JP2005509597A5 - - Google Patents
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- JP2005509597A5 JP2005509597A5 JP2003519439A JP2003519439A JP2005509597A5 JP 2005509597 A5 JP2005509597 A5 JP 2005509597A5 JP 2003519439 A JP2003519439 A JP 2003519439A JP 2003519439 A JP2003519439 A JP 2003519439A JP 2005509597 A5 JP2005509597 A5 JP 2005509597A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- 1racp
- composition according
- receptor
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 102000044594 Interleukin-1 Receptor Accessory Human genes 0.000 claims 7
- 101710180389 Interleukin-1 receptor accessory protein Proteins 0.000 claims 7
- 102000019223 Interleukin-1 receptor Human genes 0.000 claims 6
- 108050006617 Interleukin-1 receptor Proteins 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 3
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 2
- -1 IFNγ Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108090001007 Interleukin-8 Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 239000011280 coal tar Substances 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229960001330 hydroxycarbamide Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 1
- 229960001940 sulfasalazine Drugs 0.000 claims 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
- 235000005282 vitamin D3 Nutrition 0.000 claims 1
- 239000011647 vitamin D3 Substances 0.000 claims 1
- 229940021056 vitamin d3 Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31078901P | 2001-08-07 | 2001-08-07 | |
| PCT/US2002/024948 WO2003014309A2 (en) | 2001-08-07 | 2002-08-07 | Interleukin-1 receptors in the treatment of diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005509597A JP2005509597A (ja) | 2005-04-14 |
| JP2005509597A5 true JP2005509597A5 (enExample) | 2006-01-05 |
Family
ID=23204113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003519439A Pending JP2005509597A (ja) | 2001-08-07 | 2002-08-07 | 疾患の治療におけるインターロイキン−１受容体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030049255A1 (enExample) |
| EP (1) | EP1450837A4 (enExample) |
| JP (1) | JP2005509597A (enExample) |
| AU (1) | AU2002324625B2 (enExample) |
| CA (1) | CA2456762A1 (enExample) |
| MX (1) | MXPA04001187A (enExample) |
| PL (1) | PL374118A1 (enExample) |
| WO (1) | WO2003014309A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2292242T5 (es) * | 1998-05-15 | 2011-05-04 | Genentech, Inc. | Utilizaciones terapéuticas de polipéptidos homólogos de il-17. |
| US7771719B1 (en) * | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
| US20040043397A1 (en) * | 2000-01-11 | 2004-03-04 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US20030203451A1 (en) * | 2000-08-24 | 2003-10-30 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US20090035261A1 (en) * | 2000-03-21 | 2009-02-05 | Jian Chen | IL-17 homologous polypeptides and therapeutic uses thereof |
| US20030180255A1 (en) * | 2000-08-24 | 2003-09-25 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US7718397B2 (en) * | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
| US20030096969A1 (en) * | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| DK1641822T3 (da) | 2003-07-08 | 2013-07-22 | Genentech Inc | Heterologe il-17-a/f-polypeptider og terapeutiske anvendelser deraf. |
| EP1684803B1 (en) * | 2003-11-14 | 2010-07-07 | UCL Business PLC | Immune modulator comprising whole cell tsukamurella bacteria |
| EP1983000B1 (en) | 2003-11-21 | 2015-09-02 | UCB Biopharma SPRL | Method for the treatment of multiple sclerosis by inhibiting IL-17 activity |
| US8618054B2 (en) | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| EP1751175B1 (en) * | 2004-05-05 | 2012-07-25 | VALORISATION-RECHERCHE, Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| AU2006230419A1 (en) * | 2005-03-31 | 2006-10-05 | Targeted Genetics Corporation | Methods for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders |
