JP2005512569A5 - - Google Patents
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- JP2005512569A5 JP2005512569A5 JP2003554898A JP2003554898A JP2005512569A5 JP 2005512569 A5 JP2005512569 A5 JP 2005512569A5 JP 2003554898 A JP2003554898 A JP 2003554898A JP 2003554898 A JP2003554898 A JP 2003554898A JP 2005512569 A5 JP2005512569 A5 JP 2005512569A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- virion
- virions
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000002845 virion Anatomy 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 238000004806 packaging method and process Methods 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 10
- 101150044789 Cap gene Proteins 0.000 claims 9
- 238000003780 insertion Methods 0.000 claims 9
- 230000037431 insertion Effects 0.000 claims 9
- 241000700605 Viruses Species 0.000 claims 5
- 230000001413 cellular effect Effects 0.000 claims 5
- 230000003612 virological effect Effects 0.000 claims 5
- 241000125945 Protoparvovirus Species 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 101710172711 Structural protein Proteins 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 241000701931 Canine parvovirus Species 0.000 claims 2
- 108090000565 Capsid Proteins Proteins 0.000 claims 2
- 102100023321 Ceruloplasmin Human genes 0.000 claims 2
- 101001040800 Homo sapiens Integral membrane protein GPR180 Proteins 0.000 claims 2
- 102100021244 Integral membrane protein GPR180 Human genes 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000009145 protein modification Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34413101P | 2001-12-21 | 2001-12-21 | |
| US36234902P | 2002-03-07 | 2002-03-07 | |
| US40711602P | 2002-08-30 | 2002-08-30 | |
| PCT/EP2002/014750 WO2003054197A2 (en) | 2001-12-21 | 2002-12-23 | A library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005512569A JP2005512569A (ja) | 2005-05-12 |
| JP2005512569A5 true JP2005512569A5 (enExample) | 2006-03-02 |
Family
ID=27407597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554898A Pending JP2005512569A (ja) | 2001-12-21 | 2002-12-23 | 目的とする細胞指向性をもつウイルスクローンの同定に有用な修飾した構造遺伝子またはキャプシド修飾した粒子のライブラリー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050106558A1 (enExample) |
| EP (2) | EP1456383B1 (enExample) |
| JP (1) | JP2005512569A (enExample) |
| AU (2) | AU2002352261B2 (enExample) |
| CA (1) | CA2468882C (enExample) |
| ES (1) | ES2467156T3 (enExample) |
| WO (1) | WO2003054197A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| US20070172460A1 (en) * | 2003-03-19 | 2007-07-26 | Jurgen Kleinschmidt | Random peptide library displayed on aav vectors |
| EP1486567A1 (en) * | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| WO2007084773A2 (en) * | 2006-01-20 | 2007-07-26 | University Of North Carolina At Chapel Hill | Enhanced production of infectious parvovirus vectors in insect cells |
| CN101511373B (zh) * | 2006-06-19 | 2015-12-09 | 阿斯克肋匹奥生物制药公司 | 用于基因治疗的修饰的因子ⅷ和因子ⅸ基因和载体 |
| EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| EP2158211B1 (en) * | 2007-05-31 | 2016-08-10 | Medigene AG | Mutated structural protein of a parvovirus |
| EP2098536A1 (en) * | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| JP5765790B2 (ja) * | 2010-10-21 | 2015-08-19 | ドイッチェス・クレープスフォルシュングスツェントルムＤｅｕｔｓｃｈｅｓ Ｋｒｅｂｓｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ | ラットパルボウイルスｈ−１ｐｖのそのカプシドの遺伝子操作による癌細胞への再標的化 |
| DK3693025T3 (da) | 2011-04-22 | 2022-01-10 | Univ California | Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf |
| US9821043B2 (en) | 2011-09-15 | 2017-11-21 | Medigene Ag | Anti-HER2 vaccine based upon AAV derived multimeric structures |
| EP2692731A1 (en) * | 2012-07-31 | 2014-02-05 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Recombinant Adeno-Associated virus (AAV) vector particles displaying high-affinity ligands for cell-type specific gene delivery |
| EP2940131B1 (en) * | 2012-12-25 | 2019-02-20 | Takara Bio Inc. | Aav variant |
| US11136557B2 (en) | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
| ES2822551T3 (es) | 2014-03-17 | 2021-05-04 | Adverum Biotechnologies Inc | Composiciones y métodos para la expresión génica mejorada en células de los conos |
