1 (en) * | 2007-05-07 | 2008-11-13 | True Charles W | Collapsible, stackable, semi-rigid universal cotainer for hazardous and non-hazardous goods |
| CL2008001500A1 (es) | 2007-05-25 | 2008-12-26 | Amgen Inc | Compuestos derivados de hidroxietil amina sustituidas, moduladores de betasecretasa; proceso de preparacion de dichos c ompuestos; composicion farmaceutica que los comprende; y su uso para tratar un trastorno neurologico, tal como alzheimer, sindrome de down, demencia degenerativa, entre otros. |
| CA2687608C (en) | 2007-05-25 | 2013-07-02 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| US7803809B2 (en) | 2008-11-12 | 2010-09-28 | Amgen Inc. | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use |
| MX2011002705A (es) | 2008-09-11 | 2011-09-09 | Amgen Inc | Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. |
| US8822485B2 (en) | 2009-11-23 | 2014-09-02 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| WO2011063233A1 (en) | 2009-11-23 | 2011-05-26 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| WO2011090911A1 (en) | 2010-01-19 | 2011-07-28 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| MX2012010658A (es) | 2010-03-15 | 2012-12-05 | Amgen Inc | Compuestos de anillo espiro tetraciclico como moduladores de beta-secretasa. |
| US8497264B2 (en) | 2010-03-15 | 2013-07-30 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
| WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9462841B1 (en) | 2016-03-01 | 2016-10-11 | William Popejoy | Protective headgear and shoulder pad apparatus and methods |
| US11272751B2 (en) | 2016-03-01 | 2022-03-15 | Nicholas Popejoy | Protective headgear, impact diffusing systems and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| CA2462851A1 (en) * | 2001-10-04 | 2003-04-10 | Elan Pharmaceuticals, Inc. | Hydroxypropylamines |
| AR039555A1 (es) * | 2001-11-08 | 2005-02-23 | Upjohn Co | Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano |
| GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
-
2003
- 2003-06-20 JP JP2004516055A patent/JP2005533811A/ja active Pending
- 2003-06-20 CA CA002489988A patent/CA2489988A1/en not_active Abandoned
- 2003-06-20 EA EA200401510A patent/EA008389B1/ru unknown
- 2003-06-20 EP EP03761206A patent/EP1532123B1/en not_active Expired - Lifetime
- 2003-06-20 AU AU2003249344A patent/AU2003249344A1/en not_active Abandoned
- 2003-06-20 PL PL03374999A patent/PL374999A1/xx unknown
- 2003-06-20 MX MXPA04012630A patent/MXPA04012630A/es active IP Right Grant
- 2003-06-20 AT AT03761206T patent/ATE370131T1/de not_active IP Right Cessation
- 2003-06-20 WO PCT/US2003/019585 patent/WO2004000821A1/en not_active Ceased
- 2003-06-20 NZ NZ537390A patent/NZ537390A/en unknown
- 2003-06-20 CN CNB038144476A patent/CN1324017C/zh not_active Expired - Fee Related
- 2003-06-20 DE DE60315664T patent/DE60315664D1/de not_active Expired - Lifetime
- 2003-06-20 US US10/600,100 patent/US7115747B2/en not_active Expired - Fee Related
- 2003-06-20 BR BR0312439-8A patent/BR0312439A/pt not_active IP Right Cessation
-
2004
- 2004-12-14 IL IL16576304A patent/IL165763A0/xx unknown
- 2004-12-16 NO NO20045497A patent/NO20045497L/no not_active Application Discontinuation
-
2005
- 2005-01-20 CO CO05004558A patent/CO5670350A2/es not_active Application Discontinuation
-
2006
- 2006-10-03 US US11/538,155 patent/US20070105921A1/en not_active Abandoned
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