JP2005524668A - ジアミノピリミジン類及びそれらの血管新生阻害薬としての使用 - Google Patents
ジアミノピリミジン類及びそれらの血管新生阻害薬としての使用 Download PDFInfo
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- JP2005524668A JP2005524668A JP2003572983A JP2003572983A JP2005524668A JP 2005524668 A JP2005524668 A JP 2005524668A JP 2003572983 A JP2003572983 A JP 2003572983A JP 2003572983 A JP2003572983 A JP 2003572983A JP 2005524668 A JP2005524668 A JP 2005524668A
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- Prior art keywords
- methyl
- pyrimidin
- amino
- phenylamino
- benzimidazol
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- 229940121369 angiogenesis inhibitor Drugs 0.000 title 1
- 239000004037 angiogenesis inhibitor Substances 0.000 title 1
- 229940058936 antimalarials diaminopyrimidines Drugs 0.000 title 1
- MISVBCMQSJUHMH-UHFFFAOYSA-N pyrimidine-4,6-diamine Chemical class NC1=CC(N)=NC=N1 MISVBCMQSJUHMH-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 295
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims abstract description 40
- 101000753291 Homo sapiens Angiopoietin-1 receptor Proteins 0.000 claims abstract description 38
- 102100022014 Angiopoietin-1 receptor Human genes 0.000 claims abstract description 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 37
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims abstract description 35
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims abstract description 32
- 238000011282 treatment Methods 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims description 426
- -1 —NR 8 R 9 Chemical group 0.000 claims description 424
- 229910052739 hydrogen Inorganic materials 0.000 claims description 96
- 239000001257 hydrogen Substances 0.000 claims description 91
- 150000003839 salts Chemical class 0.000 claims description 83
- 150000002431 hydrogen Chemical group 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 65
- 239000012453 solvate Substances 0.000 claims description 61
- 150000001408 amides Chemical class 0.000 claims description 50
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 46
- 125000003118 aryl group Chemical group 0.000 claims description 44
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 41
- 230000000694 effects Effects 0.000 claims description 38
- 208000035475 disorder Diseases 0.000 claims description 31
- 230000033115 angiogenesis Effects 0.000 claims description 29
- 239000003814 drug Substances 0.000 claims description 29
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 26
- 239000008194 pharmaceutical composition Substances 0.000 claims description 26
- 206010028980 Neoplasm Diseases 0.000 claims description 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
- 201000011510 cancer Diseases 0.000 claims description 24
- 230000006870 function Effects 0.000 claims description 24
- 125000005843 halogen group Chemical group 0.000 claims description 24
- 241000124008 Mammalia Species 0.000 claims description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 125000000623 heterocyclic group Chemical group 0.000 claims description 19
- 239000002246 antineoplastic agent Substances 0.000 claims description 17
- 102000009465 Growth Factor Receptors Human genes 0.000 claims description 15
- 108010009202 Growth Factor Receptors Proteins 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 14
- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 claims description 12
- 125000002252 acyl group Chemical group 0.000 claims description 12
- 125000004104 aryloxy group Chemical group 0.000 claims description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 11
- 108091008605 VEGF receptors Proteins 0.000 claims description 10
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims description 10
- 229940034982 antineoplastic agent Drugs 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 230000001404 mediated effect Effects 0.000 claims description 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 9
- 125000001188 haloalkyl group Chemical group 0.000 claims description 9
- 125000003435 aroyl group Chemical group 0.000 claims description 8
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 7
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
- XZWYLPKSDKATEV-UHFFFAOYSA-N 2-(3-methoxyphenyl)-n-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2N(C3=CC=C(C=C3N=2)N(C)C=2N=C(NC=3C=CC(CS(C)(=O)=O)=CC=3)N=CC=2)C)=C1 XZWYLPKSDKATEV-UHFFFAOYSA-N 0.000 claims description 6
- BNYIQEFWGSXIKQ-UHFFFAOYSA-N 3-methylfuran-2-carboxylic acid Chemical compound CC=1C=COC=1C(O)=O BNYIQEFWGSXIKQ-UHFFFAOYSA-N 0.000 claims description 6
- IFLKEBSJTZGCJG-UHFFFAOYSA-N 3-methylthiophene-2-carboxylic acid Chemical compound CC=1C=CSC=1C(O)=O IFLKEBSJTZGCJG-UHFFFAOYSA-N 0.000 claims description 6
- 102000001301 EGF receptor Human genes 0.000 claims description 6
- 108060006698 EGF receptor Proteins 0.000 claims description 6
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims description 6
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 5
- 125000001769 aryl amino group Chemical group 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 229940124597 therapeutic agent Drugs 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- LLJGESJIVOHITE-UHFFFAOYSA-N 2-chloro-5-[[4-[methyl-[1-methyl-2-(propan-2-ylamino)benzimidazol-5-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C=1C=C2N(C)C(NC(C)C)=NC2=CC=1N(C)C(N=1)=CC=NC=1NC1=CC=C(Cl)C(S(N)(=O)=O)=C1 LLJGESJIVOHITE-UHFFFAOYSA-N 0.000 claims description 4
- SVEPWTZXIDDIJQ-UHFFFAOYSA-N 3-[[4-[[2-[(3-chlorophenyl)methylamino]-1-methylbenzimidazol-5-yl]-methylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C=1C=NC(NC=2C=C(C=CC=2)S(N)(=O)=O)=NC=1N(C)C(C=C1N=2)=CC=C1N(C)C=2NCC1=CC=CC(Cl)=C1 SVEPWTZXIDDIJQ-UHFFFAOYSA-N 0.000 claims description 4
- RCKNAENLAPRPBW-UHFFFAOYSA-N C=1C=CC=2N(C)C(NC(=O)C=3C=C4NC=NC4=CC=3)=NC=2C=1N(C)C(N=1)=CC=NC=1NC1=CC=CC(CS(C)(=O)=O)=C1 Chemical compound C=1C=CC=2N(C)C(NC(=O)C=3C=C4NC=NC4=CC=3)=NC=2C=1N(C)C(N=1)=CC=NC=1NC1=CC=CC(CS(C)(=O)=O)=C1 RCKNAENLAPRPBW-UHFFFAOYSA-N 0.000 claims description 4
- 108091008606 PDGF receptors Proteins 0.000 claims description 4
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 claims description 4
- 229940091171 VEGFR-2 tyrosine kinase inhibitor Drugs 0.000 claims description 4
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims description 4
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 claims description 4
- TYDWDJHIOGMALG-UHFFFAOYSA-N 1-(2,5-difluorophenyl)-n-[4-methyl-1-[methyl-[2-(4-methyl-3-sulfamoylanilino)pyrimidin-4-yl]amino]benzimidazol-2-yl]cyclopropane-1-carboxamide Chemical compound C1CC1(C=1C(=CC=C(F)C=1)F)C(=O)NC1=NC2=C(C)C=CC=C2N1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 TYDWDJHIOGMALG-UHFFFAOYSA-N 0.000 claims description 3
- ITAPLFRHLLOCEL-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-n-[4-methyl-1-[methyl-[2-(4-methyl-3-sulfamoylanilino)pyrimidin-4-yl]amino]benzimidazol-2-yl]cyclopropane-1-carboxamide Chemical compound C1CC1(C=1C=C(Cl)C(Cl)=CC=1)C(=O)NC1=NC2=C(C)C=CC=C2N1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 ITAPLFRHLLOCEL-UHFFFAOYSA-N 0.000 claims description 3
- BCAWJFDSNFNNGQ-UHFFFAOYSA-N 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]urea Chemical compound C=1C=NC(NC=2C=CC(CS(C)(=O)=O)=CC=2)=NC=1N(C)C(C=C1N=2)=CC=C1N(C)C=2NC(=O)NC=1C=C(C(C)(C)C)ON=1 BCAWJFDSNFNNGQ-UHFFFAOYSA-N 0.000 claims description 3
- LYISPJAHVAQSTK-UHFFFAOYSA-N 1-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]-3-phenylurea Chemical compound C=1C=NC(NC=2C=CC(CS(C)(=O)=O)=CC=2)=NC=1N(C)C(C=C1N=2)=CC=C1N(C)C=2NC(=O)NC1=CC=CC=C1 LYISPJAHVAQSTK-UHFFFAOYSA-N 0.000 claims description 3
- PGGQBCCZVDGRAS-UHFFFAOYSA-N 2-(2,3-dimethoxyphenyl)-n-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2N(C3=CC=C(C=C3N=2)N(C)C=2N=C(NC=3C=CC(CS(C)(=O)=O)=CC=3)N=CC=2)C)=C1OC PGGQBCCZVDGRAS-UHFFFAOYSA-N 0.000 claims description 3
- KYFRVPBBRPZBSZ-UHFFFAOYSA-N 2-(2,5-difluorophenyl)-n-[4-methyl-1-[methyl-[2-(4-methyl-3-sulfamoylanilino)pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound C=1C(F)=CC=C(F)C=1CC(=O)NC1=NC2=C(C)C=CC=C2N1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 KYFRVPBBRPZBSZ-UHFFFAOYSA-N 0.000 claims description 3
- QATMPMUKHIHJLS-UHFFFAOYSA-N 2-(2,5-dimethoxyphenyl)-n-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound COC1=CC=C(OC)C(CC(=O)NC=2N(C3=CC=C(C=C3N=2)N(C)C=2N=C(NC=3C=CC(CS(C)(=O)=O)=CC=3)N=CC=2)C)=C1 QATMPMUKHIHJLS-UHFFFAOYSA-N 0.000 claims description 3
- NHMJPJQHCQVSLN-UHFFFAOYSA-N 2-(2-methoxyphenyl)-n-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound COC1=CC=CC=C1CC(=O)NC1=NC2=CC(N(C)C=3N=C(NC=4C=CC(CS(C)(=O)=O)=CC=4)N=CC=3)=CC=C2N1C NHMJPJQHCQVSLN-UHFFFAOYSA-N 0.000 claims description 3
- IOYCCLXBNASNOV-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[4-[[2-(5-ethylsulfonyl-2-methoxyanilino)pyrimidin-4-yl]-methylamino]-1-methylbenzimidazol-2-yl]acetamide Chemical compound CCS(=O)(=O)C1=CC=C(OC)C(NC=2N=C(C=CN=2)N(C)C=2C=3N=C(NC(=O)CC=4C=C(Cl)C(Cl)=CC=4)N(C)C=3C=CC=2)=C1 IOYCCLXBNASNOV-UHFFFAOYSA-N 0.000 claims description 3
- QDCKWOPBRJZWNI-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[4-methyl-1-[methyl-[2-(4-methyl-3-sulfamoylanilino)pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1CC(=O)NC1=NC2=C(C)C=CC=C2N1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 QDCKWOPBRJZWNI-UHFFFAOYSA-N 0.000 claims description 3
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- XBLMGJGVFXRKFD-UHFFFAOYSA-N 2-(3,5-dimethoxyphenyl)-n-[1-methyl-5-[methyl-[2-[4-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzimidazol-2-yl]acetamide Chemical compound COC1=CC(OC)=CC(CC(=O)NC=2N(C3=CC=C(C=C3N=2)N(C)C=2N=C(NC=3C=CC(CS(C)(=O)=O)=CC=3)N=CC=2)C)=C1 XBLMGJGVFXRKFD-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Urology & Nephrology (AREA)
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- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36074102P | 2002-03-01 | 2002-03-01 | |
| PCT/US2003/006022 WO2003074515A1 (en) | 2002-03-01 | 2003-02-28 | Diamino-pyrimidines and their use as angiogenesis inhibitors |
Publications (2)
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| JP2005524668A true JP2005524668A (ja) | 2005-08-18 |
| JP2005524668A5 JP2005524668A5 (enExample) | 2006-03-09 |
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| US (1) | US7338959B2 (enExample) |
| EP (1) | EP1487824B1 (enExample) |
| JP (1) | JP2005524668A (enExample) |
| AT (1) | ATE365165T1 (enExample) |
| AU (1) | AU2003220970A1 (enExample) |
| CA (1) | CA2477505A1 (enExample) |
| DE (1) | DE60314500T2 (enExample) |
| ES (1) | ES2290479T3 (enExample) |
| MX (1) | MXPA04008458A (enExample) |