| EP3221456B1 (en) * | 2014-11-21 | 2021-09-22 | University of Florida Research Foundation, Inc. | Genome-modified recombinant adeno-associated virus vectors |
| FI3265178T3 (fi) | 2015-03-02 | 2026-08-03 | Adverum Biotechnologies Inc | Koostumuksia ja menetelmiä polynukleotidien viemiseksi intravitreaalisesti retinaalisiin tappisoluihin |
| JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | アデノ随伴ウイルス変異体及びその使用方法 |
| WO2017197355A2 (en) | 2016-05-13 | 2017-11-16 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and methods of use thereof |
| CN109640949B (zh) | 2016-07-29 | 2022-11-25 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体和其使用方法 |
| CA3034089A1 (en) * | 2016-08-18 | 2018-02-22 | The Regents Of The University Of California | Crispr-cas genome engineering via a modular aav delivery system |
| AU2017345470B2 (en) | 2016-10-19 | 2023-08-03 | Adverum Biotechnologies, Inc. | Modified AAV capsids and uses thereof |
| KR20250023600A (ko) | 2017-06-30 | 2025-02-18 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 보유한 아데노-부속 바이러스 비리온 및 이의 사용 방법 |
| MX2020001997A (es) | 2017-08-28 | 2020-07-20 | Univ California | Variantes de capside de virus adenoasociado y metodos de uso de estas. |
| DK3684423T5 (da) | 2017-09-20 | 2024-08-26 | 4D Molecular Therapeutics Inc | Adeno-associerede virusvariantcapsider og fremgangsmåder til anvendelse deraf |
| WO2019084015A1 (en) * | 2017-10-23 | 2019-05-02 | Daniel Schmidt | PROGRAMMABLE SET OF VIRUS COMPOSITES FOR ADMINISTRATION OF GENES TARGETING A RECEPTOR |
| US11766489B2 (en) | 2017-11-27 | 2023-09-26 | 4D Molecular Therapeutics, Inc. | Adeno-associated virus variant capsids and use for inhibiting angiogenesis |
| CA3097375A1 (en) * | 2018-04-27 | 2019-10-31 | Universitat Heidelberg | Modified aav capsid polypeptides for treatment of muscular diseases |
| EP3931335A2 (en) | 2019-02-25 | 2022-01-05 | Novartis AG | Compositions and methods to treat bietti crystalline dystrophy |
| US20220154210A1 (en) | 2019-02-25 | 2022-05-19 | Novartis Ag | Compositions and methods to treat bietti crystalline dystrophy |
| EP3715358A1 (en) | 2019-03-28 | 2020-09-30 | Universität zu Köln | Mutated adeno-associated virus capsid proteins, aav particle comprising the same and liver directed aav vector gene therapy |
| CN114269926A (zh) | 2019-04-26 | 2022-04-01 | 美商圣加莫治疗股份有限公司 | Aav工程化 |
| JP2022551986A (ja) * | 2019-10-16 | 2022-12-14 | ザ・ブロード・インスティテュート・インコーポレイテッド | 修飾筋肉標的化組成物 |
| CN119317718A (zh) | 2022-01-25 | 2025-01-14 | 宾夕法尼亚州大学信托人 | 用于改善心脏转导和肝脏去靶向的aav衣壳 |
| WO2025102034A1 (en) | 2023-11-10 | 2025-05-15 | The Trustees Of The University Of Pennsylvania | Gene therapy for barth syndrome |
| WO2026122921A1 (en) | 2024-12-05 | 2026-06-11 | The Trustees Of The University Of Pennsylvania | Gene therapy for barth syndrome |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6031071A (en) * | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
| WO1997038723A1 (en) * | 1996-04-16 | 1997-10-23 | Immusol Incorporated | Targeted viral vectors |
| ATE291633T1 (de) * | 1999-06-01 | 2005-04-15 | Univ Washington | Rekombinante adenovirale vektoren, die chimäre fiberproteine exprimieren, für die zellspezifische infektion und genomische integration |
| WO2002053703A2 (en) * | 2001-01-05 | 2002-07-11 | Children's Hospital, Inc. | Aav2 vectors and methods |
-
2002
- 2002-12-23 US US10/498,163 patent/US20050106558A1/en not_active Abandoned
- 2002-12-23 AU AU2002352261A patent/AU2002352261B2/en not_active Expired
- 2002-12-23 JP JP2003554898A patent/JP2005512569A/ja active Pending
- 2002-12-23 WO PCT/EP2002/014750 patent/WO2003054197A2/en not_active Ceased
- 2002-12-23 ES ES02787962.6T patent/ES2467156T3/es not_active Expired - Lifetime
- 2002-12-23 EP EP02787962.6A patent/EP1456383B1/en not_active Expired - Lifetime
- 2002-12-23 EP EP10011286A patent/EP2363487A3/en not_active Withdrawn
- 2002-12-23 CA CA2468882A patent/CA2468882C/en not_active Expired - Lifetime
-
2008
- 2008-05-07 AU AU2008202032A patent/AU2008202032B2/en not_active Expired
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