CA2477876A1 - Recombinant protein c variants - Google Patents
Recombinant protein c variants Download PDFInfo
- Publication number
- CA2477876A1 CA2477876A1 CA002477876A CA2477876A CA2477876A1 CA 2477876 A1 CA2477876 A1 CA 2477876A1 CA 002477876 A CA002477876 A CA 002477876A CA 2477876 A CA2477876 A CA 2477876A CA 2477876 A1 CA2477876 A1 CA 2477876A1
- Authority
- CA
- Canada
- Prior art keywords
- apc
- protein
- variant
- component
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36018102P | 2002-03-01 | 2002-03-01 | |
| US60/360,181 | 2002-03-01 | ||
| US40104202P | 2002-08-06 | 2002-08-06 | |
| US60/401,042 | 2002-08-06 | ||
| PCT/SE2003/000331 WO2003073980A2 (en) | 2002-03-01 | 2003-02-28 | Recombinant protein c variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2477876A1 true CA2477876A1 (en) | 2003-09-12 |
Family
ID=27791634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002477876A Abandoned CA2477876A1 (en) | 2002-03-01 | 2003-02-28 | Recombinant protein c variants |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050176083A1 (enExample) |
| EP (1) | EP1483380A2 (enExample) |
| JP (1) | JP2005518801A (enExample) |
| AU (1) | AU2003212739B2 (enExample) |
| CA (1) | CA2477876A1 (enExample) |
| WO (1) | WO2003073980A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008048646A1 (en) * | 2006-10-18 | 2008-04-24 | Socratech L.L.C. | Use of human protein c with altered glycosylation and sialic acid content as a medicament |
| EP2242875A4 (en) * | 2008-01-15 | 2012-04-04 | Univ British Columbia | PROTEIN-C-RS2069915 AS RESPONSE PREDICTOR FOR SURVIVAL RATE AND ADMINISTRATION OF AN ACTIVATED PROTEIN-C OR PROTEIN-C-SIMILAR COMPOUND |
| WO2012068519A2 (en) | 2010-11-19 | 2012-05-24 | Sirius Genomics Inc. | Markers associated with response to activated protein c administration, and uses thereof |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9701228D0 (sv) * | 1997-04-03 | 1997-04-03 | Bjoern Dahlbaeck | Rekombinanta protein-C-och protein-S-varianter |
| US6017882A (en) * | 1997-10-23 | 2000-01-25 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| CA2391651A1 (en) * | 1999-11-19 | 2001-05-25 | Eli Lilly And Company | Protein c derivatives |
| EP1255821B1 (en) * | 2000-02-02 | 2004-12-29 | Eli Lilly And Company | Protein c derivatives |
-
2003
- 2003-02-28 AU AU2003212739A patent/AU2003212739B2/en not_active Ceased
- 2003-02-28 US US10/506,080 patent/US20050176083A1/en not_active Abandoned
- 2003-02-28 JP JP2003572502A patent/JP2005518801A/ja active Pending
- 2003-02-28 CA CA002477876A patent/CA2477876A1/en not_active Abandoned
- 2003-02-28 WO PCT/SE2003/000331 patent/WO2003073980A2/en not_active Ceased
- 2003-02-28 EP EP03708766A patent/EP1483380A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003212739B2 (en) | 2008-01-17 |
| AU2003212739A1 (en) | 2003-09-16 |
| US20050176083A1 (en) | 2005-08-11 |
| JP2005518801A (ja) | 2005-06-30 |
| EP1483380A2 (en) | 2004-12-08 |
| WO2003073980A3 (en) | 2003-11-27 |
| WO2003073980A2 (en) | 2003-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |