JP2005527492A5 - - Google Patents
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- Publication number
- JP2005527492A5 JP2005527492A5 JP2003561604A JP2003561604A JP2005527492A5 JP 2005527492 A5 JP2005527492 A5 JP 2005527492A5 JP 2003561604 A JP2003561604 A JP 2003561604A JP 2003561604 A JP2003561604 A JP 2003561604A JP 2005527492 A5 JP2005527492 A5 JP 2005527492A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- phenyl
- aryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(C*(C)NC1)CC2=C1C=CC=C*2* Chemical compound C*(C*(C)NC1)CC2=C1C=CC=C*2* 0.000 description 26
- DOWKXUBAZLPNCR-YAPMYUJQSA-N CC(C)CC1(CN(C)CCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC1(CN(C)CCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O DOWKXUBAZLPNCR-YAPMYUJQSA-N 0.000 description 2
- UDANECZMJKIQTJ-UHFFFAOYSA-N CC(C)CC1NCc2c1cccc2 Chemical compound CC(C)CC1NCc2c1cccc2 UDANECZMJKIQTJ-UHFFFAOYSA-N 0.000 description 2
- AMJQHOGLKIZODY-UHFFFAOYSA-N CC(C)CC(C1)NCc2c1cccc2 Chemical compound CC(C)CC(C1)NCc2c1cccc2 AMJQHOGLKIZODY-UHFFFAOYSA-N 0.000 description 1
- ZNWANTUKXKBZLP-NLIBRCFJSA-N CC(C)CC(CC1)(CCN1C(C)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCN1C(C)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O ZNWANTUKXKBZLP-NLIBRCFJSA-N 0.000 description 1
- GSXDYZPMLCQEKT-IADGFXSZSA-N CC(C)CC(CC1)(CCN1C(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCN1C(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O GSXDYZPMLCQEKT-IADGFXSZSA-N 0.000 description 1
- DZCIIANMVNXADX-BDCODIICSA-N CC(C)CC(CC1)(CCN1S(C)(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCN1S(C)(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O DZCIIANMVNXADX-BDCODIICSA-N 0.000 description 1
- OKDLDIPTQLRFQX-YPJJGMIRSA-N CC(C)CC(CC1)(CCS1(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC(CC1)(CCS1(=O)=O)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O OKDLDIPTQLRFQX-YPJJGMIRSA-N 0.000 description 1
- WNMZATNMIABFKL-YPJJGMIRSA-N CC(C)CC1(CCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC1(CCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O WNMZATNMIABFKL-YPJJGMIRSA-N 0.000 description 1
- LWBXLZBGWUEHNG-BDCODIICSA-N CC(C)CC1(CCN(C)CC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CC(C)CC1(CCN(C)CC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O LWBXLZBGWUEHNG-BDCODIICSA-N 0.000 description 1
- GGUJTJQWIKRQER-UHFFFAOYSA-N CC(C)CC1(CCOCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O Chemical compound CC(C)CC1(CCOCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O GGUJTJQWIKRQER-UHFFFAOYSA-N 0.000 description 1
- UKQFTLKHLRAOAG-UHFFFAOYSA-N CC(C1=CC=CC(C)(C)C=C1C1)(NC=C)NC1C(C)=O Chemical compound CC(C1=CC=CC(C)(C)C=C1C1)(NC=C)NC1C(C)=O UKQFTLKHLRAOAG-UHFFFAOYSA-N 0.000 description 1
- NQKOOIJJWDMYSO-UHFFFAOYSA-N CCN(CC)CC1(CCCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(C1NCc2ccccc2C1)=O)=O Chemical compound CCN(CC)CC1(CCCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(C1NCc2ccccc2C1)=O)=O NQKOOIJJWDMYSO-UHFFFAOYSA-N 0.000 description 1
- ZBUVKSGDTHZTBY-NLIBRCFJSA-N CCN(CC1)CCC1(CC(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CCN(CC1)CCC1(CC(C)C)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O ZBUVKSGDTHZTBY-NLIBRCFJSA-N 0.000 description 1
- NMKAUOMKZJYMKD-ZHZZGXISSA-N CN(CC1)CCC1(CC1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CN(CC1)CCC1(CC1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O NMKAUOMKZJYMKD-ZHZZGXISSA-N 0.000 description 1
- URZOMUOVTVPPBR-ZHZZGXISSA-N CN(CC1)CCC1(Cc(cccc1)c1F)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O Chemical compound CN(CC1)CCC1(Cc(cccc1)c1F)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O URZOMUOVTVPPBR-ZHZZGXISSA-N 0.000 description 1
- DMGMOBQHTSJVTI-PKEIRNPWSA-N C[C@H](C1)N(C2)C1Cc1c2cccc1 Chemical compound C[C@H](C1)N(C2)C1Cc1c2cccc1 DMGMOBQHTSJVTI-PKEIRNPWSA-N 0.000 description 1
- DMGMOBQHTSJVTI-BXKDBHETSA-N C[C@H](C1)N(C2)[C@H]1Cc1c2cccc1 Chemical compound C[C@H](C1)N(C2)[C@H]1Cc1c2cccc1 DMGMOBQHTSJVTI-BXKDBHETSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35120002P | 2002-01-23 | 2002-01-23 | |
| PCT/US2003/000033 WO2003061660A1 (en) | 2002-01-23 | 2003-01-21 | Melanocortin receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527492A JP2005527492A (ja) | 2005-09-15 |
| JP2005527492A5 true JP2005527492A5 (https=) | 2006-02-02 |
Family
ID=27613471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003561604A Pending JP2005527492A (ja) | 2002-01-23 | 2003-01-21 | メラノコルチン受容体アゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7314879B2 (https=) |
| EP (1) | EP1469851B1 (https=) |
| JP (1) | JP2005527492A (https=) |
| AT (1) | ATE342057T1 (https=) |
| CA (1) | CA2473036A1 (https=) |
| DE (1) | DE60308996T2 (https=) |
| ES (1) | ES2274201T3 (https=) |
