JP2005509674A5 - - Google Patents
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- Publication number
- JP2005509674A5 JP2005509674A5 JP2003545617A JP2003545617A JP2005509674A5 JP 2005509674 A5 JP2005509674 A5 JP 2005509674A5 JP 2003545617 A JP2003545617 A JP 2003545617A JP 2003545617 A JP2003545617 A JP 2003545617A JP 2005509674 A5 JP2005509674 A5 JP 2005509674A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- phenyl
- group
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- -1 hydroxy, phenyl Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 239000002462 tachykinin receptor antagonist Substances 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 239000003185 4 aminobutyric acid B receptor stimulating agent Substances 0.000 claims 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 claims 1
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims 1
- 239000000808 adrenergic beta-agonist Substances 0.000 claims 1
- 230000000954 anitussive effect Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 claims 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 230000003419 expectorant effect Effects 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 1
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 claims 1
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33228401P | 2001-11-16 | 2001-11-16 | |
| PCT/US2002/036402 WO2003043980A1 (en) | 2001-11-16 | 2002-11-14 | Azetidinyl diamines useful as ligands of the nociceptin receptor orl-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005509674A JP2005509674A (ja) | 2005-04-14 |
| JP2005509674A5 true JP2005509674A5 (https=) | 2006-01-05 |
Family
ID=23297560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545617A Pending JP2005509674A (ja) | 2001-11-16 | 2002-11-14 | ノシセプチンレセプターｏｒｌ−１の配位子として有用なアゼチジニルジアミン |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20030195185A1 (https=) |
| EP (1) | EP1444200B1 (https=) |
| JP (1) | JP2005509674A (https=) |
| CN (1) | CN1585747A (https=) |
| AR (1) | AR037364A1 (https=) |
| AT (1) | ATE325092T1 (https=) |
| AU (1) | AU2002340476A1 (https=) |
| CA (1) | CA2466728C (https=) |
| DE (1) | DE60211198T2 (https=) |
| ES (1) | ES2259106T3 (https=) |
| MX (1) | MXPA04004676A (https=) |
| TW (1) | TW200300757A (https=) |
| WO (1) | WO2003043980A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008179541A (ja) * | 2005-05-02 | 2008-08-07 | Mochida Pharmaceut Co Ltd | 神経因性疼痛治療薬 |
| PE20071159A1 (es) * | 2005-10-31 | 2007-11-30 | Schering Corp | Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina |
| NZ573129A (en) * | 2006-06-28 | 2011-06-30 | Amgen Inc | Piperazine acetic acid glycine transporter-1 inhibitors |
| WO2008139287A1 (en) | 2007-05-10 | 2008-11-20 | Pfizer Limited | Azetidine derivatives and their use as prostaglandin e2 antagonists |
| US8455476B2 (en) * | 2009-04-22 | 2013-06-04 | Janssen Pharmaceutica, Nv | Azetidinyl diamides as monoacylglycerol lipase inhibitors |
| AU2012324015A1 (en) | 2011-12-01 | 2013-06-20 | Purdue Pharma L.P. | Azetidine-substituted quinoxaline-type piperidine compounds and uses thererof |
| CN105949103A (zh) * | 2016-07-11 | 2016-09-21 | 上海应用技术学院 | 一种1-二苯甲基-3-甲基氮杂环丁烷盐酸盐的合成工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052383A (en) * | 1974-10-30 | 1977-10-04 | Schering Corporation | N-diphenylalkyl-2-benzyl azacyclic compounds |
| US4196124A (en) * | 1974-10-30 | 1980-04-01 | Schering Corporation | 1-Benzhydryl-2-benzimidoyl-azetidine |
| TW449590B (en) * | 1995-04-14 | 2001-08-11 | Boehringer Ingelheim Kg | New arylglycinamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds |
| DE19519245C2 (de) * | 1995-04-14 | 2003-04-30 | Boehringer Ingelheim Kg | Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
-
2002
- 2002-11-13 TW TW091133259A patent/TW200300757A/zh unknown
- 2002-11-13 AR ARP020104356A patent/AR037364A1/es unknown
- 2002-11-14 ES ES02778840T patent/ES2259106T3/es not_active Expired - Lifetime
- 2002-11-14 EP EP02778840A patent/EP1444200B1/en not_active Expired - Lifetime
- 2002-11-14 CN CNA028226712A patent/CN1585747A/zh active Pending
- 2002-11-14 MX MXPA04004676A patent/MXPA04004676A/es unknown
- 2002-11-14 CA CA002466728A patent/CA2466728C/en not_active Expired - Fee Related
- 2002-11-14 DE DE60211198T patent/DE60211198T2/de not_active Expired - Fee Related
- 2002-11-14 US US10/294,814 patent/US20030195185A1/en not_active Abandoned
- 2002-11-14 AU AU2002340476A patent/AU2002340476A1/en not_active Abandoned
- 2002-11-14 JP JP2003545617A patent/JP2005509674A/ja active Pending
- 2002-11-14 AT AT02778840T patent/ATE325092T1/de not_active IP Right Cessation
- 2002-11-14 WO PCT/US2002/036402 patent/WO2003043980A1/en not_active Ceased
-
2004
- 2004-02-03 US US10/770,758 patent/US6903123B2/en not_active Expired - Fee Related
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