JP2005518801A - 組換えプロテインcバリアント - Google Patents

組換えプロテインcバリアント Download PDF

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Publication number
JP2005518801A
JP2005518801A JP2003572502A JP2003572502A JP2005518801A JP 2005518801 A JP2005518801 A JP 2005518801A JP 2003572502 A JP2003572502 A JP 2003572502A JP 2003572502 A JP2003572502 A JP 2003572502A JP 2005518801 A JP2005518801 A JP 2005518801A
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JP
Japan
Prior art keywords
variant
protein
apc
amino acid
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003572502A
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English (en)
Japanese (ja)
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JP2005518801A5 (enExample
Inventor
ダールベク,ビヨルン
Original Assignee
テイ・エイ・シー・スロムボシス・アンド・コアグラシヨン・アクテイエボラーク
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Application filed by テイ・エイ・シー・スロムボシス・アンド・コアグラシヨン・アクテイエボラーク filed Critical テイ・エイ・シー・スロムボシス・アンド・コアグラシヨン・アクテイエボラーク
Publication of JP2005518801A publication Critical patent/JP2005518801A/ja
Publication of JP2005518801A5 publication Critical patent/JP2005518801A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6464Protein C (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003572502A 2002-03-01 2003-02-28 組換えプロテインcバリアント Pending JP2005518801A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36018102P 2002-03-01 2002-03-01
US40104202P 2002-08-06 2002-08-06
PCT/SE2003/000331 WO2003073980A2 (en) 2002-03-01 2003-02-28 Recombinant protein c variants

Publications (2)

Publication Number Publication Date
JP2005518801A true JP2005518801A (ja) 2005-06-30
JP2005518801A5 JP2005518801A5 (enExample) 2006-05-18

Family

ID=27791634

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003572502A Pending JP2005518801A (ja) 2002-03-01 2003-02-28 組換えプロテインcバリアント

Country Status (6)

Country Link
US (1) US20050176083A1 (enExample)
EP (1) EP1483380A2 (enExample)
JP (1) JP2005518801A (enExample)
AU (1) AU2003212739B2 (enExample)
CA (1) CA2477876A1 (enExample)
WO (1) WO2003073980A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008048646A1 (en) * 2006-10-18 2008-04-24 Socratech L.L.C. Use of human protein c with altered glycosylation and sialic acid content as a medicament
EP2242875A4 (en) * 2008-01-15 2012-04-04 Univ British Columbia PROTEIN-C-RS2069915 AS RESPONSE PREDICTOR FOR SURVIVAL RATE AND ADMINISTRATION OF AN ACTIVATED PROTEIN-C OR PROTEIN-C-SIMILAR COMPOUND
WO2012068519A2 (en) 2010-11-19 2012-05-24 Sirius Genomics Inc. Markers associated with response to activated protein c administration, and uses thereof
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9701228D0 (sv) * 1997-04-03 1997-04-03 Bjoern Dahlbaeck Rekombinanta protein-C-och protein-S-varianter
US6017882A (en) * 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
CA2391651A1 (en) * 1999-11-19 2001-05-25 Eli Lilly And Company Protein c derivatives
EP1255821B1 (en) * 2000-02-02 2004-12-29 Eli Lilly And Company Protein c derivatives

Also Published As

Publication number Publication date
AU2003212739B2 (en) 2008-01-17
AU2003212739A1 (en) 2003-09-16
US20050176083A1 (en) 2005-08-11
CA2477876A1 (en) 2003-09-12
EP1483380A2 (en) 2004-12-08
WO2003073980A3 (en) 2003-11-27
WO2003073980A2 (en) 2003-09-12

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