DE60239407D1 - Okulare diagnose der alzheimer-krankheit - Google Patents

Okulare diagnose der alzheimer-krankheit

Info

Publication number
DE60239407D1
DE60239407D1 DE60239407T DE60239407T DE60239407D1 DE 60239407 D1 DE60239407 D1 DE 60239407D1 DE 60239407 T DE60239407 T DE 60239407T DE 60239407 T DE60239407 T DE 60239407T DE 60239407 D1 DE60239407 D1 DE 60239407D1
Authority
DE
Germany
Prior art keywords
okular
diagnosis
alzheimer disease
disease
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60239407T
Other languages
English (en)
Inventor
Lee E Goldstein
Leo T Chylack Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
General Hospital Corp
Original Assignee
Brigham and Womens Hospital Inc
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc, General Hospital Corp filed Critical Brigham and Womens Hospital Inc
Application granted granted Critical
Publication of DE60239407D1 publication Critical patent/DE60239407D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
DE60239407T 2001-04-27 2002-04-25 Okulare diagnose der alzheimer-krankheit Expired - Lifetime DE60239407D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28712401P 2001-04-27 2001-04-27
PCT/US2002/012945 WO2003018068A1 (en) 2001-04-27 2002-04-25 Ocular diagnosis of alzheimer's disease

Publications (1)

Publication Number Publication Date
DE60239407D1 true DE60239407D1 (de) 2011-04-21

Family

ID=23101559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60239407T Expired - Lifetime DE60239407D1 (de) 2001-04-27 2002-04-25 Okulare diagnose der alzheimer-krankheit

Country Status (12)

Country Link
US (2) US6849249B2 (de)
EP (2) EP1420830B1 (de)
JP (2) JP2005511498A (de)
AT (1) ATE500850T1 (de)
AU (1) AU2002307526B2 (de)
CA (1) CA2458961C (de)
DE (1) DE60239407D1 (de)
DK (1) DK1420830T3 (de)
ES (1) ES2363729T3 (de)
NZ (2) NZ531337A (de)
PT (1) PT1420830E (de)
WO (1) WO2003018068A1 (de)

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* Cited by examiner, † Cited by third party
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US7297326B2 (en) * 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
EP2151187A1 (de) * 2000-08-21 2010-02-10 The General Hospital Corporation Verfahren zur Diagnose eines neurodegenerativen Leidens
CA2458961C (en) * 2001-04-27 2008-07-08 The General Hospital Corporation Ocular diagnosis of alzheimer's disease
WO2004100998A2 (en) 2003-05-07 2004-11-25 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
JP3877754B2 (ja) * 2003-10-30 2007-02-07 株式会社同仁化学研究所 アミロイド親和性化合物
EP1814876A2 (de) * 2004-07-15 2007-08-08 The General Hospital Corporation Heterozyklische farbstoffverbindungen für in-vivo-bilderzeugung und diagnose von alzheimer-krankheit
US7384146B2 (en) * 2005-06-28 2008-06-10 Carestream Health, Inc. Health care kiosk having automated diagnostic eye examination and a fulfillment remedy based thereon
WO2007033083A2 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (dmso) or related compounds, or odors associated with same
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
EP1937286B1 (de) 2005-09-12 2016-03-09 Abela Pharmaceuticals, Inc. Zusammensetzungen aus dimethylsulfoxid (dmso)
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
JP2007127592A (ja) * 2005-11-07 2007-05-24 Tohoku Univ アミロイド蓄積性疾患の新規診断用装置およびその操作方法
US7828436B2 (en) 2006-04-11 2010-11-09 Neuroptix Corporation Ocular imaging
US20090041666A1 (en) * 2007-05-21 2009-02-12 Goldstein Lee E Ophthalmic formulations of Amyloid-beta contrast agent and methods of use thereof
ES2584512T3 (es) * 2008-03-27 2016-09-28 Cognoptix, Inc. Imágenes oculares para el diagnóstico de enfermedades neurodegenerativas
US20090287064A1 (en) * 2008-05-15 2009-11-19 Medical Interactive Education, Llc Computer implemented cognitive self test
EP2323696B1 (de) 2008-09-18 2018-09-05 Cedars-Sinai Medical Center Optisches verfahren zur erkennung der alzheimer-krankheit
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
US20120094308A1 (en) 2009-07-23 2012-04-19 Universidad Complutense De Madrid Kit and method for the premortem in vitro detection of alzheimer's disease
US9855212B2 (en) 2009-10-30 2018-01-02 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) or DMSO and methylsulfonylmethane (MSM) formulations to treat infectious diseases
US9220403B2 (en) 2010-08-16 2015-12-29 Cognoptix, Inc. System and method for detecting amyloid proteins
EP2788034B1 (de) 2011-12-09 2021-05-26 Regents of the University of Minnesota Hyperspektralen bildgebung zur früherkennung von morbus alzheimer
EP3247365A4 (de) * 2015-01-20 2018-08-01 Veloce BioPharma LLC Neuartige jodophorzusammensetzung und verfahren zur verwendung
CN113520301A (zh) 2016-03-10 2021-10-22 明尼苏达大学董事会 空间-光谱成像方法和视网膜成像设备
CA3082936A1 (en) 2017-11-27 2019-05-31 Retispec Inc. Hyperspectral image-guided raman ocular imager for alzheimer's disease pathologies
CN113527347B (zh) * 2021-07-15 2023-12-08 淮阴工学院 近红外荧光标记脂肪酸及其制备方法

