JP2005527492A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005527492A5 JP2005527492A5 JP2003561604A JP2003561604A JP2005527492A5 JP 2005527492 A5 JP2005527492 A5 JP 2005527492A5 JP 2003561604 A JP2003561604 A JP 2003561604A JP 2003561604 A JP2003561604 A JP 2003561604A JP 2005527492 A5 JP2005527492 A5 JP 2005527492A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- phenyl
- aryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(C*(C)NC1)CC2=C1C=CC=C*2* Chemical compound C*(C*(C)NC1)CC2=C1C=CC=C*2* 0.000 description 26
- DOWKXUBAZLPNCR-YAPMYUJQSA-N CC(C)CC1(CN(C)CCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC1(CN(C)CCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O DOWKXUBAZLPNCR-YAPMYUJQSA-N 0.000 description 2
- UDANECZMJKIQTJ-UHFFFAOYSA-N CC(C)CC1NCc2c1cccc2 Chemical compound CC(C)CC1NCc2c1cccc2 UDANECZMJKIQTJ-UHFFFAOYSA-N 0.000 description 2
- AMJQHOGLKIZODY-UHFFFAOYSA-N CC(C)CC(C1)NCc2c1cccc2 Chemical compound CC(C)CC(C1)NCc2c1cccc2 AMJQHOGLKIZODY-UHFFFAOYSA-N 0.000 description 1
- ZNWANTUKXKBZLP-NLIBRCFJSA-N CC(C)CC(CC1)(CCN1C(C)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCN1C(C)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O ZNWANTUKXKBZLP-NLIBRCFJSA-N 0.000 description 1
- GSXDYZPMLCQEKT-IADGFXSZSA-N CC(C)CC(CC1)(CCN1C(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCN1C(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O GSXDYZPMLCQEKT-IADGFXSZSA-N 0.000 description 1
- DZCIIANMVNXADX-BDCODIICSA-N CC(C)CC(CC1)(CCN1S(C)(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCN1S(C)(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O DZCIIANMVNXADX-BDCODIICSA-N 0.000 description 1
- OKDLDIPTQLRFQX-YPJJGMIRSA-N CC(C)CC(CC1)(CCS1(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCS1(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O OKDLDIPTQLRFQX-YPJJGMIRSA-N 0.000 description 1
- WNMZATNMIABFKL-YPJJGMIRSA-N CC(C)CC1(CCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC1(CCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O WNMZATNMIABFKL-YPJJGMIRSA-N 0.000 description 1
- LWBXLZBGWUEHNG-BDCODIICSA-N CC(C)CC1(CCN(C)CC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC1(CCN(C)CC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O LWBXLZBGWUEHNG-BDCODIICSA-N 0.000 description 1
- GGUJTJQWIKRQER-UHFFFAOYSA-N CC(C)CC1(CCOCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O Chemical compound CC(C)CC1(CCOCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O GGUJTJQWIKRQER-UHFFFAOYSA-N 0.000 description 1
- UKQFTLKHLRAOAG-UHFFFAOYSA-N CC(C1=CC=CC(C)(C)C=C1C1)(NC=C)NC1C(C)=O Chemical compound CC(C1=CC=CC(C)(C)C=C1C1)(NC=C)NC1C(C)=O UKQFTLKHLRAOAG-UHFFFAOYSA-N 0.000 description 1
- NQKOOIJJWDMYSO-UHFFFAOYSA-N CCN(CC)CC1(CCCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(C1NCc2ccccc2C1)=O)=O Chemical compound CCN(CC)CC1(CCCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(C1NCc2ccccc2C1)=O)=O NQKOOIJJWDMYSO-UHFFFAOYSA-N 0.000 description 1
- ZBUVKSGDTHZTBY-NLIBRCFJSA-N CCN(CC1)CCC1(CC(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CCN(CC1)CCC1(CC(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O ZBUVKSGDTHZTBY-NLIBRCFJSA-N 0.000 description 1
- NMKAUOMKZJYMKD-ZHZZGXISSA-N CN(CC1)CCC1(CC1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CN(CC1)CCC1(CC1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O NMKAUOMKZJYMKD-ZHZZGXISSA-N 0.000 description 1
- URZOMUOVTVPPBR-ZHZZGXISSA-N CN(CC1)CCC1(Cc(cccc1)c1F)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CN(CC1)CCC1(Cc(cccc1)c1F)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O URZOMUOVTVPPBR-ZHZZGXISSA-N 0.000 description 1
- DMGMOBQHTSJVTI-PKEIRNPWSA-N C[C@H](C1)N(C2)C1Cc1c2cccc1 Chemical compound C[C@H](C1)N(C2)C1Cc1c2cccc1 DMGMOBQHTSJVTI-PKEIRNPWSA-N 0.000 description 1
- DMGMOBQHTSJVTI-BXKDBHETSA-N C[C@H](C1)N(C2)[C@H]1Cc1c2cccc1 Chemical compound C[C@H](C1)N(C2)[C@H]1Cc1c2cccc1 DMGMOBQHTSJVTI-BXKDBHETSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35120002P | 2002-01-23 | 2002-01-23 | |
