JP2005520864A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005520864A5 JP2005520864A5 JP2003578384A JP2003578384A JP2005520864A5 JP 2005520864 A5 JP2005520864 A5 JP 2005520864A5 JP 2003578384 A JP2003578384 A JP 2003578384A JP 2003578384 A JP2003578384 A JP 2003578384A JP 2005520864 A5 JP2005520864 A5 JP 2005520864A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- lower alkyl
- independently
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 12
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 150000003568 thioethers Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 125000006245 phosphate protecting group Chemical group 0.000 claims 2
- -1 1,3-phenylene, 1,4-phenylene Chemical group 0.000 claims 1
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36594002P | 2002-03-19 | 2002-03-19 | |
| PCT/US2003/008449 WO2003080630A2 (en) | 2002-03-19 | 2003-03-19 | Phosphate transport inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520864A JP2005520864A (ja) | 2005-07-14 |
| JP2005520864A5 true JP2005520864A5 (https=) | 2006-05-18 |
| JP4465193B2 JP4465193B2 (ja) | 2010-05-19 |
Family
ID=28454730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578384A Expired - Fee Related JP4465193B2 (ja) | 2002-03-19 | 2003-03-19 | リン酸塩輸送インヒビター |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7109184B2 (https=) |
| EP (1) | EP1485391B1 (https=) |
| JP (1) | JP4465193B2 (https=) |
| AT (1) | ATE337326T1 (https=) |
| AU (1) | AU2003218270A1 (https=) |
| DE (1) | DE60307799T2 (https=) |
| WO (1) | WO2003080630A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| ATE337326T1 (de) * | 2002-03-19 | 2006-09-15 | Genzyme Corp | Hemmer des phosphattransports |
| US7985418B2 (en) * | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| AU2012205214B2 (en) * | 2005-09-15 | 2015-05-21 | Genzyme Corporation | Formulation for Amine Polymers |
| EP3000460A1 (en) * | 2005-09-15 | 2016-03-30 | Genzyme Corporation | Sachet formulation for amine polymers |
| CN101835500B (zh) * | 2007-08-29 | 2014-05-28 | 吸附剂治疗学公司 | 具有可变抗衡离子含量的吸收性聚合物组合物及其制备方法和用途 |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| US20110081413A1 (en) * | 2009-01-22 | 2011-04-07 | Ashok Omray | Pharmaceutical Compositions Comprising Phosphate-Binding Polymer |
| EP3351250A3 (en) | 2009-01-26 | 2018-10-17 | Opko Ireland Global Holdings, Ltd. | Phosphate management with small molecules |
| US8921343B2 (en) * | 2010-03-05 | 2014-12-30 | Duophos | Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport |
| MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| LT2983667T (lt) | 2013-04-12 | 2019-07-10 | Ardelyx, Inc. | Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai |
| CA3049678A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632634A (en) * | 1968-08-16 | 1972-01-04 | Ludwig Maier | Phosphorus compounds having the skeleton structure |
| DE1945146A1 (de) * | 1968-09-06 | 1970-03-12 | Monsanto Co | Verfahren zur Herstellung von alpha.omega-Bis-(O.O'-diorganophosphonylmethyl-O-organophosphinyl-alkanen |
| US4806532A (en) * | 1985-10-08 | 1989-02-21 | Mayo Foundation For Medical Education And Research | Inhibition of epithelial phosphate transport |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| CA2007641A1 (en) | 1989-02-01 | 1990-08-01 | Donald S. Karanewsky | Combination of squalene synthetase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination |
| CA2016467A1 (en) | 1989-06-05 | 1990-12-05 | Martin Eisman | Method for treating peripheral atherosclerotic disease employing an hmg coa reductase inhibitor and/or a squalene synthetase inhibitor |
| EP0563730A3 (en) * | 1992-03-28 | 1994-07-27 | Hoechst Ag | Alkenylaminoalkylene phosphonic acid esters and process for the preparation of copolymers comprising alkenylaminoalkylene phosphonates and ethylenic unsaturated compounds |
| US5278153A (en) * | 1992-05-18 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method |
| JP3526575B2 (ja) | 1993-03-08 | 2004-05-17 | エーザイ株式会社 | ホスホン酸誘導体 |
| US5667775A (en) * | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5508342A (en) * | 1994-02-01 | 1996-04-16 | The United States Of America As Represented By The Secretary Of Commerce | Polymeric amorphous calcium phosphate compositions |
| US5618851A (en) * | 1995-02-06 | 1997-04-08 | Arch Development Corp. | Grafted methylenediphosphonate ion exchange resins |
| ATE337326T1 (de) * | 2002-03-19 | 2006-09-15 | Genzyme Corp | Hemmer des phosphattransports |
-
2003
- 2003-03-19 AT AT03714264T patent/ATE337326T1/de not_active IP Right Cessation
- 2003-03-19 AU AU2003218270A patent/AU2003218270A1/en not_active Abandoned
- 2003-03-19 DE DE60307799T patent/DE60307799T2/de not_active Expired - Lifetime
- 2003-03-19 US US10/392,280 patent/US7109184B2/en not_active Expired - Lifetime
- 2003-03-19 EP EP03714264A patent/EP1485391B1/en not_active Expired - Lifetime
- 2003-03-19 WO PCT/US2003/008449 patent/WO2003080630A2/en not_active Ceased
- 2003-03-19 JP JP2003578384A patent/JP4465193B2/ja not_active Expired - Fee Related
-
2006
- 2006-05-22 US US11/438,679 patent/US7754200B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005520864A5 (https=) | ||
| RU2008152087A (ru) | Макроциклические оксимильные ингибиторы протеазы гепатита | |
| JP2004516314A5 (https=) | ||
| ME02847B (me) | Fuzionisana heterociklična jedinjenja kao modulatori jonskih kanala | |
| JP2011530500A5 (https=) | ||
| JP2007536393A5 (https=) | ||
| JP2005504789A5 (https=) | ||
| JP2012512891A5 (https=) | ||
| JP2008525416A5 (https=) | ||
| JP2007502845A5 (https=) | ||
| JP2008505117A5 (https=) | ||
| JP2008523069A5 (https=) | ||
| JP2008533191A5 (https=) | ||
| JP2015501292A5 (https=) | ||
| JP2009535307A5 (https=) | ||
| EP1826196A3 (en) | Vinyl ether compounds | |
| JP2010513498A5 (https=) | ||
| HRP20070498T3 (en) | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | |
| JP2008536833A5 (https=) | ||
| JP2021528421A5 (https=) | ||
| TW200600983A (en) | Rinse solution for lithography | |
| JP2006503143A5 (https=) | ||
| JP2021529792A5 (https=) | ||
| JP2010535706A5 (https=) | ||
| JP2021504302A5 (https=) |