JP2005520864A5 - - Google Patents
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- Publication number
- JP2005520864A5 JP2005520864A5 JP2003578384A JP2003578384A JP2005520864A5 JP 2005520864 A5 JP2005520864 A5 JP 2005520864A5 JP 2003578384 A JP2003578384 A JP 2003578384A JP 2003578384 A JP2003578384 A JP 2003578384A JP 2005520864 A5 JP2005520864 A5 JP 2005520864A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- lower alkyl
- independently
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 12
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 150000003568 thioethers Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 125000006245 phosphate protecting group Chemical group 0.000 claims 2
- -1 1,3-phenylene, 1,4-phenylene Chemical group 0.000 claims 1
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36594002P | 2002-03-19 | 2002-03-19 | |
| PCT/US2003/008449 WO2003080630A2 (en) | 2002-03-19 | 2003-03-19 | Phosphate transport inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520864A JP2005520864A (ja) | 2005-07-14 |
| JP2005520864A5 true JP2005520864A5 (enExample) | 2006-05-18 |
| JP4465193B2 JP4465193B2 (ja) | 2010-05-19 |
Family
ID=28454730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578384A Expired - Fee Related JP4465193B2 (ja) | 2002-03-19 | 2003-03-19 | リン酸塩輸送インヒビター |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7109184B2 (enExample) |
| EP (1) | EP1485391B1 (enExample) |
| JP (1) | JP4465193B2 (enExample) |
| AT (1) | ATE337326T1 (enExample) |
| AU (1) | AU2003218270A1 (enExample) |
| DE (1) | DE60307799T2 (enExample) |
| WO (1) | WO2003080630A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| ATE337326T1 (de) * | 2002-03-19 | 2006-09-15 | Genzyme Corp | Hemmer des phosphattransports |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| AU2012205214B2 (en) * | 2005-09-15 | 2015-05-21 | Genzyme Corporation | Formulation for Amine Polymers |
| KR101547925B1 (ko) * | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
| EP2601981A1 (en) * | 2007-08-29 | 2013-06-12 | Sorbent Therapeutics, Inc. | Absorbent polymeric compositions with varying counterion content and their methods of preparation and use |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| JP5502106B2 (ja) | 2008-12-31 | 2014-05-28 | アーデリクス，インコーポレーテッド | 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるｎｈｅ媒介性アンチポートを阻害するための組成物および方法 |
| AU2010209293A1 (en) * | 2009-01-22 | 2011-09-08 | Usv Limited | Pharmaceutical compositions comprising phosphate-binding polymer |
| EP3351250A3 (en) | 2009-01-26 | 2018-10-17 | Opko Ireland Global Holdings, Ltd. | Phosphate management with small molecules |
| WO2011109731A2 (en) * | 2010-03-05 | 2011-09-09 | Duophos | Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport |
| KR102138390B1 (ko) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 ｎｈｅ-매개된 역수송 저해를 위한 화합물 및 방법 |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR102287207B1 (ko) | 2013-04-12 | 2021-08-09 | 알데릭스, 인코포레이티드 | Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법 |
| CA3049679A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
| UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632634A (en) * | 1968-08-16 | 1972-01-04 | Ludwig Maier | Phosphorus compounds having the skeleton structure |
| DE1945146A1 (de) | 1968-09-06 | 1970-03-12 | Monsanto Co | Verfahren zur Herstellung von alpha.omega-Bis-(O.O'-diorganophosphonylmethyl-O-organophosphinyl-alkanen |
| US4806532A (en) | 1985-10-08 | 1989-02-21 | Mayo Foundation For Medical Education And Research | Inhibition of epithelial phosphate transport |
| IL86951A (en) | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| CA2007641A1 (en) | 1989-02-01 | 1990-08-01 | Donald S. Karanewsky | Combination of squalene synthetase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination |
| CA2016467A1 (en) | 1989-06-05 | 1990-12-05 | Martin Eisman | Method for treating peripheral atherosclerotic disease employing an hmg coa reductase inhibitor and/or a squalene synthetase inhibitor |
| EP0563730A3 (en) * | 1992-03-28 | 1994-07-27 | Hoechst Ag | Alkenylaminoalkylene phosphonic acid esters and process for the preparation of copolymers comprising alkenylaminoalkylene phosphonates and ethylenic unsaturated compounds |
| US5278153A (en) | 1992-05-18 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method |
| US5719303A (en) | 1993-03-08 | 1998-02-17 | Eisai Co., Ltd. | Phosphonic acid derivatives |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5508342A (en) * | 1994-02-01 | 1996-04-16 | The United States Of America As Represented By The Secretary Of Commerce | Polymeric amorphous calcium phosphate compositions |
| US5618851A (en) * | 1995-02-06 | 1997-04-08 | Arch Development Corp. | Grafted methylenediphosphonate ion exchange resins |
| ATE337326T1 (de) * | 2002-03-19 | 2006-09-15 | Genzyme Corp | Hemmer des phosphattransports |
-
2003
- 2003-03-19 AT AT03714264T patent/ATE337326T1/de not_active IP Right Cessation
- 2003-03-19 JP JP2003578384A patent/JP4465193B2/ja not_active Expired - Fee Related
- 2003-03-19 US US10/392,280 patent/US7109184B2/en not_active Expired - Lifetime
- 2003-03-19 AU AU2003218270A patent/AU2003218270A1/en not_active Abandoned
- 2003-03-19 DE DE60307799T patent/DE60307799T2/de not_active Expired - Lifetime
- 2003-03-19 EP EP03714264A patent/EP1485391B1/en not_active Expired - Lifetime
- 2003-03-19 WO PCT/US2003/008449 patent/WO2003080630A2/en not_active Ceased
-
2006
- 2006-05-22 US US11/438,679 patent/US7754200B2/en not_active Expired - Fee Related
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