JP2005530493A5 - - Google Patents
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- Publication number
- JP2005530493A5 JP2005530493A5 JP2003585746A JP2003585746A JP2005530493A5 JP 2005530493 A5 JP2005530493 A5 JP 2005530493A5 JP 2003585746 A JP2003585746 A JP 2003585746A JP 2003585746 A JP2003585746 A JP 2003585746A JP 2005530493 A5 JP2005530493 A5 JP 2005530493A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- vaccine
- adjuvant
- antigen
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 41
- 108090000765 processed proteins & peptides Proteins 0.000 claims 41
- 102000004196 processed proteins & peptides Human genes 0.000 claims 41
- 229960005486 vaccine Drugs 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 239000002671 adjuvant Substances 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims 6
- 108010054395 P-selectin ligand protein Proteins 0.000 claims 5
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000030902 Galactosyltransferase Human genes 0.000 claims 3
- 108060003306 Galactosyltransferase Proteins 0.000 claims 3
- 108010063954 Mucins Proteins 0.000 claims 3
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 claims 3
- 210000000481 breast Anatomy 0.000 claims 3
- 210000001072 colon Anatomy 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 210000000496 pancreas Anatomy 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 3
- 101000623897 Homo sapiens Mucin-12 Proteins 0.000 claims 2
- 102100023143 Mucin-12 Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 241000606161 Chlamydia Species 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 101001133081 Homo sapiens Mucin-2 Proteins 0.000 claims 1
- 101000972284 Homo sapiens Mucin-3A Proteins 0.000 claims 1
- 101000972286 Homo sapiens Mucin-4 Proteins 0.000 claims 1
- 101000972278 Homo sapiens Mucin-6 Proteins 0.000 claims 1
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102100039564 Leukosialin Human genes 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 102100034263 Mucin-2 Human genes 0.000 claims 1
- 102100022497 Mucin-3A Human genes 0.000 claims 1
- 102100022693 Mucin-4 Human genes 0.000 claims 1
- 102100022493 Mucin-6 Human genes 0.000 claims 1
- 101710137390 P-selectin glycoprotein ligand 1 Proteins 0.000 claims 1
- 241001631646 Papillomaviridae Species 0.000 claims 1
- 102100028688 Putative glycosylation-dependent cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000005931 immune cell recruitment Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 108010012704 sulfated glycoprotein p50 Proteins 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37509502P | 2002-04-22 | 2002-04-22 | |
| PCT/IB2003/002207 WO2003088995A2 (en) | 2002-04-22 | 2003-04-22 | Mucin fusion polypeptide vaccines, compositions and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530493A JP2005530493A (ja) | 2005-10-13 |
| JP2005530493A5 true JP2005530493A5 (https=) | 2006-06-15 |
Family
ID=29251230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003585746A Pending JP2005530493A (ja) | 2002-04-22 | 2003-04-22 | ムチン融合ポリペプチドワクチン、組成物およびそれらの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8034351B2 (https=) |
| EP (1) | EP1517700B1 (https=) |
| JP (1) | JP2005530493A (https=) |
| AT (1) | ATE551069T1 (https=) |
| AU (1) | AU2003228067B2 (https=) |
| CA (1) | CA2483473A1 (https=) |
| ES (1) | ES2385032T3 (https=) |
| WO (1) | WO2003088995A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1531842A4 (en) | 2000-12-22 | 2007-03-07 | Dana Farber Cancer Inst Inc | REGULATION OF CELL GROWTH BY MUC1 |
| JP2005532793A (ja) * | 2002-04-22 | 2005-11-04 | レコファーマ アーベー | 微生物付着を阻害するための融合ポリペプチドおよび方法 |
| WO2005042573A1 (en) * | 2003-10-24 | 2005-05-12 | Dana-Farber Cancer Institute, Inc. | Modulation of the interaction of muc1 with muc1 ligands |
| JP4549666B2 (ja) * | 2003-12-12 | 2010-09-22 | タカラバイオ株式会社 | 抗体の製造方法 |