| AU2006264567A1 (en) * | 2005-05-05 | 2007-01-11 | Valorisation Hsj, Societe En Commandite | Cytokine receptor modulators and uses thereof |
| CA2963828A1 (en) * | 2005-10-26 | 2007-05-03 | Novartis Ag | Novel use of il-1beta compounds |
| US7504106B2 (en) * | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| JP2009183176A (ja) * | 2008-02-05 | 2009-08-20 | Univ Of Tokyo | Ｉｌ−１タイプｉｉレセプター遺伝子の欠損変異体マウス |
| BRPI0908312A2 (pt) | 2008-05-05 | 2015-08-18 | Novimmune Sa | '' anticorpo monoclonal totalmente humano isolado, composição farmacêutica, método de alívio de um sintoma de uma indicação clínica e método de alívio de um sintoma de uma doença autoimune, distúrbio inflamatório ou distúrbio da proliferação celular'' |
| KR20110028457A (ko) * | 2008-05-21 | 2011-03-18 | 뉴로테즈 인코포레이티드 | 신경섬유 매듭과 연관된 신경변성 장애를 치료하는 방법 |
| EP2427203B1 (en) | 2009-05-05 | 2018-10-17 | Novimmune S.A. | Anti-il-17f antibodies and use thereof |
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| CN102946904A (zh) | 2010-06-18 | 2013-02-27 | 埃克斯生物科技公司 | 关节炎治疗 |
| JP5940093B2 (ja) | 2011-01-19 | 2016-06-29 | カンタージア アクチエボラーグ | 抗ｉｌ−１ｒａｐ抗体及びヒトを処置するためのそれらの使用 |
| US9724409B2 (en) * | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| US10703799B2 (en) | 2012-12-10 | 2020-07-07 | Vib Vzw | IL-33R and IL-1RAcP fusion proteins |
| CN108026172B (zh) | 2015-06-26 | 2022-04-29 | 赛诺菲生物技术公司 | 单克隆抗il-1racp抗体 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| WO2018231827A1 (en) | 2017-06-12 | 2018-12-20 | Bluefin Biomedicine, Inc. | Anti-il1rap antibodies and antibody drug conjugates |
| US11633425B2 (en) | 2021-05-13 | 2023-04-25 | Ahava—Dead Sea Laboratories Ltd. | Anti-glycation compositions |
| US12054552B2 (en) | 2022-09-21 | 2024-08-06 | Sanofi Biotechnology | Humanized anti-IL-1R3 antibody and methods of use |
| WO2026006472A2 (en) | 2024-06-25 | 2026-01-02 | Kiniksa Pharmaceuticals, Gmbh | Compositions of il-1r1 antibodies and methods of producing and using the same |
| WO2026003765A1 (en) | 2024-06-25 | 2026-01-02 | Kiniksa Pharmaceuticals, Gmbh | Formulations of anti-interleukin 1 receptor 1 antibodies |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004838A1 (en) * | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| US5350683A (en) * | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| WO1991018982A1 (en) * | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| DE69333027T2 (de) * | 1992-03-30 | 2004-05-06 | Immunex Corp., Seattle | Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält |
| PE64396A1 (es) * | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| NZ322197A (en) * | 1995-11-21 | 1999-02-25 | Yamanouchi Pharma Co Ltd | Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof |
| US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| HUP0002842A3 (en) * | 1997-04-24 | 2002-01-28 | Ortho Mcneil Pharm Inc | Substituted imidazoles, process for producing them, pharmaceutical compositions containing them, their use and their intermediates |
| EP1282435A2 (en) * | 2000-05-12 | 2003-02-12 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
| US7049095B2 (en) * | 2000-10-31 | 2006-05-23 | Immunex Corporation | DNA encoding IL-1 receptor accessory protein |
-
2002
- 2002-08-07 US US10/215,211 patent/US20030049255A1/en not_active Abandoned
- 2002-08-07 WO PCT/US2002/024948 patent/WO2003014309A2/en not_active Ceased
- 2002-08-07 CA CA002456762A patent/CA2456762A1/en not_active Abandoned
- 2002-08-07 AU AU2002324625A patent/AU2002324625B2/en not_active Ceased
- 2002-08-07 EP EP02759279A patent/EP1450837A4/en not_active Withdrawn
- 2002-08-07 MX MXPA04001187A patent/MXPA04001187A/es not_active Application Discontinuation
- 2002-08-07 PL PL02374118A patent/PL374118A1/xx not_active Application Discontinuation
- 2002-08-07 JP JP2003519439A patent/JP2005509597A/ja active Pending
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