JP2005517657A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005517657A5 JP2005517657A5 JP2003552758A JP2003552758A JP2005517657A5 JP 2005517657 A5 JP2005517657 A5 JP 2005517657A5 JP 2003552758 A JP2003552758 A JP 2003552758A JP 2003552758 A JP2003552758 A JP 2003552758A JP 2005517657 A5 JP2005517657 A5 JP 2005517657A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- compound according
- compound
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- -1 1-azabicyclo [2.2.2] oct-3-yl Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000008447 perception Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003828 azulenyl group Chemical group 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 150000001602 bicycloalkyls Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10162375.5 | 2001-12-19 | ||
| DE10162375A DE10162375A1 (de) | 2001-12-19 | 2001-12-19 | Bicyclische N-Aryl-amide |
| PCT/EP2002/013835 WO2003051874A1 (de) | 2001-12-19 | 2002-12-06 | Bicyclische n-arylamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005517657A JP2005517657A (ja) | 2005-06-16 |
| JP2005517657A5 true JP2005517657A5 (https=) | 2006-01-26 |
| JP4690651B2 JP4690651B2 (ja) | 2011-06-01 |
Family
ID=7709793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552758A Expired - Fee Related JP4690651B2 (ja) | 2001-12-19 | 2002-12-06 | 二環式ｎ−アリールアミド類 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7247728B2 (https=) |
| EP (1) | EP1458716B1 (https=) |
| JP (1) | JP4690651B2 (https=) |
| AU (1) | AU2002352221A1 (https=) |
| CA (1) | CA2470726C (https=) |
| DE (2) | DE10162375A1 (https=) |
| ES (1) | ES2274114T3 (https=) |
| WO (1) | WO2003051874A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| MXPA05003317A (es) * | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
| US20040157626A1 (en) * | 2003-02-10 | 2004-08-12 | Vincent Park | Paging methods and apparatus |
| US8196000B2 (en) * | 2003-04-02 | 2012-06-05 | Qualcomm Incorporated | Methods and apparatus for interleaving in a block-coherent communication system |
| US7434145B2 (en) * | 2003-04-02 | 2008-10-07 | Qualcomm Incorporated | Extracting soft information in a block-coherent communication system |
| DE10334724A1 (de) * | 2003-07-30 | 2005-02-24 | Bayer Healthcare Ag | N-Biarylamide |
| RU2389729C2 (ru) * | 2003-12-22 | 2010-05-20 | Мемори Фармасьютиклз Корпорейшн | 1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение |
| US7423164B2 (en) | 2003-12-31 | 2008-09-09 | Ut-Battelle, Llc | Synthesis of ionic liquids |
| EP1735306A2 (en) | 2004-03-25 | 2006-12-27 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| CA2567977A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| NZ551712A (en) * | 2004-05-07 | 2010-07-30 | Memory Pharm Corp | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| CA2591817A1 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| CN101312968A (zh) * | 2005-09-23 | 2008-11-26 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑、吡唑并吡啶、异噻唑并吡啶及其制备和用途 |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| LT2889033T (lt) | 2008-11-19 | 2018-07-10 | Forum Pharmaceuticals Inc. | Šizofrenijos negatyvių simptomų gydymas (r)-7-chlor-n-(chinuklidin-3-il)benzo[b]tiofen-2-karboksamidu ir jo farmaciniu požiūriu priimtinomis druskomis |
| JP5808319B2 (ja) * | 2009-05-11 | 2015-11-10 | フォルム ファーマシューティカルズ、インコーポレイテッド | アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療 |
| PE20170923A1 (es) | 2010-05-17 | 2017-07-12 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado |
| EP3461481A1 (en) | 2012-05-08 | 2019-04-03 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
| AU2015275730A1 (en) * | 2014-06-20 | 2016-12-15 | Aurigene Discovery Technologies Limited | Substituted indazole compounds as IRAK4 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605652A (en) | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| WO2002000653A2 (en) * | 2000-06-28 | 2002-01-03 | Bristol-Myers Squibb Company | Fused cyclic compounds as modulators of nuclear hormone receptor function |
| DE20013068U1 (de) * | 2000-07-27 | 2001-11-29 | AUTEFA Automation GmbH, 86316 Friedberg | Fördereinrichtung für Kannen in einem Kannenlager |
-
2001
- 2001-12-19 DE DE10162375A patent/DE10162375A1/de not_active Withdrawn
-
2002
- 2002-12-06 WO PCT/EP2002/013835 patent/WO2003051874A1/de not_active Ceased
- 2002-12-06 EP EP02787913A patent/EP1458716B1/de not_active Expired - Lifetime
- 2002-12-06 DE DE50208287T patent/DE50208287D1/de not_active Expired - Lifetime
- 2002-12-06 JP JP2003552758A patent/JP4690651B2/ja not_active Expired - Fee Related
- 2002-12-06 CA CA2470726A patent/CA2470726C/en not_active Expired - Fee Related
- 2002-12-06 ES ES02787913T patent/ES2274114T3/es not_active Expired - Lifetime
- 2002-12-06 AU AU2002352221A patent/AU2002352221A1/en not_active Abandoned
- 2002-12-06 US US10/497,511 patent/US7247728B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005517657A5 (https=) | ||
| CA2470726A1 (en) | Bicyclic n-arylamides | |
| JP5290185B2 (ja) | 置換３−イソブチル−９，１０−ジメトキシ−１，３，４，６，７，１１ｂ−ヘキサヒドロ−２Ｈ−ピリド［２，１−ａ］イソキノリン−２−オール化合物およびそれに関連する方法 | |
| CA2479103A1 (en) | 1-azabicyclic n-biarylamides with affinity for the alpha7 nicotinic acetylcholine receptor | |
| JP2006514626A5 (https=) | ||
| JP2006500370A5 (https=) | ||
| TWI363057B (en) | Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide | |
| WO2002016357A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| WO2002016358A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| ATE361287T1 (de) | Neue indol-2-on derivate | |
| EA012110B1 (ru) | Пирролодигидроизохинолины как ингибиторы pde10 | |
| WO2002016356A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| JP2006502119A5 (https=) | ||
| JP2005511698A5 (https=) | ||
| JP2009538910A5 (https=) | ||
| JP2010532387A5 (https=) | ||
| JP2012513390A5 (https=) | ||
| JP2023522177A5 (https=) | ||
| WO2004094418A8 (en) | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity | |
| Pettit et al. | Antineoplastic agents 491.1 synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine | |
| CA2479097A1 (en) | Amides of acetic and propionic acids | |
| JP2004529953A5 (https=) | ||
| Dhara et al. | Synthetic Strategies for the Regioselective Functionalization of Tribenzotriquinacenes | |
| JPH05506216A (ja) | 医薬としてのピリジン | |
| JP2005502636A5 (https=) |