JP2005517635A5 - - Google Patents
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- Publication number
- JP2005517635A5 JP2005517635A5 JP2003541840A JP2003541840A JP2005517635A5 JP 2005517635 A5 JP2005517635 A5 JP 2005517635A5 JP 2003541840 A JP2003541840 A JP 2003541840A JP 2003541840 A JP2003541840 A JP 2003541840A JP 2005517635 A5 JP2005517635 A5 JP 2005517635A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- use according
- hydrazide
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003118 aryl group Chemical group 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- 230000032770 biofilm formation Effects 0.000 claims 16
- 230000001629 suppression Effects 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 14
- 229910005965 SO 2 Inorganic materials 0.000 claims 11
- -1 NR 4 Inorganic materials 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 239000003242 anti bacterial agent Substances 0.000 claims 8
- 230000003373 anti-fouling effect Effects 0.000 claims 8
- 239000011248 coating agent Substances 0.000 claims 8
- 238000000576 coating method Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000005191 hydroxyalkylamino group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 125000000547 substituted alkyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 230000005540 biological transmission Effects 0.000 claims 4
- 238000004140 cleaning Methods 0.000 claims 4
- 230000007613 environmental effect Effects 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- LKVFCSWBKOVHAH-UHFFFAOYSA-N 4-Ethoxyphenol Chemical compound CCOC1=CC=C(O)C=C1 LKVFCSWBKOVHAH-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000589513 Burkholderia cepacia Species 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 239000003139 biocide Substances 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 239000000498 cooling water Substances 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229940127554 medical product Drugs 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 claims 2
- 230000007923 virulence factor Effects 0.000 claims 2
- 239000000304 virulence factor Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NWCRHGKLQGJSHU-UHFFFAOYSA-N 1-(3-bromo-4-chlorophenyl)-3-(thiophene-2-carbonylamino)urea Chemical compound C1=C(Br)C(Cl)=CC=C1NC(=O)NNC(=O)C1=CC=CS1 NWCRHGKLQGJSHU-UHFFFAOYSA-N 0.000 claims 1
- WYDHONZWGITXDK-UHFFFAOYSA-N 1-(3-chlorophenyl)-3-(thiophene-2-carbonylamino)urea Chemical compound ClC1=CC=CC(NC(=O)NNC(=O)C=2SC=CC=2)=C1 WYDHONZWGITXDK-UHFFFAOYSA-N 0.000 claims 1
- ZHTLSBATHZSNQU-UHFFFAOYSA-N 1-(4-methylphenyl)-3-(thiophene-2-carbonylamino)urea Chemical compound C1=CC(C)=CC=C1NC(=O)NNC(=O)C1=CC=CS1 ZHTLSBATHZSNQU-UHFFFAOYSA-N 0.000 claims 1
- VHPVACPJTROCHA-UHFFFAOYSA-N 1-phenyl-3-(thiophene-2-carbonylamino)urea Chemical compound C=1C=CC=CC=1NC(=O)NNC(=O)C1=CC=CS1 VHPVACPJTROCHA-UHFFFAOYSA-N 0.000 claims 1
- KOPFEFZSAMLEHK-UHFFFAOYSA-N 1h-pyrazole-5-carboxylic acid Chemical compound OC(=O)C=1C=CNN=1 KOPFEFZSAMLEHK-UHFFFAOYSA-N 0.000 claims 1
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 claims 1
- SDWZNSDRIKUBDL-UHFFFAOYSA-N 2-ethyl-5-methyl-n-(2-methylpyrazol-3-yl)-4-nitropyrazole-3-carboxamide Chemical compound CCN1N=C(C)C([N+]([O-])=O)=C1C(=O)NC1=CC=NN1C SDWZNSDRIKUBDL-UHFFFAOYSA-N 0.000 claims 1
- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 claims 1
- ZPRYNXKSYQQKEN-UHFFFAOYSA-N 3-chloro-4-methyl-n'-(thiophene-2-carbonyl)thiophene-2-carbohydrazide Chemical compound CC1=CSC(C(=O)NNC(=O)C=2SC=CC=2)=C1Cl ZPRYNXKSYQQKEN-UHFFFAOYSA-N 0.000 claims 1
- VJIOMBMUZCYCMZ-UHFFFAOYSA-N 3-chloro-n'-(thiophene-2-carbonyl)thiophene-2-carbohydrazide Chemical compound C1=CSC(C(=O)NNC(=O)C=2SC=CC=2)=C1Cl VJIOMBMUZCYCMZ-UHFFFAOYSA-N 0.000 claims 1
- YRUVNMHNVOFZTM-UHFFFAOYSA-N 4-butyl-n'-(4-butylthiophene-2-carbonyl)thiophene-2-carbohydrazide Chemical compound CCCCC1=CSC(C(=O)NNC(=O)C=2SC=C(CCCC)C=2)=C1 YRUVNMHNVOFZTM-UHFFFAOYSA-N 0.000 claims 1
- SUJPOGCFLVSXOZ-UHFFFAOYSA-N 5-bromo-n'-(thiophene-2-carbonyl)furan-2-carbohydrazide Chemical compound O1C(Br)=CC=C1C(=O)NNC(=O)C1=CC=CS1 SUJPOGCFLVSXOZ-UHFFFAOYSA-N 0.000 claims 1
- XVPVQUGDFAWLKO-UHFFFAOYSA-N 5-bromo-n'-(thiophene-2-carbonyl)thiophene-2-carbohydrazide Chemical compound S1C(Br)=CC=C1C(=O)NNC(=O)C1=CC=CS1 XVPVQUGDFAWLKO-UHFFFAOYSA-N 0.000 claims 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- PULQQRHHMZFIQG-UHFFFAOYSA-N 5-nitro-n'-(thiophene-2-carbonyl)thiophene-2-carbohydrazide Chemical compound S1C([N+](=O)[O-])=CC=C1C(=O)NNC(=O)C1=CC=CS1 PULQQRHHMZFIQG-UHFFFAOYSA-N 0.000 claims 1
- FYWKMBRPROCTTO-UHFFFAOYSA-N CC1(CC(=CC=C1Cl)NC(=O)NNC(=O)C=1SC=CC1)Cl Chemical compound CC1(CC(=CC=C1Cl)NC(=O)NNC(=O)C=1SC=CC1)Cl FYWKMBRPROCTTO-UHFFFAOYSA-N 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- KCYCNAKUKAQKKO-UHFFFAOYSA-N n'-(thiophene-2-carbonyl)furan-2-carbohydrazide Chemical compound C=1C=COC=1C(=O)NNC(=O)C1=CC=CS1 KCYCNAKUKAQKKO-UHFFFAOYSA-N 0.000 claims 1
- FBOFFEXPCHQWDX-UHFFFAOYSA-N n'-(thiophene-2-carbonyl)thiophene-2-carbohydrazide Chemical compound C=1C=CSC=1C(=O)NNC(=O)C1=CC=CS1 FBOFFEXPCHQWDX-UHFFFAOYSA-N 0.000 claims 1
- IQXBKZZSCIJSEJ-UHFFFAOYSA-N n-(2-methylpyrazol-3-yl)pyrazole-1-carboxamide Chemical compound CN1N=CC=C1NC(=O)N1N=CC=C1 IQXBKZZSCIJSEJ-UHFFFAOYSA-N 0.000 claims 1
- YNIKVCVLZNDSLU-UHFFFAOYSA-N n-methyl-n'-(thiophene-2-carbonyl)-1h-pyrazole-5-carbohydrazide Chemical compound C=1C=NNC=1C(=O)N(C)NC(=O)C1=CC=CS1 YNIKVCVLZNDSLU-UHFFFAOYSA-N 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2001/012875 WO2003039529A1 (en) | 2001-11-07 | 2001-11-07 | Selective antibacterial agents |
| US10/094,301 US20030105143A1 (en) | 2001-11-07 | 2002-03-08 | Selective antibacterial agents |
| PCT/EP2002/011760 WO2003039549A2 (en) | 2001-11-07 | 2002-10-21 | Selective antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517635A JP2005517635A (ja) | 2005-06-16 |
| JP2005517635A5 true JP2005517635A5 (enExample) | 2005-12-22 |
Family
ID=39817145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003541840A Pending JP2005517635A (ja) | 2001-11-07 | 2002-10-21 | 選択的な抗菌剤 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1478364B1 (enExample) |
| JP (1) | JP2005517635A (enExample) |
| CA (1) | CA2464757A1 (enExample) |
| WO (1) | WO2003039549A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1475092A1 (en) * | 2003-05-06 | 2004-11-10 | 4Sc Ag | Blockers of the quorum sensing system of Gram-negative bacteria |
