JP2005513057A5 - - Google Patents
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- Publication number
- JP2005513057A5 JP2005513057A5 JP2003552237A JP2003552237A JP2005513057A5 JP 2005513057 A5 JP2005513057 A5 JP 2005513057A5 JP 2003552237 A JP2003552237 A JP 2003552237A JP 2003552237 A JP2003552237 A JP 2003552237A JP 2005513057 A5 JP2005513057 A5 JP 2005513057A5
- Authority
- JP
- Japan
- Prior art keywords
- macrosphere
- drug
- bioadhesive
- coating
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 16
- 229940079593 drug Drugs 0.000 claims 13
- 238000000576 coating method Methods 0.000 claims 10
- 239000000227 bioadhesive Substances 0.000 claims 9
- 239000011248 coating agent Substances 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 230000000069 prophylactic effect Effects 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 2
- 229960004150 aciclovir Drugs 0.000 claims 2
- 239000003096 antiparasitic agent Substances 0.000 claims 2
- 229940125687 antiparasitic agent Drugs 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000004877 mucosa Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- GCKMFJBGXUYNAG-UHFFFAOYSA-N 17alpha-methyltestosterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C)(O)C1(C)CC2 GCKMFJBGXUYNAG-UHFFFAOYSA-N 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000224526 Trichomonas Species 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000000469 anti-sperm effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003699 antiulcer agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229940027088 carafate Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- JTZPPHUZZDKEOC-RBQAPOGLSA-A chembl2367706 Chemical compound O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 JTZPPHUZZDKEOC-RBQAPOGLSA-A 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 239000002702 enteric coating Substances 0.000 claims 1
- 238000009505 enteric coating Methods 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229960004580 glibenclamide Drugs 0.000 claims 1
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 239000003688 hormone derivative Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002608 insulinlike Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 claims 1
- 229960003439 mebendazole Drugs 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960001566 methyltestosterone Drugs 0.000 claims 1
- AQCHWTWZEMGIFD-UHFFFAOYSA-N metolazone Chemical compound CC1NC2=CC(Cl)=C(S(N)(=O)=O)C=C2C(=O)N1C1=CC=CC=C1C AQCHWTWZEMGIFD-UHFFFAOYSA-N 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229940043274 prophylactic drug Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000941 radioactive substance Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34040201P | 2001-12-15 | 2001-12-15 | |
| PCT/US2002/040025 WO2003051304A2 (en) | 2001-12-15 | 2002-12-13 | Bioadhesive drug delivery system with enhanced gastric retention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513057A JP2005513057A (ja) | 2005-05-12 |
| JP2005513057A5 true JP2005513057A5 (https=) | 2006-02-02 |
Family
ID=23333208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552237A Pending JP2005513057A (ja) | 2001-12-15 | 2002-12-13 | 胃保持が増加する生体接着性薬物送達システム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050064027A1 (https=) |
| EP (1) | EP1461019A2 (https=) |
| JP (1) | JP2005513057A (https=) |
| AU (1) | AU2002363998A1 (https=) |
| CA (1) | CA2469205A1 (https=) |
| WO (1) | WO2003051304A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050201974A1 (en) * | 2003-12-09 | 2005-09-15 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| BRPI0513508B1 (pt) | 2004-07-19 | 2021-06-01 | Biocon Limited | Conjugados de insulina-oligômero, formulações e usos desses |
| US20080311191A1 (en) * | 2004-08-27 | 2008-12-18 | Avinash Nangia | Multi-Layer Tablets and Bioadhesive Dosage Forms |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| ES2540929T3 (es) * | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
| AU2006261893A1 (en) * | 2005-06-23 | 2007-01-04 | Combinatorx, Incorporated | Improved dosage forms for movement disorder treatment |
| US20070092454A1 (en) * | 2005-10-24 | 2007-04-26 | Colgate-Palmolive Company | Oral composition containing morin |
| US8119162B2 (en) | 2005-11-10 | 2012-02-21 | Colgate-Palmolive Company | Particles that disrupt or impede bacterial adhesion, related compositions and methods |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| US9125803B2 (en) * | 2005-12-30 | 2015-09-08 | Shionogi Inc. | Gastric release pulse system for drug delivery |
| WO2007086078A2 (en) * | 2006-01-30 | 2007-08-02 | Panacea Biotec Ltd. | Novel pharmaceutical compositions and process of preparation thereof |
| WO2007103286A2 (en) * | 2006-03-02 | 2007-09-13 | Spherics, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| US7909928B2 (en) * | 2006-03-24 | 2011-03-22 | The Regents Of The University Of Michigan | Reactive coatings for regioselective surface modification |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| US7947148B2 (en) * | 2006-06-01 | 2011-05-24 | The Regents Of The University Of Michigan | Dry adhesion bonding |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| AU2007338631A1 (en) * | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| US8399047B2 (en) * | 2007-03-22 | 2013-03-19 | The Regents Of The Univeristy Of Michigan | Multifunctional CVD coatings |
