JP2005517442A5 - - Google Patents
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- Publication number
- JP2005517442A5 JP2005517442A5 JP2003569817A JP2003569817A JP2005517442A5 JP 2005517442 A5 JP2005517442 A5 JP 2005517442A5 JP 2003569817 A JP2003569817 A JP 2003569817A JP 2003569817 A JP2003569817 A JP 2003569817A JP 2005517442 A5 JP2005517442 A5 JP 2005517442A5
- Authority
- JP
- Japan
- Prior art keywords
- enone reductase
- microorganism
- molecular weight
- producing
- optimal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 8
- 244000005700 microbiome Species 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 claims 4
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- AYJXHIDNNLJQDT-UHFFFAOYSA-N 2,6,6-Trimethyl-2-cyclohexene-1,4-dione Chemical compound CC1=CC(=O)CC(C)(C)C1=O AYJXHIDNNLJQDT-UHFFFAOYSA-N 0.000 claims 2
- HVHHZSFNAYSPSA-ZCFIWIBFSA-N levodione Chemical compound C[C@@H]1CC(=O)CC(C)(C)C1=O HVHHZSFNAYSPSA-ZCFIWIBFSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02003967 | 2002-02-22 | ||
| PCT/EP2003/001473 WO2003070924A1 (en) | 2002-02-22 | 2003-02-14 | Enone reductase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517442A JP2005517442A (ja) | 2005-06-16 |
| JP2005517442A5 true JP2005517442A5 (enExample) | 2005-12-22 |
Family
ID=27741105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569817A Pending JP2005517442A (ja) | 2002-02-22 | 2003-02-14 | エノン還元酵素 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7202068B2 (enExample) |
| EP (1) | EP1476544B1 (enExample) |
| JP (1) | JP2005517442A (enExample) |
| KR (1) | KR20040088511A (enExample) |
| CN (1) | CN100523179C (enExample) |
| AT (1) | ATE382081T1 (enExample) |
| AU (1) | AU2003210271A1 (enExample) |
| CA (1) | CA2474780A1 (enExample) |
| DE (1) | DE60318297T2 (enExample) |
| WO (1) | WO2003070924A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004027065A2 (en) * | 2002-09-23 | 2004-04-01 | Dsm Ip Assets B.V. | Enone reductase gene and microbial production of levodione |
| SG172783A1 (en) | 2008-12-25 | 2011-08-29 | Codexis Inc | Enone reductases |
| CN102559553B (zh) * | 2012-01-08 | 2013-06-05 | 中国科学院成都生物研究所 | 一株无色杆菌及其不对称催化还原碳碳双键的方法 |
| CN112143764B (zh) * | 2020-09-24 | 2022-04-19 | 奥锐特药业股份有限公司 | 一种生物酶催化制备布瓦西坦中间体化合物的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072715A (en) * | 1974-08-21 | 1978-02-07 | Hoffmann-La Roche Inc. | Optically active cyclohexane derivatives |
| ATE541941T1 (de) * | 1999-08-02 | 2012-02-15 | Dsm Ip Assets Bv | Mikrobielle herstellung von levodione |
| EP1074630B1 (en) | 1999-08-02 | 2012-01-18 | DSM IP Assets B.V. | Microbial production of levodione |
| JP4688313B2 (ja) * | 2001-02-23 | 2011-05-25 | ダイセル化学工業株式会社 | 新規なエノン還元酵素、その製造方法、およびこれを利用したα，β−不飽和ケトンの炭素−炭素２重結合を選択的に還元する方法 |
-
2003
- 2003-02-14 JP JP2003569817A patent/JP2005517442A/ja active Pending
- 2003-02-14 DE DE60318297T patent/DE60318297T2/de not_active Expired - Lifetime
- 2003-02-14 CN CNB03804272XA patent/CN100523179C/zh not_active Expired - Fee Related
- 2003-02-14 EP EP03742454A patent/EP1476544B1/en not_active Expired - Lifetime
- 2003-02-14 US US10/505,396 patent/US7202068B2/en not_active Expired - Fee Related
- 2003-02-14 AT AT03742454T patent/ATE382081T1/de not_active IP Right Cessation
- 2003-02-14 AU AU2003210271A patent/AU2003210271A1/en not_active Abandoned
- 2003-02-14 KR KR10-2004-7013037A patent/KR20040088511A/ko not_active Withdrawn
- 2003-02-14 CA CA002474780A patent/CA2474780A1/en not_active Abandoned
- 2003-02-14 WO PCT/EP2003/001473 patent/WO2003070924A1/en not_active Ceased
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