JP2005533086A5

JP2005533086A5 -

Download PDF

Info

Publication number: JP2005533086A5
Authority: JP; Japan
Prior art keywords: cpp; polypeptide; protein; seq; antibody
Prior art date: 2003-06-26
Legal status : Pending

Application number

JP2004518589A

Other languages

English (en)

Japanese (ja)

Other versions

JP2005533086A (ja

Filing date

2003-06-26

Publication date

2006-08-10

2003-06-26 Application filed filed Critical

2003-06-26 Priority claimed from PCT/EP2003/006766 external-priority patent/WO2004005931A1/en

2005-11-04 Publication of JP2005533086A publication Critical patent/JP2005533086A/ja

2006-08-10 Publication of JP2005533086A5 publication Critical patent/JP2005533086A5/ja

Status Pending legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 claims description 251
238000000034 method Methods 0.000 claims description 214
102000004196 processed proteins & peptides Human genes 0.000 claims description 193
229920001184 polypeptide Polymers 0.000 claims description 153
239000000523 sample Substances 0.000 claims description 106
150000001875 compounds Chemical class 0.000 claims description 102
230000027455 binding Effects 0.000 claims description 87
238000009739 binding Methods 0.000 claims description 87
208000024172 Cardiovascular disease Diseases 0.000 claims description 82
238000012360 testing method Methods 0.000 claims description 69
239000012634 fragment Substances 0.000 claims description 65
241000282414 Homo sapiens Species 0.000 claims description 54
125000003275 alpha amino acid group Chemical group 0.000 claims description 46
230000004071 biological effect Effects 0.000 claims description 41
238000011282 treatment Methods 0.000 claims description 41
150000001413 amino acids Chemical class 0.000 claims description 39
102000004190 Enzymes Human genes 0.000 claims description 30
108090000790 Enzymes Proteins 0.000 claims description 30
239000012472 biological sample Substances 0.000 claims description 26
230000001225 therapeutic effect Effects 0.000 claims description 25
208000029078 coronary artery disease Diseases 0.000 claims description 24
238000003745 diagnosis Methods 0.000 claims description 24
238000004949 mass spectrometry Methods 0.000 claims description 24
230000001965 increasing effect Effects 0.000 claims description 23
238000006467 substitution reaction Methods 0.000 claims description 14
238000012216 screening Methods 0.000 claims description 13
238000003018 immunoassay Methods 0.000 claims description 12
239000013068 control sample Substances 0.000 claims description 11
238000002372 labelling Methods 0.000 claims description 11
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
238000003780 insertion Methods 0.000 claims description 10
230000037431 insertion Effects 0.000 claims description 10
238000012217 deletion Methods 0.000 claims description 9
230000037430 deletion Effects 0.000 claims description 9
230000008859 change Effects 0.000 claims description 8
239000000356 contaminant Substances 0.000 claims description 3
230000000069 prophylactic effect Effects 0.000 claims description 3
108090000623 proteins and genes Proteins 0.000 description 269
102000004169 proteins and genes Human genes 0.000 description 202
235000018102 proteins Nutrition 0.000 description 180
210000004027 cell Anatomy 0.000 description 138
150000007523 nucleic acids Chemical class 0.000 description 99
230000014509 gene expression Effects 0.000 description 90
102000039446 nucleic acids Human genes 0.000 description 84
108020004707 nucleic acids Proteins 0.000 description 84
238000003556 assay Methods 0.000 description 73
108020004414 DNA Proteins 0.000 description 64
241001465754 Metazoa Species 0.000 description 64
230000000694 effects Effects 0.000 description 64
102000040430 polynucleotide Human genes 0.000 description 60
108091033319 polynucleotide Proteins 0.000 description 60
239000002157 polynucleotide Substances 0.000 description 59
210000002381 plasma Anatomy 0.000 description 56
239000000203 mixture Substances 0.000 description 55
239000003795 chemical substances by application Substances 0.000 description 51
239000013598 vector Substances 0.000 description 51
238000001514 detection method Methods 0.000 description 45
235000001014 amino acid Nutrition 0.000 description 41
229940024606 amino acid Drugs 0.000 description 41
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 39
239000013604 expression vector Substances 0.000 description 37
125000003729 nucleotide group Chemical group 0.000 description 35
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 34
239000002773 nucleotide Substances 0.000 description 34
239000000126 substance Substances 0.000 description 34
108020004999 messenger RNA Proteins 0.000 description 33
241000894007 species Species 0.000 description 33
201000010099 disease Diseases 0.000 description 32
238000000746 purification Methods 0.000 description 31
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 30
239000003814 drug Substances 0.000 description 30
210000001519 tissue Anatomy 0.000 description 30
229940088598 enzyme Drugs 0.000 description 29
238000009396 hybridization Methods 0.000 description 29
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 28
238000006243 chemical reaction Methods 0.000 description 28
239000000047 product Substances 0.000 description 28
210000002966 serum Anatomy 0.000 description 27
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
229940079593 drug Drugs 0.000 description 25
108010076504 Protein Sorting Signals Proteins 0.000 description 24
-1 labeling groups Substances 0.000 description 24
102000007079 Peptide Fragments Human genes 0.000 description 22
108010033276 Peptide Fragments Proteins 0.000 description 22
240000004808 Saccharomyces cerevisiae Species 0.000 description 22
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 22
241000699666 Mus <mouse, genus> Species 0.000 description 21
230000015572 biosynthetic process Effects 0.000 description 21
201000001320 Atherosclerosis Diseases 0.000 description 20
108091028043 Nucleic acid sequence Proteins 0.000 description 20
102000051624 phosphatidylethanolamine binding protein Human genes 0.000 description 20
108700021017 phosphatidylethanolamine binding protein Proteins 0.000 description 20
239000007787 solid Substances 0.000 description 20
DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 20
108060003951 Immunoglobulin Proteins 0.000 description 19
239000000427 antigen Substances 0.000 description 19
239000008280 blood Substances 0.000 description 19
102000018358 immunoglobulin Human genes 0.000 description 19
238000004519 manufacturing process Methods 0.000 description 19
239000013612 plasmid Substances 0.000 description 19
238000003752 polymerase chain reaction Methods 0.000 description 19
238000002360 preparation method Methods 0.000 description 19
230000009261 transgenic effect Effects 0.000 description 19
108700019146 Transgenes Proteins 0.000 description 18
210000004369 blood Anatomy 0.000 description 18
239000000872 buffer Substances 0.000 description 18
239000011347 resin Substances 0.000 description 18
229920005989 resin Polymers 0.000 description 18
238000000926 separation method Methods 0.000 description 18
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 17
238000013459 approach Methods 0.000 description 17
230000000295 complement effect Effects 0.000 description 17
108020001507 fusion proteins Proteins 0.000 description 17
102000037865 fusion proteins Human genes 0.000 description 17
239000012528 membrane Substances 0.000 description 17
230000035772 mutation Effects 0.000 description 17
239000002243 precursor Substances 0.000 description 17
239000000243 solution Substances 0.000 description 17
238000003786 synthesis reaction Methods 0.000 description 17
230000035897 transcription Effects 0.000 description 17
238000013518 transcription Methods 0.000 description 17
125000000539 amino acid group Chemical group 0.000 description 16
108091007433 antigens Proteins 0.000 description 16
102000036639 antigens Human genes 0.000 description 16
230000001580 bacterial effect Effects 0.000 description 16
235000012000 cholesterol Nutrition 0.000 description 16
239000003446 ligand Substances 0.000 description 16
239000002904 solvent Substances 0.000 description 16
241000700605 Viruses Species 0.000 description 15
230000007423 decrease Effects 0.000 description 15
210000004408 hybridoma Anatomy 0.000 description 15
230000003993 interaction Effects 0.000 description 15
150000002500 ions Chemical class 0.000 description 15
239000000758 substrate Substances 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 14
108091026890 Coding region Proteins 0.000 description 14
238000004458 analytical method Methods 0.000 description 14
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 14
238000012545 processing Methods 0.000 description 14
208000024891 symptom Diseases 0.000 description 14
108091032973 (ribonucleotides)n+m Proteins 0.000 description 13
210000004899 c-terminal region Anatomy 0.000 description 13
239000002609 medium Substances 0.000 description 13
238000007423 screening assay Methods 0.000 description 13
230000028327 secretion Effects 0.000 description 13
239000011780 sodium chloride Substances 0.000 description 13
238000004885 tandem mass spectrometry Methods 0.000 description 13
108091034117 Oligonucleotide Proteins 0.000 description 12
239000001963 growth medium Substances 0.000 description 12
238000000338 in vitro Methods 0.000 description 12
239000000463 material Substances 0.000 description 12
208000006011 Stroke Diseases 0.000 description 11
238000007792 addition Methods 0.000 description 11
238000004587 chromatography analysis Methods 0.000 description 11
238000005516 engineering process Methods 0.000 description 11
210000004962 mammalian cell Anatomy 0.000 description 11
239000008194 pharmaceutical composition Substances 0.000 description 11
238000002965 ELISA Methods 0.000 description 10
206010020772 Hypertension Diseases 0.000 description 10
239000003463 adsorbent Substances 0.000 description 10
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 10
238000002744 homologous recombination Methods 0.000 description 10
230000006801 homologous recombination Effects 0.000 description 10
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 10
239000012071 phase Substances 0.000 description 10
239000002953 phosphate buffered saline Substances 0.000 description 10
230000002797 proteolythic effect Effects 0.000 description 10
230000009467 reduction Effects 0.000 description 10
238000004007 reversed phase HPLC Methods 0.000 description 10
239000007790 solid phase Substances 0.000 description 10
150000007970 thio esters Chemical group 0.000 description 10
241000238631 Hexapoda Species 0.000 description 9
101000987493 Homo sapiens Phosphatidylethanolamine-binding protein 1 Proteins 0.000 description 9
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 9
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 9
241000283973 Oryctolagus cuniculus Species 0.000 description 9
241000700159 Rattus Species 0.000 description 9
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 9
239000005557 antagonist Substances 0.000 description 9
230000037396 body weight Effects 0.000 description 9
239000003153 chemical reaction reagent Substances 0.000 description 9
238000003776 cleavage reaction Methods 0.000 description 9
