KR100652450B1 - Ｃｃｒ-3 수용체에 대한 길항제 ⅷ로서의ｎ-우레이도-피페리딘 - Google Patents
Ｃｃｒ-3 수용체에 대한 길항제 ⅷ로서의ｎ-우레이도-피페리딘 Download PDFInfo
- Publication number
- KR100652450B1 KR100652450B1 KR1020047008357A KR20047008357A KR100652450B1 KR 100652450 B1 KR100652450 B1 KR 100652450B1 KR 1020047008357 A KR1020047008357 A KR 1020047008357A KR 20047008357 A KR20047008357 A KR 20047008357A KR 100652450 B1 KR100652450 B1 KR 100652450B1
- Authority
- KR
- South Korea
- Prior art keywords
- chlorobenzyl
- piperidin
- trans
- formula
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Nc1ccc(CC2CC*CC2)cc1 Chemical compound Nc1ccc(CC2CC*CC2)cc1 0.000 description 12
- VPESQEWIPDEGSY-UHFFFAOYSA-N Clc1ccc(CC2CCNCC2)cc1 Chemical compound Clc1ccc(CC2CCNCC2)cc1 VPESQEWIPDEGSY-UHFFFAOYSA-N 0.000 description 3
- SZSVDCAYAJSULK-FOIFJWKZSA-N COc(cc(cc1OC)NC(NC(CNC2)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1OC Chemical compound COc(cc(cc1OC)NC(NC(CNC2)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1OC SZSVDCAYAJSULK-FOIFJWKZSA-N 0.000 description 2
- DLLHRMLYGGVKIQ-UHFFFAOYSA-N COc(cc(cc1OC)N=O)c1OC Chemical compound COc(cc(cc1OC)N=O)c1OC DLLHRMLYGGVKIQ-UHFFFAOYSA-N 0.000 description 1
- MXWWYHJKXTWZLY-OZAIVSQSSA-N COc(cc(cc1OC)NC(NC(CN(C2)C(CC(O)=O)=O)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1OC Chemical compound COc(cc(cc1OC)NC(NC(CN(C2)C(CC(O)=O)=O)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1OC MXWWYHJKXTWZLY-OZAIVSQSSA-N 0.000 description 1
- XPJRBNKCIXSAIR-PKTZIBPZSA-N COc(cc(cc1OC)NC(N[C@H](CCC2)[C@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1OC Chemical compound COc(cc(cc1OC)NC(N[C@H](CCC2)[C@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1OC XPJRBNKCIXSAIR-PKTZIBPZSA-N 0.000 description 1
- SFKZPTYRENGBTJ-UHFFFAOYSA-N COc1c(cccc2)c2cc(N)c1 Chemical compound COc1c(cccc2)c2cc(N)c1 SFKZPTYRENGBTJ-UHFFFAOYSA-N 0.000 description 1
- WQIMJRWQYAICTE-KAYWLYCHSA-N COc1c(cccc2)c2cc(NC(N[C@H](CCC2)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1 Chemical compound COc1c(cccc2)c2cc(NC(N[C@H](CCC2)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)c1 WQIMJRWQYAICTE-KAYWLYCHSA-N 0.000 description 1
- IJLUGKBVJWIXED-BPAKYRGESA-N COc1cc(NC(N[C@H](CC(CO)C2)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)cc(OC)c1OC Chemical compound COc1cc(NC(N[C@H](CC(CO)C2)[C@@H]2N2CCC(Cc(cc3)ccc3Cl)CC2)=O)cc(OC)c1OC IJLUGKBVJWIXED-BPAKYRGESA-N 0.000 description 1
- VHCQWQAYVBRQQC-QWWZWVQMSA-N N[C@H](CC1)[C@@H]1N Chemical compound N[C@H](CC1)[C@@H]1N VHCQWQAYVBRQQC-QWWZWVQMSA-N 0.000 description 1
- PYNGHJRZUVXEJW-SJORKVTESA-N N[C@H](CCC1)[C@H]1N1CCC(Cc(cc2)ccc2Cl)CC1 Chemical compound N[C@H](CCC1)[C@H]1N1CCC(Cc(cc2)ccc2Cl)CC1 PYNGHJRZUVXEJW-SJORKVTESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33465301P | 2001-11-30 | 2001-11-30 | |
| US60/334,653 | 2001-11-30 | ||
| PCT/EP2002/013218 WO2003045937A1 (en) | 2001-11-30 | 2002-11-25 | N-ureido-piperidines as antagonists viii for ccr-3 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040062665A KR20040062665A (ko) | 2004-07-07 |
| KR100652450B1 true KR100652450B1 (ko) | 2007-02-28 |