| WO (1) | WO2003074515A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5270553B2 (ja) * | 2007-08-23 | 2013-08-21 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP2017522339A (ja) * | 2014-07-31 | 2017-08-10 | インスティチュート パスツール コリア | 2−アミノ−ベンゾイミダゾール誘導体ならびにこれらの5−リポキシゲナーゼおよび/またはプロスタグランジンeシンターゼ阻害剤としての使用 |
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| ATE451104T1 (de) | 2002-07-29 | 2009-12-15 | Rigel Pharmaceuticals Inc | Verfahren zur behandlung oder pruvention von autoimmunkrankheiten mit 2,4-pyrimidindiamin- verbindungen |
| US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| US7531553B2 (en) | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
| EP2258365B1 (en) * | 2003-03-28 | 2013-05-29 | Novartis Vaccines and Diagnostics, Inc. | Use of organic compounds for immunopotentiation |
| ES2421139T3 (es) | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
| DE10337942A1 (de) * | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Aminobenzimidazolderivate |
| DE10342503A1 (de) * | 2003-09-12 | 2005-04-14 | Merck Patent Gmbh | Benzyl-Benzimidazolylderivate |
| JP2007505858A (ja) * | 2003-09-18 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | 増殖性障害の処置に有用な2,4−ジ(フェニルアミノ)ピリミジン |
| DE10349587A1 (de) * | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| ES2631362T3 (es) | 2004-01-30 | 2017-08-30 | Vertex Pharmaceuticals Incorporated | Moduladores de transportadores de casete de unión a ATP |
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| US7576090B2 (en) | 2004-12-27 | 2009-08-18 | 4Sc Ag | Benzazole analogues and uses thereof |
| EP1674466A1 (en) * | 2004-12-27 | 2006-06-28 | 4Sc Ag | 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors |
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| US20060247263A1 (en) * | 2005-04-19 | 2006-11-02 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
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| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| AU760020B2 (en) * | 1998-08-31 | 2003-05-08 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| ATE430742T1 (de) * | 2000-12-21 | 2009-05-15 | Smithkline Beecham Corp | Pyrimidinamine als angiogenesemodulatoren |
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- 2003-02-28 CA CA002477505A patent/CA2477505A1/en not_active Abandoned
- 2003-02-28 ES ES03743709T patent/ES2290479T3/es not_active Expired - Lifetime
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- 2003-02-28 MX MXPA04008458A patent/MXPA04008458A/es active IP Right Grant
- 2003-02-28 US US10/506,447 patent/US7338959B2/en not_active Expired - Fee Related
- 2003-02-28 EP EP03743709A patent/EP1487824B1/en not_active Expired - Lifetime
- 2003-02-28 AT AT03743709T patent/ATE365165T1/de not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5270553B2 (ja) * | 2007-08-23 | 2013-08-21 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP2017522339A (ja) * | 2014-07-31 | 2017-08-10 | インスティチュート パスツール コリア | 2−アミノ−ベンゾイミダゾール誘導体ならびにこれらの5−リポキシゲナーゼおよび/またはプロスタグランジンeシンターゼ阻害剤としての使用 |
| US11447486B2 (en) | 2014-07-31 | 2022-09-20 | Institut Pasteur Korea | 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin E synthase inhibitors |
Also Published As
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|---|---|
| EP1487824B1 (en) | 2007-06-20 |
| EP1487824A1 (en) | 2004-12-22 |
| ATE365165T1 (de) | 2007-07-15 |
| US7338959B2 (en) | 2008-03-04 |
| ES2290479T3 (es) | 2008-02-16 |
| MXPA04008458A (es) | 2004-12-06 |
| AU2003220970A1 (en) | 2003-09-16 |
| US20050234083A1 (en) | 2005-10-20 |
| DE60314500D1 (de) | 2007-08-02 |
| WO2003074515A1 (en) | 2003-09-12 |
| DE60314500T2 (de) | 2008-02-07 |
| CA2477505A1 (en) | 2003-09-12 |
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