| WO2008124632A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
| EP2630966B1 (en) | 2007-10-12 | 2017-04-19 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| US20090105561A1 (en) * | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
| US8303573B2 (en) | 2007-10-17 | 2012-11-06 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8707964B2 (en) * | 2007-10-31 | 2014-04-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8789536B2 (en) | 2007-10-17 | 2014-07-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8808276B2 (en) * | 2007-10-23 | 2014-08-19 | The Invention Science Fund I, Llc | Adaptive dispensation in a digestive tract |
| US8333754B2 (en) * | 2007-10-31 | 2012-12-18 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8808271B2 (en) * | 2007-10-31 | 2014-08-19 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US20090163894A1 (en) * | 2007-10-31 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
| US8109920B2 (en) * | 2007-10-31 | 2012-02-07 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US20090137866A1 (en) * | 2007-11-28 | 2009-05-28 | Searete Llc, A Limited Liability Corporation Of The State Delaware | Medical or veterinary digestive tract utilization systems and methods |
| ZA200903854B (en) * | 2008-06-19 | 2011-02-23 | Univ Of The Witwatesrand Johannesburg | A gastroretentive pharmaceutical dosage form |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8673359B2 (en) * | 2010-07-08 | 2014-03-18 | Brown University | Nanoparticle compositions and methods for improved oral delivery of active agents |
| US8858959B2 (en) | 2011-07-15 | 2014-10-14 | The United States Of America, As Represented By The Secretary Of Agriculture | Gel vaccine delivery system for treating poultry |
| CA2851765C (en) | 2011-10-11 | 2017-08-15 | Ranbaxy Laboratories Limited | A gastroretentive dosage system and process of preparation thereof |
| CO7200056A1 (es) * | 2013-08-27 | 2015-02-27 | Univ Antioquia | Gelación iónica sobre sólidos |
| CN103565751A (zh) * | 2013-10-17 | 2014-02-12 | 广州帝奇医药技术有限公司 | 一种长效缓释微丸及其制备方法 |
| US10722462B2 (en) * | 2014-12-10 | 2020-07-28 | Council Of Scientific And Industrial Research | Discontinuous reverse micellar composition in cubic FD3M phase for sustained release of therapeutic drugs |
| US9617230B2 (en) | 2014-12-22 | 2017-04-11 | Farmington Pharma Development | Creatine prodrugs, compositions and methods of use thereof |
| KR102678696B1 (ko) | 2017-12-01 | 2024-06-27 | 울트라제닉스 파마수티컬 인코포레이티드 | 크레아틴 전구약물, 조성물과 이의 사용 방법 |
| MX2021011314A (es) * | 2019-03-20 | 2021-12-10 | Lyndra Therapeutics Inc | Capsulas y recubrimientos de capsulas para formas de dosificacion de residencia gastrica. |
| JP2022525482A (ja) * | 2019-03-20 | 2022-05-16 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留剤形用のコーティング |
| CN116747314A (zh) * | 2023-06-14 | 2023-09-15 | 厦门君德医药科技有限公司 | 接枝改性的胃肠道涂层聚合物及其制备方法和应用 |
| WO2025048777A1 (en) * | 2023-08-28 | 2025-03-06 | The IP Law Firm of Guy Levi, LLC | Traceable oral formulations and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4167558A (en) * | 1976-02-13 | 1979-09-11 | Hoffmann-La Roche Inc. | Novel sustained release tablet formulations |
| US4795436A (en) * | 1983-11-14 | 1989-01-03 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
| US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
| US4839416A (en) * | 1987-06-09 | 1989-06-13 | Ampad Corporation | Low tack microsphere adhesive |
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| US5200181A (en) * | 1988-01-11 | 1993-04-06 | Massachusetts Institute Of Technology | Oral bilirubin therapy |
| US4959219A (en) * | 1988-08-15 | 1990-09-25 | Fisons Corporation | Coating barriers comprising ethyl cellulose |
| US4976968A (en) * | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
| US5240963A (en) * | 1990-01-19 | 1993-08-31 | Nova Pharmaceutical Corporation | Branched polyanhydrides |
| US5403750A (en) * | 1991-03-06 | 1995-04-04 | W. R. Grace & Co.-Conn. | Biocompatible, low protein adsorption affinity matrix |
| US5192802A (en) * | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5744155A (en) * | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| US5686113A (en) * | 1995-03-21 | 1997-11-11 | Temple University Of The Commonwealth System Of Higher Education | Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses |
| US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
-
2002
- 2002-12-13 AU AU2002363998A patent/AU2002363998A1/en not_active Abandoned
- 2002-12-13 US US10/498,661 patent/US20050064027A1/en not_active Abandoned
- 2002-12-13 EP EP02798517A patent/EP1461019A2/en active Pending
- 2002-12-13 WO PCT/US2002/040025 patent/WO2003051304A2/en not_active Ceased
- 2002-12-13 JP JP2003552237A patent/JP2005513057A/ja active Pending
- 2002-12-13 CA CA002469205A patent/CA2469205A1/en not_active Abandoned
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