JP2005515193A - Ｃｃｒ−３受容体に対する拮抗物質ｖｉｉｉとしてのｎ−ウレイド−ピペリジン - Google Patents
Ｃｃｒ−３受容体に対する拮抗物質ｖｉｉｉとしてのｎ−ウレイド−ピペリジン Download PDFInfo
- Publication number
- JP2005515193A JP2005515193A JP2003547387A JP2003547387A JP2005515193A JP 2005515193 A JP2005515193 A JP 2005515193A JP 2003547387 A JP2003547387 A JP 2003547387A JP 2003547387 A JP2003547387 A JP 2003547387A JP 2005515193 A JP2005515193 A JP 2005515193A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- chlorobenzyl
- piperidin
- compound
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 **C(N[C@@]1*COC1)=O Chemical compound **C(N[C@@]1*COC1)=O 0.000 description 13
- VPESQEWIPDEGSY-UHFFFAOYSA-N Clc1ccc(CC2CCNCC2)cc1 Chemical compound Clc1ccc(CC2CCNCC2)cc1 VPESQEWIPDEGSY-UHFFFAOYSA-N 0.000 description 2
- HBPXVUYFADPMTE-YTQDLUCQSA-N CC(N[C@H](CNC1)[C@@H]1N1CCC(Cc(cc2)ccc2Cl)CC1)NC(CC1OC)=CC(OC)=C1OC Chemical compound CC(N[C@H](CNC1)[C@@H]1N1CCC(Cc(cc2)ccc2Cl)CC1)NC(CC1OC)=CC(OC)=C1OC HBPXVUYFADPMTE-YTQDLUCQSA-N 0.000 description 1
- DTAFFRBRSKYSKS-UHFFFAOYSA-N CS(c1cc(N=O)ccc1)(=O)=O Chemical compound CS(c1cc(N=O)ccc1)(=O)=O DTAFFRBRSKYSKS-UHFFFAOYSA-N 0.000 description 1
- KPMGJZBMHSQWPS-YPJJGMIRSA-N CS(c1cc(NC(NC(CCCC2)[C@@H]2N2CC=C(Cc3ccc(C4CCC4)cc3)CC2)=O)ccc1)(=O)=O Chemical compound CS(c1cc(NC(NC(CCCC2)[C@@H]2N2CC=C(Cc3ccc(C4CCC4)cc3)CC2)=O)ccc1)(=O)=O KPMGJZBMHSQWPS-YPJJGMIRSA-N 0.000 description 1
- GQACHRPIDDZDMB-QNSVNVJESA-N N[C@H](CCCC1)C1N1CCC(Cc(cc2)ccc2Cl)CC1 Chemical compound N[C@H](CCCC1)C1N1CCC(Cc(cc2)ccc2Cl)CC1 GQACHRPIDDZDMB-QNSVNVJESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33465301P | 2001-11-30 | 2001-11-30 | |
| PCT/EP2002/013218 WO2003045937A1 (en) | 2001-11-30 | 2002-11-25 | N-ureido-piperidines as antagonists viii for ccr-3 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005515193A true JP2005515193A (ja) | 2005-05-26 |
| JP2005515193A5 JP2005515193A5 (https=) | 2005-12-22 |
Family
ID=23308166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547387A Pending JP2005515193A (ja) | 2001-11-30 | 2002-11-25 | Ｃｃｒ−３受容体に対する拮抗物質ｖｉｉｉとしてのｎ−ウレイド−ピペリジン |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1453825A1 (https=) |
| JP (1) | JP2005515193A (https=) |
| KR (1) | KR100652450B1 (https=) |
| CN (1) | CN1286831C (https=) |
| AR (1) | AR037458A1 (https=) |
| AU (1) | AU2002352123A1 (https=) |
| BR (1) | BR0214613A (https=) |
| CA (1) | CA2467874A1 (https=) |
| MX (1) | MXPA04005176A (https=) |
| PL (1) | PL370821A1 (https=) |
| RU (1) | RU2004120064A (https=) |
| WO (1) | WO2003045937A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006508948A (ja) * | 2002-10-30 | 2006-03-16 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のヘテロアリールピペリジンモジュレーター |
| JP2016521682A (ja) * | 2013-05-22 | 2016-07-25 | シーカ・テクノロジー・アーゲー | ヒドロキシシラン及びシラン基含有ポリマー |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1640361B9 (en) * | 2003-06-30 | 2015-11-04 | Sumitomo Chemical Company, Limited | Asymmetric urea compounds and process for producing asymmetric compounds by asymmetric conjugate addition reaction using the same as catalyst |
| WO2005058805A1 (ja) * | 2003-12-17 | 2005-06-30 | Sumitomo Chemical Company, Limited | 光学活性アミン化合物の製造方法 |
| WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006071875A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69926806D1 (de) * | 1998-12-18 | 2005-09-22 | Bristol Myers Squibb Pharma Co | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren |
-
2002
- 2002-11-25 WO PCT/EP2002/013218 patent/WO2003045937A1/en not_active Ceased
- 2002-11-25 BR BR0214613-4A patent/BR0214613A/pt not_active IP Right Cessation
- 2002-11-25 RU RU2004120064/04A patent/RU2004120064A/ru not_active Application Discontinuation
- 2002-11-25 CN CNB028239784A patent/CN1286831C/zh not_active Expired - Fee Related
- 2002-11-25 EP EP02787796A patent/EP1453825A1/en not_active Withdrawn
- 2002-11-25 KR KR1020047008357A patent/KR100652450B1/ko not_active Expired - Fee Related
- 2002-11-25 PL PL02370821A patent/PL370821A1/xx not_active Application Discontinuation
- 2002-11-25 MX MXPA04005176A patent/MXPA04005176A/es active IP Right Grant
- 2002-11-25 AU AU2002352123A patent/AU2002352123A1/en not_active Abandoned
- 2002-11-25 JP JP2003547387A patent/JP2005515193A/ja active Pending
- 2002-11-25 CA CA002467874A patent/CA2467874A1/en not_active Abandoned
- 2002-11-28 AR ARP020104581A patent/AR037458A1/es not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006508948A (ja) * | 2002-10-30 | 2006-03-16 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のヘテロアリールピペリジンモジュレーター |
| JP2016521682A (ja) * | 2013-05-22 | 2016-07-25 | シーカ・テクノロジー・アーゲー | ヒドロキシシラン及びシラン基含有ポリマー |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2467874A1 (en) | 2003-06-05 |
| EP1453825A1 (en) | 2004-09-08 |
| AR037458A1 (es) | 2004-11-10 |
| AU2002352123A1 (en) | 2003-06-10 |
| CN1286831C (zh) | 2006-11-29 |
| KR20040062665A (ko) | 2004-07-07 |
| CN1599733A (zh) | 2005-03-23 |
| WO2003045937A1 (en) | 2003-06-05 |
| RU2004120064A (ru) | 2006-01-10 |
| MXPA04005176A (es) | 2004-08-11 |
| PL370821A1 (en) | 2005-05-30 |
| BR0214613A (pt) | 2004-09-14 |
| KR100652450B1 (ko) | 2007-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080527 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090217 |