DE60315664D1 - Verfahren zur herstellung von 5-(1,3-oxazol-2-yl)benzoesäurederivaten - Google Patents
Verfahren zur herstellung von 5-(1,3-oxazol-2-yl)benzoesäurederivatenInfo
- Publication number
- DE60315664D1 DE60315664D1 DE60315664T DE60315664T DE60315664D1 DE 60315664 D1 DE60315664 D1 DE 60315664D1 DE 60315664 T DE60315664 T DE 60315664T DE 60315664 T DE60315664 T DE 60315664T DE 60315664 D1 DE60315664 D1 DE 60315664D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- oxazol
- preparing
- benzoic acid
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- IMAITKPPSLYKDS-UHFFFAOYSA-N 3-(1,3-oxazol-2-yl)benzoic acid Chemical class OC(=O)C1=CC=CC(C=2OC=CN=2)=C1 IMAITKPPSLYKDS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 150000002916 oxazoles Chemical class 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39028502P | 2002-06-20 | 2002-06-20 | |
| US45047803P | 2003-02-27 | 2003-02-27 | |
| PCT/US2003/019585 WO2004000821A1 (en) | 2002-06-20 | 2003-06-20 | Process for preparing 5-(1, 3-oxazol-2-yl) benzoic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60315664D1 true DE60315664D1 (de) | 2007-09-27 |
Family
ID=30003150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60315664T Expired - Lifetime DE60315664D1 (de) | 2002-06-20 | 2003-06-20 | Verfahren zur herstellung von 5-(1,3-oxazol-2-yl)benzoesäurederivaten |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7115747B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1532123B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005533811A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1324017C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE370131T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003249344A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0312439A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2489988A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO5670350A2 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60315664D1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA008389B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL165763A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04012630A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20045497L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ537390A (cg-RX-API-DMAC7.html) |
| PL (1) | PL374999A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004000821A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040762A1 (es) * | 2002-11-27 | 2004-11-06 | Elan Pharm Inc | Ureas substituidas y carbamatos utiles para el tratamiento de la enfermedad de alzheimer |
| TW200738701A (en) * | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| EP1971598A1 (en) | 2005-11-21 | 2008-09-24 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7745484B2 (en) * | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7872009B2 (en) | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
| US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US20080277393A1 (en) * | 2007-05-07 | 2008-11-13 | True Charles W | Collapsible, stackable, semi-rigid universal cotainer for hazardous and non-hazardous goods |
| CL2008001500A1 (es) | 2007-05-25 | 2008-12-26 | Amgen Inc | Compuestos derivados de hidroxietil amina sustituidas, moduladores de betasecretasa; proceso de preparacion de dichos c ompuestos; composicion farmaceutica que los comprende; y su uso para tratar un trastorno neurologico, tal como alzheimer, sindrome de down, demencia degenerativa, entre otros. |
| CA2687608C (en) | 2007-05-25 | 2013-07-02 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| US7803809B2 (en) | 2008-11-12 | 2010-09-28 | Amgen Inc. | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use |
| MX2011002705A (es) | 2008-09-11 | 2011-09-09 | Amgen Inc | Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. |
| US8822485B2 (en) | 2009-11-23 | 2014-09-02 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| WO2011063233A1 (en) | 2009-11-23 | 2011-05-26 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| WO2011090911A1 (en) | 2010-01-19 | 2011-07-28 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| MX2012010658A (es) | 2010-03-15 | 2012-12-05 | Amgen Inc | Compuestos de anillo espiro tetraciclico como moduladores de beta-secretasa. |
| US8497264B2 (en) | 2010-03-15 | 2013-07-30 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
| WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9462841B1 (en) | 2016-03-01 | 2016-10-11 | William Popejoy | Protective headgear and shoulder pad apparatus and methods |
| US11272751B2 (en) | 2016-03-01 | 2022-03-15 | Nicholas Popejoy | Protective headgear, impact diffusing systems and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| CA2462851A1 (en) * | 2001-10-04 | 2003-04-10 | Elan Pharmaceuticals, Inc. | Hydroxypropylamines |
| AR039555A1 (es) * | 2001-11-08 | 2005-02-23 | Upjohn Co | Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano |
| GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
-
2003
- 2003-06-20 JP JP2004516055A patent/JP2005533811A/ja active Pending
- 2003-06-20 CA CA002489988A patent/CA2489988A1/en not_active Abandoned
- 2003-06-20 EA EA200401510A patent/EA008389B1/ru unknown
- 2003-06-20 EP EP03761206A patent/EP1532123B1/en not_active Expired - Lifetime
- 2003-06-20 AU AU2003249344A patent/AU2003249344A1/en not_active Abandoned
- 2003-06-20 PL PL03374999A patent/PL374999A1/xx unknown
- 2003-06-20 MX MXPA04012630A patent/MXPA04012630A/es active IP Right Grant
- 2003-06-20 AT AT03761206T patent/ATE370131T1/de not_active IP Right Cessation
- 2003-06-20 WO PCT/US2003/019585 patent/WO2004000821A1/en not_active Ceased
- 2003-06-20 NZ NZ537390A patent/NZ537390A/en unknown
- 2003-06-20 CN CNB038144476A patent/CN1324017C/zh not_active Expired - Fee Related
- 2003-06-20 DE DE60315664T patent/DE60315664D1/de not_active Expired - Lifetime
- 2003-06-20 US US10/600,100 patent/US7115747B2/en not_active Expired - Fee Related
- 2003-06-20 BR BR0312439-8A patent/BR0312439A/pt not_active IP Right Cessation
-
2004
- 2004-12-14 IL IL16576304A patent/IL165763A0/xx unknown
- 2004-12-16 NO NO20045497A patent/NO20045497L/no not_active Application Discontinuation
-
2005
- 2005-01-20 CO CO05004558A patent/CO5670350A2/es not_active Application Discontinuation
-
2006
- 2006-10-03 US US11/538,155 patent/US20070105921A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7115747B2 (en) | 2006-10-03 |
| BR0312439A (pt) | 2005-05-10 |
| ATE370131T1 (de) | 2007-09-15 |
| EA008389B1 (ru) | 2007-04-27 |
| CN1662510A (zh) | 2005-08-31 |
| US20040063965A1 (en) | 2004-04-01 |
| CA2489988A1 (en) | 2003-12-31 |
| MXPA04012630A (es) | 2005-09-30 |
| PL374999A1 (en) | 2005-11-14 |
| EA200401510A1 (ru) | 2005-06-30 |
| US20070105921A1 (en) | 2007-05-10 |
| WO2004000821A1 (en) | 2003-12-31 |
| EP1532123A1 (en) | 2005-05-25 |
| NZ537390A (en) | 2006-07-28 |
| CN1324017C (zh) | 2007-07-04 |
| CO5670350A2 (es) | 2006-08-31 |
| JP2005533811A (ja) | 2005-11-10 |
| NO20045497D0 (no) | 2004-12-16 |
| IL165763A0 (en) | 2006-01-15 |
| EP1532123B1 (en) | 2007-08-15 |
| NO20045497L (no) | 2005-03-07 |
| AU2003249344A1 (en) | 2004-01-06 |
| HK1081543A1 (zh) | 2006-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |