JP2005511498A5 - - Google Patents
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- JP2005511498A5 JP2005511498A5 JP2003522583A JP2003522583A JP2005511498A5 JP 2005511498 A5 JP2005511498 A5 JP 2005511498A5 JP 2003522583 A JP2003522583 A JP 2003522583A JP 2003522583 A JP2003522583 A JP 2003522583A JP 2005511498 A5 JP2005511498 A5 JP 2005511498A5
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- 150000001875 compounds Chemical class 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 230000000007 visual effect Effects 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 2
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 1
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 claims 1
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 1
- 210000001742 aqueous humor Anatomy 0.000 claims 1
- 210000003710 cerebral cortex Anatomy 0.000 claims 1
- -1 chrysamine compound Chemical class 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 claims 1
Claims (26)
- 哺乳動物においてアルツハイマー病を診断する方法であって、アミロイドタンパク質に結合する検出可能に標識された化合物に、視覚組織を接触させる段階を含み、正常な対照の結合レベルに比較した該化合物の視覚組織への結合の増加が、該哺乳動物がアルツハイマー病に罹患しているか又は発症する危険性があることを示す方法。
- 検出可能に標識された化合物が蛍光体を含む、請求項1記載の方法。
- 蛍光体が青-緑スペクトル外の光の波長を放射する、請求項2記載の方法。
- 蛍光体が520nmより大きな光の波長を放射する、請求項2記載の方法。
- 蛍光体が赤外線領域の光の波長を放射する、請求項2記載の方法。
- 蛍光体が450nm未満の光の波長を放射する、請求項2記載の方法。
- 蛍光プローブがクリサミン化合物である、請求項2記載の方法。
- 化合物がアミロイド-β(Aβ)ポリペプチドに優先的に結合する、請求項1記載の方法。
- 化合物がAβ(1-42)に優先的に結合する、請求項1記載の方法。
- 蛍光プローブが、｛(トランス、トランス),-1-ブロモ-2,5-ビス-(3-ヒドロキシカルボニル-4-ヒドロキシ)スチルベンゼン(BSB)｝である、請求項2記載の方法。
- 眼の皮質領域を画像化する段階をさらに含む、請求項1記載の方法。
- 眼の核上領域を画像化する段階をさらに含む、請求項1記載の方法。
- 眼の房水領域を画像化する段階をさらに含む、請求項1記載の方法。
- 増加が正常な対照値より少なくとも10％大きい、請求項1記載の方法。
- 増加が正常な対照値より少なくとも25％大きい、請求項1記載の方法。
- 増加が正常な対照値より少なくとも50％大きい、請求項1記載の方法。
- 増加が正常な対照値より少なくとも100％大きい、請求項1記載の方法。
- 550〜700nmの間の波長の光を放射する、検出可能に標識されたAβ結合化合物。
- テキサスレッド又はその誘導体を含む、請求項18記載の化合物。
- 化合物がアミロイド前駆体タンパク質(APP)に結合する、請求項18記載の化合物。
- 化合物がAβ1-40に結合する、請求項18記載の化合物。
- 化合物がAβ2-40に結合する、請求項18記載の化合物。
- 化合物がAβ1-42に結合する、請求項18記載の化合物。
- 化合物が酸化されたAβに結合する、請求項18記載の化合物。
- 化合物が架橋されたAβに結合する、請求項18記載の化合物。
- (a)アミロイドポリペプチドに結合する化合物に、哺乳動物の視覚組織を接触させる段階；
(b)該化合物の該視覚組織との結合レベルを定量する段階；及び
(c)該結合レベルを正常な対照の結合レベルと比較する段階
を含む、アルツハイマー病を予知する方法であって、長期にわたる結合レベルの増加が不利な予後を示す方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28712401P | 2001-04-27 | 2001-04-27 | |
| PCT/US2002/012945 WO2003018068A1 (en) | 2001-04-27 | 2002-04-25 | Ocular diagnosis of alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009167348A Division JP2009280594A (ja) | 2001-04-27 | 2009-07-16 | アルツハイマー病の視覚診断 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511498A JP2005511498A (ja) | 2005-04-28 |
| JP2005511498A5 true JP2005511498A5 (ja) | 2006-01-05 |
Family
ID=23101559
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003522583A Withdrawn JP2005511498A (ja) | 2001-04-27 | 2002-04-25 | アルツハイマー病の視覚診断 |
| JP2009167348A Pending JP2009280594A (ja) | 2001-04-27 | 2009-07-16 | アルツハイマー病の視覚診断 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009167348A Pending JP2009280594A (ja) | 2001-04-27 | 2009-07-16 | アルツハイマー病の視覚診断 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6849249B2 (ja) |
| EP (2) | EP2298361A3 (ja) |
| JP (2) | JP2005511498A (ja) |
| AT (1) | ATE500850T1 (ja) |
| AU (1) | AU2002307526B2 (ja) |
| CA (1) | CA2458961C (ja) |
| DE (1) | DE60239407D1 (ja) |
| DK (1) | DK1420830T3 (ja) |
| ES (1) | ES2363729T3 (ja) |
| NZ (2) | NZ545889A (ja) |
| PT (1) | PT1420830E (ja) |
| WO (1) | WO2003018068A1 (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1322959A1 (en) * | 2000-08-21 | 2003-07-02 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
| US7297326B2 (en) * | 2000-08-21 | 2007-11-20 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
| JP2005511498A (ja) * | 2001-04-27 | 2005-04-28 | ザ・ブリガム・アンド・ウイメンズ・ホスピタル・インコーポレイテッド | アルツハイマー病の視覚診断 |
| US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| EP1631561B1 (en) | 2003-05-07 | 2010-08-18 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| WO2005042461A1 (ja) * | 2003-10-30 | 2005-05-12 | Dojindo Laboratories | アミロイド親和性化合物 |
| EP1814876A2 (en) * | 2004-07-15 | 2007-08-08 | The General Hospital Corporation | Heterocyclic dye compounds for in vivo imaging and diagnosis of alzheimer's disease |
| US7384146B2 (en) * | 2005-06-28 | 2008-06-10 | Carestream Health, Inc. | Health care kiosk having automated diagnostic eye examination and a fulfillment remedy based thereon |
| US7955418B2 (en) | 2005-09-12 | 2011-06-07 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same |
| US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
| WO2007033180A1 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds |
| EP2324838A1 (en) | 2005-09-12 | 2011-05-25 | Abela Pharmaceuticals, Inc. | Compositions Comprising Dimethyl Sulfoxide (DMSO) |
| JP2007127592A (ja) * | 2005-11-07 | 2007-05-24 | Tohoku Univ | アミロイド蓄積性疾患の新規診断用装置およびその操作方法 |
| EP2382915B1 (en) | 2006-04-11 | 2020-06-24 | Cognoptix, Inc. | Ocular imaging |
| CA2688811A1 (en) * | 2007-05-21 | 2008-11-27 | Neuroptix Corporation | Ophthalmic formulations of amyloid-beta contrast agents and methods of use thereof |
| MX2010010402A (es) * | 2008-03-27 | 2010-12-17 | Neuroptix Corp | Formacion de imagenes oculares. |
| US20090287064A1 (en) * | 2008-05-15 | 2009-11-19 | Medical Interactive Education, Llc | Computer implemented cognitive self test |
| US9839699B2 (en) | 2008-09-18 | 2017-12-12 | Yeda Research And Development Co., Ltd. | Optical method for detecting Alzheimer's disease by systemic administration of curcumin |
| BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
| US20120094308A1 (en) | 2009-07-23 | 2012-04-19 | Universidad Complutense De Madrid | Kit and method for the premortem in vitro detection of alzheimer's disease |
| US9855212B2 (en) | 2009-10-30 | 2018-01-02 | Abela Pharmaceuticals, Inc. | Dimethyl sulfoxide (DMSO) or DMSO and methylsulfonylmethane (MSM) formulations to treat infectious diseases |
| JP5863797B2 (ja) | 2010-08-16 | 2016-02-17 | コグノプティックス， インコーポレイテッド | アミロイドタンパク質を検出するためのデバイス |
| EP3922270A1 (en) | 2011-12-09 | 2021-12-15 | Regents of the University of Minnesota | Hyperspectral imaging for early detection of alzheimer's disease |
| MX2017009450A (es) * | 2015-01-20 | 2018-01-18 | Veloce Biopharma Llc | Composicion yodofora novedosa y metodos de uso. |
| CN113520301A (zh) | 2016-03-10 | 2021-10-22 | 明尼苏达大学董事会 | 空间-光谱成像方法和视网膜成像设备 |
| JP7404253B2 (ja) | 2017-11-27 | 2023-12-25 | レティスペック インコーポレイテッド | アルツハイマー病の病状のためのハイパースペクトル画像誘導ラマン眼球撮像装置 |
| CN113527347B (zh) * | 2021-07-15 | 2023-12-08 | 淮阴工学院 | 近红外荧光标记脂肪酸及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171846A (en) * | 1990-05-21 | 1992-12-15 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use |
| US5595883A (en) * | 1990-06-01 | 1997-01-21 | E. R. Squibb & Sons, Inc. | Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid |
| US6198532B1 (en) | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
| US5434050A (en) | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
| PT101290B (pt) | 1993-06-18 | 2000-10-31 | Fernandes Jose Guilherme Da Cu | Fluorometro para medicao da concentracao de fluoroforos de localizacao ocular |
| US6417178B1 (en) * | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
| US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| WO1997026919A2 (en) * | 1996-01-24 | 1997-07-31 | Warner-Lambert Company | Method of imaging amyloid deposits |
| US6054114A (en) * | 1996-05-08 | 2000-04-25 | Massachusetts Institute Of Technology | Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro |
| DE19649971A1 (de) * | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| EP1003539A4 (en) * | 1997-08-14 | 2002-09-11 | Univ California | AMYLOID beta-FLUORESCENT PEPTIDES AND USE THEREOF |
| US6245572B1 (en) * | 1998-05-01 | 2001-06-12 | University Of Tennessee Research Corporation | Flow cytometric characterization of amyloid fibrils |
| US6399314B1 (en) * | 1999-12-29 | 2002-06-04 | American Cyanamid Company | Methods of detection of amyloidogenic proteins |
| US7297326B2 (en) * | 2000-08-21 | 2007-11-20 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
| EP1322959A1 (en) * | 2000-08-21 | 2003-07-02 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
| WO2002028441A2 (en) * | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| JP2005511498A (ja) * | 2001-04-27 | 2005-04-28 | ザ・ブリガム・アンド・ウイメンズ・ホスピタル・インコーポレイテッド | アルツハイマー病の視覚診断 |
-
2002
- 2002-04-25 JP JP2003522583A patent/JP2005511498A/ja not_active Withdrawn
- 2002-04-25 AU AU2002307526A patent/AU2002307526B2/en not_active Ceased
- 2002-04-25 AT AT02796368T patent/ATE500850T1/de active
- 2002-04-25 DK DK02796368.5T patent/DK1420830T3/da active
- 2002-04-25 PT PT02796368T patent/PT1420830E/pt unknown
- 2002-04-25 EP EP11000050A patent/EP2298361A3/en not_active Withdrawn
- 2002-04-25 WO PCT/US2002/012945 patent/WO2003018068A1/en active Application Filing
- 2002-04-25 DE DE60239407T patent/DE60239407D1/de not_active Expired - Lifetime
- 2002-04-25 US US10/132,779 patent/US6849249B2/en not_active Expired - Lifetime
- 2002-04-25 NZ NZ545889A patent/NZ545889A/en not_active IP Right Cessation
- 2002-04-25 ES ES02796368T patent/ES2363729T3/es not_active Expired - Lifetime
- 2002-04-25 CA CA002458961A patent/CA2458961C/en not_active Expired - Lifetime
- 2002-04-25 EP EP02796368A patent/EP1420830B1/en not_active Expired - Lifetime
- 2002-04-25 NZ NZ531337A patent/NZ531337A/en not_active IP Right Cessation
-
2004
- 2004-12-15 US US11/012,937 patent/US20050095653A1/en not_active Abandoned
-
2009
- 2009-07-16 JP JP2009167348A patent/JP2009280594A/ja active Pending
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