JP2005527209A - 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター - Google Patents
疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37453002P | 2002-04-22 | 2002-04-22 | |
| PCT/US2003/012542 WO2003089457A2 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c ϝ for pain management |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009010402A Division JP2009091372A (ja) | 2002-04-22 | 2009-01-20 | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2005527209A true JP2005527209A (ja) | 2005-09-15 |
Family
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Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586177A Pending JP2005527209A (ja) | 2002-04-22 | 2003-04-22 | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| JP2003586176A Withdrawn JP2005523326A (ja) | 2002-04-22 | 2003-04-22 | プロテインキナーゼｃのペプチドインヒビター |
| JP2009010402A Pending JP2009091372A (ja) | 2002-04-22 | 2009-01-20 | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| JP2009011456A Pending JP2009102392A (ja) | 2002-04-22 | 2009-01-21 | プロテインキナーゼｃのペプチドインヒビター |
| JP2012128849A Pending JP2012176978A (ja) | 2002-04-22 | 2012-06-06 | プロテインキナーゼｃのペプチドインヒビター |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586176A Withdrawn JP2005523326A (ja) | 2002-04-22 | 2003-04-22 | プロテインキナーゼｃのペプチドインヒビター |
| JP2009010402A Pending JP2009091372A (ja) | 2002-04-22 | 2009-01-20 | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| JP2009011456A Pending JP2009102392A (ja) | 2002-04-22 | 2009-01-21 | プロテインキナーゼｃのペプチドインヒビター |
| JP2012128849A Pending JP2012176978A (ja) | 2002-04-22 | 2012-06-06 | プロテインキナーゼｃのペプチドインヒビター |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US7393835B2 (OSRAM) |
| EP (3) | EP1501532A4 (OSRAM) |
| JP (5) | JP2005527209A (OSRAM) |
| AU (4) | AU2003234186B2 (OSRAM) |
| CA (3) | CA2481512C (OSRAM) |
| WO (2) | WO2003089457A2 (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006525948A (ja) * | 2003-05-16 | 2006-11-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 離脱症状における使用のためのプロテインキナーゼｃペプチド |
| JP2010516709A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | 疼痛減弱のためのイプシロン阻害化合物の使用方法 |
| JP2010516707A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2010523598A (ja) * | 2007-04-06 | 2010-07-15 | カイ・ファーマシューティカルズ・インコーポレイテッド | 痛みの軽減のためのガンマ阻害剤化合物の使用方法 |
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| CA2481512C (en) | 2002-04-22 | 2013-06-18 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase c.gamma. for pain management |
| US6933275B2 (en) | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
| WO2004084889A1 (en) * | 2003-03-28 | 2004-10-07 | Pfizer Inc. | Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons |
| AU2003264918A1 (en) * | 2003-10-02 | 2005-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| ES2411962T3 (es) | 2003-10-24 | 2013-07-09 | Gencia Corporation | Métodos y composiciones para suministrar polinucleótidos |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| US20090123468A1 (en) * | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8507277B2 (en) * | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US20090208478A1 (en) * | 2003-10-24 | 2009-08-20 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| WO2005059124A2 (en) * | 2003-12-11 | 2005-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific antagonists of protein kinase c |
| US7265092B2 (en) | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| US20060148700A1 (en) * | 2004-11-10 | 2006-07-06 | Daria Mochly-Rosen | Methods and compositions for reducing injury to a transplanted organ |
| US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
| US8158586B2 (en) * | 2005-04-11 | 2012-04-17 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
