JP2005518183A5 - - Google Patents

Info

Publication number

JP2005518183A5

JP2005518183A5 JP2002579493A JP2002579493A JP2005518183A5 JP 2005518183 A5 JP2005518183 A5 JP 2005518183A5 JP 2002579493 A JP2002579493 A JP 2002579493A JP 2002579493 A JP2002579493 A JP 2002579493A JP 2005518183 A5 JP2005518183 A5 JP 2005518183A5

Authority

JP

Japan

Prior art keywords

seq

variant

polypeptide

amino acid

variant according

Prior art date

2002-04-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 claims 22
• 102000004196 processed proteins & peptides Human genes 0.000 claims 22
• 108090000765 processed proteins & peptides Proteins 0.000 claims 22
• 102220224485 rs1060502686 Human genes 0.000 claims 17
• 102000008070 Interferon-gamma Human genes 0.000 claims 16
• 108010074328 Interferon-gamma Proteins 0.000 claims 16
• 238000006467 substitution reaction Methods 0.000 claims 13
• 230000004988 N-glycosylation Effects 0.000 claims 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 11
• 238000000034 method Methods 0.000 claims 11
• 102220529221 E3 ubiquitin-protein ligase RBX1_N59C_mutation Human genes 0.000 claims 9
• 102220485938 Probable ATP-dependent RNA helicase DHX34_K94R_mutation Human genes 0.000 claims 9
• 125000000539 amino acid group Chemical group 0.000 claims 8
• 102220040657 rs199773433 Human genes 0.000 claims 8
• 102220045873 rs587782462 Human genes 0.000 claims 8
• 210000004027 cell Anatomy 0.000 claims 6
• 239000002773 nucleotide Substances 0.000 claims 6
• 125000003729 nucleotide group Chemical group 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 5
• 229960003130 interferon gamma Drugs 0.000 claims 5
• 230000004048 modification Effects 0.000 claims 5
• 238000012986 modification Methods 0.000 claims 5
• 102200156642 c.77G>C Human genes 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 238000012258 culturing Methods 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 230000035772 mutation Effects 0.000 claims 3
• 102200115810 rs1800458 Human genes 0.000 claims 3
• 208000029523 Interstitial Lung disease Diseases 0.000 claims 2
• 102220594719 Neurogenic differentiation factor 6_G26H_mutation Human genes 0.000 claims 2
• 102220537319 Protein NDRG2_G26K_mutation Human genes 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 230000013595 glycosylation Effects 0.000 claims 2
• 238000006206 glycosylation reaction Methods 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 229920000642 polymer Polymers 0.000 claims 2
• 102200060083 rs140825795 Human genes 0.000 claims 2
• 102220264038 rs1554569664 Human genes 0.000 claims 2
• 102200082935 rs34404985 Human genes 0.000 claims 2
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
• 125000005647 linker group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 102220050188 rs146793243 Human genes 0.000 claims 1
• 102220036871 rs587780095 Human genes 0.000 claims 1
• 102220165167 rs772221026 Human genes 0.000 claims 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1