| US7335779B2 (en) | 2002-03-08 | 2008-02-26 | Quonova, Llc | Modulation of pathogenicity |
| US7338969B2 (en) | 2002-03-08 | 2008-03-04 | Quonova, Llc | Modulation of pathogenicity |
| BR0215767A (pt) * | 2002-07-04 | 2005-03-15 | Aventis Pharma Sa | Novos derivados acil hidrazino de tiofeno, o repectivo processo de preparação, a respectiva aplicação a tìtulo de medicamentos, composições farmacêuticas e nova utilização |
| EP1667983A4 (en) * | 2003-09-23 | 2010-07-21 | Merck Sharp & Dohme | PYRAZOL MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS |
| TW200633998A (en) * | 2004-12-08 | 2006-10-01 | Nissan Chemical Ind Ltd | Substituted heterocyclic compounds and thrombopoietin receptor activators |
| JP2010533562A (ja) * | 2007-07-16 | 2010-10-28 | シー．アール．バード，インコーポレイテッド | 滅菌バリヤを備えたフォリイ・カテーテル |
| JP5736308B2 (ja) | 2009-06-22 | 2015-06-17 | 住友重機械工業株式会社 | 微生物活性向上剤、微生物活性向上方法及び生物学的廃棄物処理方法 |
| US8624063B2 (en) | 2009-06-30 | 2014-01-07 | Wisconsin Alumni Research Foundation | Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing |
| US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
| US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
| US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
| US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
| US10631984B2 (en) | 2015-12-15 | 2020-04-28 | Neovasc Tiara Inc. | Transseptal delivery system |
| CA3007670C (en) | 2016-01-29 | 2024-09-17 | Neovasc Tiara Inc. | PROSTHETIC VALVE PREVENTING OBSTRUCTION THAT WOULD PREVENT FLOW |
| AU2017361296B2 (en) | 2016-11-21 | 2022-09-29 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
| WO2019036810A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT |
| US10526278B2 (en) | 2017-10-19 | 2020-01-07 | Wisconsin Alumni Research Foundation | Inhibitors of quorum sensing receptor LasR |
| AU2019374743B2 (en) | 2018-11-08 | 2022-03-03 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
| EP3934591A4 (en) | 2019-03-08 | 2022-11-23 | Neovasc Tiara Inc. | RETRIEVABLE PROSTHETIC RELEASE SYSTEM |
| EP3946163B1 (en) | 2019-04-01 | 2025-08-20 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
| AU2020271896B2 (en) | 2019-04-10 | 2022-10-13 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
| CN114025813B (zh) | 2019-05-20 | 2024-05-14 | 内奥瓦斯克迪亚拉公司 | 具有止血机构的引入器 |
| AU2020295566B2 (en) | 2019-06-20 | 2023-07-20 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69836218T2 (de) | 1997-06-18 | 2007-09-06 | Montana State University - Bozeman | Homoserinlactone zum regulieren von biofilmen und methoden zur anwendung |
| GB9725599D0 (en) | 1997-12-04 | 1998-02-04 | Univ Nottingham | Control of biofilm formation |
| WO2001085664A2 (en) | 2000-05-10 | 2001-11-15 | Princeton University | Compounds and methods for regulating bacterial growth and pathogenesis |
-
2002
- 2002-10-21 WO PCT/EP2002/011760 patent/WO2003039549A2/en not_active Ceased
- 2002-10-21 EP EP02802626A patent/EP1478364B1/en not_active Expired - Lifetime
- 2002-10-21 JP JP2003541840A patent/JP2005517635A/ja active Pending
- 2002-10-21 CA CA002464757A patent/CA2464757A1/en not_active Abandoned
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