238000010367 cloning Methods 0.000 description 9
239000002299 complementary DNA Substances 0.000 description 9
230000018109 developmental process Effects 0.000 description 9
239000003623 enhancer Substances 0.000 description 9
238000002347 injection Methods 0.000 description 9
239000007924 injection Substances 0.000 description 9
150000002632 lipids Chemical class 0.000 description 9
239000011159 matrix material Substances 0.000 description 9
230000002265 prevention Effects 0.000 description 9
230000002829 reductive effect Effects 0.000 description 9
230000007017 scission Effects 0.000 description 9
238000010561 standard procedure Methods 0.000 description 9
RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 9
239000003981 vehicle Substances 0.000 description 9
241000894006 Bacteria Species 0.000 description 8
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 8
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 8
241000124008 Mammalia Species 0.000 description 8
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
239000011324 bead Substances 0.000 description 8
230000001413 cellular effect Effects 0.000 description 8
235000018417 cysteine Nutrition 0.000 description 8
238000003795 desorption Methods 0.000 description 8
238000011161 development Methods 0.000 description 8
238000002405 diagnostic procedure Methods 0.000 description 8
230000006870 function Effects 0.000 description 8
238000011534 incubation Methods 0.000 description 8
239000003112 inhibitor Substances 0.000 description 8
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
208000010125 myocardial infarction Diseases 0.000 description 8
239000001301 oxygen Substances 0.000 description 8
229910052760 oxygen Inorganic materials 0.000 description 8
239000002245 particle Substances 0.000 description 8
230000004481 post-translational protein modification Effects 0.000 description 8
102000005962 receptors Human genes 0.000 description 8
230000001105 regulatory effect Effects 0.000 description 8
238000011160 research Methods 0.000 description 8
230000004044 response Effects 0.000 description 8
230000003612 virological effect Effects 0.000 description 8
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
102000008394 Immunoglobulin Fragments Human genes 0.000 description 7
108010021625 Immunoglobulin Fragments Proteins 0.000 description 7
102000017727 Immunoglobulin Variable Region Human genes 0.000 description 7
108010067060 Immunoglobulin Variable Region Proteins 0.000 description 7
102000004877 Insulin Human genes 0.000 description 7
108090001061 Insulin Proteins 0.000 description 7
108010007622 LDL Lipoproteins Proteins 0.000 description 7
102000007330 LDL Lipoproteins Human genes 0.000 description 7
108090000631 Trypsin Proteins 0.000 description 7
102000004142 Trypsin Human genes 0.000 description 7
238000001042 affinity chromatography Methods 0.000 description 7
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 7
239000000969 carrier Substances 0.000 description 7
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 7
238000010828 elution Methods 0.000 description 7
230000004927 fusion Effects 0.000 description 7
230000012010 growth Effects 0.000 description 7
230000002163 immunogen Effects 0.000 description 7
238000001727 in vivo Methods 0.000 description 7
229940125396 insulin Drugs 0.000 description 7
239000000543 intermediate Substances 0.000 description 7
238000005040 ion trap Methods 0.000 description 7
230000005291 magnetic effect Effects 0.000 description 7
238000004393 prognosis Methods 0.000 description 7
108020003175 receptors Proteins 0.000 description 7
230000002441 reversible effect Effects 0.000 description 7
230000009870 specific binding Effects 0.000 description 7
238000001890 transfection Methods 0.000 description 7
239000012588 trypsin Substances 0.000 description 7
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
108091003079 Bovine Serum Albumin Proteins 0.000 description 6
102000053602 DNA Human genes 0.000 description 6
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
206010019280 Heart failures Diseases 0.000 description 6
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 6
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 6
241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 6
241000699670 Mus sp. Species 0.000 description 6
102100032442 Protein S100-A8 Human genes 0.000 description 6
241000283984 Rodentia Species 0.000 description 6
108091023040 Transcription factor Proteins 0.000 description 6
102000040945 Transcription factor Human genes 0.000 description 6
239000002671 adjuvant Substances 0.000 description 6
238000010171 animal model Methods 0.000 description 6
239000012707 chemical precursor Substances 0.000 description 6
230000006378 damage Effects 0.000 description 6
238000007878 drug screening assay Methods 0.000 description 6
238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 6
238000002523 gelfiltration Methods 0.000 description 6
230000002068 genetic effect Effects 0.000 description 6
239000008103 glucose Substances 0.000 description 6
235000011187 glycerol Nutrition 0.000 description 6
102000049142 human PEBP1 Human genes 0.000 description 6
230000006698 induction Effects 0.000 description 6
230000001939 inductive effect Effects 0.000 description 6
239000003550 marker Substances 0.000 description 6
238000005259 measurement Methods 0.000 description 6
230000001404 mediated effect Effects 0.000 description 6
230000011987 methylation Effects 0.000 description 6
238000007069 methylation reaction Methods 0.000 description 6
230000004048 modification Effects 0.000 description 6
238000012986 modification Methods 0.000 description 6
230000010412 perfusion Effects 0.000 description 6
230000036470 plasma concentration Effects 0.000 description 6
229920001223 polyethylene glycol Polymers 0.000 description 6
229920000642 polymer Polymers 0.000 description 6
238000002953 preparative HPLC Methods 0.000 description 6
230000008569 process Effects 0.000 description 6
238000003127 radioimmunoassay Methods 0.000 description 6
239000006228 supernatant Substances 0.000 description 6
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 6
241000701447 unidentified baculovirus Species 0.000 description 6
238000011144 upstream manufacturing Methods 0.000 description 6
238000005406 washing Methods 0.000 description 6
108010052500 Calgranulin A Proteins 0.000 description 5
206010007559 Cardiac failure congestive Diseases 0.000 description 5
108700028146 Genetic Enhancer Elements Proteins 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
101710163270 Nuclease Proteins 0.000 description 5
239000002202 Polyethylene glycol Substances 0.000 description 5
238000009825 accumulation Methods 0.000 description 5
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 5
230000003321 amplification Effects 0.000 description 5
230000000692 anti-sense effect Effects 0.000 description 5
239000003125 aqueous solvent Substances 0.000 description 5
210000000941 bile Anatomy 0.000 description 5
239000013060 biological fluid Substances 0.000 description 5
238000005341 cation exchange Methods 0.000 description 5
238000007796 conventional method Methods 0.000 description 5
230000008878 coupling Effects 0.000 description 5
238000010168 coupling process Methods 0.000 description 5
238000005859 coupling reaction Methods 0.000 description 5
230000003247 decreasing effect Effects 0.000 description 5
239000006185 dispersion Substances 0.000 description 5
238000009509 drug development Methods 0.000 description 5
230000002255 enzymatic effect Effects 0.000 description 5
239000012530 fluid Substances 0.000 description 5
239000011521 glass Substances 0.000 description 5
229960000789 guanidine hydrochloride Drugs 0.000 description 5
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 5
229910052739 hydrogen Chemical group 0.000 description 5
230000003100 immobilizing effect Effects 0.000 description 5
230000003053 immunization Effects 0.000 description 5
238000002649 immunization Methods 0.000 description 5
229940124452 immunizing agent Drugs 0.000 description 5
230000005847 immunogenicity Effects 0.000 description 5
238000011065 in-situ storage Methods 0.000 description 5
238000002955 isolation Methods 0.000 description 5
230000000670 limiting effect Effects 0.000 description 5
239000007788 liquid Substances 0.000 description 5
230000014759 maintenance of location Effects 0.000 description 5
238000012544 monitoring process Methods 0.000 description 5
238000002703 mutagenesis Methods 0.000 description 5
231100000350 mutagenesis Toxicity 0.000 description 5
230000002107 myocardial effect Effects 0.000 description 5
229910052757 nitrogen Inorganic materials 0.000 description 5
238000003199 nucleic acid amplification method Methods 0.000 description 5
238000007254 oxidation reaction Methods 0.000 description 5
229920003023 plastic Polymers 0.000 description 5
239000004033 plastic Substances 0.000 description 5
JWHAUXFOSRPERK-UHFFFAOYSA-N propafenone Chemical compound CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JWHAUXFOSRPERK-UHFFFAOYSA-N 0.000 description 5
238000003259 recombinant expression Methods 0.000 description 5
230000010076 replication Effects 0.000 description 5
208000037803 restenosis Diseases 0.000 description 5
230000003248 secreting effect Effects 0.000 description 5
150000003384 small molecules Chemical class 0.000 description 5
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 5
238000013519 translation Methods 0.000 description 5
241001515965 unidentified phage Species 0.000 description 5
102000002260 Alkaline Phosphatase Human genes 0.000 description 4
108020004774 Alkaline Phosphatase Proteins 0.000 description 4
206010002383 Angina Pectoris Diseases 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
201000006474 Brain Ischemia Diseases 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 4
206010008120 Cerebral ischaemia Diseases 0.000 description 4
102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 description 4
108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 description 4
241000699802 Cricetulus griseus Species 0.000 description 4
102000004163 DNA-directed RNA polymerases Human genes 0.000 description 4
229920002307 Dextran Polymers 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
241000282412 Homo Species 0.000 description 4
206010061218 Inflammation Diseases 0.000 description 4
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
238000008214 LDL Cholesterol Methods 0.000 description 4
102100039809 Matrix Gla protein Human genes 0.000 description 4
206010028813 Nausea Diseases 0.000 description 4
229910019142 PO4 Inorganic materials 0.000 description 4
241001494479 Pecora Species 0.000 description 4
208000018262 Peripheral vascular disease Diseases 0.000 description 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
108010029485 Protein Isoforms Proteins 0.000 description 4
102000001708 Protein Isoforms Human genes 0.000 description 4
108010091086 Recombinases Proteins 0.000 description 4
102000018120 Recombinases Human genes 0.000 description 4
229920002684 Sepharose Polymers 0.000 description 4
108010090804 Streptavidin Proteins 0.000 description 4
239000007983 Tris buffer Substances 0.000 description 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
230000005856 abnormality Effects 0.000 description 4
