JP2005512991A5 - - Google Patents

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Publication number
JP2005512991A5
JP2005512991A5 JP2003541771A JP2003541771A JP2005512991A5 JP 2005512991 A5 JP2005512991 A5 JP 2005512991A5 JP 2003541771 A JP2003541771 A JP 2003541771A JP 2003541771 A JP2003541771 A JP 2003541771A JP 2005512991 A5 JP2005512991 A5 JP 2005512991A5
Authority
JP
Japan
Prior art keywords
residue
biologically active
compound
pharmaceutical composition
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003541771A
Other languages
English (en)
Other versions
JP2005512991A (ja
JP2005512991A6 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/035868 external-priority patent/WO2003039479A2/en
Publication of JP2005512991A publication Critical patent/JP2005512991A/ja
Publication of JP2005512991A6 publication Critical patent/JP2005512991A6/ja
Publication of JP2005512991A5 publication Critical patent/JP2005512991A5/ja
Pending legal-status Critical Current

Links

Claims (2)

  1. D1が生物学的活性成分の残基である請求項１に記載の化合物を含む、医薬組成物。
  2. D1およびD1'が生物学的活性成分の残基である請求項３に記載の化合物を含む、医薬組成物。
JP2003541771A 2001-11-09 2002-11-08 高分子チオール結合プロドラッグ Pending JP2005512991A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34491401P 2001-11-09 2001-11-09
US60/344,914 2001-11-09
US36732002P 2002-03-25 2002-03-25
US60/367,320 2002-03-25
PCT/US2002/035868 WO2003039479A2 (en) 2001-11-09 2002-11-08 Polymeric thiol-linked prodrugs

Publications (3)

Publication Number Publication Date
JP2005512991A JP2005512991A (ja) 2005-05-12
JP2005512991A6 JP2005512991A6 (ja) 2005-08-04
JP2005512991A5 true JP2005512991A5 (ja) 2006-01-05

Family

ID=26994161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003541771A Pending JP2005512991A (ja) 2001-11-09 2002-11-08 高分子チオール結合プロドラッグ

Country Status (9)

Country Link
US (1) US7033583B2 (ja)
EP (1) EP1450822B1 (ja)
JP (1) JP2005512991A (ja)
AT (1) ATE452654T1 (ja)
AU (1) AU2002363334A1 (ja)
CA (1) CA2465206C (ja)
DE (1) DE60234858D1 (ja)
DK (1) DK1450822T3 (ja)
WO (1) WO2003039479A2 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7262164B2 (en) * 2001-11-09 2007-08-28 Enzon, Inc. Polymeric thiol-linked prodrugs employing benzyl elimination systems
EP1807436B1 (en) * 2004-10-25 2014-06-18 Intezyne Technologies Inc. Heterobifunctional poly(ethylene glycol) and uses thereof
CA2861601A1 (en) * 2006-04-27 2007-11-08 Intezyne Technologies, Inc. Poly (ethylene glycol) containing chemically disparate endgroups
CA2695532A1 (en) * 2007-08-20 2009-02-26 Enzon Pharmaceuticals, Inc. Polymeric linkers containing pyridyl disulfide moieties
US20090092664A1 (en) * 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
EP2288261A4 (en) * 2008-05-23 2013-09-25 Enzon Pharmaceuticals Inc POLYMER SYSTEMS CONTAINING INTRA-CELLULAR RELEASE DISULFID LINKERS FOR THE DISPOSAL OF OLIGONUCLEOTIDES

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1023376A (en) * 1972-08-04 1977-12-27 Hermann O. Wirth Hydrophilic and difficultly volatile biocidal triorganometallic compounds
US5112739A (en) 1988-08-02 1992-05-12 Polaroid Corporation Enzyme controlled release system
JPH05132431A (ja) * 1990-03-28 1993-05-28 Nippon Oil & Fats Co Ltd 高分子化薬剤およびその製造法
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
JPH05194518A (ja) * 1992-01-16 1993-08-03 Tanabe Seiyaku Co Ltd ６−メルカプトプリン誘導体及びその製法
JPH05194517A (ja) * 1992-01-16 1993-08-03 Tanabe Seiyaku Co Ltd ６−メルカプトプリン誘導体及びその製法
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
AU1825299A (en) * 1997-12-17 1999-07-05 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6251382B1 (en) * 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6468522B1 (en) * 1999-07-22 2002-10-22 University Of Medicine And Dentistry Of New Jersey Controlled release of thioamide moiety-containing therapeutic agents
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
US7262164B2 (en) * 2001-11-09 2007-08-28 Enzon, Inc. Polymeric thiol-linked prodrugs employing benzyl elimination systems

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