JP2005523259A - 二環式ｃｂ２カンナビノイド受容体リガンド - Google Patents

二環式ｃｂ２カンナビノイド受容体リガンド Download PDF

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JP2005523259A
JP2005523259A JP2003563454A JP2003563454A JP2005523259A JP 2005523259 A JP2005523259 A JP 2005523259A JP 2003563454 A JP2003563454 A JP 2003563454A JP 2003563454 A JP2003563454 A JP 2003563454A JP 2005523259 A JP2005523259 A JP 2005523259A
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alkyl
dimethyl
compound
saturated
branched
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Japanese (ja)
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ガーゾン、アーロン
フィンク、ジョージ
ダール、ダリト、エスター
メナシェ、ナイム
ヌーデルマン、アイレット
グリーンバーグ、オリト
ヤコヴァン、アヴィハイ
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ファーモス コーポレイション
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Priority claimed from IL14794102A external-priority patent/IL147941A0/xx
Priority claimed from IL150302A external-priority patent/IL150302A/en
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    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
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    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
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    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
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    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
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    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/30—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with trihydroxylic compounds
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
JP2003563454A 2002-01-31 2003-01-30 二環式ｃｂ２カンナビノイド受容体リガンド Pending JP2005523259A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL14794102A IL147941A0 (en) 2002-01-31 2002-01-31 Bicyclic cb2 cannabinoid receptor ligands
PCT/IL2002/000341 WO2003064359A1 (fr) 2002-01-31 2002-05-02 Ligands du recepteur cannabinoide cb2 bicylcique
IL150302A IL150302A (en) 2002-01-31 2002-06-18 Bicyclic cb2 cannabinoid receptor ligands
PCT/IL2003/000077 WO2003063758A2 (fr) 2002-01-31 2003-01-30 Ligands du recepteur cannabinoide cb2 bicyclique

Publications (1)

Publication Number Publication Date
JP2005523259A true JP2005523259A (ja) 2005-08-04

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JP2003563454A Pending JP2005523259A (ja) 2002-01-31 2003-01-30 二環式ｃｂ２カンナビノイド受容体リガンド

Country Status (3)

Country Link
EP (1) EP1469842A4 (fr)
JP (1) JP2005523259A (fr)
WO (1) WO2003063758A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019510806A (ja) * 2016-04-10 2019-04-18 アリーナ ファーマシューティカルズ， インコーポレイテッド 選択的ｃｂ２受容体アゴニストによる治療方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69910373T2 (de) 1998-05-04 2004-04-01 The University Of Connecticut, Farmington Analgetische und immunomodulierende cannabinoiden
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
CA2452881C (fr) * 2001-07-13 2012-03-06 University Of Connecticut Nouveaux cannabinoides bicycliques et tricycliques
EP1802293A4 (fr) * 2004-10-22 2009-04-29 Pharmos Corp Analogues cannabinoides efficaces oralement
US7763607B2 (en) 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
WO2007125049A1 (fr) * 2006-04-27 2007-11-08 Solvay Pharmaceuticals Gmbh Utilisation de modulateurs de récepteurs aux cannabinoïdes cbx en tant que modulateurs de canaux potassium
US20100004244A1 (en) * 2006-06-27 2010-01-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of cb2 receptor agonists for promoting neurogenesis
WO2009140078A1 (fr) * 2008-05-16 2009-11-19 The Procter & Gamble Company Traitement d’un dysfonctionnement de l’appareil urinaire bas par des agonistes sélectifs du récepteur cb‑2
WO2023058033A1 (fr) * 2021-10-10 2023-04-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dérivés de fenchone arylatés, compositions les comprenant, leurs procédés de préparation et leurs utilisations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208351A (en) * 1976-11-10 1980-06-17 Eli Lilly And Company Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
IL55274A (en) * 1978-08-02 1982-08-31 Yissum Res Dev Co 4-(2,6-dihydroxy-4-(dimethylheptyl)phenyl)substituted 2-pinen-10-ol and pinane derivatives,their preparation and pharmaceutical compositions comprising them
US5434295A (en) * 1994-02-07 1995-07-18 Yissum Research Development Company Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds
WO2001028497A2 (fr) * 1999-10-18 2001-04-26 University Of Connecticut Nouveaux agonistes de cannabinoides bicycliques destines au recepteur de cannabinoides
IL132661A (en) * 1999-10-31 2008-11-26 Raphael Mechoulam Agonists specific for peripheral cannabinoid receptors
CA2452881C (fr) * 2001-07-13 2012-03-06 University Of Connecticut Nouveaux cannabinoides bicycliques et tricycliques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019510806A (ja) * 2016-04-10 2019-04-18 アリーナ ファーマシューティカルズ， インコーポレイテッド 選択的ｃｂ２受容体アゴニストによる治療方法

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EP1469842A2 (fr) 2004-10-27
EP1469842A4 (fr) 2006-04-26
WO2003063758A3 (fr) 2003-12-31
WO2003063758A2 (fr) 2003-08-07

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