239000000556 agonist Substances 0.000 description 4
150000001408 amides Chemical class 0.000 description 4
238000003149 assay kit Methods 0.000 description 4
210000001124 body fluid Anatomy 0.000 description 4
239000010839 body fluid Substances 0.000 description 4
229940098773 bovine serum albumin Drugs 0.000 description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
210000001715 carotid artery Anatomy 0.000 description 4
238000004113 cell culture Methods 0.000 description 4
206010008118 cerebral infarction Diseases 0.000 description 4
239000003638 chemical reducing agent Substances 0.000 description 4
230000004087 circulation Effects 0.000 description 4
238000012258 culturing Methods 0.000 description 4
125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 description 4
229960002086 dextran Drugs 0.000 description 4
238000010790 dilution Methods 0.000 description 4
239000012895 dilution Substances 0.000 description 4
238000010494 dissociation reaction Methods 0.000 description 4
230000005593 dissociations Effects 0.000 description 4
238000000132 electrospray ionisation Methods 0.000 description 4
210000001671 embryonic stem cell Anatomy 0.000 description 4
210000003743 erythrocyte Anatomy 0.000 description 4
238000009472 formulation Methods 0.000 description 4
239000000499 gel Substances 0.000 description 4
230000013595 glycosylation Effects 0.000 description 4
238000006206 glycosylation reaction Methods 0.000 description 4
239000001257 hydrogen Chemical group 0.000 description 4
230000002209 hydrophobic effect Effects 0.000 description 4
230000016784 immunoglobulin production Effects 0.000 description 4
238000007901 in situ hybridization Methods 0.000 description 4
230000004054 inflammatory process Effects 0.000 description 4
230000005764 inhibitory process Effects 0.000 description 4
230000003834 intracellular effect Effects 0.000 description 4
208000028867 ischemia Diseases 0.000 description 4
239000007791 liquid phase Substances 0.000 description 4
210000002751 lymph Anatomy 0.000 description 4
210000004698 lymphocyte Anatomy 0.000 description 4
210000001161 mammalian embryo Anatomy 0.000 description 4
238000001906 matrix-assisted laser desorption--ionisation mass spectrometry Methods 0.000 description 4
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 4
229930182817 methionine Natural products 0.000 description 4
238000000520 microinjection Methods 0.000 description 4
208000031225 myocardial ischemia Diseases 0.000 description 4
230000008693 nausea Effects 0.000 description 4
230000003647 oxidation Effects 0.000 description 4
IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 4
238000010647 peptide synthesis reaction Methods 0.000 description 4
230000000144 pharmacologic effect Effects 0.000 description 4
150000003904 phospholipids Chemical class 0.000 description 4
230000026731 phosphorylation Effects 0.000 description 4
238000006366 phosphorylation reaction Methods 0.000 description 4
230000008488 polyadenylation Effects 0.000 description 4
230000001323 posttranslational effect Effects 0.000 description 4
239000000843 powder Substances 0.000 description 4
238000001556 precipitation Methods 0.000 description 4
125000006239 protecting group Chemical group 0.000 description 4
230000002285 radioactive effect Effects 0.000 description 4
239000000376 reactant Substances 0.000 description 4
238000011084 recovery Methods 0.000 description 4
230000000717 retained effect Effects 0.000 description 4
238000012163 sequencing technique Methods 0.000 description 4
PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 description 4
ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 4
230000003595 spectral effect Effects 0.000 description 4
238000007920 subcutaneous administration Methods 0.000 description 4
239000000725 suspension Substances 0.000 description 4
150000003573 thiols Chemical class 0.000 description 4
241000701161 unidentified adenovirus Species 0.000 description 4
238000002424 x-ray crystallography Methods 0.000 description 4
200000000007 Arterial disease Diseases 0.000 description 3
206010003210 Arteriosclerosis Diseases 0.000 description 3
206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
241000283690 Bos taurus Species 0.000 description 3
101100296937 Bos taurus PEBP1 gene Proteins 0.000 description 3
102000014914 Carrier Proteins Human genes 0.000 description 3
241000282693 Cercopithecidae Species 0.000 description 3
230000004568 DNA-binding Effects 0.000 description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
241000588724 Escherichia coli Species 0.000 description 3
241000233866 Fungi Species 0.000 description 3
108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 3
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
101710125418 Major capsid protein Proteins 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 3
229930193140 Neomycin Natural products 0.000 description 3
108010058846 Ovalbumin Proteins 0.000 description 3
102100028489 Phosphatidylethanolamine-binding protein 1 Human genes 0.000 description 3
206010035226 Plasma cell myeloma Diseases 0.000 description 3
101710182846 Polyhedrin Proteins 0.000 description 3
239000004793 Polystyrene Substances 0.000 description 3
241000288906 Primates Species 0.000 description 3
108020004511 Recombinant DNA Proteins 0.000 description 3
108700008625 Reporter Genes Proteins 0.000 description 3
101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
241000256251 Spodoptera frugiperda Species 0.000 description 3
108700026226 TATA Box Proteins 0.000 description 3
102000006601 Thymidine Kinase Human genes 0.000 description 3
108020004440 Thymidine kinase Proteins 0.000 description 3
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 3
208000005475 Vascular calcification Diseases 0.000 description 3
102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 3
IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 description 3
XUGUHTGSMPZQIW-UHFFFAOYSA-N [[4-(4-diazonioiminocyclohexa-2,5-dien-1-ylidene)cyclohexa-2,5-dien-1-ylidene]hydrazinylidene]azanide Chemical compound C1=CC(N=[N+]=[N-])=CC=C1C1=CC=C(N=[N+]=[N-])C=C1 XUGUHTGSMPZQIW-UHFFFAOYSA-N 0.000 description 3
230000001594 aberrant effect Effects 0.000 description 3
230000002159 abnormal effect Effects 0.000 description 3
230000021736 acetylation Effects 0.000 description 3
238000006640 acetylation reaction Methods 0.000 description 3
230000004913 activation Effects 0.000 description 3
238000002399 angioplasty Methods 0.000 description 3
210000004102 animal cell Anatomy 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
230000000844 anti-bacterial effect Effects 0.000 description 3
230000002788 anti-peptide Effects 0.000 description 3
230000000890 antigenic effect Effects 0.000 description 3
210000000709 aorta Anatomy 0.000 description 3
238000003491 array Methods 0.000 description 3
230000006793 arrhythmia Effects 0.000 description 3
206010003119 arrhythmia Diseases 0.000 description 3
210000001367 artery Anatomy 0.000 description 3
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 3
UENWRTRMUIOCKN-UHFFFAOYSA-N benzyl thiol Chemical compound SCC1=CC=CC=C1 UENWRTRMUIOCKN-UHFFFAOYSA-N 0.000 description 3
230000005540 biological transmission Effects 0.000 description 3
230000001851 biosynthetic effect Effects 0.000 description 3
229960002685 biotin Drugs 0.000 description 3
235000020958 biotin Nutrition 0.000 description 3
239000011616 biotin Substances 0.000 description 3
210000004204 blood vessel Anatomy 0.000 description 3
238000000423 cell based assay Methods 0.000 description 3
239000013592 cell lysate Substances 0.000 description 3
230000003196 chaotropic effect Effects 0.000 description 3
238000012512 characterization method Methods 0.000 description 3
208000026758 coronary atherosclerosis Diseases 0.000 description 3
210000004351 coronary vessel Anatomy 0.000 description 3
230000002950 deficient Effects 0.000 description 3
238000000502 dialysis Methods 0.000 description 3
230000029087 digestion Effects 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 3
238000007877 drug screening Methods 0.000 description 3
238000001035 drying Methods 0.000 description 3
238000004520 electroporation Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000001502 gel electrophoresis Methods 0.000 description 3
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
238000001114 immunoprecipitation Methods 0.000 description 3
210000000936 intestine Anatomy 0.000 description 3
230000008863 intramolecular interaction Effects 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
239000004816 latex Substances 0.000 description 3
229920000126 latex Polymers 0.000 description 3
238000013507 mapping Methods 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
239000011859 microparticle Substances 0.000 description 3
201000000050 myeloid neoplasm Diseases 0.000 description 3
229960004927 neomycin Drugs 0.000 description 3
210000004940 nucleus Anatomy 0.000 description 3
210000000287 oocyte Anatomy 0.000 description 3
230000003287 optical effect Effects 0.000 description 3
229940092253 ovalbumin Drugs 0.000 description 3
210000001672 ovary Anatomy 0.000 description 3
125000001151 peptidyl group Chemical group 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
229920002401 polyacrylamide Polymers 0.000 description 3
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
229920000053 polysorbate 80 Polymers 0.000 description 3
229920002223 polystyrene Polymers 0.000 description 3
239000013641 positive control Substances 0.000 description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
239000013615 primer Substances 0.000 description 3
239000002987 primer (paints) Substances 0.000 description 3
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 3
238000003498 protein array Methods 0.000 description 3
238000000159 protein binding assay Methods 0.000 description 3
108091008146 restriction endonucleases Proteins 0.000 description 3
230000001177 retroviral effect Effects 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
230000019491 signal transduction Effects 0.000 description 3
PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 description 3
230000000391 smoking effect Effects 0.000 description 3
238000004611 spectroscopical analysis Methods 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
210000000278 spinal cord Anatomy 0.000 description 3
238000003756 stirring Methods 0.000 description 3
230000035882 stress Effects 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
230000002194 synthesizing effect Effects 0.000 description 3
125000001984 thiazolidinyl group Chemical group 0.000 description 3
150000003626 triacylglycerols Chemical class 0.000 description 3
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
210000005253 yeast cell Anatomy 0.000 description 3
VAVNEUKAWUEHAG-UHFFFAOYSA-N (2,3,4,5,6-pentafluorophenyl) 2-acetylsulfanylacetate Chemical compound CC(=O)SCC(=O)OC1=C(F)C(F)=C(F)C(F)=C1F VAVNEUKAWUEHAG-UHFFFAOYSA-N 0.000 description 2
DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
UHPQFNXOFFPHJW-UHFFFAOYSA-N (4-methylphenyl)-phenylmethanamine Chemical compound C1=CC(C)=CC=C1C(N)C1=CC=CC=C1 UHPQFNXOFFPHJW-UHFFFAOYSA-N 0.000 description 2