| WO (1) | WO2003061660A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235625B2 (en) | 1999-06-29 | 2007-06-26 | Palatin Technologies, Inc. | Multiple agent therapy for sexual dysfunction |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| CA2462200A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| TW200504033A (en) * | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| US7550602B1 (en) | 2004-01-14 | 2009-06-23 | Palatin Technologies, Inc. | Small molecule compositions for sexual dysfunction |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| FR2873693B1 (fr) * | 2004-07-29 | 2006-09-15 | Sanofi Synthelabo | Derives d'amino-tropane, leur preparation et leur application en therapeutique |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
| EP1940401B1 (en) | 2005-10-18 | 2012-07-11 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| GB0624987D0 (en) | 2006-12-14 | 2007-01-24 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands |
| KR101687037B1 (ko) * | 2008-06-09 | 2016-12-15 | 팔라틴 테크놀로지스 인코포레이티드 | 성기능 장애 치료용 멜라노코르틴 수용체-특이적 펩티드 |
| US8227628B2 (en) | 2008-07-09 | 2012-07-24 | Northwestern University | Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein |
| JP5514831B2 (ja) | 2008-11-17 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病の治療のための置換二環式アミン |
| EP2413701A4 (en) * | 2009-03-31 | 2012-10-03 | Univ Vanderbilt | SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGUES AS GLYT1 INHIBITORS, METHODS OF MAKING THEM AND USE THEREOF IN THE TREATMENT OF PSYCHIATRIC DISORDERS |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| EP2563764B1 (en) | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| US9365539B2 (en) | 2010-05-11 | 2016-06-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US9006268B2 (en) | 2010-06-11 | 2015-04-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| EP3192796B1 (en) | 2010-07-16 | 2019-09-04 | The Trustees of Columbia University in the City of New York | Aldose reductase inhibitors and uses thereof |
| EP2632464B1 (en) * | 2010-10-29 | 2015-04-29 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2012100342A1 (en) | 2011-01-27 | 2012-08-02 | Université de Montréal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
| EP3006454B1 (en) | 2013-06-05 | 2021-01-13 | Shanghai Lumosa Therapeutics Co., Ltd. | New compounds having triple activities of thrombolysis, antithrombotic and radical scavenging, and synthesis, nano-structure and use thereof |
| PL3333165T3 (pl) * | 2015-08-04 | 2019-12-31 | Astellas Pharma Inc. | Pochodne piperazyny |
| AR105654A1 (es) * | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| DK3352754T3 (da) | 2016-06-21 | 2020-12-07 | Univ Columbia | Aldosereduktaseinhibitorer og fremgangsmåder til anvendelse deraf |
| AR109086A1 (es) * | 2016-07-19 | 2018-10-24 | Astellas Pharma Inc | Derivado de piperazina |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CN113840825A (zh) | 2019-04-01 | 2021-12-24 | 应用治疗公司 | 醛糖还原酶抑制剂 |
| WO2020227430A1 (en) | 2019-05-07 | 2020-11-12 | University Of Miami | Treatment and detection of inherited neuropathies and associated disorders |
| US11590209B2 (en) | 2020-01-21 | 2023-02-28 | Palatin Technologies, Inc. | Use of bremelanotide in patients with controlled hypertension |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ258412A (en) | 1992-12-11 | 1997-01-29 | Merck & Co Inc | Spiro-fused piperidine derivatives and pharmaceutical compositions |
| AU3768799A (en) | 1998-04-28 | 1999-11-16 | Trega Biosciences, Inc. | Isoquinoline compound melanocortin receptor ligands and methods of using same |
| AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US6294534B1 (en) | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| WO2000074679A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| EP1268000A4 (en) * | 2000-03-23 | 2004-12-29 | Merck & Co Inc | SPIROPIPERID DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS |
| AU4929601A (en) | 2000-03-23 | 2001-10-03 | Merck & Co Inc | Substituted piperidines as melanocortin receptor agonists |
| AU2001288285B2 (en) | 2000-08-23 | 2005-09-29 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| WO2002059107A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| US7169777B2 (en) | 2001-01-23 | 2007-01-30 | Eli Lilly And Company | Melanocortin receptor agonists |
| WO2002059117A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Piperazine- and piperidine-derivatives as melanocortin receptor agonists |
| JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
| US20030158209A1 (en) * | 2001-10-09 | 2003-08-21 | Neurocrine Biosciences Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
-
2003
- 2003-01-21 WO PCT/US2003/000033 patent/WO2003061660A1/en not_active Ceased
- 2003-01-21 US US10/500,476 patent/US7314879B2/en not_active Expired - Fee Related
- 2003-01-21 DE DE60308996T patent/DE60308996T2/de not_active Expired - Fee Related
- 2003-01-21 JP JP2003561604A patent/JP2005527492A/ja active Pending
- 2003-01-21 AT AT03701964T patent/ATE342057T1/de not_active IP Right Cessation
- 2003-01-21 EP EP03701964A patent/EP1469851B1/en not_active Expired - Lifetime
- 2003-01-21 ES ES03701964T patent/ES2274201T3/es not_active Expired - Lifetime
- 2003-01-21 CA CA002473036A patent/CA2473036A1/en not_active Abandoned
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