| EP2298792A3 (en) | 2005-08-05 | 2011-10-19 | Pharmagap Inc. | Peptides targeted to protein kinase C isoforms and uses thereof |
| WO2007025286A2 (en) * | 2005-08-26 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Therapy procedure for drug delivery for trigeminal pain |
| EP1934338A2 (en) * | 2005-09-19 | 2008-06-25 | Kai Pharmaceuticals, Inc. | Protein kinase c peptide modulators of angiogenesis |
| EP1998791A4 (en) * | 2006-03-30 | 2009-11-04 | Salpep Biotechnology Inc | SUPPRESSION AND TREATMENT OF NEUROPATHIC PAIN |
| WO2007143119A2 (en) * | 2006-06-01 | 2007-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Method of preventing progression of hypertension-induced heart failure with pkc peptides |
| US20090062208A1 (en) * | 2007-02-06 | 2009-03-05 | Mochly-Rosen Daria D | Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor |
| WO2008154004A2 (en) * | 2007-06-07 | 2008-12-18 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of tumor metastases using protein kinase c (pkc) inhibitors |
| JP2011507857A (ja) | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 |
| US20090318351A1 (en) * | 2008-03-12 | 2009-12-24 | Kevin Grimes | Method of treating acute st-elevation myocardial infarction with a delta pkc antagonist |
| JP5794911B2 (ja) * | 2008-03-27 | 2015-10-14 | ネステク ソシエテ アノニム | ペプチド、ペプチド模倣体及び他の胃腸内輸送タンパク質基質の吸収を増加する方法 |
| US20100048482A1 (en) * | 2008-08-15 | 2010-02-25 | Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection |
| CA2753208C (en) | 2009-02-20 | 2018-08-21 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| KR101720961B1 (ko) * | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| CA2754482A1 (en) * | 2009-03-06 | 2010-09-10 | Angstrom Pharmaceuticals, Inc. | Compositions and methods for modulation of cell migration |
| US20100311671A1 (en) * | 2009-03-25 | 2010-12-09 | Kai Pharmaceuticals | Transdermal delivery of pkc modulatory peptides through microporated skin |
| EP2942060A1 (en) | 2009-09-29 | 2015-11-11 | Joslin Diabetes Center, Inc. | Use of Protein Kinase C Delta (PKCD) Inhibitors to Treat Diabetes, Obesity and, Hepatic Steatosis |
| AU2011223563A1 (en) * | 2010-03-05 | 2012-11-01 | Angstrom Pharmaceuticals, Inc. | Modulation of intracellular signaling |
| US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
| US9217137B2 (en) | 2011-08-12 | 2015-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for specific regulation of pyruvate dehydrogenase kinase |
| JP6339998B2 (ja) | 2012-04-24 | 2018-06-06 | ダン エス． カウフマン， | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| US10124001B2 (en) | 2013-09-18 | 2018-11-13 | University Of Canberra | Stem cell modulation II |
| EP3180003B1 (en) | 2014-07-01 | 2022-01-12 | The Regents of the University of California | Pkc-epsilon inhibitors |
| JP2017528452A (ja) | 2014-08-25 | 2017-09-28 | ユニバーシティ・オブ・キャンベラＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｃａｎｂｅｒｒａ | がん幹細胞を調節するための組成物およびその使用 |
| WO2016112205A1 (en) | 2015-01-07 | 2016-07-14 | Trigemina, Inc. | Magnesium-containing oxytocin formulations and methods of use |
| EP4541348A3 (en) | 2016-04-12 | 2025-06-04 | Tonix Pharma Limited | Magnesium-containing oxytocin formulations and methods of use |
| NZ756012A (en) | 2017-01-17 | 2025-10-31 | Michael David Forrest | Therapeutic inhibitors of the reverse mode of atp synthase |
| WO2019012149A1 (en) | 2017-07-13 | 2019-01-17 | Forrest Michael David | THERAPEUTIC MODULATORS OF THE INVERSE MODE OF ATP SYNTHASE |
| JP2021502405A (ja) | 2017-11-08 | 2021-01-28 | エピアクシス セラピューティクス プロプライエタリー リミテッド | 免疫原性組成物及びその使用 |
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| CA3206148A1 (en) | 2021-01-24 | 2022-07-28 | Michael David FORREST | Therapeutic modifiers of the reverse mode of atp synthase |
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2003
