JP2005520864A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005520864A5 JP2005520864A5 JP2003578384A JP2003578384A JP2005520864A5 JP 2005520864 A5 JP2005520864 A5 JP 2005520864A5 JP 2003578384 A JP2003578384 A JP 2003578384A JP 2003578384 A JP2003578384 A JP 2003578384A JP 2005520864 A5 JP2005520864 A5 JP 2005520864A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- lower alkyl
- independently
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 12
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 150000003568 thioethers Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 125000006245 phosphate protecting group Chemical group 0.000 claims 2
- -1 1,3-phenylene, 1,4-phenylene Chemical group 0.000 claims 1
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36594002P | 2002-03-19 | 2002-03-19 | |
| PCT/US2003/008449 WO2003080630A2 (en) | 2002-03-19 | 2003-03-19 | Phosphate transport inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520864A JP2005520864A (ja) | 2005-07-14 |
| JP2005520864A5 true JP2005520864A5 (OSRAM) | 2006-05-18 |
| JP4465193B2 JP4465193B2 (ja) | 2010-05-19 |
Family
ID=28454730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578384A Expired - Fee Related JP4465193B2 (ja) | 2002-03-19 | 2003-03-19 | リン酸塩輸送インヒビター |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7109184B2 (OSRAM) |
| EP (1) | EP1485391B1 (OSRAM) |
| JP (1) | JP4465193B2 (OSRAM) |
| AT (1) | ATE337326T1 (OSRAM) |
| AU (1) | AU2003218270A1 (OSRAM) |
| DE (1) | DE60307799T2 (OSRAM) |
| WO (1) | WO2003080630A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| AU2003218270A1 (en) | 2002-03-19 | 2003-10-08 | Genzyme Corporation | Phosphate transport inhibitors |
| US7985418B2 (en) * | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| KR101547925B1 (ko) * | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
| AU2012205214B2 (en) * | 2005-09-15 | 2015-05-21 | Genzyme Corporation | Formulation for Amine Polymers |
| WO2009029829A1 (en) * | 2007-08-29 | 2009-03-05 | Sorbent Therapeutics, Inc. | Polymeric compositions with enhanced saline holding capacity and their method of preparation and use |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| NO2384318T3 (OSRAM) | 2008-12-31 | 2018-04-14 | ||
| CA2749397A1 (en) * | 2009-01-22 | 2010-08-05 | Usv Limited | Pharmaceutical compositions comprising phosphate-binding polymer |
| JP5783910B2 (ja) | 2009-01-26 | 2015-09-24 | シトクロマ インコーポレイテッド | 小分子を用いるリン酸管理 |
| EP2542560B8 (en) * | 2010-03-05 | 2015-12-30 | Duophos | Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport |
| MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| EP3552630A1 (en) | 2013-04-12 | 2019-10-16 | Ardelyx, Inc. | Nhe3-binding compounds for inhibiting phosphate transport |
| BR112019013963A2 (pt) | 2017-01-09 | 2020-04-28 | Ardelyx Inc | inibidores de antiporte mediado por nhe |
| US11242337B2 (en) | 2017-01-09 | 2022-02-08 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632634A (en) * | 1968-08-16 | 1972-01-04 | Ludwig Maier | Phosphorus compounds having the skeleton structure |
| DE1945146A1 (de) * | 1968-09-06 | 1970-03-12 | Monsanto Co | Verfahren zur Herstellung von alpha.omega-Bis-(O.O'-diorganophosphonylmethyl-O-organophosphinyl-alkanen |
| US4806532A (en) | 1985-10-08 | 1989-02-21 | Mayo Foundation For Medical Education And Research | Inhibition of epithelial phosphate transport |
| IL86951A (en) | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| CA2007641A1 (en) | 1989-02-01 | 1990-08-01 | Donald S. Karanewsky | Combination of squalene synthetase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination |
| CA2016467A1 (en) | 1989-06-05 | 1990-12-05 | Martin Eisman | Method for treating peripheral atherosclerotic disease employing an hmg coa reductase inhibitor and/or a squalene synthetase inhibitor |
| EP0563730A3 (en) * | 1992-03-28 | 1994-07-27 | Hoechst Ag | Alkenylaminoalkylene phosphonic acid esters and process for the preparation of copolymers comprising alkenylaminoalkylene phosphonates and ethylenic unsaturated compounds |
| US5278153A (en) * | 1992-05-18 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method |
| US5719303A (en) | 1993-03-08 | 1998-02-17 | Eisai Co., Ltd. | Phosphonic acid derivatives |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5508342A (en) * | 1994-02-01 | 1996-04-16 | The United States Of America As Represented By The Secretary Of Commerce | Polymeric amorphous calcium phosphate compositions |
| US5618851A (en) * | 1995-02-06 | 1997-04-08 | Arch Development Corp. | Grafted methylenediphosphonate ion exchange resins |
| AU2003218270A1 (en) | 2002-03-19 | 2003-10-08 | Genzyme Corporation | Phosphate transport inhibitors |
-
2003
- 2003-03-19 AU AU2003218270A patent/AU2003218270A1/en not_active Abandoned
- 2003-03-19 EP EP03714264A patent/EP1485391B1/en not_active Expired - Lifetime
- 2003-03-19 WO PCT/US2003/008449 patent/WO2003080630A2/en not_active Ceased
- 2003-03-19 AT AT03714264T patent/ATE337326T1/de not_active IP Right Cessation
- 2003-03-19 DE DE60307799T patent/DE60307799T2/de not_active Expired - Lifetime
- 2003-03-19 JP JP2003578384A patent/JP4465193B2/ja not_active Expired - Fee Related
- 2003-03-19 US US10/392,280 patent/US7109184B2/en not_active Expired - Lifetime
-
2006
- 2006-05-22 US US11/438,679 patent/US7754200B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005520864A5 (OSRAM) | ||
| RU2008152087A (ru) | Макроциклические оксимильные ингибиторы протеазы гепатита | |
| JP2004516314A5 (OSRAM) | ||
| JP2011530500A5 (OSRAM) | ||
| JP2007536393A5 (OSRAM) | ||
| JP2005504789A5 (OSRAM) | ||
| JP2012512891A5 (OSRAM) | ||
| JP2008525416A5 (OSRAM) | ||
| JP2007502845A5 (OSRAM) | ||
| JP2008523069A5 (OSRAM) | ||
| JP2008505117A5 (OSRAM) | ||
| JP2013503905A5 (OSRAM) | ||
| JP2008533191A5 (OSRAM) | ||
| JP2015501292A5 (OSRAM) | ||
| JP2009535307A5 (OSRAM) | ||
| RU2003122190A (ru) | Производные тетрагидропиридина, их получение и применение в качестве ингибиторов клеточной пролиферации | |
| EP1826196A3 (en) | Vinyl ether compounds | |
| JP2010513498A5 (OSRAM) | ||
| JP2008536833A5 (OSRAM) | ||
| TW200600983A (en) | Rinse solution for lithography | |
| JP2006503143A5 (OSRAM) | ||
| JP2010535706A5 (OSRAM) | ||
| RU2019113149A (ru) | Низкомолекулярные активаторы амфк | |
| JP2021504302A5 (OSRAM) | ||
| JP2011526896A5 (OSRAM) |