| US7807636B1 (en) | 2004-11-12 | 2010-10-05 | Wisconsin Alumni Research Foundation | Bovine P-selectin glycorpotein ligand-1 |
| WO2006081553A2 (en) | 2005-01-28 | 2006-08-03 | Ramot At Tel Aviv University, Ltd. | ANTI-MUC1 α/ß ANTIBODIES |
| FR2886298A1 (fr) * | 2005-05-24 | 2006-12-01 | Ifremer | Anticorps ou fragment d'anticorps couple a un agent immunogene |
| JP2009544760A (ja) * | 2006-01-23 | 2009-12-17 | レコファーマ アーベー | 酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用 |
| EP2264060B1 (en) * | 2006-01-26 | 2014-04-23 | Recopharma AB | Compositions and methods for inhibiting viral adhesion |
| US7972870B2 (en) | 2007-02-02 | 2011-07-05 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 |
| WO2008097844A2 (en) | 2007-02-02 | 2008-08-14 | Dana -Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins |
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| US20090280104A1 (en) * | 2008-05-09 | 2009-11-12 | Recopharma Ab | Compositions and methods for inhibiting shiga toxin and shiga-like toxin |
| AU2009251328B2 (en) * | 2008-05-30 | 2014-10-02 | Glycofi, Inc. | Yeast strain for the production of proteins with terminal alpha-1,3-linked galactose |
| AU2011347237A1 (en) * | 2010-12-21 | 2013-07-11 | Recopharma Ab | Tear substitutes |
| US9156897B2 (en) * | 2012-06-08 | 2015-10-13 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| CN104800838B (zh) * | 2015-04-14 | 2018-01-09 | 深圳市中联生物科技开发有限公司 | MUC1‑Fc多肽疫苗及其制备方法和应用 |
| JP6441167B2 (ja) * | 2015-05-15 | 2018-12-19 | 愛三工業株式会社 | 蒸発燃料処理装置 |
| US11918634B2 (en) * | 2017-08-10 | 2024-03-05 | Good T Cells, Inc. | Method for activating T cells for cancer treatment |
| MX2023011268A (es) | 2021-03-24 | 2023-12-14 | Alkermes Inc | Anticuerpos upar y proteínas de fusión con estos. |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4710761A (en) | 1985-07-09 | 1987-12-01 | American Telephone And Telegraph Company, At&T Bell Laboratories | Window border generation in a bitmapped graphics workstation |
| WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| EP0406857B1 (en) * | 1989-07-07 | 1995-05-24 | Takeda Chemical Industries, Ltd. | Proteins and production thereof |
| GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| ES2157225T3 (es) | 1992-10-09 | 2001-08-16 | Advanced Tissue Sciences Inc | Celulas hepaticas de reserva. |
| US5516964A (en) * | 1994-01-21 | 1996-05-14 | Sun Company, Inc. (R&M) | Hydrocarbon isomerization using solid superacid catalysts comprising platinum metal |
| AU2158995A (en) * | 1994-03-15 | 1995-10-03 | Medical College Of Pennsylvania And Hahnemann University | Compositions and methods for vaccines comprising alpha-galactosyl epitopes |
| AUPN568095A0 (en) * | 1995-09-27 | 1995-10-26 | Austin Research Institute, The | Anti-Galalpha(1,3)Gal antibody binding peptides |
| WO1998034957A1 (en) * | 1997-02-11 | 1998-08-13 | Immunomedics, Inc. | STIMULATION OF AN IMMUNE RESPONSE WITH ANTIBODIES LABELED WITH THE α-GALACTOSYL EPITOPE |
| SE9701127D0 (sv) * | 1997-03-26 | 1997-03-26 | Karolinska Innovations Ab | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
-
2003
- 2003-04-22 EP EP03725536A patent/EP1517700B1/en not_active Expired - Lifetime
- 2003-04-22 AT AT03725536T patent/ATE551069T1/de active
- 2003-04-22 CA CA002483473A patent/CA2483473A1/en not_active Abandoned
- 2003-04-22 AU AU2003228067A patent/AU2003228067B2/en not_active Ceased
- 2003-04-22 ES ES03725536T patent/ES2385032T3/es not_active Expired - Lifetime
- 2003-04-22 WO PCT/IB2003/002207 patent/WO2003088995A2/en not_active Ceased
- 2003-04-22 US US10/421,199 patent/US8034351B2/en not_active Expired - Fee Related
- 2003-04-22 JP JP2003585746A patent/JP2005530493A/ja active Pending
-
2011
- 2011-10-11 US US13/270,894 patent/US20120034220A1/en not_active Abandoned
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