JP2005530819A - 一酸化窒素を放出するビスホスホネート結合体（ｎｏ−ビスホスホネート）を使用して骨増殖を刺激するための、方法および組成物 - Google Patents
一酸化窒素を放出するビスホスホネート結合体（ｎｏ−ビスホスホネート）を使用して骨増殖を刺激するための、方法および組成物 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Rheumatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2003/013696 WO2003105752A2 (en) | 2002-05-02 | 2003-05-02 | Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate) |
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| CA (1) | CA2485090A1 (enExample) |
| WO (1) | WO2003105752A2 (enExample) |
Cited By (1)
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| WO2018190685A1 (ko) * | 2017-04-14 | 2018-10-18 | 연세대학교 산학협력단 | 비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물 |
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| US6376476B1 (en) * | 1996-12-13 | 2002-04-23 | Zymogenetics Corporation | Isoprenoid pathway inhibitors for stimulating bone growth |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| BRPI0618794A2 (pt) * | 2005-11-17 | 2011-09-13 | Biomimetic Therapeutics Inc | uso de uma matriz biocompatìvel, kit e composição para aumento ósseo, especialmente para aumento do osso maxilofacial |
| EP2311505B1 (en) * | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| ES2664229T3 (es) | 2006-06-30 | 2018-04-18 | Biomimetic Therapeutics, Llc | Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador |
| WO2008073628A2 (en) | 2006-11-03 | 2008-06-19 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| ES2422259T3 (es) | 2008-02-07 | 2013-09-10 | Biomimetic Therapeutics Inc | Composiciones para la osteogénesis por distracción |
| MX2011002555A (es) | 2008-09-09 | 2011-08-03 | Biomimetic Therapeutics Inc | Composiciones de factor de crecimiento derivadas de plaquetas y metodo para el tratamiento de lesiones de tendon y ligamentos. |
| JP2012519556A (ja) * | 2009-03-05 | 2012-08-30 | バイオミメティック セラピューティクス， インコーポレイテッド | 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法 |
| EP2523672B1 (en) | 2010-01-15 | 2016-07-13 | Rutgers, the State University of New Jersey | Use of vanadium compounds to accelerate bone healing |
| CN107080834A (zh) | 2010-02-22 | 2017-08-22 | 生物模拟治疗有限责任公司 | 用于治疗腱病的血小板衍生生长因子组合物和方法 |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
| EP2648718B1 (en) | 2010-12-10 | 2019-05-08 | Rutgers, the State University of New Jersey | Implantable devices coated with insulin-mimetic agent composites and methods thereof |
| US20140322292A1 (en) | 2010-12-10 | 2014-10-30 | Rutgers, The State University Of New Jersey | Insulin-mimetics as therapeutic adjuncts for bone regeneration |
| US9308190B2 (en) | 2011-06-06 | 2016-04-12 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
| US9931348B2 (en) | 2011-07-06 | 2018-04-03 | Rutgers, The State University Of New Jersey | Vanadium compounds as therapeutic adjuncts for cartilage injury and repair |
| US20170087175A1 (en) * | 2015-09-30 | 2017-03-30 | Elwha Llc | Nitric oxide-modulating bone-targeting complexes |
| EP3454913A4 (en) | 2016-03-15 | 2019-11-27 | The Regents of the University of California | BONE OBTAINING ANTIBODY CONJUGATE AND METHOD FOR THE PRODUCTION AND USE THEREOF |
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| IT1246778B (it) * | 1991-04-12 | 1994-11-26 | Boehringer Mannheim Italia | Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono |
| US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
| US5280040A (en) | 1993-03-11 | 1994-01-18 | Zymogenetics, Inc. | Methods for reducing bone loss using centchroman derivatives |
| US5898038A (en) * | 1996-03-19 | 1999-04-27 | Board Of Regents, The University Of Texas System | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors |
| US6214812B1 (en) * | 1998-04-02 | 2001-04-10 | Mbc Research, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| IT1303672B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali nitrati di farmaci attivi nei disordini ossei |
| US6121253A (en) * | 1998-11-20 | 2000-09-19 | Merck Frosst Canada & Co. | Prostaglandin conjugates for treating or preventing bone disease |
| WO2000051597A1 (en) * | 1999-03-05 | 2000-09-08 | Merck Frosst Canada & Co. | Methods for inhibiting cathepsin k activity for the treatment of diseases related to bone loss |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
-
2003
- 2003-05-02 JP JP2004512660A patent/JP2005530819A/ja active Pending
- 2003-05-02 WO PCT/US2003/013696 patent/WO2003105752A2/en not_active Ceased
- 2003-05-02 EP EP03724391A patent/EP1539185A4/en not_active Withdrawn
- 2003-05-02 US US10/428,309 patent/US7288535B2/en not_active Expired - Fee Related
- 2003-05-02 AU AU2003231255A patent/AU2003231255A1/en not_active Abandoned
- 2003-05-02 CA CA002485090A patent/CA2485090A1/en not_active Abandoned
-
2007
- 2007-10-30 US US11/929,701 patent/US20080108588A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018190685A1 (ko) * | 2017-04-14 | 2018-10-18 | 연세대학교 산학협력단 | 비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물 |
| US11554129B2 (en) | 2017-04-14 | 2023-01-17 | Industry-Academic Cooperation Foundation, Yonsei University | Composition for treating chronic renal transplant dysfunction comprising bisphosphonate |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003105752A2 (en) | 2003-12-24 |
| EP1539185A4 (en) | 2006-04-05 |
| US20040014727A1 (en) | 2004-01-22 |
| US20080108588A1 (en) | 2008-05-08 |
| AU2003231255A1 (en) | 2003-12-31 |
| CA2485090A1 (en) | 2003-12-24 |
| WO2003105752A3 (en) | 2004-03-25 |
| US7288535B2 (en) | 2007-10-30 |
| EP1539185A2 (en) | 2005-06-15 |
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