VYEWZWBILJHHCU-OMQUDAQFSA-N (e)-n-[(2s,3r,4r,5r,6r)-2-[(2r,3r,4s,5s,6s)-3-acetamido-5-amino-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-5-methylhex-2-enamide Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)C(O)C[C@@H]2[C@H](O)[C@H](O)[C@H]([C@@H](O2)O[C@@H]2[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O2)NC(C)=O)NC(=O)/C=C/CC(C)C)C=CC(=O)NC1=O VYEWZWBILJHHCU-OMQUDAQFSA-N 0.000 description 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 2
GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 description 2
OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
102000013563 Acid Phosphatase Human genes 0.000 description 2
108010051457 Acid Phosphatase Proteins 0.000 description 2
229920000936 Agarose Polymers 0.000 description 2
102100030988 Angiotensin-converting enzyme Human genes 0.000 description 2
108020004491 Antisense DNA Proteins 0.000 description 2
208000019901 Anxiety disease Diseases 0.000 description 2
206010003445 Ascites Diseases 0.000 description 2
241001203868 Autographa californica Species 0.000 description 2
244000063299 Bacillus subtilis Species 0.000 description 2
235000014469 Bacillus subtilis Nutrition 0.000 description 2
108020004513 Bacterial RNA Proteins 0.000 description 2
101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 2
OBIFJUGRILTRQA-JEDNCBNOSA-N CC(S)C(O)=O.CC(C)C[C@H](N)C(O)=O Chemical compound CC(S)C(O)=O.CC(C)C[C@H](N)C(O)=O OBIFJUGRILTRQA-JEDNCBNOSA-N 0.000 description 2
241000222122 Candida albicans Species 0.000 description 2
241000283707 Capra Species 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
206010008479 Chest Pain Diseases 0.000 description 2
206010008469 Chest discomfort Diseases 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
108010089254 Cholesterol oxidase Proteins 0.000 description 2
108020004705 Codon Proteins 0.000 description 2
206010009866 Cold sweat Diseases 0.000 description 2
241000701022 Cytomegalovirus Species 0.000 description 2
108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
238000009007 Diagnostic Kit Methods 0.000 description 2
208000000059 Dyspnea Diseases 0.000 description 2
206010013975 Dyspnoeas Diseases 0.000 description 2
102100021758 E3 ubiquitin-protein transferase MAEA Human genes 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
239000005977 Ethylene Substances 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
206010017711 Gangrene Diseases 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 2
108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 2
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
101710121996 Hexon protein p72 Proteins 0.000 description 2
101000616009 Homo sapiens E3 ubiquitin-protein transferase MAEA Proteins 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
208000004044 Hypesthesia Diseases 0.000 description 2
102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 2
208000026350 Inborn Genetic disease Diseases 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
108060001084 Luciferase Proteins 0.000 description 2
239000005089 Luciferase Substances 0.000 description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
108010052285 Membrane Proteins Proteins 0.000 description 2
102000003792 Metallothionein Human genes 0.000 description 2
108090000157 Metallothionein Proteins 0.000 description 2
NSTPXGARCQOSAU-VIFPVBQESA-N N-formyl-L-phenylalanine Chemical compound O=CN[C@H](C(=O)O)CC1=CC=CC=C1 NSTPXGARCQOSAU-VIFPVBQESA-N 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
239000000020 Nitrocellulose Substances 0.000 description 2
208000008589 Obesity Diseases 0.000 description 2
108700020796 Oncogene Proteins 0.000 description 2
108700026244 Open Reading Frames Proteins 0.000 description 2
101710173835 Penton protein Proteins 0.000 description 2
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 2
102000003992 Peroxidases Human genes 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 2
229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
206010039491 Sarcoma Diseases 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
238000002105 Southern blotting Methods 0.000 description 2
PZBFGYYEXUXCOF-UHFFFAOYSA-N TCEP Chemical compound OC(=O)CCP(CCC(O)=O)CCC(O)=O PZBFGYYEXUXCOF-UHFFFAOYSA-N 0.000 description 2
239000004098 Tetracycline Substances 0.000 description 2
RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
239000004473 Threonine Substances 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
108010034949 Thyroglobulin Proteins 0.000 description 2
102000009843 Thyroglobulin Human genes 0.000 description 2
101710120037 Toxin CcdB Proteins 0.000 description 2
108700009124 Transcription Initiation Site Proteins 0.000 description 2
241000255985 Trichoplusia Species 0.000 description 2
YJQCOFNZVFGCAF-UHFFFAOYSA-N Tunicamycin II Natural products O1C(CC(O)C2C(C(O)C(O2)N2C(NC(=O)C=C2)=O)O)C(O)C(O)C(NC(=O)C=CCCCCCCCCC(C)C)C1OC1OC(CO)C(O)C(O)C1NC(C)=O YJQCOFNZVFGCAF-UHFFFAOYSA-N 0.000 description 2
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
108700005077 Viral Genes Proteins 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
230000029936 alkylation Effects 0.000 description 2
238000005804 alkylation reaction Methods 0.000 description 2
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
229960000723 ampicillin Drugs 0.000 description 2
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
239000012491 analyte Substances 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
239000003416 antiarrhythmic agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
239000003816 antisense DNA Substances 0.000 description 2
239000000074 antisense oligonucleotide Substances 0.000 description 2
238000012230 antisense oligonucleotides Methods 0.000 description 2
230000036506 anxiety Effects 0.000 description 2
239000012062 aqueous buffer Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
208000011775 arteriosclerosis disease Diseases 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
235000003704 aspartic acid Nutrition 0.000 description 2
230000003143 atherosclerotic effect Effects 0.000 description 2
238000011888 autopsy Methods 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000008901 benefit Effects 0.000 description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
239000003613 bile acid Substances 0.000 description 2
108091008324 binding proteins Proteins 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
230000017531 blood circulation Effects 0.000 description 2
239000002775 capsule Substances 0.000 description 2
239000004202 carbamide Substances 0.000 description 2
150000001718 carbodiimides Chemical class 0.000 description 2
238000005277 cation exchange chromatography Methods 0.000 description 2
239000006143 cell culture medium Substances 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
238000007385 chemical modification Methods 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
238000011210 chromatographic step Methods 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000004440 column chromatography Methods 0.000 description 2
230000021615 conjugation Effects 0.000 description 2
239000000470 constituent Substances 0.000 description 2
238000010276 construction Methods 0.000 description 2
238000012937 correction Methods 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
239000013078 crystal Substances 0.000 description 2
239000012228 culture supernatant Substances 0.000 description 2
125000004122 cyclic group Chemical group 0.000 description 2
230000001461 cytolytic effect Effects 0.000 description 2
238000010511 deprotection reaction Methods 0.000 description 2
230000001066 destructive effect Effects 0.000 description 2
229960000633 dextran sulfate Drugs 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 2
229960004166 diltiazem Drugs 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
239000002612 dispersion medium Substances 0.000 description 2
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 2
238000012377 drug delivery Methods 0.000 description 2
238000009510 drug design Methods 0.000 description 2
238000007876 drug discovery Methods 0.000 description 2
230000009977 dual effect Effects 0.000 description 2
201000006549 dyspepsia Diseases 0.000 description 2
210000003989 endothelium vascular Anatomy 0.000 description 2
DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 2
238000000105 evaporative light scattering detection Methods 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
230000004151 fermentation Effects 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000010408 film Substances 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
239000012467 final product Substances 0.000 description 2
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
235000013305 food Nutrition 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
230000037433 frameshift Effects 0.000 description 2
229930182830 galactose Natural products 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
208000016361 genetic disease Diseases 0.000 description 2
235000013922 glutamic acid Nutrition 0.000 description 2
239000004220 glutamic acid Substances 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
125000003147 glycosyl group Chemical group 0.000 description 2
244000144993 groups of animals Species 0.000 description 2
210000003128 head Anatomy 0.000 description 2
230000036541 health Effects 0.000 description 2
208000024798 heartburn Diseases 0.000 description 2
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
238000000265 homogenisation Methods 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
239000005556 hormone Substances 0.000 description 2
150000002431 hydrogen Chemical class 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
230000000260 hypercholesteremic effect Effects 0.000 description 2
208000034783 hypoesthesia Diseases 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
230000008105 immune reaction Effects 0.000 description 2
230000028993 immune response Effects 0.000 description 2
230000000984 immunochemical effect Effects 0.000 description 2
238000003365 immunocytochemistry Methods 0.000 description 2
238000010166 immunofluorescence Methods 0.000 description 2
238000005462 in vivo assay Methods 0.000 description 2
238000012750 in vivo screening Methods 0.000 description 2
210000003000 inclusion body Anatomy 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
230000000977 initiatory effect Effects 0.000 description 2
208000014674 injury Diseases 0.000 description 2
239000007928 intraperitoneal injection Substances 0.000 description 2
238000000534 ion trap mass spectrometry Methods 0.000 description 2
230000000302 ischemic effect Effects 0.000 description 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
229960000310 isoleucine Drugs 0.000 description 2
239000007951 isotonicity adjuster Substances 0.000 description 2
230000003902 lesion Effects 0.000 description 2
125000005647 linker group Chemical group 0.000 description 2
239000002502 liposome Substances 0.000 description 2
238000001972 liquid chromatography-electrospray ionisation mass spectrometry Methods 0.000 description 2
230000033001 locomotion Effects 0.000 description 2
210000002540 macrophage Anatomy 0.000 description 2
230000002503 metabolic effect Effects 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
108010077055 methylated bovine serum albumin Proteins 0.000 description 2
ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 2
244000005700 microbiome Species 0.000 description 2