| PCT/US2003/000033 WO2003061660A1 (en) | 2002-01-23 | 2003-01-21 | Melanocortin receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527492A JP2005527492A (ja) | 2005-09-15 |
| JP2005527492A5 true JP2005527492A5 (https=) | 2006-02-02 |
Family
ID=27613471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003561604A Pending JP2005527492A (ja) | 2002-01-23 | 2003-01-21 | メラノコルチン受容体アゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7314879B2 (https=) |
| EP (1) | EP1469851B1 (https=) |
| JP (1) | JP2005527492A (https=) |
| AT (1) | ATE342057T1 (https=) |
| CA (1) | CA2473036A1 (https=) |
| DE (1) | DE60308996T2 (https=) |
| ES (1) | ES2274201T3 (https=) |
| WO (1) | WO2003061660A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235625B2 (en) | 1999-06-29 | 2007-06-26 | Palatin Technologies, Inc. | Multiple agent therapy for sexual dysfunction |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| AU2002331064B2 (en) | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| TW200504033A (en) | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| US7550602B1 (en) * | 2004-01-14 | 2009-06-23 | Palatin Technologies, Inc. | Small molecule compositions for sexual dysfunction |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| FR2873693B1 (fr) * | 2004-07-29 | 2006-09-15 | Sanofi Synthelabo | Derives d'amino-tropane, leur preparation et leur application en therapeutique |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| AU2006304305B2 (en) | 2005-10-18 | 2010-04-01 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| GB0624987D0 (en) | 2006-12-14 | 2007-01-24 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands |
| KR101687037B1 (ko) * | 2008-06-09 | 2016-12-15 | 팔라틴 테크놀로지스 인코포레이티드 | 성기능 장애 치료용 멜라노코르틴 수용체-특이적 펩티드 |
| US8227628B2 (en) | 2008-07-09 | 2012-07-24 | Northwestern University | Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein |
| EP2358200A4 (en) | 2008-11-17 | 2012-05-16 | Merck Sharp & Dohme | SUBSTITUTED BICYCLIC AMINES FOR THE TREATMENT OF DIABETES |
| WO2010114907A1 (en) * | 2009-03-31 | 2010-10-07 | Vanderbilt University | Sulfonyl-azetidin-3-yl-methylamine amide analogs as glyt1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| WO2011137024A1 (en) | 2010-04-26 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| EP2568812B1 (en) | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| WO2011153359A1 (en) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| WO2011156246A1 (en) | 2010-06-11 | 2011-12-15 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| HRP20221430T1 (hr) | 2010-07-16 | 2023-01-06 | The Trustees Of Columbia University In The City Of New York | Inhibitori aldozoreduktaze i njihova uporaba |
| EP2632464B1 (en) * | 2010-10-29 | 2015-04-29 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2012100342A1 (en) | 2011-01-27 | 2012-08-02 | Université de Montréal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
| BR112015027164B1 (pt) | 2013-06-05 | 2023-03-21 | Shanghai Lumosa Therapeutics Co., Ltd | Novos compostos com tripla atividade de trombólise, antitrombótica e neutralização de radical, e sua síntese, nanoestrutura e uso |
| EP3333165B1 (en) * | 2015-08-04 | 2019-09-18 | Astellas Pharma Inc. | Piperazine derivative |
| AR105654A1 (es) * | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| RS61239B1 (sr) | 2016-06-21 | 2021-01-29 | Univ Columbia | Inhibitori aldozne reduktaze i postupci korišćenja |
| WO2018016458A1 (ja) * | 2016-07-19 | 2018-01-25 | アステラス製薬株式会社 | ピペラジン誘導体 |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CA3132136A1 (en) | 2019-04-01 | 2020-10-08 | Andrew Wasmuth | Inhibitors of aldose reductase |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
| US11590209B2 (en) | 2020-01-21 | 2023-02-28 | Palatin Technologies, Inc. | Use of bremelanotide in patients with controlled hypertension |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013696A1 (en) | 1992-12-11 | 1994-06-23 | Merck & Co., Inc. | Spiro piperidines and homologs which promote release of growth hormone |