Family
ID=23308166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047008357A Expired - Fee Related KR100652450B1 (ko) | 2001-11-30 | 2002-11-25 | Ｃｃｒ-3 수용체에 대한 길항제 ⅷ로서의ｎ-우레이도-피페리딘 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1453825A1 (https=) |
| JP (1) | JP2005515193A (https=) |
| KR (1) | KR100652450B1 (https=) |
| CN (1) | CN1286831C (https=) |
| AR (1) | AR037458A1 (https=) |
| AU (1) | AU2002352123A1 (https=) |
| BR (1) | BR0214613A (https=) |
| CA (1) | CA2467874A1 (https=) |
| MX (1) | MXPA04005176A (https=) |
| PL (1) | PL370821A1 (https=) |
| RU (1) | RU2004120064A (https=) |
| WO (1) | WO2003045937A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1558599A4 (en) * | 2002-10-30 | 2007-06-27 | Merck & Co Inc | HETEROARYLPIPERIDINE MODULATORS DERCHEMOKIN RECEPTORACTIVITY |
| EP1640361B9 (en) * | 2003-06-30 | 2015-11-04 | Sumitomo Chemical Company, Limited | Asymmetric urea compounds and process for producing asymmetric compounds by asymmetric conjugate addition reaction using the same as catalyst |
| WO2005058805A1 (ja) * | 2003-12-17 | 2005-06-30 | Sumitomo Chemical Company, Limited | 光学活性アミン化合物の製造方法 |
| WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006071875A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| EP2805985A1 (de) * | 2013-05-22 | 2014-11-26 | Sika Technology AG | Hydroxysilan und Silangruppen-haltiges Polymer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000035452A1 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
-
2002
- 2002-11-25 WO PCT/EP2002/013218 patent/WO2003045937A1/en not_active Ceased
- 2002-11-25 BR BR0214613-4A patent/BR0214613A/pt not_active IP Right Cessation
- 2002-11-25 RU RU2004120064/04A patent/RU2004120064A/ru not_active Application Discontinuation
- 2002-11-25 CN CNB028239784A patent/CN1286831C/zh not_active Expired - Fee Related
- 2002-11-25 EP EP02787796A patent/EP1453825A1/en not_active Withdrawn
- 2002-11-25 KR KR1020047008357A patent/KR100652450B1/ko not_active Expired - Fee Related
- 2002-11-25 PL PL02370821A patent/PL370821A1/xx not_active Application Discontinuation
- 2002-11-25 MX MXPA04005176A patent/MXPA04005176A/es active IP Right Grant
- 2002-11-25 AU AU2002352123A patent/AU2002352123A1/en not_active Abandoned
- 2002-11-25 JP JP2003547387A patent/JP2005515193A/ja active Pending
- 2002-11-25 CA CA002467874A patent/CA2467874A1/en not_active Abandoned
- 2002-11-28 AR ARP020104581A patent/AR037458A1/es not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000035452A1 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2467874A1 (en) | 2003-06-05 |
| EP1453825A1 (en) | 2004-09-08 |
| AR037458A1 (es) | 2004-11-10 |
| AU2002352123A1 (en) | 2003-06-10 |
| CN1286831C (zh) | 2006-11-29 |
| KR20040062665A (ko) | 2004-07-07 |
| CN1599733A (zh) | 2005-03-23 |
| WO2003045937A1 (en) | 2003-06-05 |
| RU2004120064A (ru) | 2006-01-10 |
| MXPA04005176A (es) | 2004-08-11 |
| PL370821A1 (en) | 2005-05-30 |
| BR0214613A (pt) | 2004-09-14 |
| JP2005515193A (ja) | 2005-05-26 |
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