238000010369 molecular cloning Methods 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
229920001220 nitrocellulos Polymers 0.000 description 2
231100000862 numbness Toxicity 0.000 description 2
235000020824 obesity Nutrition 0.000 description 2
239000002674 ointment Substances 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 2
239000013610 patient sample Substances 0.000 description 2
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
238000012510 peptide mapping method Methods 0.000 description 2
108040007629 peroxidase activity proteins Proteins 0.000 description 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
150000004713 phosphodiesters Chemical class 0.000 description 2
239000008389 polyethoxylated castor oil Substances 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
229920002451 polyvinyl alcohol Polymers 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000002203 pretreatment Methods 0.000 description 2
230000035755 proliferation Effects 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
238000001742 protein purification Methods 0.000 description 2
LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
230000005855 radiation Effects 0.000 description 2
239000002516 radical scavenger Substances 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
238000005215 recombination Methods 0.000 description 2
230000006798 recombination Effects 0.000 description 2
230000011514 reflex Effects 0.000 description 2
230000000284 resting effect Effects 0.000 description 2
230000033764 rhythmic process Effects 0.000 description 2
210000003296 saliva Anatomy 0.000 description 2
238000004904 shortening Methods 0.000 description 2
208000013220 shortness of breath Diseases 0.000 description 2
150000004760 silicates Chemical class 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
210000002460 smooth muscle Anatomy 0.000 description 2
210000000329 smooth muscle myocyte Anatomy 0.000 description 2
239000012064 sodium phosphate buffer Substances 0.000 description 2
238000010532 solid phase synthesis reaction Methods 0.000 description 2
210000004989 spleen cell Anatomy 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000010186 staining Methods 0.000 description 2
210000000130 stem cell Anatomy 0.000 description 2
238000003860 storage Methods 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
230000002889 sympathetic effect Effects 0.000 description 2
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
229960002180 tetracycline Drugs 0.000 description 2
229930101283 tetracycline Natural products 0.000 description 2
235000019364 tetracycline Nutrition 0.000 description 2
150000003522 tetracyclines Chemical class 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
125000002769 thiazolinyl group Chemical group 0.000 description 2
229960002175 thyroglobulin Drugs 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
230000005026 transcription initiation Effects 0.000 description 2
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 2
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 2
229960001641 troglitazone Drugs 0.000 description 2
MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 2
241001430294 unidentified retrovirus Species 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
239000004474 valine Substances 0.000 description 2
230000002792 vascular Effects 0.000 description 2
229920002554 vinyl polymer Polymers 0.000 description 2
239000013603 viral vector Substances 0.000 description 2
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
HMJIYCCIJYRONP-UHFFFAOYSA-N (+-)-Isradipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC2=NON=C12 HMJIYCCIJYRONP-UHFFFAOYSA-N 0.000 description 1
YMXHPSHLTSZXKH-RVBZMBCESA-N (2,5-dioxopyrrolidin-1-yl) 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)ON1C(=O)CCC1=O YMXHPSHLTSZXKH-RVBZMBCESA-N 0.000 description 1
VLPIATFUUWWMKC-SNVBAGLBSA-N (2r)-1-(2,6-dimethylphenoxy)propan-2-amine Chemical compound C[C@@H](N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-SNVBAGLBSA-N 0.000 description 1
BUJAGSGYPOAWEI-SECBINFHSA-N (2r)-2-amino-n-(2,6-dimethylphenyl)propanamide Chemical compound C[C@@H](N)C(=O)NC1=C(C)C=CC=C1C BUJAGSGYPOAWEI-SECBINFHSA-N 0.000 description 1
NLEBIOOXCVAHBD-YHBSTRCHSA-N (2r,3r,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-dodecoxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](OCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NLEBIOOXCVAHBD-YHBSTRCHSA-N 0.000 description 1
AYMLQYFMYHISQO-QMMMGPOBSA-N (2s)-3-(1h-imidazol-3-ium-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC1=CN=CN1 AYMLQYFMYHISQO-QMMMGPOBSA-N 0.000 description 1
WXYGVKADAIJGHB-ZDUSSCGKSA-N (2s)-3-(1h-indol-2-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C1=CC=C2NC(C[C@H](NC(=O)OC(C)(C)C)C(O)=O)=CC2=C1 WXYGVKADAIJGHB-ZDUSSCGKSA-N 0.000 description 1
UYWMYJQSTUVRHR-SFHVURJKSA-N (2s)-3-[4-[(2-bromophenyl)methoxycarbonyloxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C1=CC(C[C@H](NC(=O)OC(C)(C)C)C(O)=O)=CC=C1OC(=O)OCC1=CC=CC=C1Br UYWMYJQSTUVRHR-SFHVURJKSA-N 0.000 description 1
FHOAKXBXYSJBGX-YFKPBYRVSA-N (2s)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@@H](CO)C(O)=O FHOAKXBXYSJBGX-YFKPBYRVSA-N 0.000 description 1
ATUMDPHEFWGCJF-HNNXBMFYSA-N (2s)-6-[(2-chlorophenyl)methoxycarbonylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CCCCNC(=O)OCC1=CC=CC=C1Cl ATUMDPHEFWGCJF-HNNXBMFYSA-N 0.000 description 1
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
FJWNZTPXVSWUKF-LURJTMIESA-N (4r)-3-[(2-methylpropan-2-yl)oxycarbonyl]-1,3-thiazolidine-4-carboxylic acid Chemical group CC(C)(C)OC(=O)N1CSC[C@H]1C(O)=O FJWNZTPXVSWUKF-LURJTMIESA-N 0.000 description 1
LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 description 1
102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
KXTZFUNIVVUYHB-UHFFFAOYSA-N 1-[(2-hydroxy-1H-indol-3-yl)imino]guanidine Chemical compound C1=CC=C2C(=C1)C(=C(N2)O)N=NC(=N)N KXTZFUNIVVUYHB-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
CZIHNRWJTSTCEX-UHFFFAOYSA-N 2 Acetylaminofluorene Chemical compound C1=CC=C2C3=CC=C(NC(=O)C)C=C3CC2=C1 CZIHNRWJTSTCEX-UHFFFAOYSA-N 0.000 description 1
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
HPNRHPKXQZSDFX-UHFFFAOYSA-N 2-[[2-[[2-[[2-[[2-[[6-amino-2-[[52-[[2-[[2-[[2-[[5-amino-2-[[2-[[2-[[6-amino-2-[[1-(2-amino-3-hydroxypropanoyl)pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-40-(4-aminobutyl)-49-benzyl-28-butan-2-yl-31,43-bis(3-carbamimidamidopropyl)-34-(carboxymethyl)-16,19,22,25-tetrakis(hydroxymethyl)-10-(2-methylpropyl)-37-(2-methylsulfanylethyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carbonyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid Chemical compound N1C(=O)C(NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C2N(CCC2)C(=O)C(N)CO)C(C)C)CSSCC(C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC=2N=CNC=2)C(O)=O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C1CC1=CC=CC=C1 HPNRHPKXQZSDFX-UHFFFAOYSA-N 0.000 description 1
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
UMCMPZBLKLEWAF-BCTGSCMUSA-N 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 UMCMPZBLKLEWAF-BCTGSCMUSA-N 0.000 description 1
GUQQBLRVXOUDTN-XOHPMCGNSA-N 3-[dimethyl-[3-[[(4r)-4-[(3r,5s,7r,8r,9s,10s,12s,13r,14s,17r)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CC(O)CS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 GUQQBLRVXOUDTN-XOHPMCGNSA-N 0.000 description 1
QRYXYRQPMWQIDM-UHFFFAOYSA-N 3-benzoyl-3-(2,5-dioxopyrrol-1-yl)-1-hydroxypyrrolidine-2,5-dione Chemical compound O=C1N(O)C(=O)CC1(C(=O)C=1C=CC=CC=1)N1C(=O)C=CC1=O QRYXYRQPMWQIDM-UHFFFAOYSA-N 0.000 description 1
DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 description 1
QEDXSHCYPROEOK-UHFFFAOYSA-N 3-phosphanylpropanoic acid Chemical compound OC(=O)CCP QEDXSHCYPROEOK-UHFFFAOYSA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 description 1
WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 1
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
102100033639 Acetylcholinesterase Human genes 0.000 description 1
108010022752 Acetylcholinesterase Proteins 0.000 description 1
102000007469 Actins Human genes 0.000 description 1
108010085238 Actins Proteins 0.000 description 1
102100029457 Adenine phosphoribosyltransferase Human genes 0.000 description 1
108010024223 Adenine phosphoribosyltransferase Proteins 0.000 description 1
108010000239 Aequorin Proteins 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
101710187573 Alcohol dehydrogenase 2 Proteins 0.000 description 1
101710133776 Alcohol dehydrogenase class-3 Proteins 0.000 description 1
108010025188 Alcohol oxidase Proteins 0.000 description 1
OXTYVEUAQHPPMV-UHFFFAOYSA-N Alinidine Chemical compound ClC1=CC=CC(Cl)=C1N(CC=C)C1=NCCN1 OXTYVEUAQHPPMV-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 1
108010032595 Antibody Binding Sites Proteins 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
108020005544 Antisense RNA Proteins 0.000 description 1
206010002923 Aortitis syphilitic Diseases 0.000 description 1
101150102415 Apob gene Proteins 0.000 description 1
241000203069 Archaea Species 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
208000031104 Arterial Occlusive disease Diseases 0.000 description 1
206010003178 Arterial thrombosis Diseases 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
241000271566 Aves Species 0.000 description 1
WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 1
241000304886 Bacilli Species 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
102100026189 Beta-galactosidase Human genes 0.000 description 1
ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
241000701822 Bovine papillomavirus Species 0.000 description 1
125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 1
101100008048 Caenorhabditis elegans cut-4 gene Proteins 0.000 description 1
108090000312 Calcium Channels Proteins 0.000 description 1
102000003922 Calcium Channels Human genes 0.000 description 1
229940127291 Calcium channel antagonist Drugs 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
241000222128 Candida maltosa Species 0.000 description 1
241000282465 Canis Species 0.000 description 1
101710132601 Capsid protein Proteins 0.000 description 1
108010003320 Carboxyhemoglobin Proteins 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
208000000135 Cardiovascular Syphilis Diseases 0.000 description 1
208000010867 Carotid Artery injury Diseases 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
108010001857 Cell Surface Receptors Proteins 0.000 description 1
229940123587 Cell cycle inhibitor Drugs 0.000 description 1
241000561734 Celosia cristata Species 0.000 description 1
241001000171 Chira Species 0.000 description 1
241001227713 Chiron Species 0.000 description 1
108090000317 Chymotrypsin Proteins 0.000 description 1
101710094648 Coat protein Proteins 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
108010047041 Complementarity Determining Regions Proteins 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
208000032170 Congenital Abnormalities Diseases 0.000 description 1
108091035707 Consensus sequence Proteins 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
238000011537 Coomassie blue staining Methods 0.000 description 1
108010051219 Cre recombinase Proteins 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
239000004971 Cross linker Substances 0.000 description 1