- 2003-04-22 CA CA2481512A patent/CA2481512C/en not_active Expired - Fee Related
- 2003-04-22 EP EP03728494A patent/EP1501532A4/en not_active Withdrawn
- 2003-04-22 EP EP03728495A patent/EP1501533A4/en not_active Withdrawn
- 2003-04-22 AU AU2003234186A patent/AU2003234186B2/en not_active Ceased
- 2003-04-22 WO PCT/US2003/012542 patent/WO2003089457A2/en not_active Ceased
- 2003-04-22 CA CA2785889A patent/CA2785889A1/en not_active Abandoned
- 2003-04-22 JP JP2003586177A patent/JP2005527209A/ja active Pending
- 2003-04-22 US US10/513,003 patent/US7393835B2/en not_active Expired - Fee Related
- 2003-04-22 US US10/421,503 patent/US7507711B2/en not_active Expired - Fee Related
- 2003-04-22 EP EP10178878A patent/EP2332559A1/en not_active Withdrawn
- 2003-04-22 CA CA2482598A patent/CA2482598C/en not_active Expired - Fee Related
- 2003-04-22 JP JP2003586176A patent/JP2005523326A/ja not_active Withdrawn
- 2003-04-22 AU AU2003234185A patent/AU2003234185C1/en not_active Ceased
- 2003-04-22 WO PCT/US2003/012541 patent/WO2003089456A2/en not_active Ceased
- 2003-04-22 US US10/421,548 patent/US7459424B2/en not_active Expired - Fee Related
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2007
- 2007-07-16 US US11/879,414 patent/US7833984B2/en not_active Expired - Fee Related
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2008
- 2008-06-16 US US12/214,104 patent/US7939493B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/229,992 patent/US20090143293A1/en not_active Abandoned
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2009
- 2009-01-20 JP JP2009010402A patent/JP2009091372A/ja active Pending
- 2009-01-21 JP JP2009011456A patent/JP2009102392A/ja active Pending
- 2009-04-22 AU AU2009201593A patent/AU2009201593B2/en not_active Ceased
- 2009-05-04 AU AU2009201760A patent/AU2009201760B2/en not_active Ceased
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2011
- 2011-05-05 US US13/101,540 patent/US8658594B2/en not_active Expired - Fee Related
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2012
- 2012-06-06 JP JP2012128849A patent/JP2012176978A/ja active Pending
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2014
- 2014-02-21 US US14/187,070 patent/US9365837B2/en not_active Expired - Fee Related
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| WO2000004914A1 (en) * | 1998-07-21 | 2000-02-03 | Cytovia, Inc. | Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof |
| JP2005523326A (ja) * | 2002-04-22 | 2005-08-04 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | プロテインキナーゼｃのペプチドインヒビター |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006525948A (ja) * | 2003-05-16 | 2006-11-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 離脱症状における使用のためのプロテインキナーゼｃペプチド |
| JP2010516709A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | 疼痛減弱のためのイプシロン阻害化合物の使用方法 |
| JP2010516707A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2014224126A (ja) * | 2007-01-19 | 2014-12-04 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| KR101775929B1 (ko) * | 2007-01-19 | 2017-09-07 | 카이 파마슈티컬즈 | 안정성 및 전달 효율을 증가시키기 위한 펩타이드 조성물의 변형 |
| JP2018111717A (ja) * | 2007-01-19 | 2018-07-19 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| KR20190140111A (ko) * | 2007-01-19 | 2019-12-18 | 카이 파마슈티컬즈 | 안정성 및 전달 효율을 증가시키기 위한 펩타이드 조성물의 변형 |
| JP2021098725A (ja) * | 2007-01-19 | 2021-07-01 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| KR102274003B1 (ko) | 2007-01-19 | 2021-07-08 | 카이 파마슈티컬즈 | 안정성 및 전달 효율을 증가시키기 위한 펩타이드 조성물의 변형 |
| JP2023078424A (ja) * | 2007-01-19 | 2023-06-06 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2010523598A (ja) * | 2007-04-06 | 2010-07-15 | カイ・ファーマシューティカルズ・インコーポレイテッド | 痛みの軽減のためのガンマ阻害剤化合物の使用方法 |
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