JP2005527491A5 - - Google Patents
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- JP2005527491A5 JP2005527491A5 JP2003560178A JP2003560178A JP2005527491A5 JP 2005527491 A5 JP2005527491 A5 JP 2005527491A5 JP 2003560178 A JP2003560178 A JP 2003560178A JP 2003560178 A JP2003560178 A JP 2003560178A JP 2005527491 A5 JP2005527491 A5 JP 2005527491A5
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- JP
- Japan
- Prior art keywords
- acid
- derivative
- peptide
- mch
- alanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 101150106280 Mchr1 gene Proteins 0.000 claims 15
- 108700036626 Melanin-concentrating hormone receptor 1 Proteins 0.000 claims 15
- 102100027375 Melanin-concentrating hormone receptor 1 Human genes 0.000 claims 15
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 14
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 13
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 13
- 235000004279 alanine Nutrition 0.000 claims 13
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- 235000003704 aspartic acid Nutrition 0.000 claims 13
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 13
- 235000018417 cysteine Nutrition 0.000 claims 13
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- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 12
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 12
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 12
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 7
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- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 claims 4
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- QUOGESRFPZDMMT-RXMQYKEDSA-N (2r)-2-amino-6-(diaminomethylideneamino)hexanoic acid Chemical compound OC(=O)[C@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-RXMQYKEDSA-N 0.000 claims 1
- VKBLQCDGTHFOLS-NSHDSACASA-N (2s)-2-(4-benzoylanilino)propanoic acid Chemical compound C1=CC(N[C@@H](C)C(O)=O)=CC=C1C(=O)C1=CC=CC=C1 VKBLQCDGTHFOLS-NSHDSACASA-N 0.000 claims 1
- FPDYKABXINADKS-LURJTMIESA-N (2s)-2-(methylazaniumyl)hexanoate Chemical compound CCCC[C@H](NC)C(O)=O FPDYKABXINADKS-LURJTMIESA-N 0.000 claims 1
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims 1
- XWHHYOYVRVGJJY-UHFFFAOYSA-N 4-fluorophenylalanine Chemical compound OC(=O)C(N)CC1=CC=C(F)C=C1 XWHHYOYVRVGJJY-UHFFFAOYSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 claims 1
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- 125000000217 alkyl group Chemical group 0.000 claims 1
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- ORQXBVXKBGUSBA-UHFFFAOYSA-N cyclohexyl D-alanine Natural products OC(=O)C(N)CC1CCCCC1 ORQXBVXKBGUSBA-UHFFFAOYSA-N 0.000 claims 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34719102P | 2002-01-09 | 2002-01-09 | |
| PCT/US2003/000241 WO2003060091A2 (en) | 2002-01-09 | 2003-01-06 | Selective melanin-concentrating hormone type -1 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527491A JP2005527491A (ja) | 2005-09-15 |
| JP2005527491A5 true JP2005527491A5 (enExample) | 2006-02-23 |
Family
ID=23362689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003560178A Pending JP2005527491A (ja) | 2002-01-09 | 2003-01-06 | 選択的メラニン凝集ホルモンタイプ−１受容体アゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7273846B2 (enExample) |
| EP (1) | EP1495046A2 (enExample) |
| JP (1) | JP2005527491A (enExample) |
| CA (1) | CA2473229A1 (enExample) |
| WO (1) | WO2003060091A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004537581A (ja) | 2001-08-08 | 2004-12-16 | メルク エンド カムパニー インコーポレーテッド | メラニン濃縮ホルモン拮抗物質 |
| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| WO2018160178A1 (en) | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof |
| AU2020402994A1 (en) | 2019-12-11 | 2022-06-23 | Inspirna, Inc. | Methods of treating cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049655A (en) * | 1989-03-22 | 1991-09-17 | The Salk Institute For Biological Studies | Melanin-concentrating hormones |
| US5849708A (en) * | 1995-06-06 | 1998-12-15 | Joslin Diabetes Center, Inc. | Promotion of eating behavior |
| CA2399509A1 (en) | 2000-02-03 | 2001-08-09 | Merck & Co., Inc. | Melanin-concentrating hormone analogs |
| EP1485405A4 (en) | 2001-05-31 | 2005-09-21 | Merck & Co Inc | MELANIN CONCENTRATING HORMONE ANALOG |
-
2003
- 2003-01-06 JP JP2003560178A patent/JP2005527491A/ja active Pending
- 2003-01-06 EP EP03729575A patent/EP1495046A2/en not_active Withdrawn
- 2003-01-06 US US10/500,672 patent/US7273846B2/en not_active Expired - Fee Related
- 2003-01-06 CA CA002473229A patent/CA2473229A1/en not_active Abandoned
- 2003-01-06 WO PCT/US2003/000241 patent/WO2003060091A2/en not_active Ceased
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