WO2005117895A3 - Compositions comprising meloxicam - Google Patents

Compositions comprising meloxicam Download PDF

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Publication number
WO2005117895A3
WO2005117895A3 PCT/EP2005/005747 EP2005005747W WO2005117895A3 WO 2005117895 A3 WO2005117895 A3 WO 2005117895A3 EP 2005005747 W EP2005005747 W EP 2005005747W WO 2005117895 A3 WO2005117895 A3 WO 2005117895A3
Authority
WO
WIPO (PCT)
Prior art keywords
meloxicam
compositions
vitamins
pharmaceutical composition
acceptable salt
Prior art date
Application number
PCT/EP2005/005747
Other languages
French (fr)
Other versions
WO2005117895A2 (en
WO2005117895A8 (en
Inventor
Toshiaki Horie
Minoru Okada
Hiroshi Otaki
Norimitsu Umehara
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Toshiaki Horie
Minoru Okada
Hiroshi Otaki
Norimitsu Umehara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Toshiaki Horie, Minoru Okada, Hiroshi Otaki, Norimitsu Umehara filed Critical Boehringer Ingelheim Int
Priority to JP2007513820A priority Critical patent/JP2008501655A/en
Publication of WO2005117895A2 publication Critical patent/WO2005117895A2/en
Publication of WO2005117895A8 publication Critical patent/WO2005117895A8/en
Publication of WO2005117895A3 publication Critical patent/WO2005117895A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/906—Zingiberaceae (Ginger family)
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
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    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Abstract

The invention relates to a pharmaceutical composition comprising meloxicam or a pharmaceutically acceptable salt thereof and a second pharmaceutically active compound selected from the group consisting of vitamins, antiphlogistic agents and crude drugs.
PCT/EP2005/005747 2004-06-04 2005-05-28 Compositions comprising meloxicam WO2005117895A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007513820A JP2008501655A (en) 2004-06-04 2005-05-28 Meloxicam-containing composition

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP04013217.7 2004-06-04
EP04013217 2004-06-04
EP04014409 2004-06-19
EP04014410 2004-06-19
EP04014410.7 2004-06-19
EP04014409.9 2004-06-19

Publications (3)

Publication Number Publication Date
WO2005117895A2 WO2005117895A2 (en) 2005-12-15
WO2005117895A8 WO2005117895A8 (en) 2006-05-18
WO2005117895A3 true WO2005117895A3 (en) 2006-08-17

Family

ID=34969355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/005747 WO2005117895A2 (en) 2004-06-04 2005-05-28 Compositions comprising meloxicam

Country Status (2)

Country Link
JP (1) JP2008501655A (en)
WO (1) WO2005117895A2 (en)

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JP2007182400A (en) * 2006-01-06 2007-07-19 Nichi-Iko Pharmaceutical Co Ltd Meloxicam-containing tablet composition having excellent stability with time
EP1870102A1 (en) * 2006-06-15 2007-12-26 Alpex Pharma SA Solid forms containing meloxicam with improved taste and process for their preparation
JP2009007311A (en) * 2007-06-29 2009-01-15 Lintec Corp Diphenhydramine-acesulfame adduct, method for producing the same and oral preparation containing the adduct
JP5823746B2 (en) * 2010-06-30 2015-11-25 興和株式会社 Pharmaceutical composition
CN102614344B (en) * 2012-01-13 2013-12-25 李玉芹 Traditional Chinese medicine for treating qi-blood deficiency periodontitis, preparation method and administration method thereof
CN103239706B (en) * 2013-05-13 2014-11-26 肖梅芬 Earthworm protein for reducing blood glucose, improving microcirculation and eliminating diabetic complication and application thereof
CN103263660B (en) * 2013-05-13 2015-05-20 肖梅芬 Earthworm protein for reducing blood sugar and blood pressure and eliminating diabetic complications and application pf earthworm protein
CN103301247B (en) * 2013-07-09 2014-12-10 华菊 Traditional Chinese medicine composition for treating chronic nephritis and preparation method thereof
CN104491484A (en) * 2014-12-06 2015-04-08 唐云峰 Traditional Chinese medicine composition for treating kidney deficiency and liver-yang hyperactivity
CN104524170B (en) * 2014-12-26 2018-08-14 丁鸿磊 A kind of Chinese medicine and preparation method thereof for treating acute toothache
CN104491814B (en) * 2014-12-30 2017-12-19 兰州古驰生物科技有限公司 A kind of Chinese medicine preparation for being used to nurse one's health cold chilly
CN104586979A (en) * 2015-01-17 2015-05-06 塔里木大学 Cough-relieving oral liquid and preparation method thereof
CN106983801A (en) * 2017-05-31 2017-07-28 邹圣余 It is a kind of to be used to treat medicine of fracture and preparation method thereof
CN108079051A (en) * 2018-01-13 2018-05-29 上海欧润化妆品有限公司 A kind of Radix Gentianae extract and its extraction process
JP2019142860A (en) * 2018-02-23 2019-08-29 ライオン株式会社 Pharmaceutical composition and pharmaceutical preparation
JP7209537B2 (en) * 2018-02-23 2023-01-20 ライオン株式会社 Solid pharmaceutical formulation
CN108143906A (en) * 2018-02-26 2018-06-12 威海惠高生物科技有限公司 It is a kind of to hinder the Chinese medicine composition coughed and preparation method for treating phlegm

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WO1999009988A1 (en) * 1997-08-27 1999-03-04 Hexal Ag New pharmaceutical compositions of meloxicam with improved solubility and bioavailability
EP1250921A1 (en) * 2001-04-21 2002-10-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Fast disintegrating meloxicam tablet
WO2003070251A1 (en) * 2002-02-19 2003-08-28 Adcock Ingram Limited Pharmaceutical combinations of cox-2 inhibitors and opiates
WO2005016243A2 (en) * 2003-06-09 2005-02-24 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and an antioxidant agent for the treatment of central nervous system disorders

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Patent Citations (4)

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WO1999009988A1 (en) * 1997-08-27 1999-03-04 Hexal Ag New pharmaceutical compositions of meloxicam with improved solubility and bioavailability
EP1250921A1 (en) * 2001-04-21 2002-10-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Fast disintegrating meloxicam tablet
WO2003070251A1 (en) * 2002-02-19 2003-08-28 Adcock Ingram Limited Pharmaceutical combinations of cox-2 inhibitors and opiates
WO2005016243A2 (en) * 2003-06-09 2005-02-24 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and an antioxidant agent for the treatment of central nervous system disorders

Non-Patent Citations (3)

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Title
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