235000019750 Crude protein Nutrition 0.000 description 1
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
101710185445 Cytochrome c peroxidase, mitochondrial Proteins 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 description 1
108020003215 DNA Probes Proteins 0.000 description 1
108010041986 DNA Vaccines Proteins 0.000 description 1
230000004544 DNA amplification Effects 0.000 description 1
239000003298 DNA probe Substances 0.000 description 1
238000001712 DNA sequencing Methods 0.000 description 1
229940021995 DNA vaccine Drugs 0.000 description 1
XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
108020005199 Dehydrogenases Proteins 0.000 description 1
241000702421 Dependoparvovirus Species 0.000 description 1
241000255925 Diptera Species 0.000 description 1
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
241000255601 Drosophila melanogaster Species 0.000 description 1
101000940468 Drosophila melanogaster COP9 signalosome complex subunit 2 Proteins 0.000 description 1
206010059866 Drug resistance Diseases 0.000 description 1
239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 1
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
101710146739 Enterotoxin Proteins 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241001288713 Escherichia coli MC1061 Species 0.000 description 1
241000702191 Escherichia virus P1 Species 0.000 description 1
241000206602 Eukaryota Species 0.000 description 1
108050001049 Extracellular proteins Proteins 0.000 description 1
108010046276 FLP recombinase Proteins 0.000 description 1
102000008946 Fibrinogen Human genes 0.000 description 1
108010049003 Fibrinogen Proteins 0.000 description 1
108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
108090000381 Fibroblast growth factor 4 Proteins 0.000 description 1
102100028072 Fibroblast growth factor 4 Human genes 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
DJBNUMBKLMJRSA-UHFFFAOYSA-N Flecainide Chemical compound FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(C(=O)NCC2NCCCC2)=C1 DJBNUMBKLMJRSA-UHFFFAOYSA-N 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
108091006027 G proteins Proteins 0.000 description 1
102000030782 GTP binding Human genes 0.000 description 1
108091000058 GTP-Binding Proteins 0.000 description 1
108010093031 Galactosidases Proteins 0.000 description 1
102000002464 Galactosidases Human genes 0.000 description 1
108010001515 Galectin 4 Proteins 0.000 description 1
102100039556 Galectin-4 Human genes 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
108700039691 Genetic Promoter Regions Proteins 0.000 description 1
206010071602 Genetic polymorphism Diseases 0.000 description 1
108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
102100022624 Glucoamylase Human genes 0.000 description 1
102000030595 Glucokinase Human genes 0.000 description 1
108010021582 Glucokinase Proteins 0.000 description 1
108010051815 Glutamyl endopeptidase Proteins 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
102000005720 Glutathione transferase Human genes 0.000 description 1
108010070675 Glutathione transferase Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
101150069554 HIS4 gene Proteins 0.000 description 1
101100082540 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) pcp gene Proteins 0.000 description 1
241000700721 Hepatitis B virus Species 0.000 description 1
229920000209 Hexadimethrine bromide Polymers 0.000 description 1
102000005548 Hexokinase Human genes 0.000 description 1
108700040460 Hexokinases Proteins 0.000 description 1
101001033034 Homo sapiens UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Proteins 0.000 description 1
108010001336 Horseradish Peroxidase Proteins 0.000 description 1
241000701109 Human adenovirus 2 Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
208000031226 Hyperlipidaemia Diseases 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
108010093096 Immobilized Enzymes Proteins 0.000 description 1
108010058683 Immobilized Proteins Proteins 0.000 description 1
108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 1
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 1
108091092195 Intron Proteins 0.000 description 1
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
241000235649 Kluyveromyces Species 0.000 description 1
244000285963 Kluyveromyces fragilis Species 0.000 description 1
235000014663 Kluyveromyces fragilis Nutrition 0.000 description 1
241001138401 Kluyveromyces lactis Species 0.000 description 1
241000235058 Komagataella pastoris Species 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
241001124816 LI polyomavirus Species 0.000 description 1
241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
108010013563 Lipoprotein Lipase Proteins 0.000 description 1
102100022119 Lipoprotein lipase Human genes 0.000 description 1
DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
241000282567 Macaca fascicularis Species 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
108091027974 Mature messenger RNA Proteins 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 description 1
108010021466 Mutant Proteins Proteins 0.000 description 1
102000008300 Mutant Proteins Human genes 0.000 description 1
241000186359 Mycobacterium Species 0.000 description 1
101100136062 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) PE10 gene Proteins 0.000 description 1
FYYSQDHBALBGHX-YFKPBYRVSA-N N(alpha)-t-butoxycarbonyl-L-asparagine Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC(N)=O FYYSQDHBALBGHX-YFKPBYRVSA-N 0.000 description 1
NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
KEECCEWTUVWFCV-UHFFFAOYSA-N N-acetylprocainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(NC(C)=O)C=C1 KEECCEWTUVWFCV-UHFFFAOYSA-N 0.000 description 1
241000221960 Neurospora Species 0.000 description 1
ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 description 1
108020004711 Nucleic Acid Probes Proteins 0.000 description 1
108091005461 Nucleic proteins Proteins 0.000 description 1
101710141454 Nucleoprotein Proteins 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
241000320412 Ogataea angusta Species 0.000 description 1
108020005187 Oligonucleotide Probes Proteins 0.000 description 1
102000015636 Oligopeptides Human genes 0.000 description 1
108010038807 Oligopeptides Proteins 0.000 description 1
102000043276 Oncogene Human genes 0.000 description 1
238000012408 PCR amplification Methods 0.000 description 1
108010067372 Pancreatic elastase Proteins 0.000 description 1
102000016387 Pancreatic elastase Human genes 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
208000031481 Pathologic Constriction Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
108010087702 Penicillinase Proteins 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
108010067902 Peptide Library Proteins 0.000 description 1
108091093037 Peptide nucleic acid Proteins 0.000 description 1
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
102000001105 Phosphofructokinases Human genes 0.000 description 1
108010069341 Phosphofructokinases Proteins 0.000 description 1
102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
108010004729 Phycoerythrin Proteins 0.000 description 1
241000235648 Pichia Species 0.000 description 1
241000364051 Pima Species 0.000 description 1
241000276498 Pollachius virens Species 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
229920000954 Polyglycolide Polymers 0.000 description 1
229920001710 Polyorthoester Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
101710083689 Probable capsid protein Proteins 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
239000004365 Protease Substances 0.000 description 1
101710156987 Protein S100-A8 Proteins 0.000 description 1
108010011939 Pyruvate Decarboxylase Proteins 0.000 description 1
102000013009 Pyruvate Kinase Human genes 0.000 description 1
108020005115 Pyruvate Kinase Proteins 0.000 description 1
102000009572 RNA Polymerase II Human genes 0.000 description 1
108010009460 RNA Polymerase II Proteins 0.000 description 1
108020004518 RNA Probes Proteins 0.000 description 1
239000003391 RNA probe Substances 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
102000004879 Racemases and epimerases Human genes 0.000 description 1
108090001066 Racemases and epimerases Proteins 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
229920000297 Rayon Polymers 0.000 description 1
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
108020005091 Replication Origin Proteins 0.000 description 1
206010038997 Retroviral infections Diseases 0.000 description 1
102000006382 Ribonucleases Human genes 0.000 description 1
108010083644 Ribonucleases Proteins 0.000 description 1
241000220317 Rosa Species 0.000 description 1
241000714474 Rous sarcoma virus Species 0.000 description 1
108010017324 STAT3 Transcription Factor Proteins 0.000 description 1
241000235070 Saccharomyces Species 0.000 description 1
DYAHQFWOVKZOOW-UHFFFAOYSA-N Sarin Chemical compound CC(C)OP(C)(F)=O DYAHQFWOVKZOOW-UHFFFAOYSA-N 0.000 description 1
241000235347 Schizosaccharomyces pombe Species 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
241000269319 Squalius cephalus Species 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
235000014962 Streptococcus cremoris Nutrition 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
RCTGMCJBQGBLKT-UHFFFAOYSA-N Sudan IV Chemical compound CC1=CC=CC=C1N=NC(C=C1C)=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 RCTGMCJBQGBLKT-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
239000012505 Superdex™ Substances 0.000 description 1
241000282898 Sus scrofa Species 0.000 description 1
102100036407 Thioredoxin Human genes 0.000 description 1
102000002262 Thromboplastin Human genes 0.000 description 1
108010000499 Thromboplastin Proteins 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
229940122618 Trypsin inhibitor Drugs 0.000 description 1
101710162629 Trypsin inhibitor Proteins 0.000 description 1
206010064390 Tumour invasion Diseases 0.000 description 1
102100038413 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Human genes 0.000 description 1
206010053648 Vascular occlusion Diseases 0.000 description 1
206010047295 Ventricular hypertrophy Diseases 0.000 description 1
108020005202 Viral DNA Proteins 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
108091005605 Vitamin K-dependent proteins Proteins 0.000 description 1
241000235015 Yarrowia lipolytica Species 0.000 description 1
HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
CLZISMQKJZCZDN-UHFFFAOYSA-N [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium Chemical group C1=CC=C2N(OC(N(C)C)=[N+](C)C)N=NC2=C1 CLZISMQKJZCZDN-UHFFFAOYSA-N 0.000 description 1
239000003070 absorption delaying agent Substances 0.000 description 1
229960002122 acebutolol Drugs 0.000 description 1
GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
230000000397 acetylating effect Effects 0.000 description 1
229940022698 acetylcholinesterase Drugs 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
239000012190 activator Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
238000005377 adsorption chromatography Methods 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
239000007801 affinity label Substances 0.000 description 1
238000001261 affinity purification Methods 0.000 description 1