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Publication number Priority date Publication date Assignee Title
US5171846A (en) * 1990-05-21 1992-12-15 Coulter Corporation Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use
US5595883A (en) * 1990-06-01 1997-01-21 E. R. Squibb & Sons, Inc. Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid
US6198532B1 (en) 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5434050A (en) 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
PT101290B (pt) 1993-06-18 2000-10-31 Fernandes Jose Guilherme Da Cu Fluorometro para medicao da concentracao de fluoroforos de localizacao ocular
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6417178B1 (en) * 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
WO1997026919A2 (en) * 1996-01-24 1997-07-31 Warner-Lambert Company Method of imaging amyloid deposits
WO1997041856A1 (en) * 1996-05-08 1997-11-13 Massachusetts Institute Of Technology ORGANOMETALLIC LIGANDS FOR THE LOCALIZATION AND QUANTIFICATION OF AMYLOID IN VIVO AND $i(IN VITRO)
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
CA2301142A1 (en) * 1997-08-14 1999-02-25 The Regents Of The University Of California Fluorescent amyloid a.beta. peptides and uses thereof
US6245572B1 (en) 1998-05-01 2001-06-12 University Of Tennessee Research Corporation Flow cytometric characterization of amyloid fibrils
US6399314B1 (en) * 1999-12-29 2002-06-04 American Cyanamid Company Methods of detection of amyloidogenic proteins
US7297326B2 (en) * 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
EP2151187A1 (de) * 2000-08-21 2010-02-10 The General Hospital Corporation Verfahren zur Diagnose eines neurodegenerativen Leidens
US7029655B2 (en) * 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
CA2458961C (en) * 2001-04-27 2008-07-08 The General Hospital Corporation Ocular diagnosis of alzheimer's disease

Also Published As

Publication number Publication date
AU2002307526B2 (en) 2006-08-24
EP1420830A1 (de) 2004-05-26
EP2298361A2 (de) 2011-03-23
ATE500850T1 (de) 2011-03-15
EP1420830A4 (de) 2008-12-31
WO2003018068A1 (en) 2003-03-06
PT1420830E (pt) 2011-04-20
ES2363729T3 (es) 2011-08-12
NZ545889A (en) 2006-06-30
CA2458961C (en) 2008-07-08
JP2005511498A (ja) 2005-04-28
US20050095653A1 (en) 2005-05-05
CA2458961A1 (en) 2003-03-06
NZ531337A (en) 2006-05-26
EP1420830B1 (de) 2011-03-09
US20020182152A1 (en) 2002-12-05
US6849249B2 (en) 2005-02-01
JP2009280594A (ja) 2009-12-03
DK1420830T3 (da) 2011-05-09
EP2298361A3 (de) 2011-05-04

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