| EP1076649A4 (en) | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| WO1999064002A1 (en) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US6294534B1 (en) | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| CA2377369A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| JP2003527444A (ja) | 2000-03-23 | 2003-09-16 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体アゴニストとして作用するスピロピペリジン誘導体 |
| WO2001070708A1 (en) | 2000-03-23 | 2001-09-27 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| JP2004506687A (ja) | 2000-08-23 | 2004-03-04 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作働薬としての置換ピペリジン類 |
| EP1368339A1 (en) | 2001-01-23 | 2003-12-10 | Eli Lilly & Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| CA2432988A1 (en) | 2001-01-23 | 2002-08-01 | Cristina Garcia-Paredes | Melanocortin receptor agonists |
| ES2247298T3 (es) | 2001-01-23 | 2006-03-01 | Eli Lilly And Company | Derivados de piperazina y piperidina como agonistas del receptor de melanocortina. |
| CA2438272A1 (en) * | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| EP1465867A1 (en) * | 2001-10-09 | 2004-10-13 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
-
2003
- 2003-01-21 WO PCT/US2003/000033 patent/WO2003061660A1/en not_active Ceased
- 2003-01-21 US US10/500,476 patent/US7314879B2/en not_active Expired - Fee Related
- 2003-01-21 DE DE60308996T patent/DE60308996T2/de not_active Expired - Fee Related
- 2003-01-21 CA CA002473036A patent/CA2473036A1/en not_active Abandoned
- 2003-01-21 AT AT03701964T patent/ATE342057T1/de not_active IP Right Cessation
- 2003-01-21 ES ES03701964T patent/ES2274201T3/es not_active Expired - Lifetime
- 2003-01-21 EP EP03701964A patent/EP1469851B1/en not_active Expired - Lifetime
- 2003-01-21 JP JP2003561604A patent/JP2005527492A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005527492A5 (https=) | ||
| JP2004521117A5 (https=) | ||
| RU2005118409A (ru) | Новые гидроксииндолы, их применение в качестве ингибиторов фосфодиэстеразы 4 и способ их получения | |
| RU2388750C2 (ru) | Ингибиторы фосфодиэстеразы 4, включая аналоги n-замещенного диариламина | |
| Naylor et al. | A potent new class of. kappa.-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino) methyl] piperazines | |
| ES2524916T3 (es) | Compuestos heterocíclicos de ácido borónico | |
| ES2549087T3 (es) | Derivados de aminodihidrotiazina como inhibidores de BACE para el tratamiento de la enfermedad de Alzheimer | |
| FI106200B (fi) | Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi | |
| US6777437B2 (en) | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors | |
| US20040082661A1 (en) | Urea derivatives having vanilloid receptor (vr1) antagonist activity | |
| ES2199433T5 (es) | 3,3-diarilpropilaminas, su uso y preparacion. | |
| ZA200603941B (en) | Derivatives of N-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics | |
| JP2008013556A (ja) | 新規ナフタレン化合物、その製造法、およびそれを含有する薬学的組成物 | |
| RU2002101935A (ru) | Аминовые и амидные производные как лиганды для рецептора Y5 нейропептида Y, используемые для лечения ожирения и других расстройств | |
| NL1026438C2 (nl) | Nieuwe verbindingen. | |
| PL202473B1 (pl) | Związki stanowiące 1,3-dwupodstawione pochodne pirolidyny, sposoby otrzymywania takich związków, kompozycje zawierające takie związki oraz ich zastosowanie | |
| ZA200603942B (en) | Derivatives of N-[phenyl(alkylpiperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics | |
| JP2004527571A (ja) | 複素環ウレア、それらの製造およびバニロイド受容体アンタゴニストとしてのそれらの使用 | |
| NL1025933C2 (nl) | 4-Fenyl-piperidineverbindingen en de toepassing ervan als modulatoren van opioïde receptoren. | |
| CA2369103A1 (en) | Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same | |
| CA2718959A1 (en) | Substituted pyrrolidine and piperidine compounds, derivatives thereof, and methods for treating pain | |
| RU2005111968A (ru) | Производные 4-пирролидинофенилбензилового эфира | |
| KR100258657B1 (ko) | 피롤리딘일 하이드록삼산 화합물 및 그의 제조 방법 | |
| JP4861979B2 (ja) | テトラヒドロイソキノリンスルホンアミド誘導体、その調製及び治療における同誘導体の使用 | |
| JP7185633B2 (ja) | ７員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法 |