239000008272 agar Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
229950010767 alinidine Drugs 0.000 description 1
125000002947 alkylene group Chemical group 0.000 description 1
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
HESIBZMZTMHXQS-UHFFFAOYSA-M alumanyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[AlH2] HESIBZMZTMHXQS-UHFFFAOYSA-M 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000001668 ameliorated effect Effects 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
229960005260 amiodarone Drugs 0.000 description 1
HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 description 1
229960000528 amlodipine Drugs 0.000 description 1
BIGPRXCJEDHCLP-UHFFFAOYSA-N ammonium bisulfate Chemical compound [NH4+].OS([O-])(=O)=O BIGPRXCJEDHCLP-UHFFFAOYSA-N 0.000 description 1
238000012870 ammonium sulfate precipitation Methods 0.000 description 1
238000012801 analytical assay Methods 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
230000033115 angiogenesis Effects 0.000 description 1
230000002491 angiogenic effect Effects 0.000 description 1
238000000137 annealing Methods 0.000 description 1
230000000879 anti-atherosclerotic effect Effects 0.000 description 1
210000000628 antibody-producing cell Anatomy 0.000 description 1
239000003146 anticoagulant agent Substances 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940041181 antineoplastic drug Drugs 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000004019 antithrombin Substances 0.000 description 1
229960004676 antithrombotic agent Drugs 0.000 description 1
206010002906 aortic stenosis Diseases 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
208000021328 arterial occlusion Diseases 0.000 description 1
230000027746 artery morphogenesis Effects 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
238000000376 autoradiography Methods 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000006399 behavior Effects 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
108010005774 beta-Galactosidase Proteins 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
210000000013 bile duct Anatomy 0.000 description 1
239000003833 bile salt Substances 0.000 description 1
229940093761 bile salts Drugs 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
239000000090 biomarker Substances 0.000 description 1
238000001574 biopsy Methods 0.000 description 1
238000007413 biotinylation Methods 0.000 description 1
230000006287 biotinylation Effects 0.000 description 1
230000002051 biphasic effect Effects 0.000 description 1
210000002459 blastocyst Anatomy 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
210000005013 brain tissue Anatomy 0.000 description 1
229960002624 bretylium tosilate Drugs 0.000 description 1
KVWNWTZZBKCOPM-UHFFFAOYSA-M bretylium tosylate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CC[N+](C)(C)CC1=CC=CC=C1Br KVWNWTZZBKCOPM-UHFFFAOYSA-M 0.000 description 1
210000004900 c-terminal fragment Anatomy 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000009400 cancer invasion Effects 0.000 description 1
229940095731 candida albicans Drugs 0.000 description 1
125000000837 carbohydrate group Chemical group 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
210000001168 carotid artery common Anatomy 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
239000012930 cell culture fluid Substances 0.000 description 1
238000012832 cell culture technique Methods 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
230000010307 cell transformation Effects 0.000 description 1
230000030570 cellular localization Effects 0.000 description 1
230000036755 cellular response Effects 0.000 description 1
239000004568 cement Substances 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
150000001793 charged compounds Chemical class 0.000 description 1
239000013522 chelant Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000012824 chemical production Methods 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
238000011098 chromatofocusing Methods 0.000 description 1
238000013375 chromatographic separation Methods 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
238000012411 cloning technique Methods 0.000 description 1
230000004186 co-expression Effects 0.000 description 1
238000012761 co-transfection Methods 0.000 description 1
238000004581 coalescence Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
239000005515 coenzyme Substances 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
210000001520 comb Anatomy 0.000 description 1
230000009137 competitive binding Effects 0.000 description 1
239000003184 complementary RNA Substances 0.000 description 1
230000009918 complex formation Effects 0.000 description 1
238000005094 computer simulation Methods 0.000 description 1
238000012790 confirmation Methods 0.000 description 1
230000001268 conjugating effect Effects 0.000 description 1
230000008602 contraction Effects 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
230000036461 convulsion Effects 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
229910001431 copper ion Inorganic materials 0.000 description 1
238000002586 coronary angiography Methods 0.000 description 1
238000007887 coronary angioplasty Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
210000004748 cultured cell Anatomy 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
230000001351 cycling effect Effects 0.000 description 1
125000006639 cyclohexyl carbonyl group Chemical group 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
230000034994 death Effects 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000012351 deprotecting agent Substances 0.000 description 1
238000013461 design Methods 0.000 description 1
239000003599 detergent Substances 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
150000001982 diacylglycerols Chemical class 0.000 description 1
239000000032 diagnostic agent Substances 0.000 description 1
229940039227 diagnostic agent Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
235000015872 dietary supplement Nutrition 0.000 description 1
KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
238000007865 diluting Methods 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
229960001066 disopyramide Drugs 0.000 description 1
UVTNFZQICZKOEM-UHFFFAOYSA-N disopyramide Chemical compound C=1C=CC=NC=1C(C(N)=O)(CCN(C(C)C)C(C)C)C1=CC=CC=C1 UVTNFZQICZKOEM-UHFFFAOYSA-N 0.000 description 1
238000006073 displacement reaction Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
125000002228 disulfide group Chemical group 0.000 description 1
150000002019 disulfides Chemical group 0.000 description 1
NAGJZTKCGNOGPW-UHFFFAOYSA-N dithiophosphoric acid Chemical class OP(O)(S)=S NAGJZTKCGNOGPW-UHFFFAOYSA-N 0.000 description 1
238000011833 dog model Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000003255 drug test Methods 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
230000000667 effect on insulin Effects 0.000 description 1
239000012636 effector Substances 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
210000002308 embryonic cell Anatomy 0.000 description 1
229960001142 encainide Drugs 0.000 description 1
PJWPNDMDCLXCOM-UHFFFAOYSA-N encainide Chemical compound C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1N(C)CCCC1 PJWPNDMDCLXCOM-UHFFFAOYSA-N 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
238000013171 endarterectomy Methods 0.000 description 1
230000003511 endothelial effect Effects 0.000 description 1
210000003038 endothelium Anatomy 0.000 description 1
239000002158 endotoxin Substances 0.000 description 1
231100000655 enterotoxin Toxicity 0.000 description 1
239000000147 enterotoxin Substances 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
229960003745 esmolol Drugs 0.000 description 1
AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 1
239000003797 essential amino acid Substances 0.000 description 1
235000020776 essential amino acid Nutrition 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000012869 ethanol precipitation Methods 0.000 description 1
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
210000003527 eukaryotic cell Anatomy 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000010195 expression analysis Methods 0.000 description 1
239000013613 expression plasmid Substances 0.000 description 1
238000010265 fast atom bombardment Methods 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
229940012952 fibrinogen Drugs 0.000 description 1
230000001723 fibrinogenic effect Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
229960000449 flecainide Drugs 0.000 description 1
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
238000000799 fluorescence microscopy Methods 0.000 description 1
238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
230000022244 formylation Effects 0.000 description 1
238000006170 formylation reaction Methods 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
238000002825 functional assay Methods 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical class O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 description 1
108010074605 gamma-Globulins Proteins 0.000 description 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
229960002963 ganciclovir Drugs 0.000 description 1
239000007789 gas Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
238000001415 gene therapy Methods 0.000 description 1
238000012252 genetic analysis Methods 0.000 description 1
238000010353 genetic engineering Methods 0.000 description 1
238000011686 genetic mapping animal model Methods 0.000 description 1
238000003205 genotyping method Methods 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
102000018146 globin Human genes 0.000 description 1
108060003196 globin Proteins 0.000 description 1
229930182478 glucoside Natural products 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
230000002414 glycolytic effect Effects 0.000 description 1
108091005608 glycosylated proteins Proteins 0.000 description 1
102000035122 glycosylated proteins Human genes 0.000 description 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
210000005003 heart tissue Anatomy 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 1
208000002672 hepatitis B Diseases 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
210000003405 ileum Anatomy 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
229940127121 immunoconjugate Drugs 0.000 description 1
230000000951 immunodiffusion Effects 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000011532 immunohistochemical staining Methods 0.000 description 1
238000010324 immunological assay Methods 0.000 description 1
230000002621 immunoprecipitating effect Effects 0.000 description 1
230000002637 immunotoxin Effects 0.000 description 1
239000002596 immunotoxin Substances 0.000 description 1
229940051026 immunotoxin Drugs 0.000 description 1
231100000608 immunotoxin Toxicity 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000000126 in silico method Methods 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
230000007574 infarction Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
229940102223 injectable solution Drugs 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
229920000592 inorganic polymer Polymers 0.000 description 1
102000006495 integrins Human genes 0.000 description 1
108010044426 integrins Proteins 0.000 description 1
