JP2005513024A5 - - Google Patents
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- JP2005513024A5 JP2005513024A5 JP2003545321A JP2003545321A JP2005513024A5 JP 2005513024 A5 JP2005513024 A5 JP 2005513024A5 JP 2003545321 A JP2003545321 A JP 2003545321A JP 2003545321 A JP2003545321 A JP 2003545321A JP 2005513024 A5 JP2005513024 A5 JP 2005513024A5
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- JP
- Japan
- Prior art keywords
- day
- dose
- use according
- antagonist
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 22
- 229960000890 hydrocortisone Drugs 0.000 claims 11
- 230000002093 peripheral effect Effects 0.000 claims 10
- 239000005557 antagonist Substances 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 claims 4
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 238000004448 titration Methods 0.000 claims 2
- -1 1,3-benzodioxol-5-yl Chemical group 0.000 claims 1
- 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 150000003431 steroids Chemical group 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204518 | 2001-11-23 | ||
| PCT/EP2002/012854 WO2003043640A2 (en) | 2001-11-23 | 2002-11-18 | Treatment of major depressive disorder using glucocorticoid receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513024A JP2005513024A (ja) | 2005-05-12 |
| JP2005513024A5 true JP2005513024A5 (https=) | 2006-01-05 |
Family
ID=8181289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545321A Withdrawn JP2005513024A (ja) | 2001-11-23 | 2002-11-18 | グルココルチコイド受容体アンタゴニストを用いる大うつ病性障害の治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8193172B2 (https=) |
| EP (1) | EP1453495A2 (https=) |
| JP (1) | JP2005513024A (https=) |
| AU (1) | AU2002366217A1 (https=) |
| WO (1) | WO2003043640A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8097606B2 (en) | 2003-07-23 | 2012-01-17 | Corcept Therapeutics, Inc. | Antiglucocorticoids for the treatment of catatonia |
| JP2009535430A (ja) * | 2006-05-02 | 2009-10-01 | コーセプト セラピューティクス， インコーポレイテッド | Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用 |
| CN107530435A (zh) | 2015-03-02 | 2018-01-02 | 科赛普特治疗学股份有限公司 | 使用糖皮质激素受体拮抗剂和生长抑素治疗acth分泌型肿瘤 |
| WO2016160969A1 (en) | 2015-03-30 | 2016-10-06 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
| ES2865334T3 (es) | 2015-08-13 | 2021-10-15 | Corcept Therapeutics Inc | Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH |
| CA3011728A1 (en) | 2016-01-19 | 2017-07-27 | Corcept Therapeutics, Inc. | Differential diagnosis of ectopic cushing's syndrome |
| US11702443B2 (en) * | 2016-10-04 | 2023-07-18 | Pop Test Oncology Llc | Therapeutic agents and methods |
| US11040037B2 (en) * | 2016-10-04 | 2021-06-22 | Pop Test Oncology Llc | Therapeutic agents and methods |
| AU2018289307B2 (en) | 2017-06-20 | 2024-02-01 | Corcept Therapeutics, Inc. | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814333A (en) * | 1987-07-28 | 1989-03-21 | The Trustees Of Dartmouth College | Method for treatment of hypercortisolemic, depressed patients |
| DE69500542T2 (de) | 1994-05-19 | 1998-01-02 | Akzo Nobel Nv | 11,21-Bisphenyl-19-nor-pregnan Derivate |
| IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| ATE332696T1 (de) * | 1997-10-06 | 2006-08-15 | Univ Leland Stanford Junior | Methode zur behandlung von durch glycocorticoidstörungen verursachten psychosen |
| MXPA01011018A (es) | 1999-04-30 | 2002-05-06 | Pfizer Prod Inc | Moduladores del receptor glucocorticoide. |
| US20020111337A1 (en) * | 2000-08-28 | 2002-08-15 | Fedde Kenton N. | Use of an aldosterone receptor antagonist to improve cognitive function |
| CN1820756A (zh) | 2001-03-23 | 2006-08-23 | 科塞普特治疗公司 | 使用糖皮质激素受体特效拮抗剂治疗压力症的方法 |
-
2002
- 2002-11-18 WO PCT/EP2002/012854 patent/WO2003043640A2/en not_active Ceased
- 2002-11-18 EP EP02803377A patent/EP1453495A2/en not_active Withdrawn
- 2002-11-18 US US10/496,222 patent/US8193172B2/en not_active Expired - Fee Related
- 2002-11-18 AU AU2002366217A patent/AU2002366217A1/en not_active Abandoned
- 2002-11-18 JP JP2003545321A patent/JP2005513024A/ja not_active Withdrawn
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