JP2005511629A - 持続作用生成物送達用組成物 - Google Patents

持続作用生成物送達用組成物 Download PDF

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Publication number
JP2005511629A
JP2005511629A JP2003545267A JP2003545267A JP2005511629A JP 2005511629 A JP2005511629 A JP 2005511629A JP 2003545267 A JP2003545267 A JP 2003545267A JP 2003545267 A JP2003545267 A JP 2003545267A JP 2005511629 A JP2005511629 A JP 2005511629A
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Japan
Prior art keywords
nanoparticles
particles
pharmaceutical composition
bioactive agent
spray
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Pending
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JP2003545267A
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English (en)
Japanese (ja)
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JP2005511629A5 (https=
Inventor
エドワーズ，デービッド，エイ．
バティッキー，リチャード，ピー．
シュミットケ，ジェニファー，エル．
ツァピス，ニコラス，ワイ．，ケイ．
ウィーツ，デービッド，エイ．
フルカック，ジェフリー，エス．
Original Assignee
アドバンスト インハレーション リサーチ，インコーポレイテッド
プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ
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Publication of JP2005511629A publication Critical patent/JP2005511629A/ja
Publication of JP2005511629A5 publication Critical patent/JP2005511629A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003545267A 2001-11-20 2002-11-20 持続作用生成物送達用組成物 Pending JP2005511629A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33170701P 2001-11-20 2001-11-20
US36566002P 2002-03-18 2002-03-18
PCT/US2002/037334 WO2003043586A2 (en) 2001-11-20 2002-11-20 Compositions for sustained action product delivery

Publications (2)

Publication Number Publication Date
JP2005511629A true JP2005511629A (ja) 2005-04-28
JP2005511629A5 JP2005511629A5 (https=) 2005-12-22

Family

ID=26987876

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003545267A Pending JP2005511629A (ja) 2001-11-20 2002-11-20 持続作用生成物送達用組成物

Country Status (6)

Country Link
US (1) US20030166509A1 (https=)
EP (1) EP1458361A4 (https=)
JP (1) JP2005511629A (https=)
AU (1) AU2002364701B8 (https=)
CA (1) CA2465779A1 (https=)
WO (1) WO2003043586A2 (https=)

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JP2007063230A (ja) * 2005-09-02 2007-03-15 Tokyo Univ Of Pharmacy & Life Science 難吸収性薬物含有複合粒子
WO2007111163A1 (ja) 2006-03-17 2007-10-04 Tokyo University Of Science Educational Foundation Administrative Organization ナノコンポジット粒子
JP2009532466A (ja) * 2006-04-04 2009-09-10 エスティーシー．ユーエヌエム 薬物送達用の膨潤性粒子
JP2009541271A (ja) * 2006-06-23 2009-11-26 テイボテク・フアーマシユーチカルズ・リミテツド Ｔｍｃ２７８の水性懸濁液
JP2011509287A (ja) * 2008-01-08 2011-03-24 オシャディ ドラッグ アドミニストレーション リミティッド タンパク質およびペプチドの治療薬の経口投与に関する方法および組成物
US8236504B2 (en) 2003-05-08 2012-08-07 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
JP2013545751A (ja) * 2010-11-12 2013-12-26 ゲッツ コンサルティング アンド プロジェクト マネジメント 修飾された免疫調節粒子
JP2018507916A (ja) * 2015-03-11 2018-03-22 ベフファル アタ エクソソーム送達技術
WO2021235425A1 (ja) * 2020-05-20 2021-11-25 株式会社リコー 脂質ナノ粒子を含有する粒子及びその製造方法

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MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
AU2002352836B2 (en) * 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
US20030236205A1 (en) * 2002-06-21 2003-12-25 Zhang David Y. Hybridization signal amplification method (HSAM) nanostructures for diagnostic and therapeutic uses
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WO2006038552A1 (ja) * 2004-10-01 2006-04-13 Eisai R & D Management Co., Ltd. 微粒子含有組成物およびその製造方法
WO2007011396A2 (en) * 2004-10-29 2007-01-25 President And Fellows Of Harvard College Particles for treatment of pulmonary infection
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EP1458361A2 (en) 2004-09-22
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