238000012482 interaction analysis Methods 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
230000009878 intermolecular interaction Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000002608 intravascular ultrasound Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000001573 invertase Substances 0.000 description 1
235000011073 invertase Nutrition 0.000 description 1
230000026045 iodination Effects 0.000 description 1
238000006192 iodination reaction Methods 0.000 description 1
PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
229960000201 isosorbide dinitrate Drugs 0.000 description 1
230000000155 isotopic effect Effects 0.000 description 1
229960004427 isradipine Drugs 0.000 description 1
238000005304 joining Methods 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
229960003299 ketamine Drugs 0.000 description 1
101150066555 lacZ gene Proteins 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000013147 laser angioplasty Methods 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
239000002523 lectin Substances 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
229920006008 lipopolysaccharide Polymers 0.000 description 1
108010022197 lipoprotein cholesterol Proteins 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
210000005228 liver tissue Anatomy 0.000 description 1
238000002690 local anesthesia Methods 0.000 description 1
230000004807 localization Effects 0.000 description 1
230000007774 longterm Effects 0.000 description 1
101150074251 lpp gene Proteins 0.000 description 1
HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
210000004880 lymph fluid Anatomy 0.000 description 1
210000001165 lymph node Anatomy 0.000 description 1
239000006166 lysate Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
229910001425 magnesium ion Inorganic materials 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000001819 mass spectrum Methods 0.000 description 1
102000043253 matrix Gla protein Human genes 0.000 description 1
108010057546 matrix Gla protein Proteins 0.000 description 1
238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000037353 metabolic pathway Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
229910052752 metalloid Inorganic materials 0.000 description 1
150000002738 metalloids Chemical class 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
229960005192 methoxamine Drugs 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002237 metoprolol Drugs 0.000 description 1
IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
229960003404 mexiletine Drugs 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
ZAHQPTJLOCWVPG-UHFFFAOYSA-N mitoxantrone dihydrochloride Chemical compound Cl.Cl.O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO ZAHQPTJLOCWVPG-UHFFFAOYSA-N 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000012514 monoclonal antibody product Substances 0.000 description 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
IUVIGVRSTLVOQI-UHFFFAOYSA-N n-methoxypropan-1-amine Chemical compound CCCNOC IUVIGVRSTLVOQI-UHFFFAOYSA-N 0.000 description 1
UMWKZHPREXJQGR-XOSAIJSUSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]decanamide Chemical compound CCCCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO UMWKZHPREXJQGR-XOSAIJSUSA-N 0.000 description 1
SBWGZAXBCCNRTM-CTHBEMJXSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]octanamide Chemical compound CCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SBWGZAXBCCNRTM-CTHBEMJXSA-N 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
239000006218 nasal suppository Substances 0.000 description 1
229940054205 natrecor Drugs 0.000 description 1
229930014626 natural product Natural products 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 description 1
229960001267 nesiritide Drugs 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
229960001783 nicardipine Drugs 0.000 description 1
229960001597 nifedipine Drugs 0.000 description 1
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
238000009206 nuclear medicine Methods 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
239000002853 nucleic acid probe Substances 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
229920002113 octoxynol Polymers 0.000 description 1
HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
229940005483 opioid analgesics Drugs 0.000 description 1
210000003733 optic disk Anatomy 0.000 description 1
238000005457 optimization Methods 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
238000006395 oxidase reaction Methods 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
239000000123 paper Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
229950009506 penicillinase Drugs 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
238000005897 peptide coupling reaction Methods 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
238000000955 peptide mass fingerprinting Methods 0.000 description 1
239000000816 peptidomimetic Substances 0.000 description 1
210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
210000000578 peripheral nerve Anatomy 0.000 description 1
210000001322 periplasm Anatomy 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
230000002974 pharmacogenomic effect Effects 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
229960002036 phenytoin Drugs 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000008298 phosphoramidates Chemical class 0.000 description 1
150000008300 phosphoramidites Chemical class 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
238000013310 pig model Methods 0.000 description 1
230000007505 plaque formation Effects 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
102000054765 polymorphisms of proteins Human genes 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920006324 polyoxymethylene Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
HIGSLXSBYYMVKI-UHFFFAOYSA-N pralidoxime chloride Chemical compound [Cl-].C[N+]1=CC=CC=C1\C=N\O HIGSLXSBYYMVKI-UHFFFAOYSA-N 0.000 description 1
238000011809 primate model Methods 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000000861 pro-apoptotic effect Effects 0.000 description 1
229960000244 procainamide Drugs 0.000 description 1
REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
230000000770 proinflammatory effect Effects 0.000 description 1
229960000203 propafenone Drugs 0.000 description 1
230000001902 propagating effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
229960003712 propranolol Drugs 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
210000004777 protein coat Anatomy 0.000 description 1
238000002331 protein detection Methods 0.000 description 1
238000012509 protein identification method Methods 0.000 description 1
230000006916 protein interaction Effects 0.000 description 1
238000000164 protein isolation Methods 0.000 description 1
230000009145 protein modification Effects 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
229940124272 protein stabilizer Drugs 0.000 description 1
210000001938 protoplast Anatomy 0.000 description 1
210000001147 pulmonary artery Anatomy 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000010791 quenching Methods 0.000 description 1
230000000171 quenching effect Effects 0.000 description 1
229960001404 quinidine Drugs 0.000 description 1
238000011555 rabbit model Methods 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
238000000163 radioactive labelling Methods 0.000 description 1
239000000941 radioactive substance Substances 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
238000011552 rat model Methods 0.000 description 1
239000002964 rayon Substances 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
238000006722 reduction reaction Methods 0.000 description 1
238000007634 remodeling Methods 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
238000002271 resection Methods 0.000 description 1
230000008458 response to injury Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000005464 sample preparation method Methods 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
238000013391 scatchard analysis Methods 0.000 description 1
238000003345 scintillation counting Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
229930000044 secondary metabolite Natural products 0.000 description 1
239000006152 selective media Substances 0.000 description 1
239000004065 semiconductor Substances 0.000 description 1
230000035939 shock Effects 0.000 description 1
108091006024 signal transducing proteins Proteins 0.000 description 1
102000034285 signal transducing proteins Human genes 0.000 description 1
230000008054 signal transmission Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229960002578 sitaxentan Drugs 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
239000007974 sodium acetate buffer Substances 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
MDTNUYUCUYPIHE-UHFFFAOYSA-N sodium;(4-chloro-3-methyl-1,2-oxazol-5-yl)-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophen-3-yl]sulfonylazanide Chemical compound [Na+].CC1=NOC([N-]S(=O)(=O)C2=C(SC=C2)C(=O)CC=2C(=CC=3OCOC=3C=2)C)=C1Cl MDTNUYUCUYPIHE-UHFFFAOYSA-N 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
238000000527 sonication Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
229960002370 sotalol Drugs 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
230000010473 stable expression Effects 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
230000036262 stenosis Effects 0.000 description 1
208000037804 stenosis Diseases 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
229960002317 succinimide Drugs 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
208000024868 syphilitic aortitis Diseases 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 description 1
208000001608 teratocarcinoma Diseases 0.000 description 1
KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
239000012085 test solution Substances 0.000 description 1
229910052716 thallium Inorganic materials 0.000 description 1
BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
230000008719 thickening Effects 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
239000010409 thin film Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
108060008226 thioredoxin Proteins 0.000 description 1
229940094937 thioredoxin Drugs 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
238000000954 titration curve Methods 0.000 description 1
229960002872 tocainide Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
230000005030 transcription termination Effects 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
229960001322 trypsin Drugs 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 description 1
239000002451 tumor necrosis factor inhibitor Substances 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
238000010977 unit operation Methods 0.000 description 1
238000012762 unpaired Student’s t-test Methods 0.000 description 1
208000019553 vascular disease Diseases 0.000 description 1
208000021331 vascular occlusion disease Diseases 0.000 description 1
230000002861 ventricular Effects 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
230000004304 visual acuity Effects 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
238000001262 western blot Methods 0.000 description 1
BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
229960001600 xylazine Drugs 0.000 description 1

JP2004518589A 2002-07-08 2003-06-26 心臓血管疾患に関連する、分泌ポリペプチド種 Pending JP2005533086A (ja)